| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16220172 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Ivacaftor relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL14A1 | collagen, type XIV, alpha 1 | 1.92 |
| CHRD | chordin | 1.82 |
| PRG4 | proteoglycan 4 | 1.62 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 1.47 |
| VTN | vitronectin | 1.45 |
| CCDC158 | coiled-coil domain containing 158 | 1.44 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 1.4 |
| HBA1 | hemoglobin, alpha 1 | 1.39 |
| HAL | histidine ammonia-lyase | 1.27 |
| C4BPA | complement component 4 binding protein, alpha | 1.23 |
| NRP1 | neuropilin 1 | 1.18 |
| FUT10 | fucosyltransferase 10 (alpha (1,3) fucosyltransferase) | 1.13 |
| F2 | coagulation factor II (thrombin) | 1.13 |
| MCL1 | myeloid cell leukemia 1 | 1.11 |
| GRK5 | G protein-coupled receptor kinase 5 | 1.11 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 1.09 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.07 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 1.06 |
| HMOX1 | heme oxygenase 1 | 1.04 |
| H1-0 | H1.0 linker histone | 1.03 |
| THBS1 | thrombospondin 1 | 1.01 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.01 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 1.0 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.99 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 0.98 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.98 |
| WWC2 | WW and C2 domain containing 2 | 0.95 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.95 |
| CCN2 | cellular communication network factor 2 | 0.95 |
| MARCKSL1 | MARCKS-like 1 | 0.92 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.91 |
| RWDD2A | RWD domain containing 2A | 0.88 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.88 |
| HGFAC | HGF activator | 0.88 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.88 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.86 |
| APOE | apolipoprotein E | 0.85 |
| CD82 | CD82 molecule | 0.85 |
| NLRC3 | NLR family, CARD domain containing 3 | 0.84 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.84 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.82 |
| PLEK | pleckstrin | 0.82 |
| UPP1 | uridine phosphorylase 1 | 0.79 |
| PRELID3B | PRELI domain containing 3B | 0.79 |
| C1ORF43 | chromosome 1 open reading frame 43 | 0.78 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.78 |
| LAMC2 | laminin, gamma 2 | 0.77 |
| L1RE1 | LINE1 retrotransposable element 1 | 0.77 |
| SLC35B1 | solute carrier family 35, member B1 | 0.76 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.76 |
| DAP | death-associated protein | 0.76 |
| HSPA8 | heat shock 70kDa protein 8 | 0.76 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | 0.75 |
| FHL1 | four and a half LIM domains 1 | 0.75 |
| ZNF35 | zinc finger protein 35 | 0.75 |
| NIBAN1 | niban apoptosis regulator 1 | 0.75 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.74 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.74 |
| ENTR1 | endosome associated trafficking regulator 1 | 0.73 |
| MIEF2 | mitochondrial elongation factor 2 | 0.73 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.72 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.71 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.71 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.7 |
| ENSA | endosulfine alpha | 0.7 |
| TRAM2 | translocation associated membrane protein 2 | 0.7 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.7 |
| AMACR | alpha-methylacyl-CoA racemase | 0.69 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.69 |
| CPA4 | carboxypeptidase A4 | 0.68 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.68 |
| UNC13C | unc-13 homolog C (C. elegans) | 0.68 |
| GPATCH2L | G patch domain containing 2-like | 0.68 |
| ABHD3 | abhydrolase domain containing 3 | 0.68 |
| ZNF224 | zinc finger protein 224 | 0.67 |
| CST6 | cystatin E/M | 0.66 |
| CD58 | CD58 molecule | 0.66 |
| LAMB3 | laminin, beta 3 | 0.66 |
| COL6A3 | collagen, type VI, alpha 3 | 0.66 |
| CCDC57 | coiled-coil domain containing 57 | 0.65 |
| RNF166 | ring finger protein 166 | 0.65 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.65 |
| FBXO33 | F-box protein 33 | 0.65 |
| MBP | myelin basic protein | 0.64 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.63 |
| BRD9 | bromodomain containing 9 | 0.63 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | 0.63 |
| RPL37 | ribosomal protein L37 | 0.63 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.62 |
| FANCM | Fanconi anemia, complementation group M | 0.62 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.61 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.61 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.61 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.61 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 0.61 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.6 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | 0.6 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.6 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.6 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -4.08 |
