| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib citrate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPB1 | heat shock 27kDa protein 1 | 0.187112 |
| FRMD4A | FERM domain containing 4A | 0.177986 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0964024 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0869608 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0801159 |
| NAV2 | neuron navigator 2 | 0.0741322 |
| ASPH | aspartate beta-hydroxylase | 0.0732327 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0633282 |
| UBC | ubiquitin C | 0.0510615 |
| GPC6 | glypican 6 | 0.0506694 |
| MSN | moesin | 0.0490268 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0489306 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0487227 |
| SEPTIN9 | septin 9 | 0.0381713 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.038103 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0372941 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0369824 |
| UBXN4 | UBX domain protein 4 | 0.0367572 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0364744 |
| PLK2 | polo-like kinase 2 | 0.0355481 |
| VCL | vinculin | 0.0341679 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0333601 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.03301 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0329964 |
| EXOC4 | exocyst complex component 4 | 0.0327883 |
| ARRDC3 | arrestin domain containing 3 | 0.0327736 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0324654 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.031973 |
| RAI14 | retinoic acid induced 14 | 0.0318989 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0306596 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0306112 |
| GOLGB1 | golgin B1 | 0.030154 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0298349 |
| APOL1 | apolipoprotein L, 1 | 0.0297612 |
| RND3 | Rho family GTPase 3 | 0.028466 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0277975 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0277107 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0271119 |
| PAX8 | paired box 8 | 0.0270523 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0269731 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0266334 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0262558 |
| TGFB2 | transforming growth factor, beta 2 | 0.0262211 |
| NDRG1 | N-myc downstream regulated 1 | 0.0261797 |
| TPM3 | tropomyosin 3 | 0.0260039 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0255634 |
| FNIP1 | folliculin interacting protein 1 | 0.0254909 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0253261 |
| LOXL2 | lysyl oxidase-like 2 | 0.0248525 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0242928 |
| RAD51B | RAD51 paralog B | 0.0241069 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0236853 |
| DST | dystonin | 0.0234532 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0232688 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0231763 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0230588 |
| TLN1 | talin 1 | 0.0230025 |
| SMAD3 | SMAD family member 3 | 0.0229313 |
| EGFR | epidermal growth factor receptor | 0.0227942 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0227279 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0223681 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0222665 |
| ANXA1 | annexin A1 | 0.0221137 |
| FRMD5 | FERM domain containing 5 | 0.0219589 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0219284 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0215709 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0215165 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0211861 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0205627 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0204592 |
| EHBP1 | EH domain binding protein 1 | 0.0201936 |
| TMF1 | TATA element modulatory factor 1 | 0.0201724 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0201243 |
| CRYAB | crystallin, alpha B | 0.0199757 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.0199538 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0199307 |
| TAPBP | TAP binding protein (tapasin) | 0.0197649 |
| DAPK1 | death-associated protein kinase 1 | 0.019721 |
| RUNX1 | runt-related transcription factor 1 | 0.0196046 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0195749 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.01926 |
| SCFD2 | sec1 family domain containing 2 | 0.0192346 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0191551 |
| BAG3 | BCL2-associated athanogene 3 | 0.0191006 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0190345 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.018844 |
| SMYD3 | SET and MYND domain containing 3 | 0.0187327 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0186663 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.0185348 |
| GOLGA3 | golgin A3 | 0.0185064 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.018481 |
| COL5A1 | collagen, type V, alpha 1 | 0.018475 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0183129 |
| VCP | valosin containing protein | 0.0183076 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0182665 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0182606 |
| MYOF | myoferlin | 0.0182605 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0181894 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0181796 |
