| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib citrate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.142607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.107006 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0913299 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0836114 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0738934 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0724978 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0603183 |
| DST | dystonin | 0.0496968 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0450517 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0407929 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0395352 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0367266 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0328039 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0326502 |
| H1-0 | H1.0 linker histone | 0.0318256 |
| CFL2 | cofilin 2 (muscle) | 0.0316062 |
| H1-4 | H1.4 linker histone, cluster member | 0.0311271 |
| UBC | ubiquitin C | 0.0293791 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0293345 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0282404 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0270906 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0269798 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.0267464 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0263617 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.026011 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0252815 |
| USP53 | ubiquitin specific peptidase 53 | 0.0251673 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0251132 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0251066 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0247584 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0246926 |
| H1-2 | H1.2 linker histone, cluster member | 0.0237312 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0232306 |
| PLK2 | polo-like kinase 2 | 0.0232148 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0226548 |
| NUMB | numb homolog (Drosophila) | 0.0223683 |
| TCP1 | t-complex 1 | 0.0223251 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0223162 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0221811 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0221454 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0220348 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | 0.0220148 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | 0.021746 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0217405 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0216721 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0215949 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.021223 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0210066 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0209183 |
| EAPP | E2F-associated phosphoprotein | 0.020782 |
| RPL7 | ribosomal protein L7 | 0.0205752 |
| RPL14 | ribosomal protein L14 | 0.020459 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.019891 |
| BRD2 | bromodomain containing 2 | 0.0197583 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0194396 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.019187 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0191141 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0190891 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0190044 |
| ZFP36 | ZFP36 ring finger protein | 0.0186409 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0186293 |
| HYOU1 | hypoxia up-regulated 1 | 0.0180254 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0179707 |
| H1-5 | H1.5 linker histone, cluster member | 0.0177676 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0177516 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0176136 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0172946 |
| ATG12 | autophagy related 12 | 0.0172801 |
| CORO1C | coronin, actin binding protein, 1C | 0.017155 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 0.0169924 |
| RBM4 | RNA binding motif protein 4 | 0.0169044 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0167774 |
| XPO1 | exportin 1 | 0.0167624 |
| MTREX | Mtr4 exosome RNA helicase | 0.0167026 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0166183 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0165788 |
| HDLBP | high density lipoprotein binding protein | 0.0165711 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0165574 |
| GHITM | growth hormone inducible transmembrane protein | 0.0164754 |
| CGAS | cyclic GMP-AMP synthase | 0.0164531 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.016382 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0162343 |
| TMF1 | TATA element modulatory factor 1 | 0.0161954 |
| FKBP5 | FK506 binding protein 5 | 0.0161681 |
| RNGTT | RNA guanylyltransferase and 5'-phosphatase | 0.0159933 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0159712 |
| UBE4B | ubiquitination factor E4B | 0.0159621 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0159146 |
| SSRP1 | structure specific recognition protein 1 | 0.015792 |
| KIAA1958 | KIAA1958 | 0.0157777 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0157066 |
| SLK | STE20-like kinase | 0.0156105 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.015538 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0154289 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0154044 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0152647 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0152354 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.0151924 |
| ZNF507 | zinc finger protein 507 | 0.0151621 |
| UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 | 0.0150148 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | -0.123699 |
| ITGAV | integrin, alpha V | -0.108238 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.105066 |
| COL11A1 | collagen, type XI, alpha 1 | -0.101331 |
| PEG10 | paternally expressed 10 | -0.0998051 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0981922 |
| VIM | vimentin | -0.0974121 |
| TMSB10 | thymosin beta 10 | -0.0925698 |
| HDAC9 | histone deacetylase 9 | -0.0836185 |
| CADM2 | cell adhesion molecule 2 | -0.0822918 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0729042 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0715814 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0673712 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0659938 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0641328 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0638331 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0593279 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0589292 |
| RPLP1 | ribosomal protein, large, P1 | -0.0581748 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0575343 |
| RPS16 | ribosomal protein S16 | -0.0574179 |
| TENM3 | teneurin transmembrane protein 3 | -0.054909 |
| SYT1 | synaptotagmin I | -0.0544778 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.053817 |
| PCDH9 | protocadherin 9 | -0.0537825 |
| MAP4 | microtubule-associated protein 4 | -0.0535408 |
| PFN1 | profilin 1 | -0.0532631 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0531898 |
| USP34 | ubiquitin specific peptidase 34 | -0.0530553 |
| SMYD3 | SET and MYND domain containing 3 | -0.0528232 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0520521 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0520087 |
| SRP54 | signal recognition particle 54kDa | -0.0519827 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0518257 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0512459 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0507568 |
| PDGFC | platelet derived growth factor C | -0.0480889 |
| GPC3 | glypican 3 | -0.0479016 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0477856 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0462537 |
| RPL35A | ribosomal protein L35a | -0.0458319 |
| MEIS2 | Meis homeobox 2 | -0.0454433 |
| FBXO11 | F-box protein 11 | -0.0452698 |
| NTM | neurotrimin | -0.0450098 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0435263 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0431544 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0423688 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0422716 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0420716 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0419787 |
| ZNF292 | zinc finger protein 292 | -0.0412297 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0410855 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0405058 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0399645 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0396167 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0393984 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0393078 |
| POTEF | POTE ankyrin domain family, member F | -0.0392942 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0388703 |
| ACTG1 | actin gamma 1 | -0.0376892 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0374415 |
| ANXA2 | annexin A2 | -0.0367372 |
| NRG1 | neuregulin 1 | -0.0363661 |
| PARD3 | par-3 family cell polarity regulator | -0.0360773 |
| METAP2 | methionyl aminopeptidase 2 | -0.0358424 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0353118 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0353114 |
| PRTG | protogenin | -0.0353113 |
| FAM171B | family with sequence similarity 171, member B | -0.0352799 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0352572 |
| CDH19 | cadherin 19, type 2 | -0.0351069 |
| PRR16 | proline rich 16 | -0.0350174 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0348961 |
| CENPF | centromere protein F, 350/400kDa | -0.0340514 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0339872 |
| ZNF217 | zinc finger protein 217 | -0.0339413 |
| RAD51B | RAD51 paralog B | -0.0337883 |
| URI1 | URI1, prefoldin-like chaperone | -0.0337539 |
| GNAS | GNAS complex locus | -0.0335196 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0332603 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0331076 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0330919 |
| SPAG9 | sperm associated antigen 9 | -0.0330522 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0327785 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0326417 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0323787 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0323067 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0322877 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0318982 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0313154 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0306394 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0304535 |
| MB21D2 | Mab-21 domain containing 2 | -0.0303664 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0299574 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0299218 |
| PHIP | pleckstrin homology domain interacting protein | -0.0298106 |
| BSG | basigin (Ok blood group) | -0.0297015 |
| FOXO1 | forkhead box O1 | -0.0292241 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0288359 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0287478 |
