| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127328 |
| FAM13A | family with sequence similarity 13, member A | 0.11083 |
| ENO1 | enolase 1, (alpha) | 0.0832476 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0816934 |
| DST | dystonin | 0.0771565 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0724495 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0714416 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0708034 |
| AHNAK | AHNAK nucleoprotein | 0.0679899 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0597415 |
| PCBP2 | poly(rC) binding protein 2 | 0.0579045 |
| POTEF | POTE ankyrin domain family, member F | 0.0569697 |
| PTMA | prothymosin, alpha | 0.0532752 |
| RPL3 | ribosomal protein L3 | 0.0486634 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0480628 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0478074 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0470823 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0465072 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.044909 |
| B2M | beta-2-microglobulin | 0.0448064 |
| RPS12 | ribosomal protein S12 | 0.0437302 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0435345 |
| MCL1 | myeloid cell leukemia 1 | 0.0426565 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0425165 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0415381 |
| NBAS | neuroblastoma amplified sequence | 0.0415283 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.041348 |
| RNF145 | ring finger protein 145 | 0.0401584 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0395969 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.039323 |
| YBX1 | Y box binding protein 1 | 0.0384294 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0377954 |
| FMNL2 | formin-like 2 | 0.0374286 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0367623 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0367308 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0365499 |
| COPA | coatomer protein complex, subunit alpha | 0.0359045 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0358089 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0356194 |
| TPM3 | tropomyosin 3 | 0.0350637 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0344131 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0331042 |
| VIM | vimentin | 0.0324801 |
| COG6 | component of oligomeric golgi complex 6 | 0.0320931 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0313046 |
| GOLGA4 | golgin A4 | 0.0297211 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0295852 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0294067 |
| CALR | calreticulin | 0.0287689 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0285035 |
| ACTG1 | actin gamma 1 | 0.0284359 |
| VEGFA | vascular endothelial growth factor A | 0.0282507 |
| MYO10 | myosin X | 0.0278242 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.027197 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0271937 |
| MMP12 | matrix metallopeptidase 12 | 0.0269023 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0266861 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0266636 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0264331 |
| TNS1 | tensin 1 | 0.0262269 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0260291 |
| MSN | moesin | 0.025894 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0258682 |
| CALD1 | caldesmon 1 | 0.0258508 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0258039 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0256754 |
| ASPH | aspartate beta-hydroxylase | 0.0251794 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0249344 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0247877 |
| RPS3 | ribosomal protein S3 | 0.0247105 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.024298 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0242908 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0239977 |
| PRRC2C | proline-rich coiled-coil 2C | 0.02394 |
| RPL23 | ribosomal protein L23 | 0.023857 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0237465 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0234221 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0233834 |
| MYOF | myoferlin | 0.0230858 |
| GOLGB1 | golgin B1 | 0.023062 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0229267 |
| TMF1 | TATA element modulatory factor 1 | 0.0228211 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0227449 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0223895 |
| APP | amyloid beta (A4) precursor protein | 0.0219273 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0219132 |
| NGLY1 | N-glycanase 1 | 0.0218606 |
| RPL4 | ribosomal protein L4 | 0.0218372 |
| ARF6 | ADP-ribosylation factor 6 | 0.0217665 |
| PLIN2 | perilipin 2 | 0.0216699 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.021612 |
| TLN1 | talin 1 | 0.0215725 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0215024 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0213235 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0212404 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0210105 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0207718 |
| DIAPH1 | diaphanous-related formin 1 | 0.0207366 |
| FAM120A | family with sequence similarity 120A | 0.0204844 |
| KIF5B | kinesin family member 5B | 0.0204565 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.430985 |