| CENPF | centromere protein F, 350/400kDa | 0.0181095 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19099 |
| VIM | vimentin | -0.178183 |
| TMSB10 | thymosin beta 10 | -0.157839 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.153148 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.128278 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.10738 |
| POTEF | POTE ankyrin domain family, member F | -0.0998084 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.098197 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0880847 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0861038 |
| FTL | ferritin, light polypeptide | -0.0729102 |
| RPLP1 | ribosomal protein, large, P1 | -0.0727307 |
| PKM | pyruvate kinase, muscle | -0.0694253 |
| G0S2 | G0/G1 switch 2 | -0.0656514 |
| GDF15 | growth differentiation factor 15 | -0.0644474 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0631446 |
| PFN1 | profilin 1 | -0.063077 |
| RPL23 | ribosomal protein L23 | -0.0625247 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0623835 |
| RHEB | Ras homolog enriched in brain | -0.0615368 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0581061 |
| PTMA | prothymosin, alpha | -0.0580032 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0574036 |
| B2M | beta-2-microglobulin | -0.056083 |
| RPS6 | ribosomal protein S6 | -0.0547684 |
| RPS20 | ribosomal protein S20 | -0.0512752 |
| RPS24 | ribosomal protein S24 | -0.0512461 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0494529 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0492185 |
| HMGB1 | high mobility group box 1 | -0.0491942 |
| RPL28 | ribosomal protein L28 | -0.0481623 |
| RPS5 | ribosomal protein S5 | -0.0480647 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.04757 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0469607 |
| CADM1 | cell adhesion molecule 1 | -0.0468046 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0465376 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0464381 |
| CD70 | CD70 molecule | -0.0460421 |
| TAGLN2 | transgelin 2 | -0.0458946 |
| S100A10 | S100 calcium binding protein A10 | -0.045354 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0441594 |
| RPL35A | ribosomal protein L35a | -0.0437837 |
| RPL8 | ribosomal protein L8 | -0.043597 |
| LMNA | lamin A/C | -0.0427408 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.042481 |
| RPL19 | ribosomal protein L19 | -0.0424293 |
| TKT | transketolase | -0.0421784 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0420391 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0419207 |
| RPL30 | ribosomal protein L30 | -0.0419149 |
| CTSD | cathepsin D | -0.0415842 |
| RPS19 | ribosomal protein S19 | -0.0414792 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0414769 |
| MT2A | metallothionein 2A | -0.0406618 |
| GNAS | GNAS complex locus | -0.0406417 |
| RPLP2 | ribosomal protein, large, P2 | -0.0398267 |
| USP3 | ubiquitin specific peptidase 3 | -0.0390935 |
| RPS8 | ribosomal protein S8 | -0.0386493 |
| HLA-B | major histocompatibility complex, class I, B | -0.0385955 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0381245 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0379376 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0372908 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0371961 |
| DENND2B | DENN domain containing 2B | -0.0370454 |
| ANKRD33B | ankyrin repeat domain 33B | -0.037028 |
| TUBA1B | tubulin, alpha 1b | -0.0368452 |
| RPS4X | ribosomal protein S4, X-linked | -0.0367858 |
| ACTG1 | actin gamma 1 | -0.0367126 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.036703 |
| SPAG9 | sperm associated antigen 9 | -0.0366933 |
| LOC112694756 | uncharaterized LOC112694756 | -0.036637 |
| RPS16 | ribosomal protein S16 | -0.0360934 |
| RPL34 | ribosomal protein L34 | -0.0360096 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0357933 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.035788 |
| RPL12 | ribosomal protein L12 | -0.0355263 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0353078 |
| S100A6 | S100 calcium binding protein A6 | -0.0350256 |
| DENND4A | DENN/MADD domain containing 4A | -0.0345527 |
| RPLP0 | ribosomal protein, large, P0 | -0.0340828 |
| RPL27A | ribosomal protein L27a | -0.0340436 |
| CA12 | carbonic anhydrase XII | -0.0338762 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0336357 |
| ARF1 | ADP-ribosylation factor 1 | -0.0336203 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0333286 |
| CXXC1 | CXXC finger protein 1 | -0.0332911 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0330621 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0323732 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0319772 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0319684 |
| ANXA2 | annexin A2 | -0.0311115 |
| QKI | QKI, KH domain containing, RNA binding | -0.030981 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.030899 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0303024 |
| CD44 | CD44 molecule (Indian blood group) | -0.0302327 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0301309 |
| ZNF207 | zinc finger protein 207 | -0.0300254 |
| HLA-A | major histocompatibility complex, class I, A | -0.0299522 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0298339 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.029785 |
