Ixazomib citrate_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.216514
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.214264
FTL ferritin, light polypeptide 0.0865834
HSPB1 heat shock 27kDa protein 1 0.0861095
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0728082
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0530076
HSPA8 heat shock 70kDa protein 8 0.0407056
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0369007
HSPA1A heat shock 70kDa protein 1A 0.0359047
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0358694
FXR1 fragile X mental retardation, autosomal homolog 1 0.0357275
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0354118
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0324772
HSPA4 heat shock 70kDa protein 4 0.0293721
KDM3A lysine (K)-specific demethylase 3A 0.0293106
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0292078
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0280316
UBC ubiquitin C 0.0279548
TFG TRK-fused gene 0.0274815
PUM2 pumilio RNA-binding family member 2 0.0271072
EIF4A2 eukaryotic translation initiation factor 4A2 0.0267664
HSPH1 heat shock 105kDa/110kDa protein 1 0.0264584
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260739
NCKAP1 NCK-associated protein 1 0.0241775
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0237111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.023654
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0226836
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0217788
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.021733
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0211633
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0210189
EEF1G eukaryotic translation elongation factor 1 gamma 0.020725
AKAP9 A kinase (PRKA) anchor protein 9 0.0206167
SQSTM1 sequestosome 1 0.02053
YBX1 Y box binding protein 1 0.0201518
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0201131
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197915
PLK2 polo-like kinase 2 0.0195245
PCBP2 poly(rC) binding protein 2 0.0189809
SPAG9 sperm associated antigen 9 0.0189604
ARRDC3 arrestin domain containing 3 0.018726
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0183855
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0177199
CLTC clathrin, heavy chain (Hc) 0.0174092
CHD1 chromodomain helicase DNA binding protein 1 0.0172862
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0169155
MARCHF6 membrane associated ring-CH-type finger 6 0.0167834
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0165855
BRD2 bromodomain containing 2 0.0165326
SLMAP sarcolemma associated protein 0.0164485
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0163472
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0162605
EEF2 eukaryotic translation elongation factor 2 0.0161824
HELZ helicase with zinc finger 0.0158994
PICALM phosphatidylinositol binding clathrin assembly protein 0.015878
CSDE1 cold shock domain containing E1, RNA-binding 0.0157602
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0157062
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0153442
TOP2B topoisomerase (DNA) II beta 180kDa 0.0150224
GPBP1 GC-rich promoter binding protein 1 0.0149651
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0148991
CKAP5 cytoskeleton associated protein 5 0.0148951
BIRC2 baculoviral IAP repeat containing 2 0.0147553
SFTPA2 surfactant protein A2 0.0146774
RPS2 ribosomal protein S2 0.0146195
RPL14 ribosomal protein L14 0.0146128
NFE2L1 nuclear factor, erythroid 2-like 1 0.0144043
UBE4B ubiquitination factor E4B 0.01424
KDM6A lysine (K)-specific demethylase 6A 0.0142159
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0141387
SERINC1 serine incorporator 1 0.0140695
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0139154
UBA6 ubiquitin-like modifier activating enzyme 6 0.0138206
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0136493
LEMD3 LEM domain containing 3 0.013492
DSCAM Down syndrome cell adhesion molecule 0.0133144
USP15 ubiquitin specific peptidase 15 0.0132664
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0132516
CEP70 centrosomal protein 70kDa 0.0132312
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.0132024
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0131898
NARS1 asparaginyl-tRNA synthetase 1 0.0130697
CDC73 cell division cycle 73 0.0130619
CASC3 cancer susceptibility candidate 3 0.0130067
SNX13 sorting nexin 13 0.0129855
RAD23B RAD23 homolog B (S. cerevisiae) 0.0127961
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0127457
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0127353
HELB helicase (DNA) B 0.0126194
H1-0 H1.0 linker histone 0.0125283
RIOK3 RIO kinase 3 0.0125197
TENT2 terminal nucleotidyltransferase 2 0.0124634
NBAS neuroblastoma amplified sequence 0.0124305
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0123491
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0123179
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.012259
VEZT vezatin, adherens junctions transmembrane protein 0.0122356
