Ixazomib citrate_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.178487
FTL ferritin, light polypeptide 0.125482
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.113802
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0971812
B2M beta-2-microglobulin 0.0892375
MT2A metallothionein 2A 0.0878943
HSPA8 heat shock 70kDa protein 8 0.0602982
RPS6 ribosomal protein S6 0.0574573
RPS3 ribosomal protein S3 0.0480614
UBC ubiquitin C 0.0463443
RPL12 ribosomal protein L12 0.0453184
RACK1 receptor for activated C kinase 1 0.0448159
TPT1 tumor protein, translationally-controlled 1 0.0435786
RPS8 ribosomal protein S8 0.0411548
SQSTM1 sequestosome 1 0.0404726
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0402177
PTMA prothymosin, alpha 0.0394582
MYH9 myosin, heavy chain 9, non-muscle 0.0377274
RPS19 ribosomal protein S19 0.0359301
RPL35A ribosomal protein L35a 0.0351264
BHLHE40 basic helix-loop-helix family, member e40 0.0338959
EIF1 eukaryotic translation initiation factor 1 0.0338019
RPL32 ribosomal protein L32 0.0335992
RPL26 ribosomal protein L26 0.0331508
ZFP36L1 ZFP36 ring finger protein-like 1 0.0330681
ACTG1 actin gamma 1 0.0329086
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0325531
APLP2 amyloid beta (A4) precursor-like protein 2 0.0325278
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321469
RPL19 ribosomal protein L19 0.031498
TMSB4X thymosin beta 4, X-linked 0.0297791
ENO1 enolase 1, (alpha) 0.0295604
RPS12 ribosomal protein S12 0.0293721
EEF1G eukaryotic translation elongation factor 1 gamma 0.0289169
LAMB3 laminin, beta 3 0.0288362
LDHA lactate dehydrogenase A 0.0287766
RPS27A ribosomal protein S27a 0.0283111
EIF4A2 eukaryotic translation initiation factor 4A2 0.0283046
RPL11 ribosomal protein L11 0.0272352
RPL13A ribosomal protein L13a 0.0261239
RPL18 ribosomal protein L18 0.0256652
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024571
RPS14 ribosomal protein S14 0.0241923
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0241042
PGK1 phosphoglycerate kinase 1 0.0239429
RPLP0 ribosomal protein, large, P0 0.0238172
SFTPA2 surfactant protein A2 0.0238086
KTN1 kinectin 1 (kinesin receptor) 0.0237093
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0236207
UBXN4 UBX domain protein 4 0.0233169
RPL14 ribosomal protein L14 0.0231813
RPL7 ribosomal protein L7 0.0231063
RPL34 ribosomal protein L34 0.0230827
RPL35 ribosomal protein L35 0.022694
DDIT4 DNA-damage-inducible transcript 4 0.0225091
TPI1 triosephosphate isomerase 1 0.0223583
RPS2 ribosomal protein S2 0.0222977
RPL23 ribosomal protein L23 0.0219428
RPS5 ribosomal protein S5 0.0214499
CLU clusterin 0.0212691
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0205603
APP amyloid beta (A4) precursor protein 0.0204465
SET SET nuclear proto-oncogene 0.0204199
RPL31 ribosomal protein L31 0.0202765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0201859
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.019895
S100A9 S100 calcium binding protein A9 0.0198693
YBX1 Y box binding protein 1 0.0194469
KMT2E lysine (K)-specific methyltransferase 2E 0.0191935
NCKAP1 NCK-associated protein 1 0.0191929
RSRC2 arginine/serine-rich coiled-coil 2 0.0190908
RPLP2 ribosomal protein, large, P2 0.0190888
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0190725
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0190662
TAPBP TAP binding protein (tapasin) 0.0189324
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0188453
SRRM1 serine/arginine repetitive matrix 1 0.0186572
WDR45B WD repeat domain 45B 0.0186085
RPS27 ribosomal protein S27 0.0185293
RAD23B RAD23 homolog B (S. cerevisiae) 0.0184737
RSL1D1 ribosomal L1 domain containing 1 0.0184013
GOLGA4 golgin A4 0.018384
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0183528
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0182455
UPP1 uridine phosphorylase 1 0.0182264
POTEF POTE ankyrin domain family, member F 0.0181887
RPS13 ribosomal protein S13 0.0181744
KIF5B kinesin family member 5B 0.0180596
ERRFI1 ERBB receptor feedback inhibitor 1 0.0180253
RPL8 ribosomal protein L8 0.0179086
CSDE1 cold shock domain containing E1, RNA-binding 0.0178979
RIOK3 RIO kinase 3 0.0177511
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.017454
H1-0 H1.0 linker histone 0.0173441
RPL15 ribosomal protein L15 0.0173281
RPL36 ribosomal protein L36 0.0171701
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0171414
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0169031
RPS29 ribosomal protein S29 0.0167742
NAMPT nicotinamide phosphoribosyltransferase 0.016661

decreased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 -0.105137
RAD51B RAD51 paralog B -0.104428
ASPH aspartate beta-hydroxylase -0.0958733
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0955047
FNDC3B fibronectin type III domain containing 3B -0.0901416
