Ivermectin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0510694
PDE4D phosphodiesterase 4D, cAMP-specific 0.0450037
IGFBP3 insulin-like growth factor binding protein 3 0.0446953
SAMD4A sterile alpha motif domain containing 4A 0.0392786
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0352516
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0338126
IGF2 insulin-like growth factor 2 0.0325034
RBM39 RNA binding motif protein 39 0.0314178
DOCK4 dedicator of cytokinesis 4 0.0314131
USP34 ubiquitin specific peptidase 34 0.0305786
ERRFI1 ERBB receptor feedback inhibitor 1 0.030526
GRAMD1B GRAM domain containing 1B 0.0285656
APP amyloid beta (A4) precursor protein 0.0245545
AKAP12 A kinase (PRKA) anchor protein 12 0.023566
TRIO trio Rho guanine nucleotide exchange factor 0.0234882
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0234636
PYGL phosphorylase, glycogen, liver 0.0234065
FMNL2 formin-like 2 0.022898
COPA coatomer protein complex, subunit alpha 0.0228631
UBASH3B ubiquitin associated and SH3 domain containing B 0.0228051
CCNL1 cyclin L1 0.0227975
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0219359
FNDC3B fibronectin type III domain containing 3B 0.0219329
UTRN utrophin 0.0218836
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.021804
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0216085
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0215503
THSD4 thrombospondin, type I, domain containing 4 0.0215499
PTK2 protein tyrosine kinase 2 0.0208592
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0205748
WDR43 WD repeat domain 43 0.0205065
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0203181
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0203172
DOCK5 dedicator of cytokinesis 5 0.0198818
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0194336
VMP1 vacuole membrane protein 1 0.0191486
BIRC6 baculoviral IAP repeat containing 6 0.0187062
GLG1 golgi glycoprotein 1 0.0184861
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0181415
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0179515
RICTOR RPTOR independent companion of MTOR, complex 2 0.0178728
CMIP c-Maf inducing protein 0.0178182
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0175586
TRA2A transformer 2 alpha homolog (Drosophila) 0.0173935
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0173856
SETD5 SET domain containing 5 0.0166422
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0164024
HLA-B major histocompatibility complex, class I, B 0.0163686
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0163206
SNX14 sorting nexin 14 0.0162977
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.01612
ZFHX3 zinc finger homeobox 3 0.0160372
ASPH aspartate beta-hydroxylase 0.0155797
NF1 neurofibromin 1 0.0153743
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0153379
WWTR1 WW domain containing transcription regulator 1 0.0153238
ARHGAP26 Rho GTPase activating protein 26 0.014973
SPAG9 sperm associated antigen 9 0.0148079
TTC3 tetratricopeptide repeat domain 3 0.0147752
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0147583
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0147482
KAT6B K(lysine) acetyltransferase 6B 0.0145941
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0145199
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0144907
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0144797
RAD51B RAD51 paralog B 0.0144666
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0144125
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0143602
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0143251
EXT1 exostosin glycosyltransferase 1 0.0141737
LPP LIM domain containing preferred translocation partner in lipoma 0.0140997
MACF1 microtubule-actin crosslinking factor 1 0.0140859
KDM2A lysine (K)-specific demethylase 2A 0.0140647
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.014006
TFG TRK-fused gene 0.0138248
RSRP1 arginine/serine-rich protein 1 0.0136179
MAML3 mastermind-like 3 (Drosophila) 0.0134303
RBM25 RNA binding motif protein 25 0.0133466
USP36 ubiquitin specific peptidase 36 0.0133356
CEP350 centrosomal protein 350kDa 0.0132904
SEC31A SEC31 homolog A (S. cerevisiae) 0.0132287
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0131764
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0131763
NUMB numb homolog (Drosophila) 0.0131545
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0129724
ARF4 ADP-ribosylation factor 4 0.0129595
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0129482
GOLGA4 golgin A4 0.0129052
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.012898
DGKD diacylglycerol kinase, delta 130kDa 0.0128364
FOXP1 forkhead box P1 0.0128078
KMT2C lysine (K)-specific methyltransferase 2C 0.0127739
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0127734