| FN1 | fibronectin 1 | -0.264602 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.105293 |
| EMP1 | epithelial membrane protein 1 | -0.0951656 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0907475 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0767978 |
| INHBA | inhibin, beta A | -0.0744324 |
| STC1 | stanniocalcin 1 | -0.0699693 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0631892 |
| COL1A1 | collagen, type I, alpha 1 | -0.060795 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0607569 |
| COL6A1 | collagen, type VI, alpha 1 | -0.060427 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0604088 |
| CD44 | CD44 molecule (Indian blood group) | -0.0584064 |
| TMSB10 | thymosin beta 10 | -0.0579427 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0576903 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0537001 |
| HLA-B | major histocompatibility complex, class I, B | -0.0532795 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0526548 |
| OSMR | oncostatin M receptor | -0.0509892 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.049992 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0456306 |
| CAVIN1 | caveolae associated protein 1 | -0.0428186 |
| VCL | vinculin | -0.0401719 |
| RPL35A | ribosomal protein L35a | -0.0391859 |
| LOX | lysyl oxidase | -0.0389365 |
| IER3 | immediate early response 3 | -0.0383964 |
| RPS6 | ribosomal protein S6 | -0.0343224 |
| H1-0 | H1.0 linker histone | -0.0326183 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0325056 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0321333 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0319719 |
| LMAN1 | lectin, mannose-binding, 1 | -0.030861 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0300478 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0299323 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0294351 |
| CCND1 | cyclin D1 | -0.0290939 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0284556 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0282765 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0279202 |
| SLC38A2 | solute carrier family 38, member 2 | -0.02743 |
| RPL34 | ribosomal protein L34 | -0.027362 |
| ARF1 | ADP-ribosylation factor 1 | -0.0262407 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.025371 |
| HDLBP | high density lipoprotein binding protein | -0.0252941 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0251719 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0245267 |
| HLA-E | major histocompatibility complex, class I, E | -0.0243785 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0240325 |
| MYADM | myeloid-associated differentiation marker | -0.0240024 |
| RAI14 | retinoic acid induced 14 | -0.0237665 |
| EHD2 | EH-domain containing 2 | -0.023663 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0236096 |
| GANAB | glucosidase, alpha; neutral AB | -0.0233646 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0233165 |
| MMP1 | matrix metallopeptidase 1 | -0.0231697 |
| PLPP3 | phospholipid phosphatase 3 | -0.0226461 |
| HM13 | histocompatibility (minor) 13 | -0.0225925 |
| EGR1 | early growth response 1 | -0.0223836 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0223389 |
| RRBP1 | ribosome binding protein 1 | -0.0219906 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0218956 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0215242 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0213146 |
| PFN1 | profilin 1 | -0.0208594 |
| UBC | ubiquitin C | -0.0207786 |
| RPS24 | ribosomal protein S24 | -0.0205133 |
| PALLD | palladin, cytoskeletal associated protein | -0.0204443 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0204276 |
| FUS | FUS RNA binding protein | -0.0202895 |
| CCNI | cyclin I | -0.0199754 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.019859 |
| IGF2 | insulin-like growth factor 2 | -0.0198082 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0197541 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0194451 |
| CCDC102B | coiled-coil domain containing 102B | -0.0193504 |
| TUBB | tubulin, beta class I | -0.0191989 |
| GNAS | GNAS complex locus | -0.0189205 |
| HLA-C | major histocompatibility complex, class I, C | -0.0187311 |
| RPL38 | ribosomal protein L38 | -0.01848 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0182062 |
| CLMP | CXADR-like membrane protein | -0.0179727 |
| GOLT1B | golgi transport 1B | -0.0179478 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0179292 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0177678 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0176089 |
| PARVA | parvin, alpha | -0.0174841 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.017474 |
| TMEM263 | transmembrane protein 263 | -0.0172505 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0172197 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0171872 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0171658 |
| CPA6 | carboxypeptidase A6 | -0.0171535 |
| IL6 | interleukin 6 | -0.0171338 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0168884 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0167887 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.016787 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0167805 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0164711 |
| RPL35 | ribosomal protein L35 | -0.0164685 |
