Ivermectin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0874123
SOD2 superoxide dismutase 2, mitochondrial 0.077089
FNDC3B fibronectin type III domain containing 3B 0.0687027
NAMPT nicotinamide phosphoribosyltransferase 0.0655319
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0630719
TRIO trio Rho guanine nucleotide exchange factor 0.0622861
FN1 fibronectin 1 0.0583736
OGA O-GlcNAcase 0.057939
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0484318
ARRDC3 arrestin domain containing 3 0.0470289
ATP13A3 ATPase type 13A3 0.0469236
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0462143
NAV2 neuron navigator 2 0.0416094
ZNF292 zinc finger protein 292 0.0412416
MSN moesin 0.0405742
RB1CC1 RB1-inducible coiled-coil 1 0.0389216
TENT5A terminal nucleotidyltransferase 5A 0.0386799
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0386015
VEGFA vascular endothelial growth factor A 0.037956
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.037658
USP9X ubiquitin specific peptidase 9, X-linked 0.0368825
CADM1 cell adhesion molecule 1 0.0366927
ELL2 elongation factor, RNA polymerase II, 2 0.0355642
SPAG9 sperm associated antigen 9 0.033742
AFDN afadin, adherens junction formation factor 0.0336324
FNIP1 folliculin interacting protein 1 0.0332515
ANLN anillin, actin binding protein 0.032299
RBM39 RNA binding motif protein 39 0.0318002
UBA6 ubiquitin-like modifier activating enzyme 6 0.0310055
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0308502
EEF2 eukaryotic translation elongation factor 2 0.0307127
UGCG UDP-glucose ceramide glucosyltransferase 0.0305855
HELZ helicase with zinc finger 0.0304646
PHIP pleckstrin homology domain interacting protein 0.0286626
CCNL1 cyclin L1 0.0285052
KDM3A lysine (K)-specific demethylase 3A 0.0269999
AFF4 AF4/FMR2 family, member 4 0.026748
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264854
PCBP2 poly(rC) binding protein 2 0.0257153
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025674
JMJD1C jumonji domain containing 1C 0.0254436
LAMP2 lysosomal-associated membrane protein 2 0.0253932
DENND5A DENN/MADD domain containing 5A 0.0248906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0248317
UBE2H ubiquitin-conjugating enzyme E2H 0.0245843
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0243381
APP amyloid beta (A4) precursor protein 0.0241206
MKI67 marker of proliferation Ki-67 0.0240921
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0238774
ZNF451 zinc finger protein 451 0.0238113
SMAD3 SMAD family member 3 0.0237823
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0235923
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0223288
USP37 ubiquitin specific peptidase 37 0.0221452
VMP1 vacuole membrane protein 1 0.0217635
PTBP3 polypyrimidine tract binding protein 3 0.0214172
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0213825
DSCAM Down syndrome cell adhesion molecule 0.0212476
KDM6A lysine (K)-specific demethylase 6A 0.0210902
ANXA5 annexin A5 0.0209702
ZFAND3 zinc finger, AN1-type domain 3 0.0205987
CENPF centromere protein F, 350/400kDa 0.0205811
PICALM phosphatidylinositol binding clathrin assembly protein 0.0201759
ANKRD28 ankyrin repeat domain 28 0.0201408
YEATS2 YEATS domain containing 2 0.0197462
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0196653
DENND4C DENN/MADD domain containing 4C 0.0195859
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0195629
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0193129
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0191868
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0190172
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0187802
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0186606
ERRFI1 ERBB receptor feedback inhibitor 1 0.0185566
NGLY1 N-glycanase 1 0.0185224
TOP2A topoisomerase (DNA) II alpha 170kDa 0.01828
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0181942
TEX10 testis expressed 10 0.0180977
FNBP4 formin binding protein 4 0.0179516
TSC22D2 TSC22 domain family, member 2 0.0178806
CKAP5 cytoskeleton associated protein 5 0.0178735
XPO1 exportin 1 0.0177429
GAS2L3 growth arrest-specific 2 like 3 0.0177271
IQGAP1 IQ motif containing GTPase activating protein 1 0.0175029
TPX2 TPX2, microtubule-associated 0.0174868
KMT2E lysine (K)-specific methyltransferase 2E 0.017465
TMEM123 transmembrane protein 123 0.0173701
METTL15 methyltransferase like 15 0.017239
SNX9 sorting nexin 9 0.0170596
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0170127
SBF2 SET binding factor 2 0.0168393
KIF4A kinesin family member 4A 0.0168322
CLTC clathrin, heavy chain (Hc) 0.0166853
AKAP9 A kinase (PRKA) anchor protein 9 0.0165765
SCAF8 SR-related CTD-associated factor 8 0.0163925
AHR aryl hydrocarbon receptor 0.016295