| LMOD1 | leiomodin 1 (smooth muscle) | -3.16 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -2.28 |
| PYGM | phosphorylase, glycogen, muscle | -2.01 |
| ACTN4 | actinin, alpha 4 | -1.8 |
| ZNF354B | zinc finger protein 354B | -1.79 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | -1.78 |
| GUCD1 | guanylyl cyclase domain containing 1 | -1.56 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | -1.35 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -1.33 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -1.29 |
| ANKRD39 | ankyrin repeat domain 39 | -1.28 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -1.27 |
| COQ6 | coenzyme Q6 monooxygenase | -1.25 |
| NFYB | nuclear transcription factor Y, beta | -1.21 |
| S100A2 | S100 calcium binding protein A2 | -1.16 |
| ARMC7 | armadillo repeat containing 7 | -1.15 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -1.13 |
| SLC10A4 | solute carrier family 10, member 4 | -1.08 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -1.06 |
| ANGPTL4 | angiopoietin-like 4 | -1.05 |
| TMEM135 | transmembrane protein 135 | -1.05 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | -1.04 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | -1.04 |
| TMEM175 | transmembrane protein 175 | -1.02 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -1.0 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.99 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | -0.98 |
| ZC3H14 | zinc finger CCCH-type containing 14 | -0.98 |
| SMAD1 | SMAD family member 1 | -0.96 |
| B2M | beta-2-microglobulin | -0.96 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.95 |
| COMMD9 | COMM domain containing 9 | -0.94 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.94 |
| CCDC66 | coiled-coil domain containing 66 | -0.94 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.9 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | -0.9 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.9 |
| XTBD1 | XRN2 binding domain containing 1 | -0.89 |
| FZD7 | frizzled class receptor 7 | -0.89 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.88 |
| NADK | NAD kinase | -0.85 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.85 |
| ETV6 | ets variant 6 | -0.84 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.84 |
| RNASEH2C | ribonuclease H2, subunit C | -0.84 |
| ELOC | elongin C | -0.82 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.79 |
| RNF145 | ring finger protein 145 | -0.79 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -0.79 |
| SLC12A8 | solute carrier family 12, member 8 | -0.79 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | -0.78 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.78 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.77 |
| RPA3 | replication protein A3, 14kDa | -0.77 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.77 |
| SNX16 | sorting nexin 16 | -0.76 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.76 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.75 |
| ZIC5 | Zic family member 5 | -0.74 |
| MSMO1 | methylsterol monooxygenase 1 | -0.74 |
| PTMA | prothymosin, alpha | -0.74 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.73 |
| TSPAN31 | tetraspanin 31 | -0.73 |
| WDR5B | WD repeat domain 5B | -0.73 |
| NUTF2 | nuclear transport factor 2 | -0.72 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.72 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | -0.72 |
| GRTP1 | growth hormone regulated TBC protein 1 | -0.71 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | -0.71 |
| DDTL | D-dopachrome tautomerase-like | -0.7 |
| NMNAT3 | nicotinamide nucleotide adenylyltransferase 3 | -0.69 |
| CNTRL | centriolin | -0.69 |
| SLC25A38 | solute carrier family 25, member 38 | -0.69 |
| DDT | D-dopachrome tautomerase | -0.69 |
| BOLA2 | bolA family member 2 | -0.68 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.67 |
| FBXO44 | F-box protein 44 | -0.67 |
| ENDOD1 | endonuclease domain containing 1 | -0.67 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.67 |
| HINT2 | histidine triad nucleotide binding protein 2 | -0.67 |
| ELOB | elongin B | -0.66 |
| ACY1 | aminoacylase 1 | -0.66 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.66 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.65 |
| GM2A | GM2 ganglioside activator | -0.65 |
| PFDN4 | prefoldin subunit 4 | -0.65 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.65 |
| SLC41A3 | solute carrier family 41, member 3 | -0.65 |
| TRIM32 | tripartite motif containing 32 | -0.64 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.64 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.64 |
| RGN | regucalcin | -0.63 |
| NAA20 | N(alpha)-acetyltransferase 20, NatB catalytic subunit | -0.63 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.63 |
| TMEM104 | transmembrane protein 104 | -0.63 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | -0.62 |
| NCS1 | neuronal calcium sensor 1 | -0.62 |
| CSTB | cystatin B (stefin B) | -0.62 |
