| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib citrate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.108474 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0875757 |
| ASPH | aspartate beta-hydroxylase | 0.0542243 |
| SQSTM1 | sequestosome 1 | 0.0511034 |
| RND3 | Rho family GTPase 3 | 0.0330834 |
| MAP1B | microtubule-associated protein 1B | 0.0307527 |
| DST | dystonin | 0.0307183 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0303444 |
| KIF1B | kinesin family member 1B | 0.0280495 |
| SQLE | squalene epoxidase | 0.0275658 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0250303 |
| TUSC3 | tumor suppressor candidate 3 | 0.024256 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0236246 |
| ANXA1 | annexin A1 | 0.0229582 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0215717 |
| CTSB | cathepsin B | 0.0211793 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0209244 |
| TXNRD1 | thioredoxin reductase 1 | 0.0205865 |
| NAV2 | neuron navigator 2 | 0.0204025 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0200808 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0192164 |
| SNX29 | sorting nexin 29 | 0.0183202 |
| FAM219A | family with sequence similarity 219, member A | 0.0181618 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0178555 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0176515 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.017522 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0175214 |
| TAPBP | TAP binding protein (tapasin) | 0.0171603 |
| VMP1 | vacuole membrane protein 1 | 0.0166537 |
| CENPF | centromere protein F, 350/400kDa | 0.0160857 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0158495 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0156473 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0155226 |
| TLN1 | talin 1 | 0.0153338 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0153148 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0151887 |
| SLMAP | sarcolemma associated protein | 0.0151508 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0148576 |
| HIP1 | huntingtin interacting protein 1 | 0.0143005 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0140791 |
| MKI67 | marker of proliferation Ki-67 | 0.0138828 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0136726 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0132652 |
| CCDC80 | coiled-coil domain containing 80 | 0.0131497 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0130477 |
| UBE4B | ubiquitination factor E4B | 0.0130085 |
| ANLN | anillin, actin binding protein | 0.0129688 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0128495 |
| NGLY1 | N-glycanase 1 | 0.0127884 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0127619 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0125749 |
| SPAG9 | sperm associated antigen 9 | 0.0125008 |
| BRD2 | bromodomain containing 2 | 0.0124291 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0124114 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0122785 |
| TMF1 | TATA element modulatory factor 1 | 0.0121589 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0118892 |
| CLU | clusterin | 0.0115631 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0115146 |
| UBXN4 | UBX domain protein 4 | 0.0113772 |
| SBF2 | SET binding factor 2 | 0.0113771 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0113671 |
| VCP | valosin containing protein | 0.0113463 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.011192 |
| CLTC | clathrin, heavy chain (Hc) | 0.0111776 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0111417 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | 0.0110865 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0110622 |
| UBQLN1 | ubiquilin 1 | 0.0110533 |
| FAM107B | family with sequence similarity 107, member B | 0.0110487 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0109145 |
| PFN2 | profilin 2 | 0.010844 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0106985 |
| KLF6 | Kruppel-like factor 6 | 0.0106909 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.010615 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0105761 |
| MAP4 | microtubule-associated protein 4 | 0.010516 |
| DIAPH3 | diaphanous-related formin 3 | 0.0104392 |
| ARRDC3 | arrestin domain containing 3 | 0.0103623 |
| HDAC9 | histone deacetylase 9 | 0.0103342 |
| TPX2 | TPX2, microtubule-associated | 0.0101703 |
| SERINC1 | serine incorporator 1 | 0.0101088 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.0100623 |
| GOLGB1 | golgin B1 | 0.0099493 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.00990184 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.00979008 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.00975107 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.00970685 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.0096738 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.00964386 |
| RAB1A | RAB1A, member RAS oncogene family | 0.00963858 |
| FNIP1 | folliculin interacting protein 1 | 0.00950434 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.00948986 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.00947408 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | 0.00946057 |
| ELMO1 | engulfment and cell motility 1 | 0.00939328 |
| NSD3 | nuclear receptor binding SET domain protein 3 | 0.00938296 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.00921248 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0091566 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.00914011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.244222 |
