Ivermectin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ivermectin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.212626
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.128116
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0940675
NAMPT nicotinamide phosphoribosyltransferase 0.0829307
ASPH aspartate beta-hydroxylase 0.0755714
TSC22D2 TSC22 domain family, member 2 0.0647709
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0609605
RNF145 ring finger protein 145 0.0601919
FNDC3B fibronectin type III domain containing 3B 0.0575697
CCNL1 cyclin L1 0.0540419
NDRG1 N-myc downstream regulated 1 0.0540136
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0513977
MARCHF6 membrane associated ring-CH-type finger 6 0.0513599
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0477063
TFG TRK-fused gene 0.0457451
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0449539
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0443367
FXR1 fragile X mental retardation, autosomal homolog 1 0.0442528
FAM13A family with sequence similarity 13, member A 0.0435558
ELL2 elongation factor, RNA polymerase II, 2 0.0433611
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0393295
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.039061
KMT2E lysine (K)-specific methyltransferase 2E 0.0383224
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0377175
UBA6 ubiquitin-like modifier activating enzyme 6 0.0374479
ZNF292 zinc finger protein 292 0.0364877
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0362052
MATR3 matrin 3 0.0360959
RBM39 RNA binding motif protein 39 0.0360861
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.035864
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0357007
BHLHE40 basic helix-loop-helix family, member e40 0.0356824
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0348296
NUP58 nucleoporin 58 0.0346743
DSCAM Down syndrome cell adhesion molecule 0.0341147
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0339082
HMGB2 high mobility group box 2 0.0331095
ADAM9 ADAM metallopeptidase domain 9 0.0327816
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0321137
MSMO1 methylsterol monooxygenase 1 0.0320499
MYH9 myosin, heavy chain 9, non-muscle 0.0320406
RLF rearranged L-myc fusion 0.0318174
NCKAP1 NCK-associated protein 1 0.0316575
TRIO trio Rho guanine nucleotide exchange factor 0.0313865
USP3 ubiquitin specific peptidase 3 0.0311705
PAPOLA poly(A) polymerase alpha 0.031142
HSPA8 heat shock 70kDa protein 8 0.0307968
GARS1 glycyl-tRNA synthetase 1 0.0306461
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0304211
CDC73 cell division cycle 73 0.0301297
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0292877
ANXA5 annexin A5 0.0292613
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0285493
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0284531
EEF2 eukaryotic translation elongation factor 2 0.0284206
QKI QKI, KH domain containing, RNA binding 0.0280814
RYBP RING1 and YY1 binding protein 0.0279513
YTHDC1 YTH domain containing 1 0.0278796
PTK2 protein tyrosine kinase 2 0.0271664
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0271359
SPAG9 sperm associated antigen 9 0.0264733
ATP13A3 ATPase type 13A3 0.0259951
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0259299
KDM3A lysine (K)-specific demethylase 3A 0.0255817
APP amyloid beta (A4) precursor protein 0.025477
SLMAP sarcolemma associated protein 0.0252473
RHEB Ras homolog enriched in brain 0.0250133
CD46 CD46 molecule, complement regulatory protein 0.0249028
WAC WW domain containing adaptor with coiled-coil 0.0240665
PEG10 paternally expressed 10 0.0240294
EPS8 epidermal growth factor receptor pathway substrate 8 0.0239516
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0238765
ARRDC3 arrestin domain containing 3 0.0238665
KDM6A lysine (K)-specific demethylase 6A 0.0238059
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0235069
PCBP2 poly(rC) binding protein 2 0.0234743
AZIN1 antizyme inhibitor 1 0.0233503
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0232995
ECT2 epithelial cell transforming 2 0.0230411
NPTN neuroplastin 0.0225776
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0225735
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0225171
RAD21 RAD21 homolog (S. pombe) 0.0224509
ZFAND3 zinc finger, AN1-type domain 3 0.0221208
CHD1 chromodomain helicase DNA binding protein 1 0.0217803
SEC23A Sec23 homolog A (S. cerevisiae) 0.0216713
CDK17 cyclin-dependent kinase 17 0.0215307
RYK receptor-like tyrosine kinase 0.0214979
RTN4 reticulon 4 0.0212894
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0212482
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0212443
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0211571
TOP2B topoisomerase (DNA) II beta 180kDa 0.0211445
MSN moesin 0.0210991
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0210767
