Ixazomib citrate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.248142
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.128797
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.123733
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.111993
HSPA8 heat shock 70kDa protein 8 0.111776
GOLGA4 golgin A4 0.0817357
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0666141
UBC ubiquitin C 0.0582883
TXNRD1 thioredoxin reductase 1 0.0542464
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.051315
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0430152
TMF1 TATA element modulatory factor 1 0.041876
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0401957
FDPS farnesyl diphosphate synthase 0.0398779
SQSTM1 sequestosome 1 0.0393298
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0386527
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0384587
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0381033
IARS1 isoleucyl-tRNA synthetase 1 0.0364423
GOLGB1 golgin B1 0.0354482
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0335128
BRD2 bromodomain containing 2 0.0333401
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0328579
BAG3 BCL2-associated athanogene 3 0.032749
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0326193
MYH9 myosin, heavy chain 9, non-muscle 0.0318881
HSPH1 heat shock 105kDa/110kDa protein 1 0.0310992
ZFC3H1 zinc finger, C3H1-type containing 0.0305863
CXCL8 chemokine (C-X-C motif) ligand 8 0.0305519
HSPA1B heat shock 70kDa protein 1B 0.0303419
SUCO SUN domain containing ossification factor 0.0303261
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0296598
CANX calnexin 0.0294405
COPB1 coatomer protein complex, subunit beta 1 0.029064
RAD23B RAD23 homolog B (S. cerevisiae) 0.0289521
GARS1 glycyl-tRNA synthetase 1 0.0288417
HELZ helicase with zinc finger 0.0281819
RBM39 RNA binding motif protein 39 0.0280129
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0277146
NCKAP1 NCK-associated protein 1 0.0273071
TMEM41B transmembrane protein 41B 0.0270866
OGA O-GlcNAcase 0.0265986
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0265167
ZNF654 zinc finger protein 654 0.0264857
KMT2C lysine (K)-specific methyltransferase 2C 0.026057
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0259114
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0258374
CSDE1 cold shock domain containing E1, RNA-binding 0.0257175
SPAG9 sperm associated antigen 9 0.0256488
SRP54 signal recognition particle 54kDa 0.0256195
PAPOLA poly(A) polymerase alpha 0.0252614
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0252444
SEC31A SEC31 homolog A (S. cerevisiae) 0.0251313
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.025028
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0248867
RIOK3 RIO kinase 3 0.0247045
SEC24D SEC24 family member D 0.024088
SLMAP sarcolemma associated protein 0.0240199
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0239578
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0239183
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0238961
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0238399
RNMT RNA (guanine-7-) methyltransferase 0.0237927
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0237167
PDIA4 protein disulfide isomerase family A, member 4 0.0234035
KIF1B kinesin family member 1B 0.0233231
DSCAM Down syndrome cell adhesion molecule 0.0230947
MORF4L2 mortality factor 4 like 2 0.0230928
FXR1 fragile X mental retardation, autosomal homolog 1 0.0227725
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0224202
ZC3H11A zinc finger CCCH-type containing 11A 0.0223315
RSRC2 arginine/serine-rich coiled-coil 2 0.02219
BIRC6 baculoviral IAP repeat containing 6 0.0221568
NUP58 nucleoporin 58 0.0218784
WDR26 WD repeat domain 26 0.0217933
NBAS neuroblastoma amplified sequence 0.0216605
MED13 mediator complex subunit 13 0.0214723
UBA6 ubiquitin-like modifier activating enzyme 6 0.0214048
NAMPT nicotinamide phosphoribosyltransferase 0.0213656
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0213628
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213174
KIF5B kinesin family member 5B 0.0212703
CLTC clathrin, heavy chain (Hc) 0.0211836
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0211633
MORC3 MORC family CW-type zinc finger 3 0.0210185
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.020997
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0208192
VMP1 vacuole membrane protein 1 0.0207887
GOLGA2 golgin A2 0.0206067
CHD1 chromodomain helicase DNA binding protein 1 0.0205636
HYOU1 hypoxia up-regulated 1 0.0202863
RLF rearranged L-myc fusion 0.0202652
PCDHB16 protocadherin beta 16 0.0202184
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0201879
