Ivermectin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
YAP1 Yes-associated protein 1 0.113538
HMGA2 high mobility group AT-hook 2 0.10325
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100148
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0957993
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0943152
NLGN1 neuroligin 1 0.0872155
ASPH aspartate beta-hydroxylase 0.0849124
JMJD1C jumonji domain containing 1C 0.0847325
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.080954
RRM2 ribonucleotide reductase M2 0.064023
VMP1 vacuole membrane protein 1 0.063782
EGR1 early growth response 1 0.0589126
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0560832
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0558803
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0551959
NHSL1 NHS-like 1 0.0535462
INTS6 integrator complex subunit 6 0.0517144
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0511037
USP34 ubiquitin specific peptidase 34 0.047164
EHBP1 EH domain binding protein 1 0.0455484
PDGFC platelet derived growth factor C 0.0452275
POTEF POTE ankyrin domain family, member F 0.0450982
TPM3 tropomyosin 3 0.0450353
PCBP2 poly(rC) binding protein 2 0.0437037
PCDH9 protocadherin 9 0.0435734
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0424454
RAB7A RAB7A, member RAS oncogene family 0.0420429
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0408857
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0408722
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.040649
IPO7 importin 7 0.0370574
EPHA5 EPH receptor A5 0.0366447
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0366011
DENND5A DENN/MADD domain containing 5A 0.0362375
ZSWIM6 zinc finger, SWIM-type containing 6 0.0357078
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0347426
WWOX WW domain containing oxidoreductase 0.0346141
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0343958
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0341923
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0338309
ERRFI1 ERBB receptor feedback inhibitor 1 0.0337563
EPHA6 EPH receptor A6 0.0331281
CCN2 cellular communication network factor 2 0.0320558
BRD2 bromodomain containing 2 0.0319653
RPL3 ribosomal protein L3 0.0317314
LRMDA leucine rich melanocyte differentiation associated 0.0316622
ANKRD17 ankyrin repeat domain 17 0.0314398
ZNF638 zinc finger protein 638 0.029976
BABAM2 BRISC and BRCA1 A complex member 2 0.0292863
HSPA8 heat shock 70kDa protein 8 0.0291146
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0286004
RTN4 reticulon 4 0.0285326
WDPCP WD repeat containing planar cell polarity effector 0.0284131
CCNL1 cyclin L1 0.0283624
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0283544
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0270962
RHOA ras homolog family member A 0.026937
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0267219
MBD5 methyl-CpG binding domain protein 5 0.0264201
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0262023
ASXL2 additional sex combs like transcriptional regulator 2 0.0261949
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0259153
PRH1 proline-rich protein HaeIII subfamily 1 0.0258998
FAT1 FAT atypical cadherin 1 0.0254984
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0253252
RCOR1 REST corepressor 1 0.0252463
NECTIN3 nectin cell adhesion molecule 3 0.0251229
EEF2 eukaryotic translation elongation factor 2 0.0251112
WNK1 WNK lysine deficient protein kinase 1 0.0248757
TMEM41B transmembrane protein 41B 0.0247767
KCMF1 potassium channel modulatory factor 1 0.0246955
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0240571
MSRB3 methionine sulfoxide reductase B3 0.0239644
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0239081
NEGR1 neuronal growth regulator 1 0.023846
PKM pyruvate kinase, muscle 0.0237231
RAB10 RAB10, member RAS oncogene family 0.0236137
ARL15 ADP-ribosylation factor-like 15 0.0235815
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.02339
TBK1 TANK-binding kinase 1 0.0233486
PRELID2 PRELI domain containing 2 0.0233385
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0233035
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0232914
ACTG1 actin gamma 1 0.0231775
PDE4B phosphodiesterase 4B, cAMP-specific 0.0230971
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0229924
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0228362
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0228342
AGO3 argonaute RISC catalytic component 3 0.0227332
DIAPH1 diaphanous-related formin 1 0.0226318
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0225856
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0224857
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0223545
SRRM2 serine/arginine repetitive matrix 2 0.0222004
TENM3 teneurin transmembrane protein 3 0.0221036
PCDH7 protocadherin 7 0.0220712
HOMER1 homer scaffolding protein 1 0.0220586
MCL1 myeloid cell leukemia 1 0.0215937
