Ixazomib citrate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0776581
MKI67 marker of proliferation Ki-67 0.0617642
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0520437
CES1 carboxylesterase 1 0.0505055
AGO2 argonaute RISC catalytic component 2 0.0482401
FTH1 ferritin, heavy polypeptide 1 0.0441618
RPS3 ribosomal protein S3 0.0411748
B2M beta-2-microglobulin 0.0407133
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0387008
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0386938
NAMPT nicotinamide phosphoribosyltransferase 0.0384595
LAMC2 laminin, gamma 2 0.035135
ERRFI1 ERBB receptor feedback inhibitor 1 0.0344617
CPE carboxypeptidase E 0.0341057
TOP1 topoisomerase (DNA) I 0.0339777
DSCAM Down syndrome cell adhesion molecule 0.0327851
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0326582
RPS6 ribosomal protein S6 0.0325659
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.031986
KTN1 kinectin 1 (kinesin receptor) 0.0308941
RUNX1 runt-related transcription factor 1 0.0308257
TAPBP TAP binding protein (tapasin) 0.0299857
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0284782
MCL1 myeloid cell leukemia 1 0.0284738
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0266428
CST3 cystatin C 0.0263992
PCBP2 poly(rC) binding protein 2 0.0260966
ELL2 elongation factor, RNA polymerase II, 2 0.0260103
PRRC2C proline-rich coiled-coil 2C 0.0257346
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.025694
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0244641
TXNRD1 thioredoxin reductase 1 0.0240981
CENPF centromere protein F, 350/400kDa 0.0237415
JMJD1C jumonji domain containing 1C 0.0235134
TMSB10 thymosin beta 10 0.0234118
MYO1B myosin IB 0.0231777
AREG amphiregulin 0.0231107
NGLY1 N-glycanase 1 0.0229349
CAMTA1 calmodulin binding transcription activator 1 0.0219915
ECT2 epithelial cell transforming 2 0.021234
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0210973
RPL34 ribosomal protein L34 0.0208246
CCNL1 cyclin L1 0.0207174
RICTOR RPTOR independent companion of MTOR, complex 2 0.020344
TBC1D22A TBC1 domain family, member 22A 0.0202665
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0201356
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0198932
TMF1 TATA element modulatory factor 1 0.0193708
MGST1 microsomal glutathione S-transferase 1 0.019088
ANKRD12 ankyrin repeat domain 12 0.019002
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0188262
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0187652
ZBTB1 zinc finger and BTB domain containing 1 0.0186564
MYH9 myosin, heavy chain 9, non-muscle 0.0185631
ZNF148 zinc finger protein 148 0.0185202
NSUN6 NOP2/Sun domain family, member 6 0.0184839
RTN4 reticulon 4 0.0183445
ADAR adenosine deaminase, RNA-specific 0.0182801
WDR26 WD repeat domain 26 0.0182497
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0180734
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0180343
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0178989
KIAA1217 KIAA1217 0.017675
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0176244
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0175494
BMP6 bone morphogenetic protein 6 0.0175085
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0174226
PLAUR plasminogen activator, urokinase receptor 0.0172731
MCTP1 multiple C2 domains, transmembrane 1 0.0172041
ADAM17 ADAM metallopeptidase domain 17 0.0171962
ANKRD17 ankyrin repeat domain 17 0.0171542
MT1X metallothionein 1X 0.0171073
ARL5B ADP-ribosylation factor-like 5B 0.0170503
KYNU kynureninase 0.0169955
BIRC3 baculoviral IAP repeat containing 3 0.0168258
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0167945
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0167853
ZC3H11A zinc finger CCCH-type containing 11A 0.0167042
ARRDC3 arrestin domain containing 3 0.0165563
TMEM165 transmembrane protein 165 0.0165013
RPS27 ribosomal protein S27 0.0164992
ANKRD10 ankyrin repeat domain 10 0.0164483
PNN pinin, desmosome associated protein 0.0164053
JAK1 Janus kinase 1 0.0163286
BIRC2 baculoviral IAP repeat containing 2 0.0163027
SCLT1 sodium channel and clathrin linker 1 0.0162397
N4BP2L2 NEDD4 binding protein 2-like 2 0.0160457
PUM2 pumilio RNA-binding family member 2 0.0160402
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0159972
EFNA5 ephrin-A5 0.0157243
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0154327
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0153886
SYAP1 synapse associated protein 1 0.0153864
KMT2A lysine (K)-specific methyltransferase 2A 0.0152825
SENP5 SUMO1/sentrin specific peptidase 5 0.0152696
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0152323
NDE1 nudE neurodevelopment protein 1 0.0149343
SON SON DNA binding protein 0.0148679
NPTN neuroplastin 0.014831
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0147402

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.208198
