| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/132999 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Ivabradine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 2.04 |
| PIP | prolactin-induced protein | 1.59 |
| PER2 | period circadian clock 2 | 0.99 |
| ITGA7 | integrin, alpha 7 | 0.53 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.5 |
| DNASE1L1 | deoxyribonuclease I-like 1 | 0.5 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.49 |
| FBXO31 | F-box protein 31 | 0.45 |
| MZT2B | mitotic spindle organizing protein 2B | 0.44 |
| RGS20 | regulator of G-protein signaling 20 | 0.44 |
| ATXN1L | ataxin 1-like | 0.39 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | 0.39 |
| DENND4A | DENN/MADD domain containing 4A | 0.35 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.34 |
| FBXO28 | F-box protein 28 | 0.33 |
| USP53 | ubiquitin specific peptidase 53 | 0.32 |
| C11ORF49 | chromosome 11 open reading frame 49 | 0.32 |
| RAB27B | RAB27B, member RAS oncogene family | 0.31 |
| PDZD11 | PDZ domain containing 11 | 0.31 |
| AKNA | AT-hook transcription factor | 0.31 |
| WASHC3 | WASH complex subunit 3 | 0.31 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.31 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | 0.29 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.29 |
| E2F2 | E2F transcription factor 2 | 0.29 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.28 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 0.28 |
| TBC1D14 | TBC1 domain family, member 14 | 0.28 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.28 |
| TJP1 | tight junction protein 1 | 0.27 |
| UROS | uroporphyrinogen III synthase | 0.26 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.26 |
| WDR90 | WD repeat domain 90 | 0.26 |
| FOXO1 | forkhead box O1 | 0.25 |
| GINM1 | glycoprotein integral membrane 1 | 0.25 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.25 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | 0.25 |
| ZNF316 | zinc finger protein 316 | 0.25 |
| ZNF888 | zinc finger protein 888 | 0.24 |
| CEP44 | centrosomal protein 44kDa | 0.24 |
| NOTCH3 | notch 3 | 0.24 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 0.24 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.24 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.23 |
| GKAP1 | G kinase anchoring protein 1 | 0.23 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 0.23 |
| FZD1 | frizzled class receptor 1 | 0.23 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.23 |
| ZNF440 | zinc finger protein 440 | 0.23 |
| AMOT | angiomotin | 0.22 |
| DENND11 | DENN domain containing 11 | 0.22 |
| SNX29 | sorting nexin 29 | 0.22 |
| CDX2 | caudal type homeobox 2 | 0.22 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 0.22 |
| MPZL2 | myelin protein zero-like 2 | 0.22 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | 0.22 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.22 |
| WBP4 | WW domain binding protein 4 | 0.22 |
| MIPOL1 | mirror-image polydactyly 1 | 0.22 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.22 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.21 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | 0.21 |
| PALB2 | partner and localizer of BRCA2 | 0.21 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.21 |
| FAM133A | family with sequence similarity 133, member A | 0.21 |
| METTL6 | methyltransferase like 6 | 0.21 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.21 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | 0.21 |
| ZNF564 | zinc finger protein 564 | 0.21 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.21 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.2 |
| ZFHX2 | zinc finger homeobox 2 | 0.2 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.2 |
| TTYH2 | tweety family member 2 | 0.2 |
| RNF115 | ring finger protein 115 | 0.2 |
| SEPTIN4 | septin 4 | 0.2 |
| CPD | carboxypeptidase D | 0.2 |
| ZNF654 | zinc finger protein 654 | 0.2 |
| SPPL2A | signal peptide peptidase like 2A | 0.2 |
| DPP4 | dipeptidyl-peptidase 4 | 0.2 |
| GCH1 | GTP cyclohydrolase 1 | 0.19 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | 0.19 |
| CMC4 | C-x(9)-C motif containing 4 | 0.19 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.19 |
| ZNF394 | zinc finger protein 394 | 0.19 |
| TMEM120A | transmembrane protein 120A | 0.19 |
| TEAD3 | TEA domain family member 3 | 0.19 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | 0.19 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.19 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.18 |
| CYB5D2 | cytochrome b5 domain containing 2 | 0.18 |
| LIN37 | lin-37 DREAM MuvB core complex component | 0.18 |
| HBA1 | hemoglobin, alpha 1 | 0.18 |
| CBR1 | carbonyl reductase 1 | 0.18 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.18 |
| LYRM1 | LYR motif containing 1 | 0.18 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.18 |
| GSE1 | Gse1 coiled-coil protein | 0.18 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.18 |
| Symbol | Name | Standardized Value |
