| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.296755 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.160111 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.119652 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0948389 |
| UBC | ubiquitin C | 0.0886973 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0654933 |
| ASPH | aspartate beta-hydroxylase | 0.0616863 |
| DST | dystonin | 0.0598577 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0593268 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.058414 |
| MSN | moesin | 0.0551465 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0548919 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0526405 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0505725 |
| GRAMD1B | GRAM domain containing 1B | 0.0485367 |
| TPM3 | tropomyosin 3 | 0.044456 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0425717 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0406882 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0405493 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0394846 |
| SQSTM1 | sequestosome 1 | 0.0393644 |
| VMP1 | vacuole membrane protein 1 | 0.0375655 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0372571 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0358775 |
| NRCAM | neuronal cell adhesion molecule | 0.0354092 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0353521 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0336429 |
| PCBP3 | poly(rC) binding protein 3 | 0.0324437 |
| PCBP2 | poly(rC) binding protein 2 | 0.0320266 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0310874 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0294166 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.028877 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.028052 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0275454 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0255736 |
| UBXN4 | UBX domain protein 4 | 0.0247514 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0245097 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0243635 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0238253 |
| RPS3 | ribosomal protein S3 | 0.0237418 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0233578 |
| SET | SET nuclear proto-oncogene | 0.0228893 |
| NCKAP1 | NCK-associated protein 1 | 0.0225898 |
| KIF21A | kinesin family member 21A | 0.0220203 |
| MCL1 | myeloid cell leukemia 1 | 0.0215294 |
| CCL3 | chemokine (C-C motif) ligand 3 | 0.0214159 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0213261 |
| RPL3 | ribosomal protein L3 | 0.0212665 |
| ZFP36 | ZFP36 ring finger protein | 0.021045 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0206419 |
| ENO1 | enolase 1, (alpha) | 0.0204427 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0199771 |
| RAD51B | RAD51 paralog B | 0.019894 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 0.0197877 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0195784 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0194506 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0191308 |
| MAP1B | microtubule-associated protein 1B | 0.0191069 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0190805 |
| TBXT | T-box transcription factor T | 0.0188376 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0187304 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0187226 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0185406 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0182397 |
| HDGF | hepatoma-derived growth factor | 0.018138 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0180554 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0180416 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0179668 |
| UBQLN1 | ubiquilin 1 | 0.0176517 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0175738 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.0175501 |
| FAM219A | family with sequence similarity 219, member A | 0.0171441 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0165795 |
| CTSL | cathepsin L | 0.0165786 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0164309 |
| PRELID2 | PRELI domain containing 2 | 0.0163445 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0159001 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0157453 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.015488 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0154532 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0153498 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0153468 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0151147 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.01506 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0150547 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0150244 |
| FAT1 | FAT atypical cadherin 1 | 0.0150196 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0150176 |
| CLU | clusterin | 0.0149706 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0148503 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0148008 |
| COL5A2 | collagen, type V, alpha 2 | 0.0147851 |
| FLNB | filamin B, beta | 0.0146574 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.014646 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0145605 |
| TUSC3 | tumor suppressor candidate 3 | 0.014511 |
| RPL14 | ribosomal protein L14 | 0.0144759 |
| ANXA1 | annexin A1 | 0.0144263 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0143587 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0143571 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.26851 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.263733 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.177547 |
| TMSB10 | thymosin beta 10 | -0.126365 |
| RPLP1 | ribosomal protein, large, P1 | -0.103573 |
| VIM | vimentin | -0.0848685 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0814334 |
| RPS24 | ribosomal protein S24 | -0.074315 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0701626 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0672912 |
| PTMA | prothymosin, alpha | -0.0647323 |
| GNAS | GNAS complex locus | -0.0640844 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0623274 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0619519 |
| RPLP0 | ribosomal protein, large, P0 | -0.0597121 |
| S100A6 | S100 calcium binding protein A6 | -0.0558607 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0518412 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.051525 |
| ACTG1 | actin gamma 1 | -0.050881 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0499815 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0491176 |
| EFNA5 | ephrin-A5 | -0.0474226 |
| S100A10 | S100 calcium binding protein A10 | -0.0460043 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0450918 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0439266 |
| FTL | ferritin, light polypeptide | -0.0423758 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0408482 |
| ABLIM1 | actin binding LIM protein 1 | -0.0400834 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0393859 |
| RPS16 | ribosomal protein S16 | -0.0378499 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0370735 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0368994 |
| RPL35A | ribosomal protein L35a | -0.0365081 |
| ARF1 | ADP-ribosylation factor 1 | -0.0363138 |
| RPL36A | ribosomal protein L36a | -0.0354622 |
| RPL19 | ribosomal protein L19 | -0.035057 |
| RPL12 | ribosomal protein L12 | -0.0342626 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0341339 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0339245 |
| RPL23 | ribosomal protein L23 | -0.0338379 |
| RPL7A | ribosomal protein L7a | -0.0338344 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0337347 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0336928 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0329586 |
| HLA-B | major histocompatibility complex, class I, B | -0.0328707 |
| RPS28 | ribosomal protein S28 | -0.0321661 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0314614 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0313172 |
| CDH13 | cadherin 13 | -0.0309905 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0308521 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0308136 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0306724 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0302021 |
| RPL39 | ribosomal protein L39 | -0.0300293 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0300223 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0299121 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0298172 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0296655 |
| CANX | calnexin | -0.0295156 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0292249 |
| RPS19 | ribosomal protein S19 | -0.0283865 |
| GOLGA4 | golgin A4 | -0.0280683 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0279099 |
| RPL38 | ribosomal protein L38 | -0.0278861 |
| RPL31 | ribosomal protein L31 | -0.0277869 |
| LAMA1 | laminin, alpha 1 | -0.0274951 |
| RPL34 | ribosomal protein L34 | -0.0274221 |
| RPS25 | ribosomal protein S25 | -0.0273074 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0269401 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.026926 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0269065 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0268334 |
| WDR43 | WD repeat domain 43 | -0.026619 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0265453 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0265212 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.026492 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.026334 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0263081 |
| WDR45B | WD repeat domain 45B | -0.026278 |
| SMYD3 | SET and MYND domain containing 3 | -0.0255549 |
| RPS14 | ribosomal protein S14 | -0.0255394 |
| RPS23 | ribosomal protein S23 | -0.0252282 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.024923 |
| RPS21 | ribosomal protein S21 | -0.0247271 |
| RPL27A | ribosomal protein L27a | -0.024718 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0247151 |
| FN1 | fibronectin 1 | -0.0245933 |
| RPL8 | ribosomal protein L8 | -0.024488 |
| JMJD1C | jumonji domain containing 1C | -0.0244373 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0243063 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0242364 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0242255 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.0241918 |
| PHF20 | PHD finger protein 20 | -0.0241774 |
| PLCB4 | phospholipase C, beta 4 | -0.0241022 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0239473 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0238124 |
| ASTN2 | astrotactin 2 | -0.0231486 |
| RPL26 | ribosomal protein L26 | -0.0229339 |
| MORF4L2 | mortality factor 4 like 2 | -0.0227487 |
