Ixazomib citrate_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.227008
FTL ferritin, light polypeptide 0.186347
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.166309
HSPA8 heat shock 70kDa protein 8 0.134762
HSPH1 heat shock 105kDa/110kDa protein 1 0.055036
UBC ubiquitin C 0.0434473
HSPA1A heat shock 70kDa protein 1A 0.0411635
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0401534
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0334372
MSN moesin 0.0310328
APLP2 amyloid beta (A4) precursor-like protein 2 0.0293663
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0267058
EEF1G eukaryotic translation elongation factor 1 gamma 0.0211185
BRD2 bromodomain containing 2 0.0210817
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.018732
RND3 Rho family GTPase 3 0.0179111
HSPB1 heat shock 27kDa protein 1 0.0178289
ANXA1 annexin A1 0.0171324
TPM3 tropomyosin 3 0.0164023
FXR1 fragile X mental retardation, autosomal homolog 1 0.0163766
RPS2 ribosomal protein S2 0.016199
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0159344
VCP valosin containing protein 0.0146963
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0140198
HSPA1B heat shock 70kDa protein 1B 0.0140094
MYH9 myosin, heavy chain 9, non-muscle 0.0130249
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0128374
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0124096
MAP1B microtubule-associated protein 1B 0.0122557
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0122108
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0119525
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0118427
SQSTM1 sequestosome 1 0.0116415
BAG3 BCL2-associated athanogene 3 0.0115945
PAPOLA poly(A) polymerase alpha 0.0110976
PLK2 polo-like kinase 2 0.0110397
ERRFI1 ERBB receptor feedback inhibitor 1 0.011036
RPL3 ribosomal protein L3 0.0106674
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0105417
UBQLN1 ubiquilin 1 0.0105137
DST dystonin 0.0102971
CXCL8 chemokine (C-X-C motif) ligand 8 0.0101153
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0101106
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.00994557
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.00991138
RAD23B RAD23 homolog B (S. cerevisiae) 0.00990771
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00981078
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.00954019
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00936164
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.00924079
RPS18 ribosomal protein S18 0.00919684
SOD1 superoxide dismutase 1, soluble 0.00917477
RSRC2 arginine/serine-rich coiled-coil 2 0.00895721
PNN pinin, desmosome associated protein 0.00887437
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00871521
SRRM2 serine/arginine repetitive matrix 2 0.00865447
PCBP2 poly(rC) binding protein 2 0.00859002
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00856507
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.00849588
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0083356
ABHD3 abhydrolase domain containing 3 0.00796507
TAPBP TAP binding protein (tapasin) 0.00788553
RPS3 ribosomal protein S3 0.00783804
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.00777629
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00767785
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00766034
PLAA phospholipase A2-activating protein 0.00747271
CLU clusterin 0.00746519
UBXN4 UBX domain protein 4 0.00745324
TXNL1 thioredoxin-like 1 0.00741633
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00738838
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.00728961
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.00704342
RBM12 RNA binding motif protein 12 0.00695059
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.00678946
BHLHE40 basic helix-loop-helix family, member e40 0.00672745
GCLM glutamate-cysteine ligase, modifier subunit 0.00672514
JUN jun proto-oncogene 0.00669119
FLNA filamin A, alpha 0.00659101
H1-2 H1.2 linker histone, cluster member 0.0065836
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.00656332
CASC3 cancer susceptibility candidate 3 0.00655194
FAM219A family with sequence similarity 219, member A 0.00650873
SET SET nuclear proto-oncogene 0.0064959
BCL6 B-cell CLL/lymphoma 6 0.00649203
CD163L1 CD163 molecule-like 1 0.00647923
TCP1 t-complex 1 0.00647725
KTN1 kinectin 1 (kinesin receptor) 0.0064352
CCN2 cellular communication network factor 2 0.00642812
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.00641119
HSPA4 heat shock 70kDa protein 4 0.00632287
CACYBP calcyclin binding protein 0.0062696
RB1CC1 RB1-inducible coiled-coil 1 0.0062437
KIF1B kinesin family member 1B 0.00618431
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.00617374
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.00617182
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.00607867
