Ivermectin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.269686
COL6A3 collagen, type VI, alpha 3 0.196673
FN1 fibronectin 1 0.14662
TRIO trio Rho guanine nucleotide exchange factor 0.113403
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.112787
STC1 stanniocalcin 1 0.0884779
CD44 CD44 molecule (Indian blood group) 0.0855234
ATP13A3 ATPase type 13A3 0.0750199
LOXL2 lysyl oxidase-like 2 0.0745608
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0721425
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.067809
FMNL2 formin-like 2 0.0636843
VEGFA vascular endothelial growth factor A 0.0633917
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0550877
APP amyloid beta (A4) precursor protein 0.0550139
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0539471
LTBP1 latent transforming growth factor beta binding protein 1 0.0522197
MTSS1 metastasis suppressor 1 0.0519774
ERRFI1 ERBB receptor feedback inhibitor 1 0.0512979
JARID2 jumonji, AT rich interactive domain 2 0.051182
CXCL8 chemokine (C-X-C motif) ligand 8 0.0490711
ESYT2 extended synaptotagmin-like protein 2 0.0473676
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0440129
SPAG9 sperm associated antigen 9 0.0432156
GRB10 growth factor receptor-bound protein 10 0.0426093
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0421886
RUNX1 runt-related transcription factor 1 0.0415522
CADM1 cell adhesion molecule 1 0.0413256
FNDC3B fibronectin type III domain containing 3B 0.0399263
LDHA lactate dehydrogenase A 0.0394254
PTK2 protein tyrosine kinase 2 0.0393781
PDE10A phosphodiesterase 10A 0.0391245
NAV2 neuron navigator 2 0.0381704
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0377857
SMAD3 SMAD family member 3 0.0374305
EXT1 exostosin glycosyltransferase 1 0.0364533
MACF1 microtubule-actin crosslinking factor 1 0.0362894
MYH9 myosin, heavy chain 9, non-muscle 0.0357519
DOCK5 dedicator of cytokinesis 5 0.0355702
ARRDC3 arrestin domain containing 3 0.0353417
COL5A1 collagen, type V, alpha 1 0.034917
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0344783
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0340267
PICALM phosphatidylinositol binding clathrin assembly protein 0.0333277
ANXA1 annexin A1 0.032778
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0315422
EFNA5 ephrin-A5 0.0314164
ANTXR2 anthrax toxin receptor 2 0.0312684
LOX lysyl oxidase 0.0298512
CAMTA1 calmodulin binding transcription activator 1 0.0297391
RLF rearranged L-myc fusion 0.029485
RB1CC1 RB1-inducible coiled-coil 1 0.0287778
CA12 carbonic anhydrase XII 0.0286238
ANKRD36 ankyrin repeat domain 36 0.0283023
NBAS neuroblastoma amplified sequence 0.0277477
GSK3B glycogen synthase kinase 3 beta 0.0276945
TM4SF1 transmembrane 4 L six family member 1 0.0273458
ANKRD11 ankyrin repeat domain 11 0.0272446
CD109 CD109 molecule 0.0268916
YEATS2 YEATS domain containing 2 0.0266218
TMEM165 transmembrane protein 165 0.0261475
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.026122
TNIP1 TNFAIP3 interacting protein 1 0.0260852
COL7A1 collagen, type VII, alpha 1 0.0260301
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0259777
COL6A2 collagen, type VI, alpha 2 0.0259654
ICAM1 intercellular adhesion molecule 1 0.0250463
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0245063
RNF145 ring finger protein 145 0.0236456
RIGI RNA sensor RIG-I 0.0234901
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0230436
MRTFA myocardin related transcription factor A 0.0229889
SEC23A Sec23 homolog A (S. cerevisiae) 0.0227586
TMF1 TATA element modulatory factor 1 0.0223936
PRELID2 PRELI domain containing 2 0.0223146
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.021398
AZIN1 antizyme inhibitor 1 0.0213332
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0212352
MYO9B myosin IXB 0.0212206
HILPDA hypoxia inducible lipid droplet-associated 0.021019
IGFBP3 insulin-like growth factor binding protein 3 0.020882
MYO10 myosin X 0.0207585
HOOK2 hook microtubule-tethering protein 2 0.0205901
UBE2O ubiquitin-conjugating enzyme E2O 0.0205742
USP34 ubiquitin specific peptidase 34 0.0205583
SCAF8 SR-related CTD-associated factor 8 0.0203566
IQGAP1 IQ motif containing GTPase activating protein 1 0.02031
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0202546
MARCHF6 membrane associated ring-CH-type finger 6 0.0201552
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0200827
WRN Werner syndrome, RecQ helicase-like 0.0200624
EP300 E1A binding protein p300 0.0198634
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0196717
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.01961
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0196008
RYK receptor-like tyrosine kinase 0.0194212
SHB Src homology 2 domain containing adaptor protein B 0.0193744
