Ivermectin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.139893
ADAM10 ADAM metallopeptidase domain 10 0.126282
PKM pyruvate kinase, muscle 0.112559
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0897941
NBEA neurobeachin 0.088512
FOXP1 forkhead box P1 0.0850731
TJP1 tight junction protein 1 0.0850287
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.084091
VCL vinculin 0.0838288
EGFR epidermal growth factor receptor 0.0826051
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0780513
TXNRD1 thioredoxin reductase 1 0.076247
PYGB phosphorylase, glycogen; brain 0.0752429
EEF2 eukaryotic translation elongation factor 2 0.073272
ZFAND3 zinc finger, AN1-type domain 3 0.0724563
FLNB filamin B, beta 0.0709213
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0700273
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0697387
HDAC9 histone deacetylase 9 0.0679663
RBM39 RNA binding motif protein 39 0.066989
EFNA5 ephrin-A5 0.06683
PDGFC platelet derived growth factor C 0.0660194
PTMA prothymosin, alpha 0.0642562
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0640719
ANK2 ankyrin 2, neuronal 0.0638819
ANKRD11 ankyrin repeat domain 11 0.0633047
ZEB1 zinc finger E-box binding homeobox 1 0.0593357
SSBP2 single-stranded DNA binding protein 2 0.0576633
JMJD1C jumonji domain containing 1C 0.0573892
TMSB4X thymosin beta 4, X-linked 0.0573045
TMEM65 transmembrane protein 65 0.0563374
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0540443
LPP LIM domain containing preferred translocation partner in lipoma 0.0523982
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0523904
LDHA lactate dehydrogenase A 0.0522648
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.051706
DUSP4 dual specificity phosphatase 4 0.0496329
RPS6 ribosomal protein S6 0.0486156
NF1 neurofibromin 1 0.0483976
DPYD dihydropyrimidine dehydrogenase 0.0477267
SOX6 SRY (sex determining region Y)-box 6 0.0473293
DSCAM Down syndrome cell adhesion molecule 0.0458686
DOCK3 dedicator of cytokinesis 3 0.0449081
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0446777
PDE4B phosphodiesterase 4B, cAMP-specific 0.0439968
RHOA ras homolog family member A 0.0436278
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0432909
PTPRG protein tyrosine phosphatase, receptor type, G 0.0431432
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0427422
EML4 echinoderm microtubule associated protein like 4 0.0427356
ZBTB20 zinc finger and BTB domain containing 20 0.0426261
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0414119
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0406921
IARS1 isoleucyl-tRNA synthetase 1 0.0398201
SMYD3 SET and MYND domain containing 3 0.0396032
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0395755
TCF12 transcription factor 12 0.03897
GOLGA4 golgin A4 0.0388693
CCNL1 cyclin L1 0.0388079
SQSTM1 sequestosome 1 0.0387207
TBC1D5 TBC1 domain family, member 5 0.0373668
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0371202
EIF4A2 eukaryotic translation initiation factor 4A2 0.0370741
VMP1 vacuole membrane protein 1 0.0370452
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0368913
PARD3 par-3 family cell polarity regulator 0.0358743
PTBP2 polypyrimidine tract binding protein 2 0.0358233
BMP2K BMP2 inducible kinase 0.03487
BTBD9 BTB (POZ) domain containing 9 0.0347236
RTN4 reticulon 4 0.0343534
CLIP1 CAP-GLY domain containing linker protein 1 0.0339979
LOC112694756 uncharaterized LOC112694756 0.0334931
GSK3B glycogen synthase kinase 3 beta 0.0334329
DIAPH2 diaphanous-related formin 2 0.0331104
NCEH1 neutral cholesterol ester hydrolase 1 0.0330678
ANKRD17 ankyrin repeat domain 17 0.0327469
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0325899
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0323817
MAP4 microtubule-associated protein 4 0.0322925
SPIDR scaffolding protein involved in DNA repair 0.032007
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0317929
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0317756
METTL15 methyltransferase like 15 0.0314909
ZCCHC7 zinc finger, CCHC domain containing 7 0.031241
NBAS neuroblastoma amplified sequence 0.0311813
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.031181
USP34 ubiquitin specific peptidase 34 0.0309534
SPATS2L spermatogenesis associated, serine-rich 2-like 0.030793
LOXL3 lysyl oxidase-like 3 0.0304809
TMEM41B transmembrane protein 41B 0.0302716
NCKAP1 NCK-associated protein 1 0.0301634
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0298155
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0296828
PNISR PNN-interacting serine/arginine-rich protein 0.0296707
POTEF POTE ankyrin domain family, member F 0.0296614
ANXA1 annexin A1 0.029445
OSMR oncostatin M receptor 0.0294448
ARL4C ADP-ribosylation factor-like 4C 0.02924
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0291448
GLI2 GLI family zinc finger 2 0.029117

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0357053
