Ivermectin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivermectin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivermectin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0383096
FTH1 ferritin, heavy polypeptide 1 0.0328046
CCDC88A coiled-coil domain containing 88A 0.0289118
DGKD diacylglycerol kinase, delta 130kDa 0.0273403
NCOA6 nuclear receptor coactivator 6 0.0254044
TRA2A transformer 2 alpha homolog (Drosophila) 0.0232038
NCEH1 neutral cholesterol ester hydrolase 1 0.0230808
SMYD3 SET and MYND domain containing 3 0.0227554
KMT2E lysine (K)-specific methyltransferase 2E 0.0222771
IARS1 isoleucyl-tRNA synthetase 1 0.0220928
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0213402
ZNF609 zinc finger protein 609 0.0210686
CAPRIN2 caprin family member 2 0.0210621
MSN moesin 0.0209998
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0207952
CHD1 chromodomain helicase DNA binding protein 1 0.0205709
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0201926
PNN pinin, desmosome associated protein 0.0201479
EGR1 early growth response 1 0.0196487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0193212
MAP1B microtubule-associated protein 1B 0.0182517
FMNL2 formin-like 2 0.0182379
RTN4 reticulon 4 0.0182284
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0181222
CHD7 chromodomain helicase DNA binding protein 7 0.017756
UGCG UDP-glucose ceramide glucosyltransferase 0.0174681
MACF1 microtubule-actin crosslinking factor 1 0.017457
YME1L1 YME1-like 1 ATPase 0.0169797
PSME4 proteasome (prosome, macropain) activator subunit 4 0.016809
ACTN1 actinin, alpha 1 0.0165063
AFF4 AF4/FMR2 family, member 4 0.0163854
SMAD5 SMAD family member 5 0.0163442
RAB7A RAB7A, member RAS oncogene family 0.0160589
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0160127
ANKRD12 ankyrin repeat domain 12 0.0159168
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.015875
ETF1 eukaryotic translation termination factor 1 0.0157119
PHC3 polyhomeotic homolog 3 (Drosophila) 0.015657
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0156152
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.015227
NDRG1 N-myc downstream regulated 1 0.0152039
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0147796
SASH1 SAM and SH3 domain containing 1 0.0145709
ZBTB1 zinc finger and BTB domain containing 1 0.0145569
TRIO trio Rho guanine nucleotide exchange factor 0.014541
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.014502
CSNK1A1 casein kinase 1, alpha 1 0.014479
ELL2 elongation factor, RNA polymerase II, 2 0.0144249
USP34 ubiquitin specific peptidase 34 0.0144004
ZC3H11A zinc finger CCCH-type containing 11A 0.0141341
JMY junction mediating and regulatory protein, p53 cofactor 0.0140706
KIAA1328 KIAA1328 0.0139731
OASL 2'-5'-oligoadenylate synthetase-like 0.013913
JMJD1C jumonji domain containing 1C 0.0138978
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0138962
MRPL3 mitochondrial ribosomal protein L3 0.0138595
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0138496
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0138125
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0138018
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0137216
UBXN4 UBX domain protein 4 0.0136308
MAPK14 mitogen-activated protein kinase 14 0.0135235
BICD1 bicaudal D homolog 1 (Drosophila) 0.0134557
FAM168A family with sequence similarity 168, member A 0.0134329
MBNL2 muscleblind-like splicing regulator 2 0.0133738
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0133584
EGFR epidermal growth factor receptor 0.0132191
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0131953
CEP250 centrosomal protein 250kDa 0.0131911
AXL AXL receptor tyrosine kinase 0.0130792
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0130199
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0128143
PRPF3 pre-mRNA processing factor 3 0.0127748
SPAG9 sperm associated antigen 9 0.0126219
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0126194
EIF4H eukaryotic translation initiation factor 4H 0.0125813
KPNB1 karyopherin (importin) beta 1 0.012506
PACS1 phosphofurin acidic cluster sorting protein 1 0.0124295
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0124049
SNX14 sorting nexin 14 0.0123814
SETD5 SET domain containing 5 0.0123113
MED17 mediator complex subunit 17 0.0122754
SRRM1 serine/arginine repetitive matrix 1 0.0122091
NCOA3 nuclear receptor coactivator 3 0.0121914
PAPOLA poly(A) polymerase alpha 0.0121674
GOLGA4 golgin A4 0.0121625
CDC14A cell division cycle 14A 0.0121606
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0121574
PRKCE protein kinase C, epsilon 0.0119373
TARS3 threonyl-tRNA synthetase 3 0.0119307
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0119
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0118405
ZBTB10 zinc finger and BTB domain containing 10 0.0118308
PCNX1 pecanex 1 0.0117971
COG5 component of oligomeric golgi complex 5 0.0117769