|---|---|---|
| N4BP3 | NEDD4 binding protein 3 | -0.99 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.97 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.73 |
| NALCN | sodium leak channel, non selective | -0.71 |
| VGF | VGF nerve growth factor inducible | -0.63 |
| RWDD3 | RWD domain containing 3 | -0.61 |
| ALPK1 | alpha-kinase 1 | -0.6 |
| FBXO10 | F-box protein 10 | -0.57 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.56 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.55 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.53 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.53 |
| HOMEZ | homeobox and leucine zipper encoding | -0.52 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.51 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.5 |
| TEN1 | TEN1 CST complex subunit | -0.49 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.49 |
| ZFP36 | ZFP36 ring finger protein | -0.48 |
| ZNF76 | zinc finger protein 76 | -0.47 |
| FN1 | fibronectin 1 | -0.45 |
| TMOD1 | tropomodulin 1 | -0.44 |
| GALNT13 | polypeptide N-acetylgalactosaminyltransferase 13 | -0.43 |
| FUT10 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | -0.39 |
| RNASEH1 | ribonuclease H1 | -0.39 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.38 |
| CCDC85B | coiled-coil domain containing 85B | -0.38 |
| DOLK | dolichol kinase | -0.38 |
| MYNN | myoneurin | -0.37 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.37 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.37 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.37 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.36 |
| NRP1 | neuropilin 1 | -0.36 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.36 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.36 |
| FJX1 | four jointed box 1 (Drosophila) | -0.36 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.36 |
| DIPK1B | divergent protein kinase domain 1B | -0.36 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | -0.36 |
| CBX7 | chromobox homolog 7 | -0.35 |
| TSPYL2 | TSPY-like 2 | -0.35 |
| RPAIN | RPA interacting protein | -0.35 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.35 |
| HCFC2 | host cell factor C2 | -0.35 |
| APLF | aprataxin and PNKP like factor | -0.35 |
| SMAD1 | SMAD family member 1 | -0.35 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | -0.35 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.34 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.34 |
| ING5 | inhibitor of growth family, member 5 | -0.34 |
| KIF27 | kinesin family member 27 | -0.34 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.34 |
| MAGEF1 | melanoma antigen family F1 | -0.34 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.34 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.33 |
| HEMK1 | HemK methyltransferase family member 1 | -0.33 |
| RNF135 | ring finger protein 135 | -0.33 |
| TDRD9 | tudor domain containing 9 | -0.33 |
| SUSD1 | sushi domain containing 1 | -0.33 |
| AHI1 | Abelson helper integration site 1 | -0.32 |
| GK5 | glycerol kinase 5 (putative) | -0.32 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.32 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.32 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.32 |
| TSNARE1 | t-SNARE domain containing 1 | -0.32 |
| SASH1 | SAM and SH3 domain containing 1 | -0.32 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.32 |
| TMEM231 | transmembrane protein 231 | -0.32 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.31 |
| TMEM41B | transmembrane protein 41B | -0.31 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.31 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.31 |
| ZNF655 | zinc finger protein 655 | -0.31 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.31 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.31 |
| KIAA1958 | KIAA1958 | -0.31 |
| TOX2 | TOX high mobility group box family member 2 | -0.3 |
| EEF1AKMT1 | EEF1A lysine methyltransferase 1 | -0.3 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.3 |
| PDE9A | phosphodiesterase 9A | -0.3 |
| C15ORF40 | chromosome 15 open reading frame 40 | -0.3 |
| OPHN1 | oligophrenin 1 | -0.3 |
| NFYB | nuclear transcription factor Y, beta | -0.29 |
| TSPYL4 | TSPY-like 4 | -0.29 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.29 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.29 |
| ATG2B | autophagy related 2B | -0.29 |
| CDC26 | cell division cycle 26 | -0.29 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.29 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.29 |
| MTSS1 | metastasis suppressor 1 | -0.29 |
| S100A10 | S100 calcium binding protein A10 | -0.29 |
| ETNK2 | ethanolamine kinase 2 | -0.28 |
| CENPI | centromere protein I | -0.28 |
| MIDN | midnolin | -0.28 |
| TNNC2 | troponin C type 2 (fast) | -0.28 |
| CCDC66 | coiled-coil domain containing 66 | -0.28 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | -0.27 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | -0.27 |
| FBXO34 | F-box protein 34 | -0.27 |