RRBP1 ribosome binding protein 1 -0.0240728
INTS6 integrator complex subunit 6 -0.0222107
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0194241
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0189096
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0175299
RFC3 replication factor C (activator 1) 3, 38kDa -0.0169824
BMP10 bone morphogenetic protein 10 -0.0166108
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0155109
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0150347
FN1 fibronectin 1 -0.014491
NAV2 neuron navigator 2 -0.0142986
RRM2 ribonucleotide reductase M2 -0.0141998
TSC22D2 TSC22 domain family, member 2 -0.0141168
ERRFI1 ERBB receptor feedback inhibitor 1 -0.013866
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0138616
CENPP centromere protein P -0.0135698
FTL ferritin, light polypeptide -0.0133262
RPLP1 ribosomal protein, large, P1 -0.0133249
NDRG1 N-myc downstream regulated 1 -0.013076
CENPE centromere protein E, 312kDa -0.0127172
MYOF myoferlin -0.0121624
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0121162
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0120901
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0114474
MSH4 mutS homolog 4 -0.0114336
HILPDA hypoxia inducible lipid droplet-associated -0.011315
CFAP251 cilia and flagella associated protein 251 -0.0111256
SCG5 secretogranin V -0.0109462
AEBP2 AE binding protein 2 -0.0107229
CADM1 cell adhesion molecule 1 -0.0105439
SMC4 structural maintenance of chromosomes 4 -0.0103746
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0100179
ZNF106 zinc finger protein 106 -0.00996195
FER1L6 fer-1-like family member 6 -0.00979713
TXK TXK tyrosine kinase -0.00976342
H1-4 H1.4 linker histone, cluster member -0.00965112
RPL36 ribosomal protein L36 -0.00956699
REEP3 receptor accessory protein 3 -0.00950267
CD44 CD44 molecule (Indian blood group) -0.00917924
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.00917172
EED embryonic ectoderm development -0.00903086
PAIP2 poly(A) binding protein interacting protein 2 -0.00899571
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -0.00881918
ATAD2 ATPase family, AAA domain containing 2 -0.00881905
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -0.00878592
FBH1 F-box DNA helicase 1 -0.00875983
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.00862641
MT2A metallothionein 2A -0.00860468
RAD18 RAD18 E3 ubiquitin protein ligase -0.00857156
CALR calreticulin -0.00848317
TBCA tubulin folding cofactor A -0.00843366
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00840619
ORAI2 ORAI calcium release-activated calcium modulator 2 -0.00836456
MYH15 myosin, heavy chain 15 -0.00836066
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.00822162
TOP1 topoisomerase (DNA) I -0.00820239
TM4SF1 transmembrane 4 L six family member 1 -0.00818828
CDH13 cadherin 13 -0.00807776
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.00804794
IGF2 insulin-like growth factor 2 -0.00803237
HELZ helicase with zinc finger -0.00793236
GPR75-ASB3 GPR75-ASB3 readthrough -0.00790157
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.00784545
ANXA2 annexin A2 -0.00782832
FLCN folliculin -0.00780467
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0077793
PTCD3 pentatricopeptide repeat domain 3 -0.00775916
PDIA3 protein disulfide isomerase family A, member 3 -0.00773669
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.00767489
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -0.00764729
GPC6 glypican 6 -0.00764387
RNF169 ring finger protein 169 -0.00762872
MED26 mediator complex subunit 26 -0.00762321
FOXN3 forkhead box N3 -0.00762211
FGF18 fibroblast growth factor 18 -0.00756164
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00754031
TNIK TRAF2 and NCK interacting kinase -0.00752329
TNS3 tensin 3 -0.00751851
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00751606
TMSB10 thymosin beta 10 -0.0075156
CEP128 centrosomal protein 128kDa -0.00750126
SRP19 signal recognition particle 19kDa -0.00746938
VIM vimentin -0.00746591
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.00745394
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.00739313
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.00739015
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00737255
NEK10 NIMA-related kinase 10 -0.00737034
UGDH UDP-glucose 6-dehydrogenase -0.00734007
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.00732566
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00730606
ANKDD1B ankyrin repeat and death domain containing 1B -0.00727437
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.00725084
ELL2 elongation factor, RNA polymerase II, 2 -0.00718599
POLH polymerase (DNA directed), eta -0.00715467
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00711712
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.00711691
PCNX4 pecanex 4 -0.00705889
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00704424