Ixazomib citrate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib citrate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib citrate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0973597
RPS6 ribosomal protein S6 0.0897434
TPT1 tumor protein, translationally-controlled 1 0.072183
RPS8 ribosomal protein S8 0.0611771
MT2A metallothionein 2A 0.0607954
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0583635
RPS3 ribosomal protein S3 0.0557001
RPS12 ribosomal protein S12 0.0534343
LAMB3 laminin, beta 3 0.0505434
B2M beta-2-microglobulin 0.0470723
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0467391
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0447989
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0438431
RPL35A ribosomal protein L35a 0.0427206
ARRDC3 arrestin domain containing 3 0.0422208
TAPBP TAP binding protein (tapasin) 0.0418899
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0418878
BRD2 bromodomain containing 2 0.0409246
RACK1 receptor for activated C kinase 1 0.040665
RPL12 ribosomal protein L12 0.0405849
FAM3C family with sequence similarity 3, member C 0.0392273
EIF4A2 eukaryotic translation initiation factor 4A2 0.0391285
RPS13 ribosomal protein S13 0.0381944
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0374878
RPL23 ribosomal protein L23 0.0362991
MYH9 myosin, heavy chain 9, non-muscle 0.0360104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0351748
PLAUR plasminogen activator, urokinase receptor 0.0350124
POTEF POTE ankyrin domain family, member F 0.034645
RPS21 ribosomal protein S21 0.0345126
VEGFA vascular endothelial growth factor A 0.0343942
TGM2 transglutaminase 2 0.0342536
RPL11 ribosomal protein L11 0.0321391
IFI27 interferon, alpha-inducible protein 27 0.0320519
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0310746
RPS17 ribosomal protein S17 0.0303558
OPTN optineurin 0.0301799
RPL26 ribosomal protein L26 0.0299053
GOLGA4 golgin A4 0.0296992
APLP2 amyloid beta (A4) precursor-like protein 2 0.0292143
RPL5 ribosomal protein L5 0.0291
RPL37A ribosomal protein L37a 0.0288484
TPM3 tropomyosin 3 0.0286286
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0283613
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0282727
BRD4 bromodomain containing 4 0.0278551
PCBP2 poly(rC) binding protein 2 0.027765
RPS23 ribosomal protein S23 0.0275317
AREG amphiregulin 0.0272893
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0270293
PTMA prothymosin, alpha 0.0269985
RPL37 ribosomal protein L37 0.0269723
EEF1G eukaryotic translation elongation factor 1 gamma 0.0265615
BIRC3 baculoviral IAP repeat containing 3 0.0264634
ZFP36L1 ZFP36 ring finger protein-like 1 0.026248
RPL9 ribosomal protein L9 0.0262318
TNIP1 TNFAIP3 interacting protein 1 0.025841
RPL19 ribosomal protein L19 0.0257361
PNN pinin, desmosome associated protein 0.0251594
RPS19 ribosomal protein S19 0.025024
DIAPH1 diaphanous-related formin 1 0.0249979
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.024708
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0241576
RPS29 ribosomal protein S29 0.0239142
CCNL1 cyclin L1 0.0238964
BHLHE40 basic helix-loop-helix family, member e40 0.0237633
VMP1 vacuole membrane protein 1 0.0236474
SET SET nuclear proto-oncogene 0.0233654
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0233637
FOSL1 FOS-like antigen 1 0.0231259
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0229403
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0225991
KTN1 kinectin 1 (kinesin receptor) 0.0223522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221591
RTN4 reticulon 4 0.0219453
RPL34 ribosomal protein L34 0.0215889
RPLP2 ribosomal protein, large, P2 0.0214349
SRRM2 serine/arginine repetitive matrix 2 0.0211768
TMED9 transmembrane emp24 protein transport domain containing 9 0.0211577
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0210373
KRT19 keratin 19, type I 0.020978
RPS27 ribosomal protein S27 0.0209719
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.020911
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0208304
LOC102724023 ES1 protein homolog, mitochondrial 0.0204448
RBM25 RNA binding motif protein 25 0.0202856
RPS15 ribosomal protein S15 0.0200031
RPL27 ribosomal protein L27 0.0199447
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0198733
RPS14 ribosomal protein S14 0.0197359
SOX9 SRY (sex determining region Y)-box 9 0.0196212
NAP1L1 nucleosome assembly protein 1-like 1 0.0194103
RPS27A ribosomal protein S27a 0.0192093
TMF1 TATA element modulatory factor 1 0.0191764
DUSP5 dual specificity phosphatase 5 0.019033
MYO5B myosin VB 0.0187518
RPLP1 ribosomal protein, large, P1 0.0186897
ANO6 anoctamin 6 0.0186578
UBA6 ubiquitin-like modifier activating enzyme 6 0.0186127
HSPA1A heat shock 70kDa protein 1A 0.0184329

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.162056