GOLGA2 golgin A2 0.011771
NUP98 nucleoporin 98kDa 0.0116772
RBM39 RNA binding motif protein 39 0.0116608
ZBTB38 zinc finger and BTB domain containing 38 0.0116176
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0116094

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341129
TMSB10 thymosin beta 10 -0.098887
VIM vimentin -0.0988704
PTMA prothymosin, alpha -0.075308
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0623637
UBC ubiquitin C -0.0590308
AHNAK AHNAK nucleoprotein -0.0436234
RPS27A ribosomal protein S27a -0.0375594
ENO1 enolase 1, (alpha) -0.037136
RPL23 ribosomal protein L23 -0.0349054
MT2A metallothionein 2A -0.0344789
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.033123
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0328492
NAP1L1 nucleosome assembly protein 1-like 1 -0.0317915
ANKRD28 ankyrin repeat domain 28 -0.0299759
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0284818
RPLP0 ribosomal protein, large, P0 -0.0280422
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.026845
BIRC3 baculoviral IAP repeat containing 3 -0.0265938
RPL19 ribosomal protein L19 -0.0261175
RPS8 ribosomal protein S8 -0.0257672
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0253828
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0253569
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0246441
TM4SF1 transmembrane 4 L six family member 1 -0.024442
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0244024
TPT1 tumor protein, translationally-controlled 1 -0.0243934
LDHA lactate dehydrogenase A -0.0237251
RPL26 ribosomal protein L26 -0.0234797
RPLP1 ribosomal protein, large, P1 -0.0234569
RPL37A ribosomal protein L37a -0.0232864
RPS29 ribosomal protein S29 -0.0230917
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0224988
ACTG1 actin gamma 1 -0.0223374
RPLP2 ribosomal protein, large, P2 -0.0220725
LIMS1 LIM and senescent cell antigen-like domains 1 -0.021685
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0213076
GNAS GNAS complex locus -0.0210344
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0208757
CENPF centromere protein F, 350/400kDa -0.0208061
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0207109
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0205044
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0204447
ATG10 autophagy related 10 -0.0204431
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -0.0203498
H3-3B H3.3 histone B -0.02031
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0202469
TRIM56 tripartite motif containing 56 -0.0200192
RPS6 ribosomal protein S6 -0.0199236
LPP LIM domain containing preferred translocation partner in lipoma -0.0198906
RPL27A ribosomal protein L27a -0.0198421
RPL37 ribosomal protein L37 -0.0198033
CCNI cyclin I -0.0197001
ANLN anillin, actin binding protein -0.0195266
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0195227
RPL32 ribosomal protein L32 -0.0195156
RPS13 ribosomal protein S13 -0.0194758
DIAPH3 diaphanous-related formin 3 -0.0194509
CELF1 CUGBP, Elav-like family member 1 -0.0194247
IGFBP3 insulin-like growth factor binding protein 3 -0.0194153
RNF169 ring finger protein 169 -0.0193611
ANXA2 annexin A2 -0.0193596
SMC4 structural maintenance of chromosomes 4 -0.0192364
EEF2 eukaryotic translation elongation factor 2 -0.0190444
CALU calumenin -0.0190133
FTL ferritin, light polypeptide -0.018777
ZBTB20 zinc finger and BTB domain containing 20 -0.0187743
USP22 ubiquitin specific peptidase 22 -0.0187696
SUN1 Sad1 and UNC84 domain containing 1 -0.0186795
TUBA1B tubulin, alpha 1b -0.0186511
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.018567
MTPN myotrophin -0.0180288
RPL35A ribosomal protein L35a -0.017918
POTEF POTE ankyrin domain family, member F -0.0178982
ARB2A ARB2 cotranscriptional regulator A -0.0178893
ETV6 ets variant 6 -0.0178242
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0178066
S100A9 S100 calcium binding protein A9 -0.017718
RPL31 ribosomal protein L31 -0.0175936
TBC1D5 TBC1 domain family, member 5 -0.0173119
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0172803
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0172676
SEC11A SEC11 homolog A (S. cerevisiae) -0.0171251
FUS FUS RNA binding protein -0.0171112
LMNA lamin A/C -0.0170946
YBX1 Y box binding protein 1 -0.0170366
POMP proteasome maturation protein -0.0169321
RPL12 ribosomal protein L12 -0.0167806
VDAC1 voltage-dependent anion channel 1 -0.0166631
RPL34 ribosomal protein L34 -0.0165079
CALR calreticulin -0.0164913
AVL9 AVL9 homolog (S. cerevisiase) -0.0162415
RPS27 ribosomal protein S27 -0.01618
RPL5 ribosomal protein L5 -0.0160215
NAV2 neuron navigator 2 -0.0159578
LCORL ligand dependent nuclear receptor corepressor-like -0.0159407
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0159271
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0159175
KHSRP KH-type splicing regulatory protein -0.0158406
MYO9A myosin IXA -0.01575