| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.112023 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0780012 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0729835 |
| FTL | ferritin, light polypeptide | 0.0679482 |
| MT2A | metallothionein 2A | 0.0587524 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0539568 |
| UBC | ubiquitin C | 0.0480811 |
| RPS6 | ribosomal protein S6 | 0.044655 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0408954 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0400112 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0375831 |
| MT1X | metallothionein 1X | 0.0359025 |
| MSN | moesin | 0.034224 |
| ZFP36 | ZFP36 ring finger protein | 0.031906 |
| PFN1 | profilin 1 | 0.0295751 |
| PCBP2 | poly(rC) binding protein 2 | 0.0290775 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0282594 |
| RTN4 | reticulon 4 | 0.0261859 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0256142 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0245614 |
| USP3 | ubiquitin specific peptidase 3 | 0.024399 |
| RPS3 | ribosomal protein S3 | 0.0234631 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0234538 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0228828 |
| AXL | AXL receptor tyrosine kinase | 0.0225073 |
| RPS19 | ribosomal protein S19 | 0.0220064 |
| HELZ | helicase with zinc finger | 0.0217395 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0212366 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0209732 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0206541 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0204474 |
| NUP58 | nucleoporin 58 | 0.019504 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0194103 |
| RNF145 | ring finger protein 145 | 0.0193015 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0185662 |
| PNN | pinin, desmosome associated protein | 0.018508 |
| POTEF | POTE ankyrin domain family, member F | 0.0184934 |
| RPL18 | ribosomal protein L18 | 0.0175052 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0171893 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0171864 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0170158 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.016861 |
| WDR43 | WD repeat domain 43 | 0.0167167 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.016648 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.016586 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0164583 |
| GOLGA4 | golgin A4 | 0.0164189 |
| SPAG9 | sperm associated antigen 9 | 0.0161578 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0158889 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0158018 |
| USP47 | ubiquitin specific peptidase 47 | 0.0157678 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0156712 |
| PTMA | prothymosin, alpha | 0.0156047 |
| RBM25 | RNA binding motif protein 25 | 0.0154478 |
| TBK1 | TANK-binding kinase 1 | 0.0154401 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0154174 |
| CLU | clusterin | 0.0151904 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.015032 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.014907 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0147963 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0147287 |
| ECT2 | epithelial cell transforming 2 | 0.0142843 |
| TFG | TRK-fused gene | 0.0141 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0139441 |
| CDCA2 | cell division cycle associated 2 | 0.0138566 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0137054 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0136233 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0136192 |
| TAPBP | TAP binding protein (tapasin) | 0.0132913 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0132434 |
| TPI1 | triosephosphate isomerase 1 | 0.0132326 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0132123 |
| VMP1 | vacuole membrane protein 1 | 0.0131292 |
| CORO1C | coronin, actin binding protein, 1C | 0.0129474 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0129202 |
| CCNL1 | cyclin L1 | 0.0128653 |
| MKI67 | marker of proliferation Ki-67 | 0.0127834 |
| CASC3 | cancer susceptibility candidate 3 | 0.012739 |
| ATP13A3 | ATPase type 13A3 | 0.0127194 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0126685 |
| RACK1 | receptor for activated C kinase 1 | 0.0126266 |
| RASA2 | RAS p21 protein activator 2 | 0.0125016 |
| LDHB | lactate dehydrogenase B | 0.0124723 |
| RPL7 | ribosomal protein L7 | 0.0121482 |
| FOSL1 | FOS-like antigen 1 | 0.0121276 |
| CENPF | centromere protein F, 350/400kDa | 0.0119614 |
| RPL11 | ribosomal protein L11 | 0.0118859 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0117933 |
| SIN3A | SIN3 transcription regulator family member A | 0.0117552 |
| ANLN | anillin, actin binding protein | 0.0115052 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0114778 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.011378 |
| NCKAP1 | NCK-associated protein 1 | 0.0112991 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0111863 |
| SSRP1 | structure specific recognition protein 1 | 0.0110215 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0110179 |
| YBX1 | Y box binding protein 1 | 0.0109748 |
| SET | SET nuclear proto-oncogene | 0.0109503 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0109171 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0109045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.259504 |