THSD4 thrombospondin, type I, domain containing 4 -0.126971
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119845
ASPH aspartate beta-hydroxylase -0.102885
PTPRM protein tyrosine phosphatase, receptor type, M -0.0967787
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0953763
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0930966
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0862942
CAV1 caveolin 1, caveolae protein, 22kDa -0.0806585
LMO7 LIM domain 7 -0.0747919
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0662122
ANXA2 annexin A2 -0.061465
PDE4D phosphodiesterase 4D, cAMP-specific -0.0573775
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0556301
ACTG1 actin gamma 1 -0.0552786
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0535337
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.052282
FNDC3B fibronectin type III domain containing 3B -0.0513951
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0509297
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0478308
AKAP12 A kinase (PRKA) anchor protein 12 -0.0477236
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0428408
AHNAK AHNAK nucleoprotein -0.0424737
PM20D1 peptidase M20 domain containing 1 -0.042314
NDRG1 N-myc downstream regulated 1 -0.0412448
LDHA lactate dehydrogenase A -0.0406527
SMAD3 SMAD family member 3 -0.040473
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0390969
ENO1 enolase 1, (alpha) -0.0385482
MYOF myoferlin -0.037195
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0369067
IGFBP5 insulin-like growth factor binding protein 5 -0.0363068
MACF1 microtubule-actin crosslinking factor 1 -0.0348046
BZW1 basic leucine zipper and W2 domains 1 -0.0338958
EGR1 early growth response 1 -0.0337902
NPAS2 neuronal PAS domain protein 2 -0.0337102
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0333452
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0329594
KRT18 keratin 18, type I -0.0326467
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0325917
SQSTM1 sequestosome 1 -0.0325182
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0311511
RNF213 ring finger protein 213 -0.0310802
AHNAK2 AHNAK nucleoprotein 2 -0.0308198
S100A10 S100 calcium binding protein A10 -0.0305662
RIMS2 regulating synaptic membrane exocytosis 2 -0.030451
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0294171
SCEL sciellin -0.0291291
TPM4 tropomyosin 4 -0.0279512
MAML3 mastermind-like 3 (Drosophila) -0.0273428
ABHD3 abhydrolase domain containing 3 -0.0269416
IGFBP3 insulin-like growth factor binding protein 3 -0.0264577
LPP LIM domain containing preferred translocation partner in lipoma -0.0257466
H1-0 H1.0 linker histone -0.0256337
SUMF1 sulfatase modifying factor 1 -0.0255611
NCOA7 nuclear receptor coactivator 7 -0.0252475
CCND1 cyclin D1 -0.0250704
INTS6 integrator complex subunit 6 -0.0244686
TRIO trio Rho guanine nucleotide exchange factor -0.0244595
RAB27B RAB27B, member RAS oncogene family -0.0244436
KRT7 keratin 7, type II -0.0241457
MORF4L2 mortality factor 4 like 2 -0.0234892
TAS2R14 taste receptor, type 2, member 14 -0.0233669
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.022896
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0225445
PKM pyruvate kinase, muscle -0.0225214
JUN jun proto-oncogene -0.0224837
PDE8A phosphodiesterase 8A -0.0222862
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0222216
DSPP dentin sialophosphoprotein -0.0220702
CEMIP cell migration inducing protein, hyaluronan binding -0.0217371
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0217285
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0216119
FLNB filamin B, beta -0.0214863
CUX1 cut-like homeobox 1 -0.0214164
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0210481
GRB10 growth factor receptor-bound protein 10 -0.0209037
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0208808
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0208772
SLC35F3 solute carrier family 35, member F3 -0.020563
IGF1R insulin-like growth factor 1 receptor -0.0204222
DSG2 desmoglein 2 -0.0203902
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0202264
CAV2 caveolin 2 -0.0195614
DENND5B DENN/MADD domain containing 5B -0.0195209
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0194595
CLOCK clock circadian regulator -0.0194239
HBP1 HMG-box transcription factor 1 -0.0194131
MYO5C myosin VC -0.0193738
RAD51B RAD51 paralog B -0.0192782
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0192744
FAM13A family with sequence similarity 13, member A -0.0191969
RAB7A RAB7A, member RAS oncogene family -0.0189941
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0188085
LARP1 La ribonucleoprotein domain family, member 1 -0.018205
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0181275
KRT8 keratin 8, type II -0.0180634
SEC31A SEC31 homolog A (S. cerevisiae) -0.0180566
UPP1 uridine phosphorylase 1 -0.0179547
RABGAP1L RAB GTPase activating protein 1-like -0.0177236