| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib citrate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.181498 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.148251 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0709104 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0601354 |
| HDAC9 | histone deacetylase 9 | 0.0465909 |
| LAMB3 | laminin, beta 3 | 0.0454275 |
| RPS3 | ribosomal protein S3 | 0.0398806 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0384886 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0351687 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0346012 |
| POTEF | POTE ankyrin domain family, member F | 0.0338028 |
| FTL | ferritin, light polypeptide | 0.0334185 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0330295 |
| TTR | transthyretin | 0.0291009 |
| RPS2 | ribosomal protein S2 | 0.0282067 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0281599 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0278082 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0272619 |
| LDHA | lactate dehydrogenase A | 0.0267551 |
| RPS6 | ribosomal protein S6 | 0.0266475 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0265429 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.025706 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0251724 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0251111 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0248199 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.024295 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0242722 |
| RPL3 | ribosomal protein L3 | 0.0231663 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0226502 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0224511 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0222873 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0221465 |
| CAPRIN2 | caprin family member 2 | 0.0219469 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0219227 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0210286 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0210111 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0208258 |
| CALR | calreticulin | 0.020756 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0205446 |
| FRMD4A | FERM domain containing 4A | 0.0203546 |
| RACK1 | receptor for activated C kinase 1 | 0.0199532 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0198435 |
| SET | SET nuclear proto-oncogene | 0.0196035 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.01873 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0187254 |
| TPM3 | tropomyosin 3 | 0.0184945 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0179162 |
| DGKI | diacylglycerol kinase, iota | 0.0178518 |
| UBB | ubiquitin B | 0.0174958 |
| CORO1C | coronin, actin binding protein, 1C | 0.0172603 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0171989 |
| SFTPA2 | surfactant protein A2 | 0.0170369 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0169618 |
| RPL14 | ribosomal protein L14 | 0.0167511 |
| PAPOLA | poly(A) polymerase alpha | 0.0166483 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0163422 |
| DSTN | destrin (actin depolymerizing factor) | 0.0160601 |
| BRD2 | bromodomain containing 2 | 0.0160256 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0159454 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0156151 |
| YTHDC1 | YTH domain containing 1 | 0.0153724 |
| FLNB | filamin B, beta | 0.0151908 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0151888 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0151648 |
| SPAG9 | sperm associated antigen 9 | 0.0151288 |
| RPS12 | ribosomal protein S12 | 0.0151156 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0149612 |
| FKBP15 | FK506 binding protein 15, 133kDa | 0.014849 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0145644 |
| KIF1B | kinesin family member 1B | 0.0145288 |
| TMF1 | TATA element modulatory factor 1 | 0.0143613 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.014277 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0142692 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0140439 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0140198 |
| TOX4 | TOX high mobility group box family member 4 | 0.0138107 |
| CLU | clusterin | 0.0134022 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0133792 |
| CALD1 | caldesmon 1 | 0.0132066 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0129431 |
| CACYBP | calcyclin binding protein | 0.0128867 |
| JUN | jun proto-oncogene | 0.0127508 |
| EFNB2 | ephrin-B2 | 0.0127304 |
| YBX1 | Y box binding protein 1 | 0.0126644 |
| ETNK1 | ethanolamine kinase 1 | 0.0126575 |
| UBC | ubiquitin C | 0.0125471 |
| RIOK3 | RIO kinase 3 | 0.0125363 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0124341 |
| CRY1 | cryptochrome circadian clock 1 | 0.0124122 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0123533 |
| OPTN | optineurin | 0.0123299 |
| NRDC | nardilysin convertase | 0.0120801 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0119618 |
| ZNF654 | zinc finger protein 654 | 0.0117971 |
| ACTG1 | actin gamma 1 | 0.0117911 |
| CD68 | CD68 molecule | 0.0116771 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0116125 |
| DAPK3 | death-associated protein kinase 3 | 0.0115873 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.011566 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0115031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0585073 |
| PARD3 | par-3 family cell polarity regulator | -0.0431682 |
| RPLP1 | ribosomal protein, large, P1 | -0.0423186 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0407976 |
| RPS24 | ribosomal protein S24 | -0.0401577 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0399283 |
| PTMA | prothymosin, alpha | -0.0382173 |
| PTK2 | protein tyrosine kinase 2 | -0.037205 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0369435 |
| TMSB10 | thymosin beta 10 | -0.0357009 |
| DIAPH3 | diaphanous-related formin 3 | -0.0350193 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0348837 |
| RBM25 | RNA binding motif protein 25 | -0.0339491 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.032904 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0316337 |
| TCF12 | transcription factor 12 | -0.0314719 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0310547 |
| HMGA1 | high mobility group AT-hook 1 | -0.0287027 |
| MTAP | methylthioadenosine phosphorylase | -0.0278381 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0277444 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0272895 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0259461 |
| RPLP0 | ribosomal protein, large, P0 | -0.0258192 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0255658 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0255565 |
| TXNRD1 | thioredoxin reductase 1 | -0.0246473 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0244978 |
| HMGA2 | high mobility group AT-hook 2 | -0.0244788 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0236486 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0235825 |
| RPLP2 | ribosomal protein, large, P2 | -0.0234573 |
| NF1 | neurofibromin 1 | -0.0231262 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0229791 |
| RPL35A | ribosomal protein L35a | -0.0226869 |
| RPS25 | ribosomal protein S25 | -0.0225873 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0217197 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0213716 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0213631 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0211363 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0208802 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0208599 |
| RPL23 | ribosomal protein L23 | -0.020794 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0207654 |
| ZNF438 | zinc finger protein 438 | -0.0207161 |
| GNAS | GNAS complex locus | -0.0206372 |
| HM13 | histocompatibility (minor) 13 | -0.0206127 |
| NUP214 | nucleoporin 214kDa | -0.0205383 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0204533 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0198756 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0198331 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.01981 |
| PHF14 | PHD finger protein 14 | -0.0197331 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0195395 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0194462 |
| HMGB1 | high mobility group box 1 | -0.0192089 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0190586 |
| RPL38 | ribosomal protein L38 | -0.0188897 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0187583 |
| GTPBP4 | GTP binding protein 4 | -0.0187126 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0186867 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0186237 |
| MAP4 | microtubule-associated protein 4 | -0.0184944 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0184522 |
| KPNB1 | karyopherin (importin) beta 1 | -0.018403 |
| RPL36A | ribosomal protein L36a | -0.0183217 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0183009 |
| GOLM2 | golgi membrane protein 2 | -0.0178601 |
| RPS15 | ribosomal protein S15 | -0.0178107 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0176985 |
| RPS16 | ribosomal protein S16 | -0.0176199 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0173838 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | -0.0172379 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0171066 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.017086 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0170653 |
| GPHN | gephyrin | -0.0170537 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.0170256 |
| RPS13 | ribosomal protein S13 | -0.016941 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0168756 |
| SNX14 | sorting nexin 14 | -0.0168605 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0167682 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0167527 |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | -0.0167161 |
| RPL7A | ribosomal protein L7a | -0.0166004 |
| AHNAK | AHNAK nucleoprotein | -0.0163768 |
| EXOC6B | exocyst complex component 6B | -0.0163188 |
| XPO4 | exportin 4 | -0.0162314 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0160191 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0158581 |
| RBL1 | retinoblastoma-like 1 | -0.0158097 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0157499 |
| FOXP1 | forkhead box P1 | -0.0157094 |
| SETX | senataxin | -0.0155331 |
| RPS20 | ribosomal protein S20 | -0.0155274 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.015505 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0152533 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0151749 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0150759 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0149938 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0149092 |