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0193528
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019258
CALU calumenin 0.0191489

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.153
TMSB10 thymosin beta 10 -0.15185
MT2A metallothionein 2A -0.126758
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.124964
FTL ferritin, light polypeptide -0.0829624
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0693275
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0664763
PTMA prothymosin, alpha -0.0601103
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0592551
MARCKS myristoylated alanine-rich protein kinase C substrate -0.056363
YBX1 Y box binding protein 1 -0.0563616
RPS19 ribosomal protein S19 -0.0543373
B2M beta-2-microglobulin -0.0528311
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0524779
TMSB4X thymosin beta 4, X-linked -0.0523581
RPS3 ribosomal protein S3 -0.0504081
RPS8 ribosomal protein S8 -0.0486465
RPLP1 ribosomal protein, large, P1 -0.04851
RACK1 receptor for activated C kinase 1 -0.0483129
RPS6 ribosomal protein S6 -0.047895
RPL26 ribosomal protein L26 -0.046659
CALD1 caldesmon 1 -0.0452706
PALLD palladin, cytoskeletal associated protein -0.0427508
TPM2 tropomyosin 2 (beta) -0.0416447
RPL23 ribosomal protein L23 -0.0415976
ENO1 enolase 1, (alpha) -0.0414975
RPL12 ribosomal protein L12 -0.0411588
RPL7 ribosomal protein L7 -0.0405713
TPI1 triosephosphate isomerase 1 -0.0403492
PKM pyruvate kinase, muscle -0.0395947
RPS20 ribosomal protein S20 -0.039171
RPL19 ribosomal protein L19 -0.0383868
RPL35A ribosomal protein L35a -0.0360719
RPS17 ribosomal protein S17 -0.0352993
EGR1 early growth response 1 -0.0352198
S100A6 S100 calcium binding protein A6 -0.0350918
MAP1B microtubule-associated protein 1B -0.034595
IFITM3 interferon induced transmembrane protein 3 -0.0337664
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0334484
CAV1 caveolin 1, caveolae protein, 22kDa -0.0329314
INHBA inhibin, beta A -0.0326343
RPL11 ribosomal protein L11 -0.0323752
RPL8 ribosomal protein L8 -0.0321143
PFN1 profilin 1 -0.0310517
CALR calreticulin -0.0309533
RPL30 ribosomal protein L30 -0.030604
TPM4 tropomyosin 4 -0.0305933
WASF2 WAS protein family, member 2 -0.0301811
CYB5R3 cytochrome b5 reductase 3 -0.0298587
CAVIN1 caveolae associated protein 1 -0.0295339
RPL36 ribosomal protein L36 -0.0291332
POTEF POTE ankyrin domain family, member F -0.0277848
SEPTIN7 septin 7 -0.0277468
EEF2 eukaryotic translation elongation factor 2 -0.0275209
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0273631
VCL vinculin -0.0273367
AKAP12 A kinase (PRKA) anchor protein 12 -0.0269785
RPLP0 ribosomal protein, large, P0 -0.0263891
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0263688
ACTG1 actin gamma 1 -0.0263093
NALF1 NALCN channel auxiliary factor 1 -0.0258893
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0256404
FTH1 ferritin, heavy polypeptide 1 -0.0252956
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.02526
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0249722
C12ORF75 chromosome 12 open reading frame 75 -0.0246339
RPS12 ribosomal protein S12 -0.0245966
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0242068
S100A9 S100 calcium binding protein A9 -0.02418
RPS2 ribosomal protein S2 -0.0240126
TPM1 tropomyosin 1 (alpha) -0.0239209
RPL13A ribosomal protein L13a -0.0237802
RPL37A ribosomal protein L37a -0.0236606
RPL32 ribosomal protein L32 -0.0234332
HMGA1 high mobility group AT-hook 1 -0.0231446
SERBP1 SERPINE1 mRNA binding protein 1 -0.0230718
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0230399
ADAM12 ADAM metallopeptidase domain 12 -0.0229604
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0229486
SRGN serglycin -0.02292
BSG basigin (Ok blood group) -0.0228177
NUCB2 nucleobindin 2 -0.0227764
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226787
SLC38A1 solute carrier family 38, member 1 -0.0226553
HMGB1 high mobility group box 1 -0.0223672
RAP1B RAP1B, member of RAS oncogene family -0.0223072
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0222985
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0222658
POSTN periostin, osteoblast specific factor -0.0222463
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0221231
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0219762
RPL34 ribosomal protein L34 -0.0218278
TSC22D2 TSC22 domain family, member 2 -0.0215954
ERBIN erbb2 interacting protein -0.02157
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0215626
IGFBP7 insulin-like growth factor binding protein 7 -0.0214584
RPL5 ribosomal protein L5 -0.0210749
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0209175
NAP1L1 nucleosome assembly protein 1-like 1 -0.0208766
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0206354