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0200675
UBQLN1 ubiquilin 1 0.019957
RANBP2 RAN binding protein 2 0.0198853
BCLAF1 BCL2-associated transcription factor 1 0.0198425
WAC WW domain containing adaptor with coiled-coil 0.019818
KDM2A lysine (K)-specific demethylase 2A 0.0196586

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.246918
FAT1 FAT atypical cadherin 1 -0.214409
TMSB10 thymosin beta 10 -0.137842
PTMA prothymosin, alpha -0.104585
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0935776
TPT1 tumor protein, translationally-controlled 1 -0.0907116
PKM pyruvate kinase, muscle -0.0706426
EGR1 early growth response 1 -0.066769
RPL35A ribosomal protein L35a -0.0629846
RPLP1 ribosomal protein, large, P1 -0.0617838
RAD51B RAD51 paralog B -0.0606388
FHIT fragile histidine triad -0.0585288
MT2A metallothionein 2A -0.0570432
NDRG1 N-myc downstream regulated 1 -0.0558727
TPM4 tropomyosin 4 -0.0546657
S100A10 S100 calcium binding protein A10 -0.0536756
RPS8 ribosomal protein S8 -0.0486682
LOC112694756 uncharaterized LOC112694756 -0.0483211
POTEF POTE ankyrin domain family, member F -0.0479487
WWOX WW domain containing oxidoreductase -0.0470792
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0464726
SMYD3 SET and MYND domain containing 3 -0.0454476
TENM3 teneurin transmembrane protein 3 -0.0435252
KRT18 keratin 18, type I -0.0423428
HMGA1 high mobility group AT-hook 1 -0.0421936
RPLP2 ribosomal protein, large, P2 -0.0412434
RPLP0 ribosomal protein, large, P0 -0.038689
ACTG1 actin gamma 1 -0.0372706
RPS19 ribosomal protein S19 -0.0368581
RPS24 ribosomal protein S24 -0.0358206
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0358009
KRT8 keratin 8, type II -0.0354304
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0342992
RPS6 ribosomal protein S6 -0.0338684
RPL23 ribosomal protein L23 -0.0337341
VCL vinculin -0.0337181
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0334818
RPL8 ribosomal protein L8 -0.0332241
INTS6 integrator complex subunit 6 -0.0331153
RPL34 ribosomal protein L34 -0.0325705
SPIDR scaffolding protein involved in DNA repair -0.0323878
TPI1 triosephosphate isomerase 1 -0.0322493
S100A9 S100 calcium binding protein A9 -0.0318559
LPP LIM domain containing preferred translocation partner in lipoma -0.0315556
RPL7A ribosomal protein L7a -0.0314555
RPS25 ribosomal protein S25 -0.0314112
LDHA lactate dehydrogenase A -0.0297645
RPS15 ribosomal protein S15 -0.0294657
PATJ PATJ crumbs cell polarity complex component -0.0293757
RPS13 ribosomal protein S13 -0.0290896
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0290262
ASPH aspartate beta-hydroxylase -0.028819
ENO1 enolase 1, (alpha) -0.028556
RPL9 ribosomal protein L9 -0.0284927
EGFR epidermal growth factor receptor -0.0284849
MED13L mediator complex subunit 13-like -0.0283485
RPL26 ribosomal protein L26 -0.0280142
RPS11 ribosomal protein S11 -0.0279455
TUBB4B tubulin, beta 4B class IVb -0.0278643
TBC1D22A TBC1 domain family, member 22A -0.0278291
RPL19 ribosomal protein L19 -0.0278285
SUMF1 sulfatase modifying factor 1 -0.0277094
SLC38A2 solute carrier family 38, member 2 -0.0276802
MSI2 musashi RNA-binding protein 2 -0.0274664
RPL36 ribosomal protein L36 -0.0273994
FAF1 Fas (TNFRSF6) associated factor 1 -0.0273553
KRT19 keratin 19, type I -0.0271612
MCL1 myeloid cell leukemia 1 -0.0270849
TBC1D5 TBC1 domain family, member 5 -0.0270352
RPS29 ribosomal protein S29 -0.0269539
RPS12 ribosomal protein S12 -0.0268907
RRM2 ribonucleotide reductase M2 -0.0268782
RPS16 ribosomal protein S16 -0.0266871
DIAPH3 diaphanous-related formin 3 -0.0265979
TUBA1B tubulin, alpha 1b -0.0265327
RABGAP1L RAB GTPase activating protein 1-like -0.0264875
CADPS Ca++-dependent secretion activator -0.0263774
RPL31 ribosomal protein L31 -0.02589
HMGB1 high mobility group box 1 -0.0257254
EXOC4 exocyst complex component 4 -0.0255012
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0254492
SERINC5 serine incorporator 5 -0.0252884
RPL37A ribosomal protein L37a -0.0248696
RPS27A ribosomal protein S27a -0.0247985
CCND1 cyclin D1 -0.0246618
PARD3B par-3 family cell polarity regulator beta -0.0243515
MKI67 marker of proliferation Ki-67 -0.024349
RNF213 ring finger protein 213 -0.0243399
RPL38 ribosomal protein L38 -0.0242713
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0241423
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0240986
PFN1 profilin 1 -0.0239337
RPS23 ribosomal protein S23 -0.0238976
RPL27A ribosomal protein L27a -0.0237218
HOXB3 homeobox B3 -0.0235874
GPHN gephyrin -0.0233262
RPL5 ribosomal protein L5 -0.023302
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0230507
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0228122
MIDN midnolin -0.0227905