Ixazomib citrate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MGP matrix Gla protein 0.16863
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110511
MEST mesoderm specific transcript 0.10939
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0500286
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0496178
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0484751
UBC ubiquitin C 0.0466206
HSPA8 heat shock 70kDa protein 8 0.0434263
SPAG9 sperm associated antigen 9 0.0344956
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0326135
KIF1B kinesin family member 1B 0.0316953
PRKG1 protein kinase, cGMP-dependent, type I 0.0314876
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.0305119
HSPA4 heat shock 70kDa protein 4 0.0296153
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0292725
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.028488
TSHZ2 teashirt zinc finger homeobox 2 0.0275551
TMSB4X thymosin beta 4, X-linked 0.0272669
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0270495
RBM33 RNA binding motif protein 33 0.0269102
FNIP1 folliculin interacting protein 1 0.0262726
TOP2B topoisomerase (DNA) II beta 180kDa 0.0256027
PNN pinin, desmosome associated protein 0.0252379
WBP11 WW domain binding protein 11 0.0249663
DOCK1 dedicator of cytokinesis 1 0.0246628
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0239007
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0237455
RBM25 RNA binding motif protein 25 0.0236492
GOLGA4 golgin A4 0.0235718
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232441
UTRN utrophin 0.0231238
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0226994
ZNF608 zinc finger protein 608 0.0223977
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0221963
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0220156
AMBRA1 autophagy/beclin-1 regulator 1 0.0218305
MAP1B microtubule-associated protein 1B 0.0216463
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0216283
USP9X ubiquitin specific peptidase 9, X-linked 0.0215734
TRIP12 thyroid hormone receptor interactor 12 0.0215128
CASC3 cancer susceptibility candidate 3 0.0215026
UBQLN1 ubiquilin 1 0.0214883
TAS2R14 taste receptor, type 2, member 14 0.0214685
SLMAP sarcolemma associated protein 0.0212976
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0212856
GLRX3 glutaredoxin 3 0.0208512
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0206829
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0205247
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0201585
FAM219A family with sequence similarity 219, member A 0.0201147
WDR43 WD repeat domain 43 0.019959
ARHGAP21 Rho GTPase activating protein 21 0.0198922
SERINC1 serine incorporator 1 0.0197308
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0194783
SOD2 superoxide dismutase 2, mitochondrial 0.0194111
QKI QKI, KH domain containing, RNA binding 0.019362
VEGFA vascular endothelial growth factor A 0.0192026
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0186084
RB1CC1 RB1-inducible coiled-coil 1 0.0186013
CNN3 calponin 3, acidic 0.0185322
UBAP1 ubiquitin associated protein 1 0.0184984
SRRM2 serine/arginine repetitive matrix 2 0.0182133
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0179798
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0179062
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0178237
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0176702
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.0175331
NRDC nardilysin convertase 0.0175178
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0174698
H1-4 H1.4 linker histone, cluster member 0.0173485
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0173307
KIAA0232 KIAA0232 0.0172963
ZMIZ1 zinc finger, MIZ-type containing 1 0.0171975
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0171137
AOPEP aminopeptidase O (putative) 0.0171035
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0170761
EEF1G eukaryotic translation elongation factor 1 gamma 0.0170527
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.0168687
MOB1B MOB kinase activator 1B 0.016864
SUN1 Sad1 and UNC84 domain containing 1 0.0165106
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0163951
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0163928
MEMO1 mediator of cell motility 1 0.0163428
FRS2 fibroblast growth factor receptor substrate 2 0.0162475
AFF4 AF4/FMR2 family, member 4 0.0161913
YTHDC1 YTH domain containing 1 0.0161259
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0160729
EZR ezrin 0.0160131
SIK3 SIK family kinase 3 0.0159424
SFTPA2 surfactant protein A2 0.0159076
CECR2 cat eye syndrome chromosome region, candidate 2 0.0158871
CRY1 cryptochrome circadian clock 1 0.0158803
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0158413
PNISR PNN-interacting serine/arginine-rich protein 0.015808
