| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.37307 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0973956 |
| TENM1 | teneurin transmembrane protein 1 | 0.0865011 |
| PDE10A | phosphodiesterase 10A | 0.0620397 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.058902 |
| CENPF | centromere protein F, 350/400kDa | 0.0546705 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0467246 |
| VGF | VGF nerve growth factor inducible | 0.0418838 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0415351 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.039485 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0358269 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.03272 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0302653 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0302398 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0296463 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0293416 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0290579 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0284266 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0277769 |
| TPM3 | tropomyosin 3 | 0.0269095 |
| HMGB3 | high mobility group box 3 | 0.0266442 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0265846 |
| XPO1 | exportin 1 | 0.0265419 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0260557 |
| RTN4 | reticulon 4 | 0.0252852 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0251509 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0249901 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0249183 |
| MATR3 | matrin 3 | 0.023131 |
| PCBP2 | poly(rC) binding protein 2 | 0.0227824 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.022684 |
| FTL | ferritin, light polypeptide | 0.0223935 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.022045 |
| YBX1 | Y box binding protein 1 | 0.0219478 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0212832 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0211456 |
| TXNRD1 | thioredoxin reductase 1 | 0.0211116 |
| SET | SET nuclear proto-oncogene | 0.0210934 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0210456 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0207207 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0203581 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0203562 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0202947 |
| PCM1 | pericentriolar material 1 | 0.020229 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0198866 |
| ZNF292 | zinc finger protein 292 | 0.0198291 |
| MKI67 | marker of proliferation Ki-67 | 0.0198249 |
| PNN | pinin, desmosome associated protein | 0.0194472 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0194352 |
| MTMR7 | myotubularin related protein 7 | 0.019429 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0193312 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.01931 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0191539 |
| NCKAP1 | NCK-associated protein 1 | 0.019079 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0189748 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0188447 |
| HMGB2 | high mobility group box 2 | 0.0187623 |
| SMAD9 | SMAD family member 9 | 0.0185648 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0184756 |
| AOPEP | aminopeptidase O (putative) | 0.0184428 |
| HLTF | helicase-like transcription factor | 0.0184175 |
| RBM25 | RNA binding motif protein 25 | 0.018357 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0181094 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.018027 |
| FAT1 | FAT atypical cadherin 1 | 0.0179244 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0178482 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0177956 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0176571 |
| UBB | ubiquitin B | 0.0175881 |
| TPX2 | TPX2, microtubule-associated | 0.0175633 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0174965 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.017385 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.017364 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0170275 |
| H1-0 | H1.0 linker histone | 0.0169823 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0167172 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0166614 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0165246 |
| USP3 | ubiquitin specific peptidase 3 | 0.0164479 |
| ECT2 | epithelial cell transforming 2 | 0.0163225 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0163176 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.0162922 |
| PBK | PDZ binding kinase | 0.0162904 |
| SIN3A | SIN3 transcription regulator family member A | 0.016095 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0160773 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0160726 |
| EP400 | E1A binding protein p400 | 0.0160661 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0160486 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0158608 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0157966 |
| KIF1B | kinesin family member 1B | 0.0155935 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0155295 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0154672 |
| RDX | radixin | 0.0154455 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.0154418 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0154266 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0153757 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0152879 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0152116 |
| ZFR | zinc finger RNA binding protein | 0.0150322 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | -0.164506 |
| NRG1 | neuregulin 1 | -0.116605 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.10255 |
| RORA | RAR-related orphan receptor A | -0.0906532 |
| MCL1 | myeloid cell leukemia 1 | -0.0813762 |
| SNTG1 | syntrophin, gamma 1 | -0.0792752 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.078182 |
| NDRG1 | N-myc downstream regulated 1 | -0.077098 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0706141 |
| ESRRG | estrogen-related receptor gamma | -0.070594 |
| ACTG1 | actin gamma 1 | -0.0614713 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0573461 |
| KIF26B | kinesin family member 26B | -0.0562987 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0548131 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0510006 |
| CNKSR3 | CNKSR family member 3 | -0.0506261 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0503587 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0487672 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0482267 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.046408 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0460232 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0456251 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0453144 |
| GPC5 | glypican 5 | -0.0442908 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0442595 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0430935 |
| EFNA5 | ephrin-A5 | -0.0415786 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.039699 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0394672 |
| SMYD3 | SET and MYND domain containing 3 | -0.0394025 |
| LSAMP | limbic system-associated membrane protein | -0.0386452 |
| KLHL29 | kelch-like family member 29 | -0.0381573 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0379932 |
| HOMER1 | homer scaffolding protein 1 | -0.0368867 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0368783 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0364524 |
| RPL37A | ribosomal protein L37a | -0.0363239 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0356478 |
| NCKAP5 | NCK-associated protein 5 | -0.0348875 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.034182 |
| RNF213 | ring finger protein 213 | -0.0338843 |
| HM13 | histocompatibility (minor) 13 | -0.0332904 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0330231 |
| CDK13 | cyclin-dependent kinase 13 | -0.0330093 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0325577 |
| MYT1L | myelin transcription factor 1-like | -0.0324251 |
| PTCHD4 | patched domain containing 4 | -0.0315087 |
| SP100 | SP100 nuclear antigen | -0.0314989 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0311253 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0310508 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0308206 |
| SCFD1 | sec1 family domain containing 1 | -0.0307969 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0304538 |
| RPS25 | ribosomal protein S25 | -0.0302899 |
| NELL1 | NEL-like 1 (chicken) | -0.0294758 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0294547 |
| IGF2 | insulin-like growth factor 2 | -0.0291474 |
| CADM1 | cell adhesion molecule 1 | -0.0286734 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.02866 |
| DTNA | dystrobrevin, alpha | -0.0282208 |
| RPL31 | ribosomal protein L31 | -0.028109 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0280449 |
| FGF14 | fibroblast growth factor 14 | -0.0278477 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0275048 |
| EGR1 | early growth response 1 | -0.0273829 |
| SETX | senataxin | -0.0273558 |
| EPHA6 | EPH receptor A6 | -0.0273274 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0271591 |
| STC1 | stanniocalcin 1 | -0.0271445 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0268793 |
| NAV1 | neuron navigator 1 | -0.0262305 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0257636 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0256518 |
| CPE | carboxypeptidase E | -0.0254944 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0254931 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0254742 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0248925 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0248797 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0247342 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0244958 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0243 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0240851 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0238734 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0238557 |
| NF1 | neurofibromin 1 | -0.0236684 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0235761 |
| RPL38 | ribosomal protein L38 | -0.0235141 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.023298 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0232327 |
| RPL30 | ribosomal protein L30 | -0.0229572 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0227563 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0225358 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0224684 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0223495 |
| NAV2 | neuron navigator 2 | -0.0223314 |
| GSE1 | Gse1 coiled-coil protein | -0.0223189 |
| GPATCH8 | G patch domain containing 8 | -0.0221333 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0220439 |
| RPLP1 | ribosomal protein, large, P1 | -0.0220323 |
| ZFHX3 | zinc finger homeobox 3 | -0.0220097 |