| EFNA5 | ephrin-A5 | -0.183807 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.128423 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.123293 |
| EGFR | epidermal growth factor receptor | -0.097428 |
| ANXA2 | annexin A2 | -0.0945316 |
| ACTG1 | actin gamma 1 | -0.0842556 |
| RNF213 | ring finger protein 213 | -0.0785908 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0772232 |
| PDE10A | phosphodiesterase 10A | -0.0756721 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0726895 |
| AHNAK | AHNAK nucleoprotein | -0.0718573 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0703423 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0692709 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0675571 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0666858 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0661717 |
| EHBP1 | EH domain binding protein 1 | -0.0654523 |
| NDRG1 | N-myc downstream regulated 1 | -0.0640855 |
| MYO1E | myosin IE | -0.063661 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0635889 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0620252 |
| AUTS2 | autism susceptibility candidate 2 | -0.0592682 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0586248 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0568304 |
| CA12 | carbonic anhydrase XII | -0.0557441 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0528831 |
| KYNU | kynureninase | -0.0523136 |
| SP100 | SP100 nuclear antigen | -0.0514497 |
| TNS3 | tensin 3 | -0.0510108 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0484365 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0472879 |
| RIGI | RNA sensor RIG-I | -0.0468016 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0444383 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0443881 |
| ANXA4 | annexin A4 | -0.0437747 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0433079 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0431152 |
| RAI14 | retinoic acid induced 14 | -0.0427898 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0413301 |
| PRKCA | protein kinase C, alpha | -0.0412732 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0411093 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0407147 |
| OSMR | oncostatin M receptor | -0.0403288 |
| ASPH | aspartate beta-hydroxylase | -0.0389118 |
| VIM | vimentin | -0.0373414 |
| RAD51B | RAD51 paralog B | -0.0372503 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0369482 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.036444 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0356963 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0354454 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0352902 |
| VCL | vinculin | -0.0351427 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0349597 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.034829 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0344627 |
| RRBP1 | ribosome binding protein 1 | -0.033736 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333969 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0330181 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0329807 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0327732 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0320956 |
| DUSP16 | dual specificity phosphatase 16 | -0.0320331 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0320105 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0318302 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0317691 |
| CUX1 | cut-like homeobox 1 | -0.0314734 |
| LOXL2 | lysyl oxidase-like 2 | -0.0309091 |
| RIN2 | Ras and Rab interactor 2 | -0.0305135 |
| FBXO11 | F-box protein 11 | -0.0303893 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0303751 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0302582 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0299064 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0299047 |
| HMGA2 | high mobility group AT-hook 2 | -0.029902 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0298484 |
| DAPK1 | death-associated protein kinase 1 | -0.0296627 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0296319 |
| DIAPH2 | diaphanous-related formin 2 | -0.0295785 |
| MYO9A | myosin IXA | -0.029411 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0293111 |
| PRKCE | protein kinase C, epsilon | -0.0291871 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0290501 |
| SMAD3 | SMAD family member 3 | -0.0289019 |
| SQSTM1 | sequestosome 1 | -0.0287969 |
| ZFHX3 | zinc finger homeobox 3 | -0.0287176 |
| NRG1 | neuregulin 1 | -0.028587 |
| INTS6 | integrator complex subunit 6 | -0.0285507 |
| GOLGB1 | golgin B1 | -0.0284432 |
| NPAS2 | neuronal PAS domain protein 2 | -0.028077 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0277754 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0277522 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0273692 |
| PLSCR1 | phospholipid scramblase 1 | -0.0272343 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0270678 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0268722 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0267493 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0266046 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0265206 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.0262352 |
