Ivermectin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.0901267
FN1 fibronectin 1 0.0896809
EFNA5 ephrin-A5 0.0688256
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0645312
IGFBP3 insulin-like growth factor binding protein 3 0.0620451
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0599138
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0580322
ERRFI1 ERBB receptor feedback inhibitor 1 0.0495803
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0382152
LIMCH1 LIM and calponin homology domains 1 0.0369428
MSN moesin 0.0364724
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0329444
ESYT2 extended synaptotagmin-like protein 2 0.0314549
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0313951
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0305754
FAM13A family with sequence similarity 13, member A 0.0295516
FNDC3B fibronectin type III domain containing 3B 0.0275579
KMT2C lysine (K)-specific methyltransferase 2C 0.0274475
USP34 ubiquitin specific peptidase 34 0.0271315
VMP1 vacuole membrane protein 1 0.0270182
KMT2E lysine (K)-specific methyltransferase 2E 0.0262052
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0261027
FNIP1 folliculin interacting protein 1 0.0258058
PICALM phosphatidylinositol binding clathrin assembly protein 0.0250702
COL4A6 collagen, type IV, alpha 6 0.0248387
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0248146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0246762
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0238874
NCOR2 nuclear receptor corepressor 2 0.0238492
COPA coatomer protein complex, subunit alpha 0.0233209
KDM6A lysine (K)-specific demethylase 6A 0.0229527
ELL2 elongation factor, RNA polymerase II, 2 0.0228937
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224522
PTEN phosphatase and tensin homolog 0.0224327
DNER delta/notch-like EGF repeat containing 0.0222453
ATP13A3 ATPase type 13A3 0.0219586
SDK1 sidekick cell adhesion molecule 1 0.021937
ZNF638 zinc finger protein 638 0.0219296
RTN4 reticulon 4 0.0216682
NDRG1 N-myc downstream regulated 1 0.02143
FLNB filamin B, beta 0.0213598
ANXA1 annexin A1 0.0212676
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207847
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0207231
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0199355
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.019935
PCBP2 poly(rC) binding protein 2 0.0197124
CD46 CD46 molecule, complement regulatory protein 0.0193764
AVL9 AVL9 homolog (S. cerevisiase) 0.0193322
SEC31A SEC31 homolog A (S. cerevisiae) 0.0193162
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.019259
HELZ helicase with zinc finger 0.019204
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0191722
NGLY1 N-glycanase 1 0.0190221
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0190119
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.0187715
ITPRID2 ITPR interacting domain containing 2 0.0182536
PHF21A PHD finger protein 21A 0.0182365
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0178416
TRIO trio Rho guanine nucleotide exchange factor 0.0178209
CEP170 centrosomal protein 170kDa 0.0178141
PYGL phosphorylase, glycogen, liver 0.0176875
RUNX1 runt-related transcription factor 1 0.0174898
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0174329
NBAS neuroblastoma amplified sequence 0.0171234
BIRC6 baculoviral IAP repeat containing 6 0.016768
LAMA5 laminin, alpha 5 0.0166245
NBEAL1 neurobeachin-like 1 0.0164489
NUP58 nucleoporin 58 0.0163933
FAM219A family with sequence similarity 219, member A 0.0163649
GIGYF2 GRB10 interacting GYF protein 2 0.0163555
PRELID2 PRELI domain containing 2 0.0163183
ANXA5 annexin A5 0.0162422
ANKRD36 ankyrin repeat domain 36 0.0162181
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0160794
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0160251
UBAP2L ubiquitin associated protein 2-like 0.0160107
SEC24A SEC24 family member A 0.015983
HYOU1 hypoxia up-regulated 1 0.0155963
MFF mitochondrial fission factor 0.0154736
TNIP1 TNFAIP3 interacting protein 1 0.0152232
CHD1L chromodomain helicase DNA binding protein 1-like 0.0152092
FAT1 FAT atypical cadherin 1 0.0150987
STC2 stanniocalcin 2 0.0149945
PDGFA platelet-derived growth factor alpha polypeptide 0.0147532
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0147329
RPL3 ribosomal protein L3 0.0147127
EZR ezrin 0.0146025
HDAC4 histone deacetylase 4 0.0145811
DENND1A DENN/MADD domain containing 1A 0.0145568
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0144729
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0144509
CDC73 cell division cycle 73 0.0144055
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0141852
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0141511
CTBP2 C-terminal binding protein 2 0.0139834
COG5 component of oligomeric golgi complex 5 0.0139787
