Ixazomib citrate_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.193892
HSPA8 heat shock 70kDa protein 8 0.142176
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.137723
LAMB3 laminin, beta 3 0.130667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.130499
FLNB filamin B, beta 0.12992
ERRFI1 ERBB receptor feedback inhibitor 1 0.112974
BZW1 basic leucine zipper and W2 domains 1 0.0640473
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0624303
BHLHE40 basic helix-loop-helix family, member e40 0.0623178
FTL ferritin, light polypeptide 0.0617991
EZR ezrin 0.0608343
ASPH aspartate beta-hydroxylase 0.0571847
FAM107B family with sequence similarity 107, member B 0.0568444
MYH9 myosin, heavy chain 9, non-muscle 0.0558162
APLP2 amyloid beta (A4) precursor-like protein 2 0.0551347
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0550384
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0504508
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.050255
RPS3 ribosomal protein S3 0.0497966
SPTBN1 spectrin, beta, non-erythrocytic 1 0.048147
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0471323
ACTG1 actin gamma 1 0.0456447
HSPH1 heat shock 105kDa/110kDa protein 1 0.0452024
CORO1C coronin, actin binding protein, 1C 0.045122
PTMA prothymosin, alpha 0.0445888
DSPP dentin sialophosphoprotein 0.0440286
KTN1 kinectin 1 (kinesin receptor) 0.0433985
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0420281
SQSTM1 sequestosome 1 0.0409219
RPS8 ribosomal protein S8 0.0388655
RPS2 ribosomal protein S2 0.0387392
UBC ubiquitin C 0.038596
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0378626
DSG2 desmoglein 2 0.0375899
ITPRID2 ITPR interacting domain containing 2 0.036713
LMTK2 lemur tyrosine kinase 2 0.0362834
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0350006
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0344317
CTSB cathepsin B 0.0340445
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0335951
H1-0 H1.0 linker histone 0.0334252
SERINC1 serine incorporator 1 0.0326078
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0321436
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0320932
ITGA6 integrin, alpha 6 0.0314318
RACK1 receptor for activated C kinase 1 0.0314041
RPS6 ribosomal protein S6 0.0304344
B2M beta-2-microglobulin 0.030004
ANXA1 annexin A1 0.0297867
NCKAP1 NCK-associated protein 1 0.0292793
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0287839
RSL1D1 ribosomal L1 domain containing 1 0.0287503
MSN moesin 0.028485
PRRC2C proline-rich coiled-coil 2C 0.0278367
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0278203
TMSB4X thymosin beta 4, X-linked 0.0276887
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0264895
ARRDC3 arrestin domain containing 3 0.0261544
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261348
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0260572
LAMC2 laminin, gamma 2 0.0259703
RALB v-ral simian leukemia viral oncogene homolog B 0.0256652
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0254637
SFTPA2 surfactant protein A2 0.0249533
RPL26 ribosomal protein L26 0.0249227
RPL14 ribosomal protein L14 0.0245418
AHNAK AHNAK nucleoprotein 0.0235499
RPL12 ribosomal protein L12 0.0231156
LDHA lactate dehydrogenase A 0.0227874
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0227787
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0226826
TPM3 tropomyosin 3 0.0226437
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0226031
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 0.0225611
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0224711
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0223318
NAP1L1 nucleosome assembly protein 1-like 1 0.0221351
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0221112
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0220499
PNN pinin, desmosome associated protein 0.0218315
UPP1 uridine phosphorylase 1 0.0211628
EEF1G eukaryotic translation elongation factor 1 gamma 0.0207332
SET SET nuclear proto-oncogene 0.0207018
RPL37A ribosomal protein L37a 0.0205695
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0205455
CDCP1 CUB domain containing protein 1 0.0205364
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0204964
KDM3A lysine (K)-specific demethylase 3A 0.0202054
RPL4 ribosomal protein L4 0.0201685
KIF5B kinesin family member 5B 0.0201435
RPS19 ribosomal protein S19 0.0201192
PGK1 phosphoglycerate kinase 1 0.0200432
KRT19 keratin 19, type I 0.0200265
EIF1 eukaryotic translation initiation factor 1 0.0199054
RPL7 ribosomal protein L7 0.0198644
RPL37 ribosomal protein L37 0.0197927
RIOK3 RIO kinase 3 0.0197925
ZFP36L1 ZFP36 ring finger protein-like 1 0.019544
FMNL2 formin-like 2 0.0194484

decreased expression

Symbol Name Standardized Value
MUC17 mucin 17, cell surface associated -0.133653
EGFR epidermal growth factor receptor -0.106081
HMGA1 high mobility group AT-hook 1 -0.104769
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0984725
