Ivermectin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.0701682
AKAP12 A kinase (PRKA) anchor protein 12 0.0677749
ITPRID2 ITPR interacting domain containing 2 0.0480462
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0461408
PTPRD protein tyrosine phosphatase, receptor type, D 0.0445735
VMP1 vacuole membrane protein 1 0.0379708
PLAT plasminogen activator, tissue 0.0348191
TLE4 transducin-like enhancer of split 4 0.0346319
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338768
MEIS2 Meis homeobox 2 0.0314907
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0309216
DST dystonin 0.0306157
NCAM2 neural cell adhesion molecule 2 0.030153
ZBTB20 zinc finger and BTB domain containing 20 0.0298623
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0298229
DPH6 diphthamine biosynthesis 6 0.0294006
VEGFA vascular endothelial growth factor A 0.0288888
PRRC2C proline-rich coiled-coil 2C 0.0282988
FNDC3B fibronectin type III domain containing 3B 0.0278248
USP34 ubiquitin specific peptidase 34 0.0269655
LIMCH1 LIM and calponin homology domains 1 0.0267344
SOS1 son of sevenless homolog 1 (Drosophila) 0.0267001
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0262844
ZNF638 zinc finger protein 638 0.0259155
RNF213 ring finger protein 213 0.0242808
NALF1 NALCN channel auxiliary factor 1 0.0241796
ATRNL1 attractin-like 1 0.0240746
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0240316
NRIP1 nuclear receptor interacting protein 1 0.0236673
GPC5 glypican 5 0.0236273
FAM13A family with sequence similarity 13, member A 0.0235589
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0232841
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0232469
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0231368
UNC5C unc-5 homolog C (C. elegans) 0.0231136
STC1 stanniocalcin 1 0.0228629
LSAMP limbic system-associated membrane protein 0.0225712
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0225286
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0220005
MBNL2 muscleblind-like splicing regulator 2 0.0217443
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0216057
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0211897
LINGO2 leucine rich repeat and Ig domain containing 2 0.019885
CSNK1A1 casein kinase 1, alpha 1 0.0198275
SMYD3 SET and MYND domain containing 3 0.0197863
NAMPT nicotinamide phosphoribosyltransferase 0.0197586
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0192352
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0192338
PFKP phosphofructokinase, platelet 0.0189826
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.018856
ATXN1 ataxin 1 0.0186956
AHR aryl hydrocarbon receptor 0.0186855
PDE4D phosphodiesterase 4D, cAMP-specific 0.0186438
AUTS2 autism susceptibility candidate 2 0.0184211
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0183922
LIMS1 LIM and senescent cell antigen-like domains 1 0.0179556
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0176085
ARHGAP5 Rho GTPase activating protein 5 0.0176025
ZNF148 zinc finger protein 148 0.0175828
AEBP2 AE binding protein 2 0.0174388
ATM ATM serine/threonine kinase 0.0172601
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.01724
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0171122
MBD5 methyl-CpG binding domain protein 5 0.0170821
TRIO trio Rho guanine nucleotide exchange factor 0.0170603
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0170021
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0168327
PCBP3 poly(rC) binding protein 3 0.0168086
PTPRM protein tyrosine phosphatase, receptor type, M 0.0167946
IFI16 interferon, gamma-inducible protein 16 0.0164212
PTEN phosphatase and tensin homolog 0.0163188
WDR26 WD repeat domain 26 0.0162265
COL3A1 collagen, type III, alpha 1 0.0161875
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0161106
CHD9 chromodomain helicase DNA binding protein 9 0.0160249
BABAM2 BRISC and BRCA1 A complex member 2 0.0158615
BIRC6 baculoviral IAP repeat containing 6 0.0158374
FAM13B family with sequence similarity 13, member B 0.0158205
CSDE1 cold shock domain containing E1, RNA-binding 0.0157513
SNX13 sorting nexin 13 0.0157362
TET1 tet methylcytosine dioxygenase 1 0.0154498
PSD3 pleckstrin and Sec7 domain containing 3 0.0154428
ANTXR1 anthrax toxin receptor 1 0.0154051
DSCAM Down syndrome cell adhesion molecule 0.0153892
BBX bobby sox homolog (Drosophila) 0.0153783
MDN1 MDN1, midasin homolog (yeast) 0.0151475
NGLY1 N-glycanase 1 0.015144
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0150263
NBEA neurobeachin 0.0148781
ADGRG6 adhesion G protein-coupled receptor G6 0.0147793
KDM4C lysine (K)-specific demethylase 4C 0.0146563
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.014547
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0144763
TTC17 tetratricopeptide repeat domain 17 0.0144202
