| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.149063 |
| HSPA8 | heat shock 70kDa protein 8 | 0.111053 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0929533 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0822322 |
| UBC | ubiquitin C | 0.0785032 |
| HSPA1B | heat shock 70kDa protein 1B | 0.034528 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0299022 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0298477 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0290997 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0290623 |
| TPM3 | tropomyosin 3 | 0.028823 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0276531 |
| BRD2 | bromodomain containing 2 | 0.0266418 |
| FTL | ferritin, light polypeptide | 0.0263289 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0242619 |
| PNN | pinin, desmosome associated protein | 0.0241034 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0233619 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0220129 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0218644 |
| KIF1B | kinesin family member 1B | 0.0196354 |
| RPS3 | ribosomal protein S3 | 0.0186385 |
| MSN | moesin | 0.0180576 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0180425 |
| HYOU1 | hypoxia up-regulated 1 | 0.0177379 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0174374 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0169545 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0163011 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0161983 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.015904 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0149617 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0147588 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0147418 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0145318 |
| YTHDC1 | YTH domain containing 1 | 0.0144259 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0139964 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0138132 |
| HDGF | hepatoma-derived growth factor | 0.0137338 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0136652 |
| COPA | coatomer protein complex, subunit alpha | 0.0135413 |
| RPL14 | ribosomal protein L14 | 0.0134457 |
| RBM25 | RNA binding motif protein 25 | 0.013375 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0132853 |
| UBQLN1 | ubiquilin 1 | 0.0130975 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0130615 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.013048 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0128259 |
| CASC3 | cancer susceptibility candidate 3 | 0.0126903 |
| SFTPA2 | surfactant protein A2 | 0.0126876 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0126264 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0126146 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0125909 |
| RPL3 | ribosomal protein L3 | 0.0123391 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0122476 |
| TLN1 | talin 1 | 0.0121837 |
| CCNL1 | cyclin L1 | 0.0119826 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0114556 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0114057 |
| ZFP36 | ZFP36 ring finger protein | 0.0113856 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0113694 |
| POTEF | POTE ankyrin domain family, member F | 0.0112697 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0110075 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0108349 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0108205 |
| RPS18 | ribosomal protein S18 | 0.0107593 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0106751 |
| TMF1 | TATA element modulatory factor 1 | 0.0106422 |
| RBM12 | RNA binding motif protein 12 | 0.01058 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.010536 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0104418 |
| SRP54 | signal recognition particle 54kDa | 0.0101212 |
| VCP | valosin containing protein | 0.0100703 |
| DAXX | death-domain associated protein | 0.0100321 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00982546 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.00970736 |
| FYTTD1 | forty-two-three domain containing 1 | 0.00964548 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00961256 |
| USP36 | ubiquitin specific peptidase 36 | 0.00956794 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.00954798 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.00936386 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00931717 |
| H1-2 | H1.2 linker histone, cluster member | 0.00927112 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.00926019 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.00911003 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.00907898 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.00906048 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.00905154 |
| NCKAP1 | NCK-associated protein 1 | 0.00904479 |
| RPS2 | ribosomal protein S2 | 0.00900544 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.00894496 |
| COPS2 | COP9 signalosome subunit 2 | 0.00894033 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.00893938 |
| CLU | clusterin | 0.00892261 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00889682 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0088717 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00884795 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.00884232 |
| TCP1 | t-complex 1 | 0.00883669 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00872773 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.00872513 |
| TAPBP | TAP binding protein (tapasin) | 0.00849155 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.323256 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.191595 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.160205 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.156258 |
| TMSB10 | thymosin beta 10 | -0.156123 |
| GRAMD1B | GRAM domain containing 1B | -0.154643 |
| VIM | vimentin | -0.144314 |
| TXNRD1 | thioredoxin reductase 1 | -0.138543 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0964927 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0922516 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0861972 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0847733 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0765748 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0698371 |
| BICC1 | BicC family RNA binding protein 1 | -0.068964 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0686781 |
| WWOX | WW domain containing oxidoreductase | -0.0666638 |
| ASPH | aspartate beta-hydroxylase | -0.0651564 |
| RPLP1 | ribosomal protein, large, P1 | -0.0583685 |
| SVIL | supervillin | -0.0551282 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0545692 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0544965 |
| S100A6 | S100 calcium binding protein A6 | -0.0511665 |
| IGF2 | insulin-like growth factor 2 | -0.0497113 |
| RAD51B | RAD51 paralog B | -0.0494731 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.049384 |
| RPL23 | ribosomal protein L23 | -0.0491623 |
| ACTG1 | actin gamma 1 | -0.0483433 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0478387 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0463715 |
| EFNA5 | ephrin-A5 | -0.04627 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0461867 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0457398 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0456611 |
| OSMR | oncostatin M receptor | -0.0456239 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0455119 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0451548 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0436157 |
| NEGR1 | neuronal growth regulator 1 | -0.0433573 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0421462 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0419485 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0418341 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0415411 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0414082 |
| USP34 | ubiquitin specific peptidase 34 | -0.0412199 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.038139 |
| CMIP | c-Maf inducing protein | -0.0377449 |
| RPS24 | ribosomal protein S24 | -0.036735 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0364277 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0363364 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0361201 |
| GLIS3 | GLIS family zinc finger 3 | -0.0358367 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0356522 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.035535 |
| ANXA2 | annexin A2 | -0.0350479 |
| PTMA | prothymosin, alpha | -0.0344244 |
| AHR | aryl hydrocarbon receptor | -0.0343794 |
| PKM | pyruvate kinase, muscle | -0.0341994 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0340721 |
| IER3 | immediate early response 3 | -0.0330612 |
| RPL19 | ribosomal protein L19 | -0.0329503 |
| NHSL1 | NHS-like 1 | -0.0328306 |
| KYNU | kynureninase | -0.0326484 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0325033 |
| NNMT | nicotinamide N-methyltransferase | -0.0323528 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0323047 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.03197 |
| NRG1 | neuregulin 1 | -0.0319683 |
| S100A10 | S100 calcium binding protein A10 | -0.0315923 |
| CAVIN1 | caveolae associated protein 1 | -0.031214 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0310515 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0309969 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0309949 |
| MYOF | myoferlin | -0.0308102 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.030705 |
| NTN4 | netrin 4 | -0.0306344 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0305382 |
| STC1 | stanniocalcin 1 | -0.0303109 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0300103 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0298226 |
| GNAS | GNAS complex locus | -0.0297594 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0293342 |
| DST | dystonin | -0.0292637 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0291699 |
| LDHA | lactate dehydrogenase A | -0.0291339 |
| NCOA7 | nuclear receptor coactivator 7 | -0.028992 |
| RPS25 | ribosomal protein S25 | -0.0289826 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0285294 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0284397 |
| HMGB1 | high mobility group box 1 | -0.0281666 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0280407 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0275156 |
| FOXP1 | forkhead box P1 | -0.0273765 |
| RPL35A | ribosomal protein L35a | -0.027299 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0272908 |
| ZNF292 | zinc finger protein 292 | -0.0268562 |
| AHNAK | AHNAK nucleoprotein | -0.0267873 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0265096 |
| MYL12B | myosin, light chain 12B, regulatory | -0.026435 |
| LMNA | lamin A/C | -0.0262619 |