FXR1 fragile X mental retardation, autosomal homolog 1 0.0210794
HELZ helicase with zinc finger 0.0209798

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.100211
VIM vimentin -0.0873976
CELF2 CUGBP, Elav-like family member 2 -0.0867592
AHNAK AHNAK nucleoprotein -0.0780546
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0709551
MYL12B myosin, light chain 12B, regulatory -0.0682783
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.067728
CLDN1 claudin 1 -0.0664538
LMO7 LIM domain 7 -0.0547545
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0522696
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.05151
FTL ferritin, light polypeptide -0.0512693
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0507261
AREG amphiregulin -0.0482704
MMP12 matrix metallopeptidase 12 -0.046384
IFIH1 interferon induced with helicase C domain 1 -0.0454364
H1-0 H1.0 linker histone -0.043097
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0429808
RAD21 RAD21 homolog (S. pombe) -0.0425517
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.042487
ADGRG6 adhesion G protein-coupled receptor G6 -0.0419457
PTMA prothymosin, alpha -0.0405813
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0401773
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0396732
YBX3 Y box binding protein 3 -0.039653
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0390639
RPL12 ribosomal protein L12 -0.0375398
BIRC3 baculoviral IAP repeat containing 3 -0.0374234
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0373033
RPLP1 ribosomal protein, large, P1 -0.0370841
DLC1 DLC1 Rho GTPase activating protein -0.0361955
RPL19 ribosomal protein L19 -0.0356992
RPS27A ribosomal protein S27a -0.033233
RASAL2 RAS protein activator like 2 -0.0321285
DST dystonin -0.0320659
KIF5B kinesin family member 5B -0.0317394
CENPF centromere protein F, 350/400kDa -0.0315021
LARP1 La ribonucleoprotein domain family, member 1 -0.0314729
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0303544
XPO1 exportin 1 -0.0295546
CENPE centromere protein E, 312kDa -0.0294064
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0292469
RPL8 ribosomal protein L8 -0.0284933
TMEM131 transmembrane protein 131 -0.0283571
NIPSNAP2 nipsnap homolog 2 -0.0283117
U2SURP U2 snRNP-associated SURP domain containing -0.0281954
RPS8 ribosomal protein S8 -0.0280622
PCNP PEST proteolytic signal containing nuclear protein -0.027831
ATP5F1B ATP synthase F1 subunit beta -0.0269295
RPL35A ribosomal protein L35a -0.0269012
THOC2 THO complex 2 -0.0267779
CAVIN1 caveolae associated protein 1 -0.025985
NAP1L1 nucleosome assembly protein 1-like 1 -0.0259278
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0255189
RPS24 ribosomal protein S24 -0.0252326
RPL11 ribosomal protein L11 -0.0250464
RPS16 ribosomal protein S16 -0.0247689
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0244616
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0244092
TM4SF1 transmembrane 4 L six family member 1 -0.0242893
SLC38A2 solute carrier family 38, member 2 -0.0240042
NF1 neurofibromin 1 -0.0239665
CNRIP1 cannabinoid receptor interacting protein 1 -0.0238559
RPL34 ribosomal protein L34 -0.0233381
TM7SF3 transmembrane 7 superfamily member 3 -0.0230237
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0229264
NCOR1 nuclear receptor corepressor 1 -0.02262
RPL32 ribosomal protein L32 -0.0225602
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0224763
RPL38 ribosomal protein L38 -0.0222912
KDM3A lysine (K)-specific demethylase 3A -0.0220242
SYT1 synaptotagmin I -0.022006
RAI14 retinoic acid induced 14 -0.0219471
RBM27 RNA binding motif protein 27 -0.0217851
HSPB1 heat shock 27kDa protein 1 -0.0217534
EGFR epidermal growth factor receptor -0.0217472
LARS1 leucyl-tRNA synthetase 1 -0.0216429
SRP72 signal recognition particle 72kDa -0.0216218
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.021577
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0215565
MAP1B microtubule-associated protein 1B -0.0215554
OXR1 oxidation resistance 1 -0.0210569
CCDC47 coiled-coil domain containing 47 -0.0209252
DPYD dihydropyrimidine dehydrogenase -0.0209065
KPNB1 karyopherin (importin) beta 1 -0.0207032
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0206938
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0206626
ZFAND6 zinc finger, AN1-type domain 6 -0.0204921
LMAN1 lectin, mannose-binding, 1 -0.0203368
RSL1D1 ribosomal L1 domain containing 1 -0.0202741
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.020172
EIF1 eukaryotic translation initiation factor 1 -0.0201266
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0200926
TXNRD1 thioredoxin reductase 1 -0.0200705
PDCD10 programmed cell death 10 -0.0200567
WDR43 WD repeat domain 43 -0.0200325
RAB1A RAB1A, member RAS oncogene family -0.0199539
SSB Sjogren syndrome antigen B (autoantigen La) -0.0199201
PLK2 polo-like kinase 2 -0.0198454
S100A6 S100 calcium binding protein A6 -0.019771