Ixazomib citrate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0951886
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0887512
KDM3A lysine (K)-specific demethylase 3A 0.0703827
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0569563
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0548065
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0521229
KMT2C lysine (K)-specific methyltransferase 2C 0.0510885
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0510298
HSPA8 heat shock 70kDa protein 8 0.0491159
NGLY1 N-glycanase 1 0.0475702
TOP2B topoisomerase (DNA) II beta 180kDa 0.0471023
NUP58 nucleoporin 58 0.0465846
OGA O-GlcNAcase 0.0458575
KMT2E lysine (K)-specific methyltransferase 2E 0.0444559
CABIN1 calcineurin binding protein 1 0.0444066
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0430049
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0420452
NAMPT nicotinamide phosphoribosyltransferase 0.0405817
ZNF292 zinc finger protein 292 0.0404848
H1-0 H1.0 linker histone 0.0385357
QKI QKI, KH domain containing, RNA binding 0.0379393
PIAS2 protein inhibitor of activated STAT, 2 0.0368517
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0367381
ATRN attractin 0.0363328
CDC73 cell division cycle 73 0.0348783
RLF rearranged L-myc fusion 0.0348641
PHIP pleckstrin homology domain interacting protein 0.0345306
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0340942
MXI1 MAX interactor 1, dimerization protein 0.0334772
BRWD3 bromodomain and WD repeat domain containing 3 0.0328611
EIF4A2 eukaryotic translation initiation factor 4A2 0.0319344
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0316699
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0314445
UBA6 ubiquitin-like modifier activating enzyme 6 0.0314076
RNF145 ring finger protein 145 0.0313233
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0309626
HELZ helicase with zinc finger 0.0307756
TRA2A transformer 2 alpha homolog (Drosophila) 0.0305665
SLF1 SMC5-SMC6 complex localization factor 1 0.0302196
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0293939
FNBP1L formin binding protein 1-like 0.0290808
ZMYM2 zinc finger, MYM-type 2 0.0288275
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0281825
RNMT RNA (guanine-7-) methyltransferase 0.0279244
CASC3 cancer susceptibility candidate 3 0.0277303
ZFP36L1 ZFP36 ring finger protein-like 1 0.0276377
FAM168A family with sequence similarity 168, member A 0.0273617
SEC63 SEC63 homolog (S. cerevisiae) 0.0270099
APP amyloid beta (A4) precursor protein 0.026365
WDR45B WD repeat domain 45B 0.0263482
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0263119
KDM6A lysine (K)-specific demethylase 6A 0.0262954
ANKRD36 ankyrin repeat domain 36 0.0261668
DST dystonin 0.0260378
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0258783
NKTR natural killer cell triggering receptor 0.0258671
TPD52 tumor protein D52 0.0258591
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0257533
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0256559
CHD1 chromodomain helicase DNA binding protein 1 0.0255043
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0254333
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0254252
FAM162A family with sequence similarity 162, member A 0.0251348
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0250454
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.025043
FAM13A family with sequence similarity 13, member A 0.0245029
PUM2 pumilio RNA-binding family member 2 0.0244006
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0236817
USP3 ubiquitin specific peptidase 3 0.0236046
SUN1 Sad1 and UNC84 domain containing 1 0.0235874
WSB1 WD repeat and SOCS box containing 1 0.023284
EFNA5 ephrin-A5 0.0231178
KDM5B lysine (K)-specific demethylase 5B 0.0230676
ZNF638 zinc finger protein 638 0.0229766
SSBP2 single-stranded DNA binding protein 2 0.0229363
ARFGEF3 ARFGEF family member 3 0.0228781
INSIG2 insulin induced gene 2 0.0228284
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0228036
RAB6A RAB6A, member RAS oncogene family 0.0226024
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0223355
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0223101
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0223005
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0220346
SREBF2 sterol regulatory element binding transcription factor 2 0.0219435
KDM1A lysine (K)-specific demethylase 1A 0.0217565
SEPTIN7 septin 7 0.0217138
BRWD1 bromodomain and WD repeat domain containing 1 0.0216462
MEF2A myocyte enhancer factor 2A 0.0216332
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0213304
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0209072
PTCH1 patched 1 0.0208868
KDM5C lysine (K)-specific demethylase 5C 0.0208621
TRIM33 tripartite motif containing 33 0.0207526
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0206941
ZEB1 zinc finger E-box binding homeobox 1 0.0206502