PUM1 pumilio RNA-binding family member 1 0.0210163
SSBP2 single-stranded DNA binding protein 2 0.0208486
RBM33 RNA binding motif protein 33 0.0205976
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0204948
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0203763

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175335
FTL ferritin, light polypeptide -0.153482
TMSB10 thymosin beta 10 -0.142185
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.131861
ACTG1 actin gamma 1 -0.125611
IFI27 interferon, alpha-inducible protein 27 -0.0972508
PTMA prothymosin, alpha -0.0944948
FBXO32 F-box protein 32 -0.0724879
RPL35A ribosomal protein L35a -0.0699022
LPP LIM domain containing preferred translocation partner in lipoma -0.069177
RPLP1 ribosomal protein, large, P1 -0.0668133
IFI6 interferon, alpha-inducible protein 6 -0.0653842
TPT1 tumor protein, translationally-controlled 1 -0.0645852
SAMD4A sterile alpha motif domain containing 4A -0.0621855
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0614743
EXT1 exostosin glycosyltransferase 1 -0.0613618
S100A6 S100 calcium binding protein A6 -0.0603328
CSTB cystatin B (stefin B) -0.0590553
ISG15 ISG15 ubiquitin-like modifier -0.0574818
RPL34 ribosomal protein L34 -0.0570295
IFITM3 interferon induced transmembrane protein 3 -0.0526129
S100A10 S100 calcium binding protein A10 -0.0525582
SOX4 SRY (sex determining region Y)-box 4 -0.0500687
TMSB4X thymosin beta 4, X-linked -0.0487415
LIMCH1 LIM and calponin homology domains 1 -0.0486941
RPS8 ribosomal protein S8 -0.0478764
LAMB3 laminin, beta 3 -0.0463952
IFI16 interferon, gamma-inducible protein 16 -0.0457253
EIF1 eukaryotic translation initiation factor 1 -0.04478
TPM4 tropomyosin 4 -0.044128
EFNA5 ephrin-A5 -0.0435769
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0432765
HLA-B major histocompatibility complex, class I, B -0.0429927
IGFBP3 insulin-like growth factor binding protein 3 -0.04259
RPLP2 ribosomal protein, large, P2 -0.0415892
IFITM1 interferon induced transmembrane protein 1 -0.0399092
RPL8 ribosomal protein L8 -0.0396533
HLA-A major histocompatibility complex, class I, A -0.0394548
GOLGB1 golgin B1 -0.0393216
S100A9 S100 calcium binding protein A9 -0.0392468
RPS19 ribosomal protein S19 -0.0386343
RPS29 ribosomal protein S29 -0.0385281
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0384332
RNF213 ring finger protein 213 -0.0376253
MDK midkine (neurite growth-promoting factor 2) -0.0371955
MX2 MX dynamin-like GTPase 2 -0.0367902
RPS13 ribosomal protein S13 -0.0364715
MYO1E myosin IE -0.0363858
RPL12 ribosomal protein L12 -0.0357261
CCND1 cyclin D1 -0.0356192
KRT7 keratin 7, type II -0.0349326
RPL23 ribosomal protein L23 -0.0348598
TM4SF1 transmembrane 4 L six family member 1 -0.0346522
ZBTB20 zinc finger and BTB domain containing 20 -0.0343143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0342892
RACK1 receptor for activated C kinase 1 -0.0336716
AHNAK AHNAK nucleoprotein -0.0335941
WSB1 WD repeat and SOCS box containing 1 -0.0331417
SQSTM1 sequestosome 1 -0.0330494
RPL37 ribosomal protein L37 -0.032938
VIM vimentin -0.0327639
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0322388
RPS14 ribosomal protein S14 -0.0318059
RPS6 ribosomal protein S6 -0.0317915
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0313244
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0312566
RPL9 ribosomal protein L9 -0.030767
RPS23 ribosomal protein S23 -0.0306958
HSPB1 heat shock 27kDa protein 1 -0.0303713
RPL19 ribosomal protein L19 -0.0300423
VCL vinculin -0.0298635
RPL37A ribosomal protein L37a -0.0293382
C15ORF48 chromosome 15 open reading frame 48 -0.0291997
ARHGAP5 Rho GTPase activating protein 5 -0.0291028
STAT1 signal transducer and activator of transcription 1, 91kDa -0.029017
MT2A metallothionein 2A -0.0287344
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0284166
RPS25 ribosomal protein S25 -0.028171
LY6E lymphocyte antigen 6 complex, locus E -0.0278312
KRT19 keratin 19, type I -0.0277557
RAI14 retinoic acid induced 14 -0.0276319
ETV6 ets variant 6 -0.0276091
RPS27 ribosomal protein S27 -0.0275936
PLSCR1 phospholipid scramblase 1 -0.0273318
RPL31 ribosomal protein L31 -0.0272098
MAP1B microtubule-associated protein 1B -0.0268649
RPL32 ribosomal protein L32 -0.0264878
LMO7 LIM domain 7 -0.0263941
RPS21 ribosomal protein S21 -0.0263934
UBE2H ubiquitin-conjugating enzyme E2H -0.0263149
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0262654
BASP1 brain abundant, membrane attached signal protein 1 -0.0256994
UBC ubiquitin C -0.0256858
POTEF POTE ankyrin domain family, member F -0.0256576
SP100 SP100 nuclear antigen -0.0256176
RPS27A ribosomal protein S27a -0.025435
RPS17 ribosomal protein S17 -0.0252416
FNIP1 folliculin interacting protein 1 -0.0245519
MAML2 mastermind-like 2 (Drosophila) -0.0244654
RBM47 RNA binding motif protein 47 -0.0243428