| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.175193 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.157789 |
| TXNRD1 | thioredoxin reductase 1 | 0.148261 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.123082 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.113198 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0856838 |
| RAI1 | retinoic acid induced 1 | 0.0837918 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0760671 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0720666 |
| EZR | ezrin | 0.0710699 |
| CENPF | centromere protein F, 350/400kDa | 0.0646293 |
| SET | SET nuclear proto-oncogene | 0.0593404 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0573748 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.056773 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0566046 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0561906 |
| PTMA | prothymosin, alpha | 0.0538255 |
| MKI67 | marker of proliferation Ki-67 | 0.0533531 |
| RPS3 | ribosomal protein S3 | 0.0533051 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0530573 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0527651 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0526572 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0512364 |
| TMSB4X | thymosin beta 4, X-linked | 0.0506025 |
| RTN4 | reticulon 4 | 0.0502782 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0495153 |
| TMEM41B | transmembrane protein 41B | 0.0490946 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0486957 |
| RPS6 | ribosomal protein S6 | 0.047784 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0472902 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0461983 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0461971 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0460622 |
| UPP1 | uridine phosphorylase 1 | 0.045736 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0454009 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0448158 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0423296 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0415487 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0405679 |
| MSN | moesin | 0.0400132 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0381132 |
| TAPBP | TAP binding protein (tapasin) | 0.0378126 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0372566 |
| RGS4 | regulator of G-protein signaling 4 | 0.0372184 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0370802 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0363191 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0361438 |
| TPM3 | tropomyosin 3 | 0.0360472 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0349748 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.034612 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0345459 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0345297 |
| CEP170 | centrosomal protein 170kDa | 0.0345082 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0341806 |
| FLNB | filamin B, beta | 0.0339794 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0338957 |
| KLF6 | Kruppel-like factor 6 | 0.0337715 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.03244 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0320862 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0319384 |
| YBX3 | Y box binding protein 3 | 0.0317201 |
| ANXA1 | annexin A1 | 0.0316548 |
| CLTC | clathrin, heavy chain (Hc) | 0.0314625 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0314355 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0311102 |
| AHNAK | AHNAK nucleoprotein | 0.030796 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0304781 |
| RACK1 | receptor for activated C kinase 1 | 0.0300659 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0299671 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0299624 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0297613 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0295975 |
| UBXN4 | UBX domain protein 4 | 0.0293596 |
| TPM4 | tropomyosin 4 | 0.0293114 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0292355 |
| EREG | epiregulin | 0.0290814 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0290661 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0290059 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.028649 |
| EMP1 | epithelial membrane protein 1 | 0.0286379 |
| KIF5B | kinesin family member 5B | 0.0285032 |
| AREG | amphiregulin | 0.0283678 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0282339 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.028137 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0281357 |
| SRGN | serglycin | 0.0277028 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.027536 |
| BRD4 | bromodomain containing 4 | 0.0273357 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0271384 |
| PAPOLA | poly(A) polymerase alpha | 0.0269993 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0267513 |
| YEATS2 | YEATS domain containing 2 | 0.0264896 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.026267 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0261229 |
| ARRDC3 | arrestin domain containing 3 | 0.0259663 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0257013 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0255084 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0254273 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0253746 |
| ANGPTL4 | angiopoietin-like 4 | 0.0253704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.32591 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.152233 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.117803 |
| TP63 | tumor protein p63 | -0.103267 |
| CADM2 | cell adhesion molecule 2 | -0.10021 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0958291 |
| TMSB10 | thymosin beta 10 | -0.0756214 |
| CD44 | CD44 molecule (Indian blood group) | -0.0739015 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0657986 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0654325 |
| SP100 | SP100 nuclear antigen | -0.055356 |
| HMGA1 | high mobility group AT-hook 1 | -0.0527782 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0514913 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0505326 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0503505 |
| HLA-B | major histocompatibility complex, class I, B | -0.0486888 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0482128 |
| EPHA4 | EPH receptor A4 | -0.0476173 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0472397 |
| TNS3 | tensin 3 | -0.0440435 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0439189 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0439064 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0419137 |
| NEK10 | NIMA-related kinase 10 | -0.0414834 |
| PRELID2 | PRELI domain containing 2 | -0.0406764 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0397167 |
| INTS6 | integrator complex subunit 6 | -0.0389741 |
| PLSCR1 | phospholipid scramblase 1 | -0.038753 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0386151 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0378045 |
| EGR1 | early growth response 1 | -0.0374237 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0370759 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0366363 |
| TMEM123 | transmembrane protein 123 | -0.0365452 |
| MYOF | myoferlin | -0.0353668 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0343667 |
| RIGI | RNA sensor RIG-I | -0.0319829 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0311358 |
| RPS24 | ribosomal protein S24 | -0.0310896 |
| HDAC9 | histone deacetylase 9 | -0.0309958 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0309368 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0308127 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0300329 |
| AEBP2 | AE binding protein 2 | -0.0294666 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.029219 |
| EGFR | epidermal growth factor receptor | -0.0290706 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0290535 |
| GNAS | GNAS complex locus | -0.0280471 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0280337 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0276796 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0271825 |
| RPLP1 | ribosomal protein, large, P1 | -0.0268032 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0266226 |
| FOXK1 | forkhead box K1 | -0.0263375 |
| RNF213 | ring finger protein 213 | -0.0256024 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0244291 |
| TXNIP | thioredoxin interacting protein | -0.0244237 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244037 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0243702 |
| ACTG1 | actin gamma 1 | -0.0240656 |
| ZNF207 | zinc finger protein 207 | -0.0236922 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0236211 |
| RPS20 | ribosomal protein S20 | -0.0236088 |
| EHBP1 | EH domain binding protein 1 | -0.0235397 |
| VIM | vimentin | -0.0229544 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0228367 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.022782 |
| TFRC | transferrin receptor | -0.0227329 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0226986 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0221868 |
| CALR | calreticulin | -0.0221802 |
| PKM | pyruvate kinase, muscle | -0.0220437 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0215292 |
| ARF1 | ADP-ribosylation factor 1 | -0.0214357 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0212217 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.021137 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0210872 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0210803 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0210718 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0209906 |
| S100A10 | S100 calcium binding protein A10 | -0.020979 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -0.0209752 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0208862 |
| RPL28 | ribosomal protein L28 | -0.0208543 |
| LRRC49 | leucine rich repeat containing 49 | -0.0206806 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.02042 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0202325 |
| SPAG9 | sperm associated antigen 9 | -0.0201997 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0201936 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0200251 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0194688 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0192737 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.019272 |
| ANXA2 | annexin A2 | -0.0191186 |
| NDRG1 | N-myc downstream regulated 1 | -0.0190688 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0187449 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0187242 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0186054 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.018548 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0182842 |