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.020604
SERINC1 serine incorporator 1 0.0205005
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.020064
MATR3 matrin 3 0.0200476
BRD2 bromodomain containing 2 0.0196452

decreased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.214083
SLIT2 slit homolog 2 (Drosophila) -0.202213
TENM3 teneurin transmembrane protein 3 -0.156417
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.156075
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.15361
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0987344
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0937409
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0776623
ARHGAP32 Rho GTPase activating protein 32 -0.0700368
RPLP1 ribosomal protein, large, P1 -0.0587245
WLS wntless Wnt ligand secretion mediator -0.0573818
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0565933
TMSB10 thymosin beta 10 -0.0554733
CDH18 cadherin 18, type 2 -0.0554674
RAD51B RAD51 paralog B -0.0552904
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0536266
NPAS3 neuronal PAS domain protein 3 -0.0530458
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0525547
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0516735
CADM2 cell adhesion molecule 2 -0.047506
ACTG1 actin gamma 1 -0.0473866
TRIO trio Rho guanine nucleotide exchange factor -0.0457148
IFI6 interferon, alpha-inducible protein 6 -0.0432121
HMGA1 high mobility group AT-hook 1 -0.0431475
CELF2 CUGBP, Elav-like family member 2 -0.0427682
MLIP muscular LMNA-interacting protein -0.0425718
PRICKLE1 prickle homolog 1 (Drosophila) -0.0415685
EEF2 eukaryotic translation elongation factor 2 -0.0411086
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0401782
RCC1 regulator of chromosome condensation 1 -0.0393814
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0386839
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0381341
NEBL nebulette -0.038043
VCL vinculin -0.0366115
TOX thymocyte selection-associated high mobility group box -0.0357298
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0354022
CENPF centromere protein F, 350/400kDa -0.0349119
RPLP2 ribosomal protein, large, P2 -0.0346147
IARS1 isoleucyl-tRNA synthetase 1 -0.0345298
SHROOM3 shroom family member 3 -0.0344383
RIGI RNA sensor RIG-I -0.0334797
HMGB1 high mobility group box 1 -0.0331147
RPS19 ribosomal protein S19 -0.0316799
RPL7A ribosomal protein L7a -0.0316575
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0312415
RPL9 ribosomal protein L9 -0.0301557
ATP11A ATPase, class VI, type 11A -0.0299071
RPS11 ribosomal protein S11 -0.0294329
DCDC2 doublecortin domain containing 2 -0.0292907
BPTF bromodomain PHD finger transcription factor -0.02839
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0283541
SOX4 SRY (sex determining region Y)-box 4 -0.0283145
PRH1 proline-rich protein HaeIII subfamily 1 -0.028203
MKI67 marker of proliferation Ki-67 -0.0280643
ATP9A ATPase, class II, type 9A -0.0276646
CCSER1 coiled-coil serine-rich protein 1 -0.0276087
ADGRG6 adhesion G protein-coupled receptor G6 -0.0275806
SETX senataxin -0.0273766
PDE4D phosphodiesterase 4D, cAMP-specific -0.0268048
BNC2 basonuclin 2 -0.0262905
RPS13 ribosomal protein S13 -0.0261779
BICD1 bicaudal D homolog 1 (Drosophila) -0.0261661
ISG15 ISG15 ubiquitin-like modifier -0.0259239
RPL23 ribosomal protein L23 -0.0257781
C6ORF62 chromosome 6 open reading frame 62 -0.0254315
RPS8 ribosomal protein S8 -0.025255
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.025254
RPS24 ribosomal protein S24 -0.0249758
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0245288
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0244546
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0243577
EGR1 early growth response 1 -0.024254
SLC38A2 solute carrier family 38, member 2 -0.0230536
RPS29 ribosomal protein S29 -0.0230262
RPS25 ribosomal protein S25 -0.0228365
ANKRD11 ankyrin repeat domain 11 -0.0226455
TPM4 tropomyosin 4 -0.0226207
RPS21 ribosomal protein S21 -0.0226141
NRG1 neuregulin 1 -0.0225737
MAP4 microtubule-associated protein 4 -0.0225579
DENND1A DENN/MADD domain containing 1A -0.0225463
PTPRG protein tyrosine phosphatase, receptor type, G -0.0224524
RPLP0 ribosomal protein, large, P0 -0.0223491
PFN1 profilin 1 -0.0223226
RPS10 ribosomal protein S10 -0.0223049
MCTP1 multiple C2 domains, transmembrane 1 -0.0221081
SALL4 spalt-like transcription factor 4 -0.022004
TMEM41B transmembrane protein 41B -0.0218832
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0218094
TUBA1B tubulin, alpha 1b -0.0217315
CCDC138 coiled-coil domain containing 138 -0.0216989
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.021619
RPL31 ribosomal protein L31 -0.0215987
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0211269
DOCK3 dedicator of cytokinesis 3 -0.0209389
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0208662
RPS16 ribosomal protein S16 -0.0208192
VIM vimentin -0.0207487
AEBP2 AE binding protein 2 -0.0206994