| COL1A1 | collagen, type I, alpha 1 | -0.150914 |
| VIM | vimentin | -0.144552 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.137565 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.118449 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.109735 |
| COL6A3 | collagen, type VI, alpha 3 | -0.106925 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0955671 |
| COL1A2 | collagen, type I, alpha 2 | -0.0911319 |
| UBC | ubiquitin C | -0.0797778 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0704479 |
| TMSB10 | thymosin beta 10 | -0.0645506 |
| CD44 | CD44 molecule (Indian blood group) | -0.0636339 |
| VCAN | versican | -0.0626409 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0613244 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0576394 |
| CDH13 | cadherin 13 | -0.05531 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0522852 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0510677 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0496839 |
| MT2A | metallothionein 2A | -0.0458341 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0438897 |
| VEGFA | vascular endothelial growth factor A | -0.041942 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0413515 |
| NRP1 | neuropilin 1 | -0.0394082 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0392143 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0389009 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0388333 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0376428 |
| ENO1 | enolase 1, (alpha) | -0.0370049 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0365973 |
| HMGA2 | high mobility group AT-hook 2 | -0.0357732 |
| PTK2 | protein tyrosine kinase 2 | -0.0355636 |
| CADM1 | cell adhesion molecule 1 | -0.0343391 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0341145 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0334987 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0332963 |
| ECE1 | endothelin converting enzyme 1 | -0.0325285 |
| PRELID2 | PRELI domain containing 2 | -0.0319793 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0309971 |
| PKM | pyruvate kinase, muscle | -0.0302419 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0297032 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0295443 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0294511 |
| CLIC4 | chloride intracellular channel 4 | -0.028431 |
| IL6ST | interleukin 6 signal transducer | -0.0282603 |
| ATP13A3 | ATPase type 13A3 | -0.0279551 |
| CALD1 | caldesmon 1 | -0.0277402 |
| TPM1 | tropomyosin 1 (alpha) | -0.0277213 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0276194 |
| RPS8 | ribosomal protein S8 | -0.0273514 |
| NAV1 | neuron navigator 1 | -0.0272445 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.026516 |
| HSPB1 | heat shock 27kDa protein 1 | -0.026303 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0262416 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0261405 |
| GLIS3 | GLIS family zinc finger 3 | -0.0260442 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0251091 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0249524 |
| RPL23 | ribosomal protein L23 | -0.0246039 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0245425 |
| ATXN1 | ataxin 1 | -0.0243113 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0227678 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0227493 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0226861 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0225621 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0225265 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0220606 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0220373 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0214816 |
| HSPA1B | heat shock 70kDa protein 1B | -0.0211818 |
| POSTN | periostin, osteoblast specific factor | -0.0211198 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0206659 |
| COL5A1 | collagen, type V, alpha 1 | -0.0204265 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0198493 |
| RPL30 | ribosomal protein L30 | -0.0198401 |
| NREP | neuronal regeneration related protein | -0.0197318 |
| OSMR | oncostatin M receptor | -0.0196961 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0194613 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0193593 |
| ACTG1 | actin gamma 1 | -0.0193267 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0193026 |
| POTEF | POTE ankyrin domain family, member F | -0.018467 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0183842 |
| RPL35A | ribosomal protein L35a | -0.0183819 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0182122 |
| RPS20 | ribosomal protein S20 | -0.0179417 |
| RPS12 | ribosomal protein S12 | -0.0178995 |
| S100A9 | S100 calcium binding protein A9 | -0.0178529 |
| PTMA | prothymosin, alpha | -0.0177611 |
| TAGLN2 | transgelin 2 | -0.0173466 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0172717 |
| VEGFC | vascular endothelial growth factor C | -0.0171817 |
| RPLP1 | ribosomal protein, large, P1 | -0.0171802 |
| IL6 | interleukin 6 | -0.0171691 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0171219 |
| HMGA1 | high mobility group AT-hook 1 | -0.0171046 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0170269 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0168725 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0168665 |