LPIN1 lipin 1 0.0144046
BPTF bromodomain PHD finger transcription factor 0.0140518
NCOR1 nuclear receptor corepressor 1 0.0140498
TBX2 T-box 2 0.0139634
SLITRK6 SLIT and NTRK-like family, member 6 0.0139213
GIGYF2 GRB10 interacting GYF protein 2 0.0139061

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.081444
VIM vimentin -0.0810171
RPS6 ribosomal protein S6 -0.0646947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0540416
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0510845
RPLP1 ribosomal protein, large, P1 -0.0498385
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0482456
ACTG1 actin gamma 1 -0.0475145
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0454823
RPL19 ribosomal protein L19 -0.0444958
RPL23 ribosomal protein L23 -0.0422786
IER3 immediate early response 3 -0.0411204
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0410393
RPL35A ribosomal protein L35a -0.0405316
LMNA lamin A/C -0.0368186
TMSB10 thymosin beta 10 -0.0353026
TPT1 tumor protein, translationally-controlled 1 -0.0344107
RPL34 ribosomal protein L34 -0.0310265
RPS19 ribosomal protein S19 -0.0293553
FTL ferritin, light polypeptide -0.0291552
POTEF POTE ankyrin domain family, member F -0.0277479
WAC WW domain containing adaptor with coiled-coil -0.0269842
RPS27A ribosomal protein S27a -0.0259162
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0257389
RPL38 ribosomal protein L38 -0.0246505
RPLP0 ribosomal protein, large, P0 -0.0242666
S100A6 S100 calcium binding protein A6 -0.0233438
CCND1 cyclin D1 -0.0229434
EXT1 exostosin glycosyltransferase 1 -0.0229244
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0228642
RPL12 ribosomal protein L12 -0.0226166
RPL26 ribosomal protein L26 -0.022387
RPS8 ribosomal protein S8 -0.0217938
SPAG9 sperm associated antigen 9 -0.0215117
COL1A1 collagen, type I, alpha 1 -0.0210292
RPL36 ribosomal protein L36 -0.0209448
RPS25 ribosomal protein S25 -0.0209058
TPM4 tropomyosin 4 -0.0202932
RPS24 ribosomal protein S24 -0.0199581
VCL vinculin -0.0195456
RPS27 ribosomal protein S27 -0.0193062
RNF145 ring finger protein 145 -0.019209
RPL11 ribosomal protein L11 -0.0191882
RPL9 ribosomal protein L9 -0.0189022
RPS14 ribosomal protein S14 -0.0187573
RPL37 ribosomal protein L37 -0.0185447
SIK3 SIK family kinase 3 -0.0181771
RPS15 ribosomal protein S15 -0.0177954
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0176177
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0173867
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0172221
RPL27 ribosomal protein L27 -0.0168878
COPA coatomer protein complex, subunit alpha -0.0166757
RPL28 ribosomal protein L28 -0.0166087
RPS20 ribosomal protein S20 -0.0164808
GNAS GNAS complex locus -0.0162783
RPS29 ribosomal protein S29 -0.0160895
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0158611
RPL31 ribosomal protein L31 -0.0156917
B2M beta-2-microglobulin -0.0156752
NPR2 natriuretic peptide receptor 2 -0.0154636
RPS21 ribosomal protein S21 -0.015352
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0153429
RPS3 ribosomal protein S3 -0.015332
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0152829
WDR43 WD repeat domain 43 -0.014905
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0148742
PTK2 protein tyrosine kinase 2 -0.0147782
RPL37A ribosomal protein L37a -0.0147643
SYT1 synaptotagmin I -0.0147131
RAB1A RAB1A, member RAS oncogene family -0.0146617
SQSTM1 sequestosome 1 -0.0146556
RACK1 receptor for activated C kinase 1 -0.0146147
PHIP pleckstrin homology domain interacting protein -0.0145371
RPS16 ribosomal protein S16 -0.0144525
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0144523
TAOK1 TAO kinase 1 -0.0144068
SEC11A SEC11 homolog A (S. cerevisiae) -0.0143875
RPL36A ribosomal protein L36a -0.0143032
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.014225
H3-3B H3.3 histone B -0.0141289
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0141074
CADM2 cell adhesion molecule 2 -0.0140468
H1-0 H1.0 linker histone -0.0140441
USP15 ubiquitin specific peptidase 15 -0.0139039
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0135451
SLIT2 slit homolog 2 (Drosophila) -0.0134414
FN1 fibronectin 1 -0.0133696
VDAC1 voltage-dependent anion channel 1 -0.0133311
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0131128
HMGB2 high mobility group box 2 -0.0129207
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0128606
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0128317
SET SET nuclear proto-oncogene -0.0127076
SEPTIN7 septin 7 -0.0124983
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0124771
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0123819
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.012336
MRTFA myocardin related transcription factor A -0.0123335
RPS11 ribosomal protein S11 -0.0121606