| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.202639 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.143244 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.105445 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100264 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0835085 |
| FTL | ferritin, light polypeptide | 0.0766049 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0661464 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0627834 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0619185 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0562572 |
| ENO1 | enolase 1, (alpha) | 0.0531009 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0516944 |
| AFDN | afadin, adherens junction formation factor | 0.0495883 |
| TF | transferrin | 0.048866 |
| DSPP | dentin sialophosphoprotein | 0.0485126 |
| H1-0 | H1.0 linker histone | 0.0441824 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0426229 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0400774 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0396478 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0391227 |
| C3 | complement component 3 | 0.0384337 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0376028 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0356035 |
| GOLGA4 | golgin A4 | 0.0353295 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0339304 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0338319 |
| RPL14 | ribosomal protein L14 | 0.0333825 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0331402 |
| LDHA | lactate dehydrogenase A | 0.0305653 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0304723 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0300675 |
| TNS1 | tensin 1 | 0.0295109 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0293878 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0293707 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0275152 |
| ASPH | aspartate beta-hydroxylase | 0.0270985 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.026981 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0267401 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0259246 |
| CTSB | cathepsin B | 0.0256487 |
| CORO1C | coronin, actin binding protein, 1C | 0.0253929 |
| KYNU | kynureninase | 0.0250055 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0249613 |
| RAI14 | retinoic acid induced 14 | 0.0241262 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0238447 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0235988 |
| CFB | complement factor B | 0.0235163 |
| SDC4 | syndecan 4 | 0.0232017 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0231754 |
| RPS3 | ribosomal protein S3 | 0.0228519 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0227035 |
| SERINC1 | serine incorporator 1 | 0.0221516 |
| SFTPA2 | surfactant protein A2 | 0.021961 |
| VEGFA | vascular endothelial growth factor A | 0.0214461 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0212495 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0202293 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0201079 |
| FAM107B | family with sequence similarity 107, member B | 0.0199469 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0197877 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0193699 |
| LAMB1 | laminin, beta 1 | 0.0193427 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0192246 |
| COPA | coatomer protein complex, subunit alpha | 0.0190938 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0187025 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0182533 |
| MTSS1 | metastasis suppressor 1 | 0.0182084 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0179164 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0176414 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0173551 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0171963 |
| ARRDC3 | arrestin domain containing 3 | 0.0169862 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0169547 |
| DTNA | dystrobrevin, alpha | 0.0166948 |
| BRD4 | bromodomain containing 4 | 0.0161132 |
| RPL3 | ribosomal protein L3 | 0.0161085 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0160947 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0160332 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0159428 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0156445 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0156445 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0155899 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0154441 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0153611 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0153519 |
| BRD2 | bromodomain containing 2 | 0.015338 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0153328 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0152633 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0152473 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0151202 |
| NCKAP1 | NCK-associated protein 1 | 0.0150398 |
| SQSTM1 | sequestosome 1 | 0.0150313 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0150298 |
| UBXN4 | UBX domain protein 4 | 0.0149566 |
| RPL4 | ribosomal protein L4 | 0.014914 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0148644 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0147298 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.01438 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0143632 |
| INSIG2 | insulin induced gene 2 | 0.0142912 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0141459 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.625214 |
| MT2A | metallothionein 2A | -0.114396 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.101445 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0740015 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0693281 |
| RPLP1 | ribosomal protein, large, P1 | -0.0687402 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.059474 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0573977 |
| RPS24 | ribosomal protein S24 | -0.0560245 |
| TMSB10 | thymosin beta 10 | -0.0489845 |
| GPC6 | glypican 6 | -0.0475921 |
| APOA2 | apolipoprotein A-II | -0.0453657 |
| TMEM123 | transmembrane protein 123 | -0.0434731 |
| RPL37A | ribosomal protein L37a | -0.0425344 |
| AHSG | alpha-2-HS-glycoprotein | -0.0422074 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0416501 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0414115 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0407766 |
| RPLP2 | ribosomal protein, large, P2 | -0.0392613 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0391192 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0380026 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0374904 |
| RPL23 | ribosomal protein L23 | -0.0358006 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0341744 |
| RRBP1 | ribosome binding protein 1 | -0.0341325 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0339941 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0335819 |
| RPL35A | ribosomal protein L35a | -0.0335439 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0323367 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0319642 |
| EHBP1 | EH domain binding protein 1 | -0.0313004 |
| RPS19 | ribosomal protein S19 | -0.0304829 |
| RPS16 | ribosomal protein S16 | -0.0290241 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0290152 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0283352 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0280568 |
| JMJD1C | jumonji domain containing 1C | -0.0279384 |
| GNAS | GNAS complex locus | -0.0271859 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0268571 |
| HMGA1 | high mobility group AT-hook 1 | -0.0267601 |
| EGR1 | early growth response 1 | -0.025357 |
| RPL9 | ribosomal protein L9 | -0.0252227 |
| RPL31 | ribosomal protein L31 | -0.0252005 |
| RPL34 | ribosomal protein L34 | -0.0247456 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0246583 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0239859 |
| FAM135A | family with sequence similarity 135, member A | -0.0237482 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0233709 |
| ATXN1 | ataxin 1 | -0.0233284 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0233027 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0231681 |
| PERP | PERP, TP53 apoptosis effector | -0.0231262 |
| PEG10 | paternally expressed 10 | -0.0227211 |
| FN1 | fibronectin 1 | -0.0226187 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0222558 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0221455 |
| KRT8 | keratin 8, type II | -0.0220778 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0220039 |
| IER3 | immediate early response 3 | -0.02198 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0218548 |
| RPS23 | ribosomal protein S23 | -0.0218071 |
| NHSL1 | NHS-like 1 | -0.0215787 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0213844 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0213599 |
| CST3 | cystatin C | -0.0212727 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.021172 |
| LYZ | lysozyme | -0.0211145 |
| KIAA1217 | KIAA1217 | -0.0210283 |
| PARD3 | par-3 family cell polarity regulator | -0.0209713 |
| RPS14 | ribosomal protein S14 | -0.0208065 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0207799 |
| RPL7A | ribosomal protein L7a | -0.0206746 |
| RPL38 | ribosomal protein L38 | -0.0205907 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0205828 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0204213 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0202023 |
| LCN2 | lipocalin 2 | -0.0200721 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0196922 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0194287 |
| RPL11 | ribosomal protein L11 | -0.0189669 |
| RPS21 | ribosomal protein S21 | -0.0187817 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.018781 |
| APOA1 | apolipoprotein A-I | -0.0186366 |
| RPS25 | ribosomal protein S25 | -0.0186138 |
| RPL28 | ribosomal protein L28 | -0.0183908 |
| SYN3 | synapsin III | -0.0182393 |
| RBM39 | RNA binding motif protein 39 | -0.0180783 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0179715 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0179503 |
| RPS29 | ribosomal protein S29 | -0.0178325 |
| APOE | apolipoprotein E | -0.0177996 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.017782 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0177592 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0175976 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.016988 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0169378 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0167803 |
| KIF1B | kinesin family member 1B | -0.0167318 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0167292 |
| RPS10 | ribosomal protein S10 | -0.0166904 |
