| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.189711 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0860478 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0764787 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0741592 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0698626 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0688943 |
| RPS3 | ribosomal protein S3 | 0.0618124 |
| HSPA8 | heat shock 70kDa protein 8 | 0.057399 |
| YBX3 | Y box binding protein 3 | 0.0517835 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0488507 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.047683 |
| TPM3 | tropomyosin 3 | 0.0441612 |
| BRD2 | bromodomain containing 2 | 0.0439515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0407989 |
| YBX1 | Y box binding protein 1 | 0.039865 |
| PCBP2 | poly(rC) binding protein 2 | 0.0391114 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0371566 |
| UBC | ubiquitin C | 0.0368419 |
| TPI1 | triosephosphate isomerase 1 | 0.0347863 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0347358 |
| RTN4 | reticulon 4 | 0.0344145 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0342565 |
| RPS12 | ribosomal protein S12 | 0.0340335 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0335382 |
| MSN | moesin | 0.0321355 |
| OGA | O-GlcNAcase | 0.0316821 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0316205 |
| TXNRD1 | thioredoxin reductase 1 | 0.0316129 |
| RPS6 | ribosomal protein S6 | 0.0310851 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.031036 |
| PNN | pinin, desmosome associated protein | 0.0307548 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0302082 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0300192 |
| RPS8 | ribosomal protein S8 | 0.0297419 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0282692 |
| RPS2 | ribosomal protein S2 | 0.0281576 |
| TAPBP | TAP binding protein (tapasin) | 0.0278559 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0270606 |
| RPL37 | ribosomal protein L37 | 0.0264514 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0252984 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0244559 |
| SET | SET nuclear proto-oncogene | 0.0244356 |
| KIF5B | kinesin family member 5B | 0.0240718 |
| RPL37A | ribosomal protein L37a | 0.0239626 |
| RACK1 | receptor for activated C kinase 1 | 0.0237938 |
| RPL26 | ribosomal protein L26 | 0.0235964 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.023388 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0228294 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0227795 |
| TLN1 | talin 1 | 0.022542 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0225145 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0223771 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.0223313 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0219934 |
| IPO7 | importin 7 | 0.0219748 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0219042 |
| RPS27 | ribosomal protein S27 | 0.0217544 |
| MKI67 | marker of proliferation Ki-67 | 0.0217404 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0216497 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0215823 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0215272 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0214663 |
| LDHB | lactate dehydrogenase B | 0.0212948 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0212091 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0208793 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.020336 |
| RPL12 | ribosomal protein L12 | 0.0200445 |
| RPS17 | ribosomal protein S17 | 0.0199217 |
| RPS19 | ribosomal protein S19 | 0.0199145 |
| RECQL | RecQ helicase-like | 0.0197632 |
| SPAG9 | sperm associated antigen 9 | 0.0197102 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0197062 |
| H1-0 | H1.0 linker histone | 0.0196001 |
| ARRDC3 | arrestin domain containing 3 | 0.0194438 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0192757 |
| PHIP | pleckstrin homology domain interacting protein | 0.0192596 |
| PER1 | period circadian clock 1 | 0.0191319 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0189845 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0189547 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0188002 |
| RPS4X | ribosomal protein S4, X-linked | 0.0186291 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0186056 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0183451 |
| VMP1 | vacuole membrane protein 1 | 0.0181964 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.018193 |
| EZR | ezrin | 0.0181323 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0181243 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0180786 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0180625 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0180503 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0180444 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0179518 |
| CORO1C | coronin, actin binding protein, 1C | 0.0179052 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0177742 |
| NCKAP1 | NCK-associated protein 1 | 0.0175794 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.01749 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0174886 |
| PTMA | prothymosin, alpha | 0.0173957 |
| GOLGA4 | golgin A4 | 0.0173305 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0172618 |
| Symbol | Name | Standardized Value |
|---|---|---|
| THSD4 | thrombospondin, type I, domain containing 4 | -0.128085 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.118207 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.10683 |
| RAD51B | RAD51 paralog B | -0.106115 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0994963 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0871675 |
| HMGA2 | high mobility group AT-hook 2 | -0.0811856 |
| EXOC4 | exocyst complex component 4 | -0.0751699 |
| OSMR | oncostatin M receptor | -0.0736843 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0722289 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0683099 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0668238 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0608435 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0580908 |
| NF1 | neurofibromin 1 | -0.0580242 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0569837 |
| IGF1R | insulin-like growth factor 1 receptor | -0.056742 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0564572 |
| GRAMD1B | GRAM domain containing 1B | -0.0538631 |
| AFF3 | AF4/FMR2 family, member 3 | -0.053653 |
| EGFR | epidermal growth factor receptor | -0.0535441 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0531636 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0522365 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0519223 |
| RNF213 | ring finger protein 213 | -0.0512136 |
| DENND5B | DENN/MADD domain containing 5B | -0.0509708 |
| ATXN1 | ataxin 1 | -0.0499862 |
| USP34 | ubiquitin specific peptidase 34 | -0.049439 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0477502 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0463445 |
| AHNAK | AHNAK nucleoprotein | -0.0462335 |
| CUX1 | cut-like homeobox 1 | -0.0460654 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0444212 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0440277 |
| RYR3 | ryanodine receptor 3 | -0.0440164 |
| PDE10A | phosphodiesterase 10A | -0.0439321 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0438275 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0434966 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0424544 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0424239 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0424058 |
| ATG7 | autophagy related 7 | -0.0419149 |
| SMAD3 | SMAD family member 3 | -0.0411747 |
| EHBP1 | EH domain binding protein 1 | -0.0408873 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.039236 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0388331 |
| VCL | vinculin | -0.038182 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0377085 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0374455 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0370528 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0370443 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0365093 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0359342 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0358874 |
| WWOX | WW domain containing oxidoreductase | -0.0357724 |
| NABP1 | nucleic acid binding protein 1 | -0.0355648 |
| ETV6 | ets variant 6 | -0.0355558 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.035408 |
| VIM | vimentin | -0.0345757 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0337795 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0336069 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0334641 |
| SMYD3 | SET and MYND domain containing 3 | -0.0331398 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.03234 |
| FMNL2 | formin-like 2 | -0.032273 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0322457 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0322363 |
| R3HDM2 | R3H domain containing 2 | -0.0314131 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0313613 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0312312 |
| SSH2 | slingshot protein phosphatase 2 | -0.0311007 |
| PYGL | phosphorylase, glycogen, liver | -0.0303279 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0302152 |
| BPTF | bromodomain PHD finger transcription factor | -0.0297632 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0294102 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0283536 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0282383 |
| PHF14 | PHD finger protein 14 | -0.028174 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0281013 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0280656 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0277779 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0272934 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0272458 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0272125 |
| RSF1 | remodeling and spacing factor 1 | -0.0271316 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0270067 |
| ZNF609 | zinc finger protein 609 | -0.0268299 |
| CDK17 | cyclin-dependent kinase 17 | -0.0268299 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0268048 |
| TPM4 | tropomyosin 4 | -0.0267993 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0262539 |
| PHF20 | PHD finger protein 20 | -0.026089 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0259292 |
| DENND1A | DENN/MADD domain containing 1A | -0.0256332 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0255573 |
| TMSB10 | thymosin beta 10 | -0.0254099 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0253241 |
| SBF2 | SET binding factor 2 | -0.0252892 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0252149 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0252128 |
