Ixazomib citrate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.151708
EPS8 epidermal growth factor receptor pathway substrate 8 0.107314
GARS1 glycyl-tRNA synthetase 1 0.0864234
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0821052
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.073725
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.073409
TXNRD1 thioredoxin reductase 1 0.0719727
VCL vinculin 0.0702411
FAT1 FAT atypical cadherin 1 0.0686458
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0654837
GOLGA4 golgin A4 0.0642101
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.062941
EIF1 eukaryotic translation initiation factor 1 0.0622639
DSCAM Down syndrome cell adhesion molecule 0.0601147
GDF15 growth differentiation factor 15 0.0538961
PLAC8 placenta-specific 8 0.0509687
RPS3 ribosomal protein S3 0.049607
SHROOM3 shroom family member 3 0.0464346
TRIM2 tripartite motif containing 2 0.0463462
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0449702
LAMB3 laminin, beta 3 0.0449502
PKP2 plakophilin 2 0.0449179
HSPA8 heat shock 70kDa protein 8 0.0446302
FLNB filamin B, beta 0.0417574
EREG epiregulin 0.041243
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0396225
ABHD17C abhydrolase domain containing 17C 0.0390609
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0388058
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0379549
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0377234
ANKRD11 ankyrin repeat domain 11 0.0369609
MYO6 myosin VI 0.0357634
RPL13A ribosomal protein L13a 0.0354482
TTC3 tetratricopeptide repeat domain 3 0.0342738
TMEM41B transmembrane protein 41B 0.0341862
NKTR natural killer cell triggering receptor 0.033739
RBM39 RNA binding motif protein 39 0.0331334
PRELID2 PRELI domain containing 2 0.0327225
AREG amphiregulin 0.0316885
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0315531
PRSS3 protease, serine, 3 0.0315123
RPL14 ribosomal protein L14 0.0314296
AKAP9 A kinase (PRKA) anchor protein 9 0.0312845
FHL2 four and a half LIM domains 2 0.0312664
YBX3 Y box binding protein 3 0.0312094
BTBD9 BTB (POZ) domain containing 9 0.030812
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0306944
MKI67 marker of proliferation Ki-67 0.0306536
PCDHB16 protocadherin beta 16 0.0298721
IARS1 isoleucyl-tRNA synthetase 1 0.0296566
CDK19 cyclin-dependent kinase 19 0.0296336
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0293799
MON2 MON2 homolog (S. cerevisiae) 0.0292809
CTNND1 catenin (cadherin-associated protein), delta 1 0.0292797
SETD5 SET domain containing 5 0.0291063
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0282119
KIF5B kinesin family member 5B 0.027166
MYOF myoferlin 0.0271104
UBC ubiquitin C 0.0270942
NAP1L1 nucleosome assembly protein 1-like 1 0.0269887
CCNG1 cyclin G1 0.0269605
CARS1 cysteinyl-tRNA synthetase 1 0.0267007
ZFC3H1 zinc finger, C3H1-type containing 0.0265499
MARS1 methionyl-tRNA synthetase 1 0.0264776
PNISR PNN-interacting serine/arginine-rich protein 0.0264562
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0264178
CCPG1 cell cycle progression 1 0.0262804
DDIT4 DNA-damage-inducible transcript 4 0.0259636
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.025949
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0259328
NAMPT nicotinamide phosphoribosyltransferase 0.0258182
CENPF centromere protein F, 350/400kDa 0.0253911
PSAT1 phosphoserine aminotransferase 1 0.0249615
ITGA6 integrin, alpha 6 0.0249187
RB1CC1 RB1-inducible coiled-coil 1 0.0249147
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0248669
AHCYL2 adenosylhomocysteinase-like 2 0.024825
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0244606
TMF1 TATA element modulatory factor 1 0.0243274
TRIM31 tripartite motif containing 31 0.0242392
RAB1A RAB1A, member RAS oncogene family 0.0237143
CLINT1 clathrin interactor 1 0.0235739
COPB1 coatomer protein complex, subunit beta 1 0.0234534
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0234438
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.022976
OGA O-GlcNAcase 0.0229072
PHF3 PHD finger protein 3 0.0225311
MARCHF6 membrane associated ring-CH-type finger 6 0.0222798
EXT1 exostosin glycosyltransferase 1 0.0217761
RTN4 reticulon 4 0.021667
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.021556
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0215403
ANLN anillin, actin binding protein 0.0215053
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0214313
PLAUR plasminogen activator, urokinase receptor 0.0213782
HMGB2 high mobility group box 2 0.021326
SUCO SUN domain containing ossification factor 0.0213024
TMEM263 transmembrane protein 263 0.021273
ETNK1 ethanolamine kinase 1 0.0212396
YARS1 tyrosyl-tRNA synthetase 1 0.0212299

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.15688
PDE4D phosphodiesterase 4D, cAMP-specific -0.137136
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.12909