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0124515
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0123748
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0123501
BRD2 bromodomain containing 2 0.0123428
ALCAM activated leukocyte cell adhesion molecule 0.0122716
GPC6 glypican 6 0.0122692
ZEB1 zinc finger E-box binding homeobox 1 0.0122525

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.183773
FTL ferritin, light polypeptide -0.173748
MT2A metallothionein 2A -0.163076
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151938
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.126434
RPL23 ribosomal protein L23 -0.0876702
RPL19 ribosomal protein L19 -0.0750304
FTH1 ferritin, heavy polypeptide 1 -0.0577911
RPLP1 ribosomal protein, large, P1 -0.0564598
VIM vimentin -0.0551734
RPS27A ribosomal protein S27a -0.0497496
RPS12 ribosomal protein S12 -0.0459969
RPS19 ribosomal protein S19 -0.0442522
PTMA prothymosin, alpha -0.0421155
RPL36 ribosomal protein L36 -0.0408581
S100A6 S100 calcium binding protein A6 -0.0397009
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0394738
TXNRD1 thioredoxin reductase 1 -0.0373282
PFN1 profilin 1 -0.0365352
TFPI2 tissue factor pathway inhibitor 2 -0.0361351
RPS8 ribosomal protein S8 -0.0341249
UBC ubiquitin C -0.0340606
FGB fibrinogen beta chain -0.0339627
RPL8 ribosomal protein L8 -0.0313824
YBX1 Y box binding protein 1 -0.0303268
RPL26 ribosomal protein L26 -0.0296652
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0289292
RACK1 receptor for activated C kinase 1 -0.0282993
RPL30 ribosomal protein L30 -0.0278151
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0275518
ATP5F1E ATP synthase F1 subunit epsilon -0.0271544
RPL12 ribosomal protein L12 -0.026774
RPS17 ribosomal protein S17 -0.0250866
RPS6 ribosomal protein S6 -0.0244946
RPS5 ribosomal protein S5 -0.0240977
RPS21 ribosomal protein S21 -0.0240462
S100A9 S100 calcium binding protein A9 -0.0228771
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0218391
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0216765
RPL37 ribosomal protein L37 -0.0213614
HMGB1 high mobility group box 1 -0.0213348
EEF1G eukaryotic translation elongation factor 1 gamma -0.0211571
RPS3 ribosomal protein S3 -0.0210916
RPLP0 ribosomal protein, large, P0 -0.0209668
RPS20 ribosomal protein S20 -0.0207843
RPL18 ribosomal protein L18 -0.0201467
RPS29 ribosomal protein S29 -0.0200849
PM20D1 peptidase M20 domain containing 1 -0.0200478
LDHB lactate dehydrogenase B -0.0198668
RPL28 ribosomal protein L28 -0.0188814
GNAS GNAS complex locus -0.0188799
PFDN2 prefoldin subunit 2 -0.0188525
SERF2 small EDRK-rich factor 2 -0.0187291
RPS16 ribosomal protein S16 -0.0184584
IER3 immediate early response 3 -0.0184272
RPL4 ribosomal protein L4 -0.0183694
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0183397
TAGLN2 transgelin 2 -0.0182563
RPS25 ribosomal protein S25 -0.0171879
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0168583
RPL35A ribosomal protein L35a -0.0168448
RPS23 ribosomal protein S23 -0.0168411
RPL7 ribosomal protein L7 -0.0166701
RPS14 ribosomal protein S14 -0.0166588
RPL9 ribosomal protein L9 -0.0164128
RPL35 ribosomal protein L35 -0.0164033
RPS2 ribosomal protein S2 -0.0163049
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0161676
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0161301
PCBP2 poly(rC) binding protein 2 -0.0159608
GSTP1 glutathione S-transferase pi 1 -0.0159422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0159365
RPS11 ribosomal protein S11 -0.0159287
RPS27 ribosomal protein S27 -0.0156952
S100A10 S100 calcium binding protein A10 -0.0156356
RPLP2 ribosomal protein, large, P2 -0.0155617
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0155614
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0154768
POTEF POTE ankyrin domain family, member F -0.0152443
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.0151904
RPL37A ribosomal protein L37a -0.0151412
IFITM3 interferon induced transmembrane protein 3 -0.0148579
MYL12B myosin, light chain 12B, regulatory -0.0148031
HMGA1 high mobility group AT-hook 1 -0.0147731
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0144119
RPL5 ribosomal protein L5 -0.0143932
CALR calreticulin -0.0143533
ROMO1 reactive oxygen species modulator 1 -0.0142892
RPL34 ribosomal protein L34 -0.0140705
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.013866
RPS15 ribosomal protein S15 -0.0137995
TUBB tubulin, beta class I -0.0137892
RPL36AL ribosomal protein L36a-like -0.0136853
HDGF hepatoma-derived growth factor -0.0134983
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0134431
RPL23A ribosomal protein L23a -0.0134004
RPL11 ribosomal protein L11 -0.013399
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0131894
S100A11 S100 calcium binding protein A11 -0.0131216
SLC38A1 solute carrier family 38, member 1 -0.0131171