| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.392536 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.165883 |
| HSPA8 | heat shock 70kDa protein 8 | 0.124807 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.10795 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.100465 |
| KRT17 | keratin 17, type I | 0.0941242 |
| IGF2 | insulin-like growth factor 2 | 0.0888553 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0860428 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0833199 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0795236 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0794515 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0772905 |
| ASPH | aspartate beta-hydroxylase | 0.0732502 |
| PRKCA | protein kinase C, alpha | 0.0694527 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0672095 |
| UBC | ubiquitin C | 0.066409 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.065145 |
| C3 | complement component 3 | 0.0636323 |
| TUSC3 | tumor suppressor candidate 3 | 0.0600265 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0590487 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0533627 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0521205 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0506466 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0488751 |
| RNF149 | ring finger protein 149 | 0.047318 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.046888 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0449946 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0442726 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0440618 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0435894 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0435396 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0423114 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0418289 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0415249 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0414279 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0412433 |
| KYNU | kynureninase | 0.0411951 |
| PDLIM5 | PDZ and LIM domain 5 | 0.041061 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0409208 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0399974 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0398281 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0395414 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0395202 |
| RPL10A | ribosomal protein L10a | 0.0387752 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0386216 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0379902 |
| PDE10A | phosphodiesterase 10A | 0.0377553 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0375892 |
| FN1 | fibronectin 1 | 0.037421 |
| HPCAL1 | hippocalcin-like 1 | 0.0373138 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0370448 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0367257 |
| LOXL2 | lysyl oxidase-like 2 | 0.0366101 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0364148 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0360309 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.035991 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0355979 |
| PCBP3 | poly(rC) binding protein 3 | 0.0352661 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0350868 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0348177 |
| STK24 | serine/threonine kinase 24 | 0.0343389 |
| MYOF | myoferlin | 0.0338343 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0336817 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0331603 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0331512 |
| PNN | pinin, desmosome associated protein | 0.0327978 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0327949 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0327089 |
| KIF5B | kinesin family member 5B | 0.0318438 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0316425 |
| USP34 | ubiquitin specific peptidase 34 | 0.0316087 |
| MAP4 | microtubule-associated protein 4 | 0.0315415 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0312675 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0311138 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0310795 |
| NCKAP1 | NCK-associated protein 1 | 0.0310328 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0309107 |
| WDR43 | WD repeat domain 43 | 0.0306487 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0305344 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 0.0304729 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0304024 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0303479 |
| RPS24 | ribosomal protein S24 | 0.0300848 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0295538 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.029327 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.0293129 |
| COPA | coatomer protein complex, subunit alpha | 0.0290171 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0288959 |
| RPL13A | ribosomal protein L13a | 0.0285108 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0284924 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0283305 |
| NEMF | nuclear export mediator factor | 0.0282416 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0282064 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0280537 |
| RND3 | Rho family GTPase 3 | 0.0279468 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0278445 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.02759 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0274855 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0273536 |
| TANK | TRAF family member-associated NFKB activator | 0.0272385 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.191493 |
| VIM | vimentin | -0.154437 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13588 |
| TMSB10 | thymosin beta 10 | -0.10818 |
| PTMA | prothymosin, alpha | -0.0972234 |
| RPS6 | ribosomal protein S6 | -0.086011 |
| NDRG1 | N-myc downstream regulated 1 | -0.0830458 |
| RPL23 | ribosomal protein L23 | -0.0723451 |
| ACTG1 | actin gamma 1 | -0.0721806 |
| MYO1E | myosin IE | -0.0690857 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0673054 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0665739 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0638915 |
| PKM | pyruvate kinase, muscle | -0.0630153 |
| RPS19 | ribosomal protein S19 | -0.0615206 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0604675 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0601217 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0587581 |
| PTK2 | protein tyrosine kinase 2 | -0.0586905 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0576508 |
| POTEF | POTE ankyrin domain family, member F | -0.0575943 |
| HELZ | helicase with zinc finger | -0.0572715 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0561638 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.055591 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0552514 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0537486 |
| CALD1 | caldesmon 1 | -0.0535668 |
| CD109 | CD109 molecule | -0.0527676 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0519594 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0512282 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.05012 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0497007 |
| B2M | beta-2-microglobulin | -0.047761 |
| RPL35A | ribosomal protein L35a | -0.0472109 |
| GPC6 | glypican 6 | -0.0471216 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0462639 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0459464 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0455852 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.045417 |
| CALU | calumenin | -0.0452999 |
| AHNAK | AHNAK nucleoprotein | -0.0446123 |
| PHF21A | PHD finger protein 21A | -0.0443089 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.044223 |
| CCNI | cyclin I | -0.0441262 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0430212 |
| GOLGA4 | golgin A4 | -0.0425759 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0424248 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0423797 |
| S100A10 | S100 calcium binding protein A10 | -0.0422825 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0414454 |
| RRBP1 | ribosome binding protein 1 | -0.0413781 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0411751 |
| SRPK2 | SRSF protein kinase 2 | -0.041133 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0405938 |
| CEP350 | centrosomal protein 350kDa | -0.0402498 |
| TXNIP | thioredoxin interacting protein | -0.0402397 |
| HBP1 | HMG-box transcription factor 1 | -0.0401208 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0398652 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.03985 |
| SPAG9 | sperm associated antigen 9 | -0.0393586 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0393108 |
| S100A6 | S100 calcium binding protein A6 | -0.0392666 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0391913 |
| HLA-B | major histocompatibility complex, class I, B | -0.0385426 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0380643 |
| PCBP2 | poly(rC) binding protein 2 | -0.0380156 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0374341 |
| ATXN1 | ataxin 1 | -0.0373773 |
| TSC22D2 | TSC22 domain family, member 2 | -0.037373 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0372907 |
| YBX3 | Y box binding protein 3 | -0.0371851 |
| YAP1 | Yes-associated protein 1 | -0.0371516 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0367893 |
| FAM162A | family with sequence similarity 162, member A | -0.0362599 |
| RPL12 | ribosomal protein L12 | -0.0362104 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.036176 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0360735 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0359278 |
| RYBP | RING1 and YY1 binding protein | -0.0358341 |
| PTGES2 | prostaglandin E synthase 2 | -0.0356152 |
| PRRC2C | proline-rich coiled-coil 2C | -0.035565 |
| RPS15 | ribosomal protein S15 | -0.0354055 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0351883 |
| XPO1 | exportin 1 | -0.0346297 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.034577 |
| CD44 | CD44 molecule (Indian blood group) | -0.0342996 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0342894 |
| RPLP2 | ribosomal protein, large, P2 | -0.0342769 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0342627 |
| ATP11B | ATPase, class VI, type 11B | -0.0342024 |
| RPL37 | ribosomal protein L37 | -0.034115 |
| PHIP | pleckstrin homology domain interacting protein | -0.0339293 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0338565 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0338112 |
| MEF2A | myocyte enhancer factor 2A | -0.0336172 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0332112 |
| FOXO3 | forkhead box O3 | -0.0328993 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0328339 |
| RPL21 | ribosomal protein L21 | -0.0327081 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0326804 |