POTEF POTE ankyrin domain family, member F -0.113135
RPLP1 ribosomal protein, large, P1 -0.0808018
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0797469
THSD4 thrombospondin, type I, domain containing 4 -0.0770577
PKM pyruvate kinase, muscle -0.0760873
KRT18 keratin 18, type I -0.07378
F3 coagulation factor III (thromboplastin, tissue factor) -0.0729602
GMDS GDP-mannose 4,6-dehydratase -0.0709437
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0693204
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.063514
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0601824
RREB1 ras responsive element binding protein 1 -0.0589123
EGFR epidermal growth factor receptor -0.0573621
ITGB4 integrin, beta 4 -0.0572932
NPSR1 neuropeptide S receptor 1 -0.0569588
MPRIP myosin phosphatase Rho interacting protein -0.0566401
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.056174
CAV2 caveolin 2 -0.0508651
FRMD5 FERM domain containing 5 -0.0486831
SVIL supervillin -0.0481336
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0467912
PERP PERP, TP53 apoptosis effector -0.0466313
PSD3 pleckstrin and Sec7 domain containing 3 -0.0455315
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0453602
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0453058
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0452921
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0442011
PDIA3 protein disulfide isomerase family A, member 3 -0.042661
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.042483
CATSPERB catsper channel auxiliary subunit beta -0.0422761
RPS6 ribosomal protein S6 -0.0420372
MYO1E myosin IE -0.0418762
DSG2 desmoglein 2 -0.0413809
DENND1A DENN/MADD domain containing 1A -0.0406339
LMO7 LIM domain 7 -0.0405603
IFI27 interferon, alpha-inducible protein 27 -0.0403777
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0403195
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0401049
ANXA2 annexin A2 -0.0401016
TRAPPC9 trafficking protein particle complex 9 -0.03998
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0399721
LOC112694756 uncharaterized LOC112694756 -0.0399404
IFI6 interferon, alpha-inducible protein 6 -0.0395144
RABGAP1L RAB GTPase activating protein 1-like -0.038964
ALCAM activated leukocyte cell adhesion molecule -0.0379182
IGF1R insulin-like growth factor 1 receptor -0.0371692
RPS25 ribosomal protein S25 -0.0369475
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0369465
INTS6 integrator complex subunit 6 -0.0369055
HLA-B major histocompatibility complex, class I, B -0.0366592
ACTG1 actin gamma 1 -0.0364918
PTPRR protein tyrosine phosphatase, receptor type, R -0.0363927
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0362311
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0359249
DIAPH1 diaphanous-related formin 1 -0.0357186
CUX1 cut-like homeobox 1 -0.03556
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0353541
RPL37A ribosomal protein L37a -0.0352214
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0350259
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0348517
MSI2 musashi RNA-binding protein 2 -0.0343779
HMGA1 high mobility group AT-hook 1 -0.03397
FHIT fragile histidine triad -0.033093
STK39 serine threonine kinase 39 -0.0328976
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0328087
RNF217 ring finger protein 217 -0.0327495
TUBA1B tubulin, alpha 1b -0.0322697
LRPPRC leucine-rich pentatricopeptide repeat containing -0.032213
PTPRB protein tyrosine phosphatase, receptor type, B -0.0321067
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0320365
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.031946
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0319424
MAML2 mastermind-like 2 (Drosophila) -0.031673
CTBP2 C-terminal binding protein 2 -0.0314527
RNF213 ring finger protein 213 -0.0310701
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0310016
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0309205
LDHA lactate dehydrogenase A -0.0307651
CLIC5 chloride intracellular channel 5 -0.0300769
DIAPH2 diaphanous-related formin 2 -0.0298617
RPL31 ribosomal protein L31 -0.0296945
MCU mitochondrial calcium uniporter -0.0294506
CCDC91 coiled-coil domain containing 91 -0.0294321
RPLP2 ribosomal protein, large, P2 -0.0293217
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0292687
RPL28 ribosomal protein L28 -0.0291077
DSPP dentin sialophosphoprotein -0.0290862
SERBP1 SERPINE1 mRNA binding protein 1 -0.0287723
WWOX WW domain containing oxidoreductase -0.0287416
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0286854
ESYT2 extended synaptotagmin-like protein 2 -0.0282148
AOPEP aminopeptidase O (putative) -0.0281892
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0281866
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.028099
OSBPL8 oxysterol binding protein-like 8 -0.0280403
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0280391
RPS23 ribosomal protein S23 -0.0279905