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0139674
USP9X ubiquitin specific peptidase 9, X-linked 0.0139612
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0139426

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.263897
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.16098
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153024
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.135193
TMSB10 thymosin beta 10 -0.134512
FTL ferritin, light polypeptide -0.107231
RPLP1 ribosomal protein, large, P1 -0.107109
VIM vimentin -0.101857
PTMA prothymosin, alpha -0.101847
COL5A2 collagen, type V, alpha 2 -0.0936766
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0927884
SMYD3 SET and MYND domain containing 3 -0.0889015
TPT1 tumor protein, translationally-controlled 1 -0.086138
RPL12 ribosomal protein L12 -0.0830204
PDE10A phosphodiesterase 10A -0.0826332
RPS6 ribosomal protein S6 -0.0811454
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0811068
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0802769
RPL23 ribosomal protein L23 -0.0722806
PSD3 pleckstrin and Sec7 domain containing 3 -0.0706353
P3H2 prolyl 3-hydroxylase 2 -0.0702609
NALF1 NALCN channel auxiliary factor 1 -0.0701941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0684511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0682293
RPS8 ribosomal protein S8 -0.0675669
NAP1L1 nucleosome assembly protein 1-like 1 -0.0671332
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0661092
TXNRD1 thioredoxin reductase 1 -0.0648045
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0644773
RPS24 ribosomal protein S24 -0.063651
RPL37A ribosomal protein L37a -0.0635716
RPS12 ribosomal protein S12 -0.0580839
RPL19 ribosomal protein L19 -0.0574463
ASPH aspartate beta-hydroxylase -0.0571957
RPL35A ribosomal protein L35a -0.0571722
TFPI2 tissue factor pathway inhibitor 2 -0.0566025
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0561581
RPS27A ribosomal protein S27a -0.055665
RPL31 ribosomal protein L31 -0.0545258
S100A6 S100 calcium binding protein A6 -0.0543569
RPLP0 ribosomal protein, large, P0 -0.0532559
RPL26 ribosomal protein L26 -0.0530585
RPL34 ribosomal protein L34 -0.0527137
RPS19 ribosomal protein S19 -0.0514429
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0503046
KYNU kynureninase -0.0486032
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0479389
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.047205
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0468509
GDA guanine deaminase -0.0462797
ANTXR1 anthrax toxin receptor 1 -0.0461749
MT2A metallothionein 2A -0.0457394
GNAS GNAS complex locus -0.0447526
RPL36A ribosomal protein L36a -0.0440238
ACTG1 actin gamma 1 -0.0435556
RPS3 ribosomal protein S3 -0.0427317
TM4SF1 transmembrane 4 L six family member 1 -0.0424812
RPL11 ribosomal protein L11 -0.041027
RACK1 receptor for activated C kinase 1 -0.0408321
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0394249
PRKN parkin RBR E3 ubiquitin protein ligase -0.0387854
RPL36 ribosomal protein L36 -0.0383496
RPS14 ribosomal protein S14 -0.0381174
COL8A1 collagen, type VIII, alpha 1 -0.0379846
RPL9 ribosomal protein L9 -0.0379768
RPS27 ribosomal protein S27 -0.0372282
RPL38 ribosomal protein L38 -0.0371269
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0369995
RPL37 ribosomal protein L37 -0.0369393
B2M beta-2-microglobulin -0.0369209
RPLP2 ribosomal protein, large, P2 -0.0358563
S100A10 S100 calcium binding protein A10 -0.0356091
RPL35 ribosomal protein L35 -0.0351124
NCOA7 nuclear receptor coactivator 7 -0.0348766
RPL7A ribosomal protein L7a -0.0342402
SRGN serglycin -0.0338498
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0337197
PM20D1 peptidase M20 domain containing 1 -0.0334881
RPS29 ribosomal protein S29 -0.0333504
AKR1C1 aldo-keto reductase family 1, member C1 -0.0331855
RPS25 ribosomal protein S25 -0.0330156
SH3KBP1 SH3-domain kinase binding protein 1 -0.0320821
RPS21 ribosomal protein S21 -0.0316954
RPL13A ribosomal protein L13a -0.0312021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.03074
RPL5 ribosomal protein L5 -0.0305743
RPS23 ribosomal protein S23 -0.0304577
BASP1 brain abundant, membrane attached signal protein 1 -0.0303811
PRDX1 peroxiredoxin 1 -0.0303761
EIF1 eukaryotic translation initiation factor 1 -0.0301195
CDH13 cadherin 13 -0.0300629
RPS16 ribosomal protein S16 -0.0297372
LSAMP limbic system-associated membrane protein -0.0296698
RPL32 ribosomal protein L32 -0.0295225
RGS2 regulator of G-protein signaling 2 -0.0292355
SERBP1 SERPINE1 mRNA binding protein 1 -0.0289894
TMSB4X thymosin beta 4, X-linked -0.0286045
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0284631
NRCAM neuronal cell adhesion molecule -0.0284169
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0275339