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0122051
AFDN afadin, adherens junction formation factor 0.0121474
UBQLN1 ubiquilin 1 0.012107

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.270129
VIM vimentin -0.239985
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.22862
TMSB10 thymosin beta 10 -0.155509
PDE4D phosphodiesterase 4D, cAMP-specific -0.133907
PCDH7 protocadherin 7 -0.112828
ANKRD12 ankyrin repeat domain 12 -0.0960612
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0819584
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0777087
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.073879
HMGA2 high mobility group AT-hook 2 -0.0731401
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0714982
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0705291
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0666571
ACTG1 actin gamma 1 -0.0658464
YAP1 Yes-associated protein 1 -0.0597199
MYL12B myosin, light chain 12B, regulatory -0.0591244
NHSL1 NHS-like 1 -0.0569922
DPYD dihydropyrimidine dehydrogenase -0.0541436
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.053948
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0534321
SMC4 structural maintenance of chromosomes 4 -0.051507
TENM3 teneurin transmembrane protein 3 -0.050801
AREG amphiregulin -0.0490945
DLC1 DLC1 Rho GTPase activating protein -0.0485034
MMP12 matrix metallopeptidase 12 -0.0469988
IFIH1 interferon induced with helicase C domain 1 -0.0458079
EHBP1 EH domain binding protein 1 -0.0456703
RPL35A ribosomal protein L35a -0.0453602
TPT1 tumor protein, translationally-controlled 1 -0.0452507
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0452302
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0449471
RASAL2 RAS protein activator like 2 -0.0443178
DST dystonin -0.0439332
CCND1 cyclin D1 -0.0434703
JMJD1C jumonji domain containing 1C -0.0418846
CELF2 CUGBP, Elav-like family member 2 -0.0416342
RIMS2 regulating synaptic membrane exocytosis 2 -0.0412941
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0410451
RPLP1 ribosomal protein, large, P1 -0.0409896
ZNF804A zinc finger protein 804A -0.0401436
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0397051
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0383212
BCHE butyrylcholinesterase -0.0378607
HMGA1 high mobility group AT-hook 1 -0.0376704
CNRIP1 cannabinoid receptor interacting protein 1 -0.0359016
RAB7A RAB7A, member RAS oncogene family -0.0358219
KPNB1 karyopherin (importin) beta 1 -0.0357076
PDGFC platelet derived growth factor C -0.0354131
EGR1 early growth response 1 -0.0336787
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0335154
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0334993
CMIP c-Maf inducing protein -0.0334621
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0333339
TAS2R14 taste receptor, type 2, member 14 -0.0326896
RPS6 ribosomal protein S6 -0.0326628
BPTF bromodomain PHD finger transcription factor -0.0326531
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0319386
USP34 ubiquitin specific peptidase 34 -0.0316504
VDAC1 voltage-dependent anion channel 1 -0.0311757
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0307462
MTAP methylthioadenosine phosphorylase -0.0306501
CCN2 cellular communication network factor 2 -0.0305957
SLC38A2 solute carrier family 38, member 2 -0.0296453
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0293552
NEBL nebulette -0.0292554
GNAS GNAS complex locus -0.0291954
RABGAP1L RAB GTPase activating protein 1-like -0.0289968
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0286674
DTNA dystrobrevin, alpha -0.0286378
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0285822
RPL9 ribosomal protein L9 -0.0285737
PTMA prothymosin, alpha -0.0281475
TUBA1B tubulin, alpha 1b -0.0277217
RPS19 ribosomal protein S19 -0.0274818
TMEM41B transmembrane protein 41B -0.0274469
MSRB3 methionine sulfoxide reductase B3 -0.0271184
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0269708
S100A10 S100 calcium binding protein A10 -0.026893
TMEM123 transmembrane protein 123 -0.0267269
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0266369
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0264051
RPS23 ribosomal protein S23 -0.0263476
RPS24 ribosomal protein S24 -0.0263238
ERBIN erbb2 interacting protein -0.025999
CLDN1 claudin 1 -0.0259328
SYT1 synaptotagmin I -0.0256719
MACF1 microtubule-actin crosslinking factor 1 -0.024788
MKI67 marker of proliferation Ki-67 -0.0247189
CUX1 cut-like homeobox 1 -0.0244058
BIRC3 baculoviral IAP repeat containing 3 -0.0242195
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0241578
R3HDM2 R3H domain containing 2 -0.024075
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0239119
CCSER1 coiled-coil serine-rich protein 1 -0.0236797
EDARADD EDAR-associated death domain -0.0233727
ANKRD28 ankyrin repeat domain 28 -0.0233394
YBX3 Y box binding protein 3 -0.0231469
LPP LIM domain containing preferred translocation partner in lipoma -0.0230582
DEK DEK proto-oncogene -0.0230378