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0162247
USP47 ubiquitin specific peptidase 47 0.0160896
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0160789
WDFY1 WD repeat and FYVE domain containing 1 0.0158659

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.230957
HLA-B major histocompatibility complex, class I, B -0.135453
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12657
FTL ferritin, light polypeptide -0.126043
TMSB10 thymosin beta 10 -0.118884
IER3 immediate early response 3 -0.101412
TPT1 tumor protein, translationally-controlled 1 -0.0865152
FRMD4A FERM domain containing 4A -0.0824789
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0767167
AKAP12 A kinase (PRKA) anchor protein 12 -0.0677108
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0664049
B2M beta-2-microglobulin -0.065186
RPS12 ribosomal protein S12 -0.0633018
RPL37A ribosomal protein L37a -0.0605261
MT2A metallothionein 2A -0.0579921
PTMA prothymosin, alpha -0.0579798
RPS8 ribosomal protein S8 -0.0570695
RPL35A ribosomal protein L35a -0.0558706
RPL23 ribosomal protein L23 -0.0541095
RPLP1 ribosomal protein, large, P1 -0.0529913
IGFBP3 insulin-like growth factor binding protein 3 -0.0525436
HLA-A major histocompatibility complex, class I, A -0.0506661
IFITM3 interferon induced transmembrane protein 3 -0.0494491
ENO1 enolase 1, (alpha) -0.0482473
VCL vinculin -0.0467543
RPLP2 ribosomal protein, large, P2 -0.0461315
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0436074
RPS24 ribosomal protein S24 -0.0433239
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0426891
RPS6 ribosomal protein S6 -0.0423488
RPS19 ribosomal protein S19 -0.0416386
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0411231
GLIS3 GLIS family zinc finger 3 -0.0397391
CALR calreticulin -0.0392704
RPL9 ribosomal protein L9 -0.0385537
ACTG1 actin gamma 1 -0.038136
RPS3 ribosomal protein S3 -0.0374018
CTSD cathepsin D -0.0360903
CDH13 cadherin 13 -0.0349488
RPL36 ribosomal protein L36 -0.0346877
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0345645
EGR1 early growth response 1 -0.0322641
RPL19 ribosomal protein L19 -0.031797
IFITM1 interferon induced transmembrane protein 1 -0.0315218
RPL31 ribosomal protein L31 -0.0309569
EXT1 exostosin glycosyltransferase 1 -0.0309565
RACK1 receptor for activated C kinase 1 -0.0307075
RPL36A ribosomal protein L36a -0.0305709
RPS23 ribosomal protein S23 -0.0305668
RPL12 ribosomal protein L12 -0.030439
S100A9 S100 calcium binding protein A9 -0.0303037
TPM4 tropomyosin 4 -0.0300705
HMGA2 high mobility group AT-hook 2 -0.0299695
ZMYND8 zinc finger, MYND-type containing 8 -0.0295449
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0294974
RPL26 ribosomal protein L26 -0.0286247
IFI6 interferon, alpha-inducible protein 6 -0.0285517
RPS13 ribosomal protein S13 -0.0281973
RPL37 ribosomal protein L37 -0.028004
RPL7A ribosomal protein L7a -0.0277665
NAV1 neuron navigator 1 -0.0277065
RPS21 ribosomal protein S21 -0.0275825
TMSB4X thymosin beta 4, X-linked -0.027506
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0274195
VCAN versican -0.0273973
RPS29 ribosomal protein S29 -0.0271061
RPL27A ribosomal protein L27a -0.0268583
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265717
SLC38A1 solute carrier family 38, member 1 -0.0263211
BICC1 BicC family RNA binding protein 1 -0.0255528
RPS25 ribosomal protein S25 -0.0251266
RPL35 ribosomal protein L35 -0.0250824
RPLP0 ribosomal protein, large, P0 -0.0248176
IFI16 interferon, gamma-inducible protein 16 -0.0246203
GNAS GNAS complex locus -0.0246143
RPS10 ribosomal protein S10 -0.0245185
RPL5 ribosomal protein L5 -0.0243718
RPL11 ribosomal protein L11 -0.0241369
ENO2 enolase 2 (gamma, neuronal) -0.0239311
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0239271
ISG15 ISG15 ubiquitin-like modifier -0.0231487
SQSTM1 sequestosome 1 -0.0230041
RPS14 ribosomal protein S14 -0.0230026
COL1A1 collagen, type I, alpha 1 -0.022819
INTS6 integrator complex subunit 6 -0.0224488
RPL34 ribosomal protein L34 -0.0223674
LOC102724023 ES1 protein homolog, mitochondrial -0.0222539
RPL38 ribosomal protein L38 -0.0222032
RPL28 ribosomal protein L28 -0.0221431
EGFR epidermal growth factor receptor -0.0219188
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0217779
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0213817
RRBP1 ribosome binding protein 1 -0.0213103
HLA-E major histocompatibility complex, class I, E -0.0210079
SFRP1 secreted frizzled-related protein 1 -0.0208124
ARL4C ADP-ribosylation factor-like 4C -0.0207894
KRT19 keratin 19, type I -0.020561
TENM2 teneurin transmembrane protein 2 -0.0204446
BTG1 B-cell translocation gene 1, anti-proliferative -0.0203819
RPS27A ribosomal protein S27a -0.0201021