H1-4 H1.4 linker histone, cluster member 0.00605275
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00603177
RGS2 regulator of G-protein signaling 2 0.00586564

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.183697
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144633
TMSB10 thymosin beta 10 -0.107034
TPT1 tumor protein, translationally-controlled 1 -0.0757926
PTMA prothymosin, alpha -0.0673492
GPC6 glypican 6 -0.0546748
ACTG1 actin gamma 1 -0.0515106
RPL23 ribosomal protein L23 -0.0503959
RPLP1 ribosomal protein, large, P1 -0.0487951
MT2A metallothionein 2A -0.0471895
AHNAK AHNAK nucleoprotein -0.0429233
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0426724
RPS24 ribosomal protein S24 -0.0410162
EFNA5 ephrin-A5 -0.0381771
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0376083
DTNA dystrobrevin, alpha -0.0369479
WSB1 WD repeat and SOCS box containing 1 -0.0363459
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0361289
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0355215
NALF1 NALCN channel auxiliary factor 1 -0.0349283
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0348918
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0333364
RPL35A ribosomal protein L35a -0.0325659
CDK6 cyclin-dependent kinase 6 -0.0323769
EXT1 exostosin glycosyltransferase 1 -0.0315889
FNDC3B fibronectin type III domain containing 3B -0.030842
RPS25 ribosomal protein S25 -0.030738
UGCG UDP-glucose ceramide glucosyltransferase -0.0300665
RPLP0 ribosomal protein, large, P0 -0.0297306
PDE4D phosphodiesterase 4D, cAMP-specific -0.0296397
HMGA1 high mobility group AT-hook 1 -0.029566
RPL36A ribosomal protein L36a -0.0290872
RPLP2 ribosomal protein, large, P2 -0.0290712
VCL vinculin -0.0289299
PTK2 protein tyrosine kinase 2 -0.0287709
MMP12 matrix metallopeptidase 12 -0.0283026
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0281631
RPS13 ribosomal protein S13 -0.0278965
KIAA1549L KIAA1549-like -0.0278784
GNAS GNAS complex locus -0.0275607
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0268248
STC1 stanniocalcin 1 -0.0265608
ANXA2 annexin A2 -0.026246
CDH13 cadherin 13 -0.0254783
RPS8 ribosomal protein S8 -0.0253525
PKM pyruvate kinase, muscle -0.0252723
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0243042
TPM4 tropomyosin 4 -0.0242319
NF1 neurofibromin 1 -0.0239575
RUNX1 runt-related transcription factor 1 -0.0239082
VDAC1 voltage-dependent anion channel 1 -0.0236924
AKAP12 A kinase (PRKA) anchor protein 12 -0.0236913
PTPRG protein tyrosine phosphatase, receptor type, G -0.0234864
LIMCH1 LIM and calponin homology domains 1 -0.023442
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0234397
BTG1 B-cell translocation gene 1, anti-proliferative -0.0233315
RPL12 ribosomal protein L12 -0.0228878
PRKG1 protein kinase, cGMP-dependent, type I -0.0228745
SAMD3 sterile alpha motif domain containing 3 -0.0227875
TM4SF1 transmembrane 4 L six family member 1 -0.0226604
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224695
PARD3 par-3 family cell polarity regulator -0.0222846
PHACTR1 phosphatase and actin regulator 1 -0.0222657
KIAA1217 KIAA1217 -0.0222524
LPP LIM domain containing preferred translocation partner in lipoma -0.0221271
RPL38 ribosomal protein L38 -0.0219799
RAD21 RAD21 homolog (S. pombe) -0.0219433
TMEM123 transmembrane protein 123 -0.0218188
TRIO trio Rho guanine nucleotide exchange factor -0.0217019
RPS23 ribosomal protein S23 -0.0214214
RPL31 ribosomal protein L31 -0.0213957
KPNB1 karyopherin (importin) beta 1 -0.0213007
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0212334
PGK1 phosphoglycerate kinase 1 -0.0210751
RPS19 ribosomal protein S19 -0.0209655
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0209294
HMGA2 high mobility group AT-hook 2 -0.0208752
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0208282
RPS27A ribosomal protein S27a -0.0206844
RTN4 reticulon 4 -0.0206297
RPL7A ribosomal protein L7a -0.0203192
FOXP1 forkhead box P1 -0.0202934
USP34 ubiquitin specific peptidase 34 -0.020204
RPL34 ribosomal protein L34 -0.0201533
RPS16 ribosomal protein S16 -0.020104
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.019909
DLG1 discs, large homolog 1 (Drosophila) -0.019842
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0198276
SDCCAG8 serologically defined colon cancer antigen 8 -0.0198084
IER3 immediate early response 3 -0.0196935
RPL8 ribosomal protein L8 -0.0196539
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.019628
CD44 CD44 molecule (Indian blood group) -0.0196189
CFAP251 cilia and flagella associated protein 251 -0.0195965
NTM neurotrimin -0.0195885
NAP1L1 nucleosome assembly protein 1-like 1 -0.0195162
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0189958
RPL37A ribosomal protein L37a -0.0189697
SBF2 SET binding factor 2 -0.0189396
NAV1 neuron navigator 1 -0.0187224