| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.127567 |
| RPS3 | ribosomal protein S3 | 0.0640348 |
| SFTPA2 | surfactant protein A2 | 0.0606582 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0509942 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0509812 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0415689 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0381474 |
| FMNL2 | formin-like 2 | 0.0368893 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.036756 |
| GOLGA4 | golgin A4 | 0.0344225 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0343652 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0338367 |
| PGK1 | phosphoglycerate kinase 1 | 0.0331792 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0323338 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0320983 |
| CANX | calnexin | 0.0319208 |
| KAZN | kazrin, periplakin interacting protein | 0.0313596 |
| MSN | moesin | 0.031045 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0307099 |
| PEX5L | peroxisomal biogenesis factor 5-like | 0.0302689 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.030178 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0294951 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0293761 |
| CTSB | cathepsin B | 0.029198 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0291218 |
| CCDC47 | coiled-coil domain containing 47 | 0.0286696 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0285197 |
| ARRDC3 | arrestin domain containing 3 | 0.0282346 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0279124 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0275417 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0272907 |
| VMP1 | vacuole membrane protein 1 | 0.0267721 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0267658 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0263965 |
| PMM2 | phosphomannomutase 2 | 0.0259884 |
| TPM3 | tropomyosin 3 | 0.0244897 |
| SERINC1 | serine incorporator 1 | 0.0243176 |
| PTMA | prothymosin, alpha | 0.0239238 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0235204 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0232598 |
| ENO1 | enolase 1, (alpha) | 0.0229956 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.02288 |
| ANGPTL4 | angiopoietin-like 4 | 0.0228327 |
| CORO1C | coronin, actin binding protein, 1C | 0.0226688 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0222269 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.022115 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0220278 |
| MT2A | metallothionein 2A | 0.0219845 |
| CTTN | cortactin | 0.0215219 |
| GPR137B | G protein-coupled receptor 137B | 0.0214621 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.0213228 |
| RPL14 | ribosomal protein L14 | 0.0211822 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0210718 |
| NGLY1 | N-glycanase 1 | 0.0209929 |
| NCKAP1 | NCK-associated protein 1 | 0.0209608 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0207257 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0207046 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0205145 |
| EZR | ezrin | 0.0205097 |
| CEP250 | centrosomal protein 250kDa | 0.0202622 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0201498 |
| FLNB | filamin B, beta | 0.0201432 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0200032 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0198831 |
| SET | SET nuclear proto-oncogene | 0.0198578 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0198158 |
| YBX3 | Y box binding protein 3 | 0.0196821 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0196106 |
| AFDN | afadin, adherens junction formation factor | 0.0195987 |
| AHNAK | AHNAK nucleoprotein | 0.0193571 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0193179 |
| CD44 | CD44 molecule (Indian blood group) | 0.0191885 |
| GOLGB1 | golgin B1 | 0.019188 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0191822 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0191209 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0187947 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0186796 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0186017 |
| CLINT1 | clathrin interactor 1 | 0.0181785 |
| MT1X | metallothionein 1X | 0.0181759 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.018149 |
| VCL | vinculin | 0.018109 |
| CALD1 | caldesmon 1 | 0.0179049 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0177917 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 0.0177603 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0175989 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0175385 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0174543 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0173786 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.0173437 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0171563 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.017062 |
| PCBP3 | poly(rC) binding protein 3 | 0.0170358 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.016939 |
| CLTC | clathrin, heavy chain (Hc) | 0.0167827 |
| ACO2 | aconitase 2, mitochondrial | 0.016775 |
| RTN4 | reticulon 4 | 0.0167443 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0166909 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0166402 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0165511 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.236199 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.209958 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.171519 |
| NLGN1 | neuroligin 1 | -0.135664 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0847508 |
| VIM | vimentin | -0.0744335 |
| NRG3 | neuregulin 3 | -0.0724683 |
| FMN1 | formin 1 | -0.0715442 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0651655 |
| CCND1 | cyclin D1 | -0.0545128 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0542863 |
| LSAMP | limbic system-associated membrane protein | -0.05175 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0483658 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.047709 |
| FTL | ferritin, light polypeptide | -0.0457661 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.045375 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0453318 |
| PKM | pyruvate kinase, muscle | -0.044634 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0446259 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0418746 |
| FRMD5 | FERM domain containing 5 | -0.041135 |
| RAD51B | RAD51 paralog B | -0.0396917 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0395797 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0369112 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0365167 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.034274 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0340726 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0339684 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0339652 |
| HMGA1 | high mobility group AT-hook 1 | -0.0327924 |
| MACROD2 | MACRO domain containing 2 | -0.0310996 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0306255 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0304298 |
| RUNX1 | runt-related transcription factor 1 | -0.0301551 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0282633 |
| CDH13 | cadherin 13 | -0.0280166 |
| FRMD4A | FERM domain containing 4A | -0.0277431 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0273755 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0272523 |
| FHIT | fragile histidine triad | -0.0269998 |
| RNF213 | ring finger protein 213 | -0.0258513 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0255808 |
| HSPA1B | heat shock 70kDa protein 1B | -0.0252991 |
| CADM1 | cell adhesion molecule 1 | -0.0251454 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0248463 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0248039 |
| CDK6 | cyclin-dependent kinase 6 | -0.0246985 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0246266 |
| EHBP1 | EH domain binding protein 1 | -0.024531 |
| UBC | ubiquitin C | -0.0240669 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0234792 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.023462 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0234495 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.0234387 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0233317 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0233007 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0228745 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0227679 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0225977 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0225625 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0225292 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0225206 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0218286 |
| BPTF | bromodomain PHD finger transcription factor | -0.0216758 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0216455 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0216038 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0207682 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0206453 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0205791 |
| CRYAB | crystallin, alpha B | -0.0203979 |
| ERBIN | erbb2 interacting protein | -0.0201911 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0201824 |
| CCDC91 | coiled-coil domain containing 91 | -0.0201453 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0200402 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0199224 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0198373 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0196841 |
| CLEC2D | C-type lectin domain family 2, member D | -0.0194078 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0188536 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0187068 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0182052 |
| NRXN3 | neurexin 3 | -0.018122 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0180149 |
| LDLRAD3 | low density lipoprotein receptor class A domain containing 3 | -0.0179906 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0177353 |
| AUTS2 | autism susceptibility candidate 2 | -0.0176899 |
| NF1 | neurofibromin 1 | -0.0175962 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0175869 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0175713 |
| RPLP1 | ribosomal protein, large, P1 | -0.0174223 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | -0.0173754 |
| SOX10 | SRY (sex determining region Y)-box 10 | -0.0172327 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.017145 |
| COMMD10 | COMM domain containing 10 | -0.0169539 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0169468 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0169206 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0169104 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0168398 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0168076 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0164584 |