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0915949
F3 coagulation factor III (thromboplastin, tissue factor) -0.090602
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0892982
FTH1 ferritin, heavy polypeptide 1 -0.0720719
TRRAP transformation/transcription domain-associated protein -0.0693743
GREB1L growth regulation by estrogen in breast cancer-like -0.0670751
IGFBP3 insulin-like growth factor binding protein 3 -0.0601725
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0559377
LMO7 LIM domain 7 -0.0555166
PERP PERP, TP53 apoptosis effector -0.0522181
SLC35F3 solute carrier family 35, member F3 -0.051699
NPSR1 neuropeptide S receptor 1 -0.0510062
MAML2 mastermind-like 2 (Drosophila) -0.0506869
EGR1 early growth response 1 -0.0490391
VIM vimentin -0.0483762
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0483245
PTPRR protein tyrosine phosphatase, receptor type, R -0.0479842
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0479795
ITCH itchy E3 ubiquitin protein ligase -0.047094
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0467556
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0461881
TMSB10 thymosin beta 10 -0.0455337
TXNIP thioredoxin interacting protein -0.0452092
PDE4D phosphodiesterase 4D, cAMP-specific -0.0448051
ITGB4 integrin, beta 4 -0.0447827
LAMA4 laminin, alpha 4 -0.0443452
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0424221
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0422154
BIRC6 baculoviral IAP repeat containing 6 -0.0420052
SULF2 sulfatase 2 -0.0409503
DIAPH2 diaphanous-related formin 2 -0.0408664
VCAN versican -0.0400367
PDLIM5 PDZ and LIM domain 5 -0.0400115
PRSS3 protease, serine, 3 -0.0398466
ERBIN erbb2 interacting protein -0.0395365
RABGAP1L RAB GTPase activating protein 1-like -0.0385085
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0369766
COG5 component of oligomeric golgi complex 5 -0.0364877
FNDC3B fibronectin type III domain containing 3B -0.0364681
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.036047
PRELID2 PRELI domain containing 2 -0.0351229
ZBTB20 zinc finger and BTB domain containing 20 -0.0349546
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0346894
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.034177
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0336981
EFNA5 ephrin-A5 -0.033656
JUP junction plakoglobin -0.0335794
CDK13 cyclin-dependent kinase 13 -0.0327963
HMGA2 high mobility group AT-hook 2 -0.0323807
TJP1 tight junction protein 1 -0.0311194
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0308827
UBE2H ubiquitin-conjugating enzyme E2H -0.0305901
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0305164
JMJD1C jumonji domain containing 1C -0.0300513
AKAP9 A kinase (PRKA) anchor protein 9 -0.029966
LY6E lymphocyte antigen 6 complex, locus E -0.0295249
S100A4 S100 calcium binding protein A4 -0.02941
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0289871
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0288837
USP34 ubiquitin specific peptidase 34 -0.0286721
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0281969
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0281685
SEC31A SEC31 homolog A (S. cerevisiae) -0.0281343
NBEAL1 neurobeachin-like 1 -0.0279694
TAOK3 TAO kinase 3 -0.0276154
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0274218
ARHGAP12 Rho GTPase activating protein 12 -0.0272905
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0272897
ESYT2 extended synaptotagmin-like protein 2 -0.0272765
NT5C2 5'-nucleotidase, cytosolic II -0.0269842
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0266898
TMEM165 transmembrane protein 165 -0.0265178
LPP LIM domain containing preferred translocation partner in lipoma -0.0263438
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0263405
MRPS6 mitochondrial ribosomal protein S6 -0.0259375
SP100 SP100 nuclear antigen -0.0257119
RAB22A RAB22A, member RAS oncogene family -0.0254129
PKN2 protein kinase N2 -0.0254047
SLC38A2 solute carrier family 38, member 2 -0.0252272
RASAL2 RAS protein activator like 2 -0.0250196
ANTXR2 anthrax toxin receptor 2 -0.0248284
FOXO3 forkhead box O3 -0.0248214
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0247446
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0247188
ADAM9 ADAM metallopeptidase domain 9 -0.0243292
CD2AP CD2-associated protein -0.0242445
ARF4 ADP-ribosylation factor 4 -0.0242259
PPARG peroxisome proliferator-activated receptor gamma -0.0239895
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0239469
PTPRK protein tyrosine phosphatase, receptor type, K -0.0239134
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0238752
COPA coatomer protein complex, subunit alpha -0.0238046
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0237607
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0237345
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0237089
VDAC1 voltage-dependent anion channel 1 -0.0236774