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.135659
DLG1 discs, large homolog 1 (Drosophila) -0.11903
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105145
F3 coagulation factor III (thromboplastin, tissue factor) -0.104704
MAML2 mastermind-like 2 (Drosophila) -0.103149
ZBTB20 zinc finger and BTB domain containing 20 -0.102987
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0991573
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0896856
MUC4 mucin 4, cell surface associated -0.0879775
CANX calnexin -0.0835441
FN1 fibronectin 1 -0.082552
MUC16 mucin 16, cell surface associated -0.0758902
AHNAK AHNAK nucleoprotein -0.0742355
ANXA2 annexin A2 -0.0734031
EGFR epidermal growth factor receptor -0.0728766
ASPH aspartate beta-hydroxylase -0.0709632
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0695106
CD2AP CD2-associated protein -0.0653401
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0649561
ZFAND3 zinc finger, AN1-type domain 3 -0.0646974
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0618138
EFNA5 ephrin-A5 -0.061304
TMEM123 transmembrane protein 123 -0.061004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0600128
DPYD dihydropyrimidine dehydrogenase -0.0590332
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.05895
RNF213 ring finger protein 213 -0.0588481
IGFBP3 insulin-like growth factor binding protein 3 -0.0559354
TPM4 tropomyosin 4 -0.0559332
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0559218
RAD51B RAD51 paralog B -0.0546935
PDLIM5 PDZ and LIM domain 5 -0.0545644
SQSTM1 sequestosome 1 -0.0541649
NF1 neurofibromin 1 -0.0539593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0484411
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0484222
MYOF myoferlin -0.0480109
PATJ PATJ crumbs cell polarity complex component -0.0457118
MBNL2 muscleblind-like splicing regulator 2 -0.0452259
WSB1 WD repeat and SOCS box containing 1 -0.0447398
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0434851
CAV1 caveolin 1, caveolae protein, 22kDa -0.0434029
NRP1 neuropilin 1 -0.0431482
MECOM MDS1 and EVI1 complex locus -0.0431001
PARD6B par-6 family cell polarity regulator beta -0.042928
EMP1 epithelial membrane protein 1 -0.0427329
DAPK1 death-associated protein kinase 1 -0.0425651
JMJD1C jumonji domain containing 1C -0.0422083
DSG2 desmoglein 2 -0.0420321
EHBP1 EH domain binding protein 1 -0.0407987
LPP LIM domain containing preferred translocation partner in lipoma -0.0403343
ANLN anillin, actin binding protein -0.039964
ADAM10 ADAM metallopeptidase domain 10 -0.0392079
FNDC3B fibronectin type III domain containing 3B -0.0387756
RUNX1 runt-related transcription factor 1 -0.038733
INTS6 integrator complex subunit 6 -0.0381227
MEF2A myocyte enhancer factor 2A -0.0379683
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.037688
ZNF292 zinc finger protein 292 -0.036972
HMGA1 high mobility group AT-hook 1 -0.0369344
ADGRF1 adhesion G protein-coupled receptor F1 -0.0369258
SORBS2 sorbin and SH3 domain containing 2 -0.0368513
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0368492
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0365411
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0363956
PLSCR1 phospholipid scramblase 1 -0.0362251
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0358352
ADGRG6 adhesion G protein-coupled receptor G6 -0.0355589
FTL ferritin, light polypeptide -0.0353482
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0349961
MX1 MX dynamin-like GTPase 1 -0.0341914
PHF3 PHD finger protein 3 -0.0338377
AFF4 AF4/FMR2 family, member 4 -0.0337664
ERBIN erbb2 interacting protein -0.0335476
SYT14 synaptotagmin XIV -0.0333019
SAMD12 sterile alpha motif domain containing 12 -0.0332545
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0331384
BPTF bromodomain PHD finger transcription factor -0.0329471
DST dystonin -0.0324823
PGK1 phosphoglycerate kinase 1 -0.0324053
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032154
DIAPH3 diaphanous-related formin 3 -0.0321302
GMDS GDP-mannose 4,6-dehydratase -0.0319677
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0318058
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0317279
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0316048
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0315879
ETV6 ets variant 6 -0.0309465
MBD5 methyl-CpG binding domain protein 5 -0.0306073
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.030524
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0304492
FOXO1 forkhead box O1 -0.0302029
ARHGAP5 Rho GTPase activating protein 5 -0.0298775
MBNL1 muscleblind-like splicing regulator 1 -0.0297563
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0296029
TCF12 transcription factor 12 -0.0295665
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0294419
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0294257
KYNU kynureninase -0.0293376