HDGF hepatoma-derived growth factor 0.0157142
BRD4 bromodomain containing 4 0.0156996
UBE3A ubiquitin protein ligase E3A 0.015674
TMEM131 transmembrane protein 131 0.0156291
PDCD11 programmed cell death 11 0.015604
BRD2 bromodomain containing 2 0.0155644

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22698
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.112814
VIM vimentin -0.111322
PDE4D phosphodiesterase 4D, cAMP-specific -0.0949438
NDRG1 N-myc downstream regulated 1 -0.0747115
CADM2 cell adhesion molecule 2 -0.064539
RPLP1 ribosomal protein, large, P1 -0.0611572
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0609318
MT2A metallothionein 2A -0.0554242
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0551271
TPT1 tumor protein, translationally-controlled 1 -0.0506624
TMSB10 thymosin beta 10 -0.0500154
RPS6 ribosomal protein S6 -0.0479392
RPS19 ribosomal protein S19 -0.045385
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0452063
PDIA3 protein disulfide isomerase family A, member 3 -0.0450406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043216
CENPF centromere protein F, 350/400kDa -0.0431774
ACTG1 actin gamma 1 -0.0425525
PKM pyruvate kinase, muscle -0.0418111
IER3 immediate early response 3 -0.0415413
RPS8 ribosomal protein S8 -0.0413395
GPC6 glypican 6 -0.0406795
RPS24 ribosomal protein S24 -0.0401664
ENO1 enolase 1, (alpha) -0.0396228
RPL35A ribosomal protein L35a -0.0379379
ASPH aspartate beta-hydroxylase -0.0373858
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0364261
B2M beta-2-microglobulin -0.0351911
DLG1 discs, large homolog 1 (Drosophila) -0.0351041
GNAS GNAS complex locus -0.034748
PTMA prothymosin, alpha -0.0345369
RPS25 ribosomal protein S25 -0.0344343
RPS13 ribosomal protein S13 -0.0341635
NIPBL Nipped-B homolog (Drosophila) -0.03377
FNDC3B fibronectin type III domain containing 3B -0.0335165
TUBB tubulin, beta class I -0.0334449
RPL23 ribosomal protein L23 -0.0333365
FTL ferritin, light polypeptide -0.0316795
RPLP0 ribosomal protein, large, P0 -0.0315565
FN1 fibronectin 1 -0.0308508
HMGB1 high mobility group box 1 -0.0305671
VDAC1 voltage-dependent anion channel 1 -0.0304531
TPM4 tropomyosin 4 -0.0297108
DIAPH3 diaphanous-related formin 3 -0.0287919
RAD51B RAD51 paralog B -0.028571
ANXA2 annexin A2 -0.0285491
EXT1 exostosin glycosyltransferase 1 -0.0280626
TPI1 triosephosphate isomerase 1 -0.0279917
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0279624
PTK2 protein tyrosine kinase 2 -0.0279155
MBD5 methyl-CpG binding domain protein 5 -0.0278327
EGR1 early growth response 1 -0.0276816
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.027665
RPLP2 ribosomal protein, large, P2 -0.0275736
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0274575
RANBP17 RAN binding protein 17 -0.0273746
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0273546
WWOX WW domain containing oxidoreductase -0.0272978
USP34 ubiquitin specific peptidase 34 -0.0271691
KTN1 kinectin 1 (kinesin receptor) -0.0267141
KPNB1 karyopherin (importin) beta 1 -0.0266362
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0266065
CCNI cyclin I -0.0265599
RPS23 ribosomal protein S23 -0.0265528
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.026511
PRELID2 PRELI domain containing 2 -0.026412
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0263768
FGFR1 fibroblast growth factor receptor 1 -0.0263525
FOXC1 forkhead box C1 -0.026336
RPL19 ribosomal protein L19 -0.0262608
LOC112694756 uncharaterized LOC112694756 -0.0262314
RPS16 ribosomal protein S16 -0.0261298
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0260604
NAP1L1 nucleosome assembly protein 1-like 1 -0.0260389
S100A10 S100 calcium binding protein A10 -0.0255725
RPS20 ribosomal protein S20 -0.0255684
BSG basigin (Ok blood group) -0.0254305
RPL12 ribosomal protein L12 -0.0252822
FBXO11 F-box protein 11 -0.0252757
WSB1 WD repeat and SOCS box containing 1 -0.0248491
PFN1 profilin 1 -0.0247804
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0245623
NFIB nuclear factor I/B -0.0245285
FAM13A family with sequence similarity 13, member A -0.0243736
NEK7 NIMA-related kinase 7 -0.0243691
NUP58 nucleoporin 58 -0.0243665
RPL9 ribosomal protein L9 -0.0243094
YAP1 Yes-associated protein 1 -0.0242648
MKI67 marker of proliferation Ki-67 -0.0242615
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0242242
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.024218
SSBP2 single-stranded DNA binding protein 2 -0.0242144
ANKRD11 ankyrin repeat domain 11 -0.024042
RPS11 ribosomal protein S11 -0.0238801
RSF1 remodeling and spacing factor 1 -0.0237024
LDHA lactate dehydrogenase A -0.0236364
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0236276
USP3 ubiquitin specific peptidase 3 -0.0234509
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0233487