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0852861
LPP LIM domain containing preferred translocation partner in lipoma -0.0840151
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0823215
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0756312
PSD3 pleckstrin and Sec7 domain containing 3 -0.0740386
FHIT fragile histidine triad -0.0707105
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0697422
ALCAM activated leukocyte cell adhesion molecule -0.0695007
ZBTB20 zinc finger and BTB domain containing 20 -0.0675473
SMYD3 SET and MYND domain containing 3 -0.0670956
SVIL supervillin -0.0639553
OSBPL10 oxysterol binding protein-like 10 -0.061795
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0604556
EGFR epidermal growth factor receptor -0.0600237
ITGB8 integrin, beta 8 -0.060019
HMGA2 high mobility group AT-hook 2 -0.0591392
MACROD2 MACRO domain containing 2 -0.0580644
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0533406
DIAPH3 diaphanous-related formin 3 -0.0531379
TBC1D5 TBC1 domain family, member 5 -0.0496609
VCL vinculin -0.0482787
DLC1 DLC1 Rho GTPase activating protein -0.0482418
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0468082
BICD1 bicaudal D homolog 1 (Drosophila) -0.0462631
NF1 neurofibromin 1 -0.0462609
ATXN1 ataxin 1 -0.0462209
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.04602
PTPRK protein tyrosine phosphatase, receptor type, K -0.0447657
WWOX WW domain containing oxidoreductase -0.0429874
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0428156
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0422518
ATG7 autophagy related 7 -0.040961
CREB5 cAMP responsive element binding protein 5 -0.0397016
FLNB filamin B, beta -0.0396061
FNIP1 folliculin interacting protein 1 -0.0394434
ANKRD11 ankyrin repeat domain 11 -0.0392945
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0392772
DLG1 discs, large homolog 1 (Drosophila) -0.039118
RUNX1 runt-related transcription factor 1 -0.0377046
PTK2 protein tyrosine kinase 2 -0.0375482
LIMCH1 LIM and calponin homology domains 1 -0.0371946
CTBP2 C-terminal binding protein 2 -0.0369647
DENND1A DENN/MADD domain containing 1A -0.0368948
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0361446
ECT2 epithelial cell transforming 2 -0.0359719
INTS6 integrator complex subunit 6 -0.0357417
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0356639
PAX8 paired box 8 -0.0356566
TTC3 tetratricopeptide repeat domain 3 -0.0356432
MBD5 methyl-CpG binding domain protein 5 -0.0355523
CDK13 cyclin-dependent kinase 13 -0.0352561
GPR39 G protein-coupled receptor 39 -0.0347506
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0346721
TBC1D22A TBC1 domain family, member 22A -0.0346564
PCED1B PC-esterase domain containing 1B -0.0343906
EXOC4 exocyst complex component 4 -0.0343761
EHBP1 EH domain binding protein 1 -0.034267
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0342208
BBX bobby sox homolog (Drosophila) -0.0339073
ZNF638 zinc finger protein 638 -0.033789
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.033779
AEBP2 AE binding protein 2 -0.033753
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0335018
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0332967
WWC1 WW and C2 domain containing 1 -0.033283
IARS1 isoleucyl-tRNA synthetase 1 -0.0326621
TRIO trio Rho guanine nucleotide exchange factor -0.0323791
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0323623
SSH2 slingshot protein phosphatase 2 -0.0319956
SMAD3 SMAD family member 3 -0.0318873
ERBIN erbb2 interacting protein -0.0317855
ZNF609 zinc finger protein 609 -0.0317664
RFC3 replication factor C (activator 1) 3, 38kDa -0.0316768
FER fer (fps/fes related) tyrosine kinase -0.0316032
MYO1E myosin IE -0.0315096
ANKRD17 ankyrin repeat domain 17 -0.0311228
BPTF bromodomain PHD finger transcription factor -0.0311178
CCDC138 coiled-coil domain containing 138 -0.0310583
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0307335
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0306593
PATJ PATJ crumbs cell polarity complex component -0.0304686
SPATA13 spermatogenesis associated 13 -0.0304494
RNF213 ring finger protein 213 -0.0301522
TJP1 tight junction protein 1 -0.0296441
EXT1 exostosin glycosyltransferase 1 -0.0293955
PLCB4 phospholipase C, beta 4 -0.0292671
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.029219
SUMF1 sulfatase modifying factor 1 -0.0291431
UBASH3B ubiquitin associated and SH3 domain containing B -0.0289872
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0289433
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0289
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0288743
USP34 ubiquitin specific peptidase 34 -0.0288228
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0287675
ZFHX3 zinc finger homeobox 3 -0.0286657