| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib citrate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib citrate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.403273 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103546 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0941494 |
| FTL | ferritin, light polypeptide | 0.0803585 |
| UBC | ubiquitin C | 0.0724897 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0611591 |
| ASPH | aspartate beta-hydroxylase | 0.0586624 |
| DST | dystonin | 0.049602 |
| SQSTM1 | sequestosome 1 | 0.042589 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0424754 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0424404 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0405174 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0401065 |
| MMP1 | matrix metallopeptidase 1 | 0.0359244 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0356565 |
| INHBA | inhibin, beta A | 0.0342317 |
| MSN | moesin | 0.0321084 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0307692 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0284742 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0281821 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0256941 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0252647 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0245867 |
| GLIS3 | GLIS family zinc finger 3 | 0.0240621 |
| MAP1B | microtubule-associated protein 1B | 0.0236404 |
| ANXA1 | annexin A1 | 0.0232649 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0230441 |
| RPS6 | ribosomal protein S6 | 0.022813 |
| TAPBP | TAP binding protein (tapasin) | 0.022622 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0225181 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0220076 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0216786 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0216686 |
| CTSB | cathepsin B | 0.0213464 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0207324 |
| VCP | valosin containing protein | 0.0204247 |
| RPS3 | ribosomal protein S3 | 0.0203641 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.020134 |
| TPM3 | tropomyosin 3 | 0.0200492 |
| KIF1B | kinesin family member 1B | 0.019795 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0194954 |
| HSPB1 | heat shock 27kDa protein 1 | 0.019432 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0192397 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0180711 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0180321 |
| SFTPA2 | surfactant protein A2 | 0.0178572 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0177915 |
| NAV1 | neuron navigator 1 | 0.0177251 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0174532 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | 0.0174181 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0172022 |
| RPL14 | ribosomal protein L14 | 0.0171809 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0171313 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0170556 |
| VMP1 | vacuole membrane protein 1 | 0.0169763 |
| SRGN | serglycin | 0.0169447 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.016702 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0166113 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0164806 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0161459 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.016123 |
| FAM219A | family with sequence similarity 219, member A | 0.0161081 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0160721 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0156945 |
| CLTC | clathrin, heavy chain (Hc) | 0.015621 |
| KIF5B | kinesin family member 5B | 0.015533 |
| BAG3 | BCL2-associated athanogene 3 | 0.015521 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0154782 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0152134 |
| NMT1 | N-myristoyltransferase 1 | 0.0151608 |
| NCKAP1 | NCK-associated protein 1 | 0.0149717 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0149693 |
| UBQLN1 | ubiquilin 1 | 0.014962 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.014943 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0149301 |
| SNX29 | sorting nexin 29 | 0.014736 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0147048 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0146799 |
| SOD1 | superoxide dismutase 1, soluble | 0.0144485 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0144113 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0139833 |
| UBXN4 | UBX domain protein 4 | 0.0139389 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0138969 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.013544 |
| FBN1 | fibrillin 1 | 0.0135418 |
| SERINC1 | serine incorporator 1 | 0.0133282 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0131985 |
| RAI14 | retinoic acid induced 14 | 0.0131197 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0130881 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0129859 |
| TXNRD1 | thioredoxin reductase 1 | 0.0127929 |
| UBB | ubiquitin B | 0.0126518 |
| TMF1 | TATA element modulatory factor 1 | 0.0126352 |
| NAV3 | neuron navigator 3 | 0.0125913 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0125695 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0124368 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.012215 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.012082 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0118683 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0118548 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.308518 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.243519 |
| STC1 | stanniocalcin 1 | -0.167151 |
| NDRG1 | N-myc downstream regulated 1 | -0.109478 |
| TMSB10 | thymosin beta 10 | -0.106895 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.105274 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0993468 |
| FN1 | fibronectin 1 | -0.089859 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0757401 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0724268 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0676173 |
| ADM | adrenomedullin | -0.0599512 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0574849 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0524236 |
| RPLP1 | ribosomal protein, large, P1 | -0.0488143 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0481385 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0467656 |
| GOLGA4 | golgin A4 | -0.0463761 |
| PKM | pyruvate kinase, muscle | -0.0456387 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0423506 |
| LOC112694756 | uncharaterized LOC112694756 | -0.040962 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0392858 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0385899 |
| SPAG9 | sperm associated antigen 9 | -0.0381505 |
| RUNX1 | runt-related transcription factor 1 | -0.0359409 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0355195 |
| USP3 | ubiquitin specific peptidase 3 | -0.0352492 |
| LOX | lysyl oxidase | -0.03424 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0338336 |
| FAM13A | family with sequence similarity 13, member A | -0.0332359 |
| ZNF292 | zinc finger protein 292 | -0.0325573 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0319066 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0310159 |
| IER3 | immediate early response 3 | -0.0303473 |
| ATP13A3 | ATPase type 13A3 | -0.0300223 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.029909 |
| LDHA | lactate dehydrogenase A | -0.0292877 |
| HLA-A | major histocompatibility complex, class I, A | -0.0285136 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0285009 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0280505 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0278322 |
| CALU | calumenin | -0.0277404 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0276942 |
| SETD5 | SET domain containing 5 | -0.0269803 |
| SEC24D | SEC24 family member D | -0.0268642 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.026843 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0268409 |
| NUP58 | nucleoporin 58 | -0.0265911 |
| MT2A | metallothionein 2A | -0.0265022 |
| RNF145 | ring finger protein 145 | -0.0262963 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0262222 |
| CD44 | CD44 molecule (Indian blood group) | -0.025893 |
| OGA | O-GlcNAcase | -0.0257998 |
| HMGA1 | high mobility group AT-hook 1 | -0.0257032 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0256371 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0256324 |
| LMNA | lamin A/C | -0.0252155 |
| S100A6 | S100 calcium binding protein A6 | -0.0251282 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0250912 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0249852 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0247816 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246237 |
| RPL28 | ribosomal protein L28 | -0.0245006 |
| PFN1 | profilin 1 | -0.0240548 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0236489 |
| PER1 | period circadian clock 1 | -0.0235446 |
| GNAS | GNAS complex locus | -0.0233845 |
| RLF | rearranged L-myc fusion | -0.0233427 |
| HELZ | helicase with zinc finger | -0.0225433 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0224543 |
| ACTG1 | actin gamma 1 | -0.0219252 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0219031 |
| COPA | coatomer protein complex, subunit alpha | -0.0218224 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.021648 |
| CDC27 | cell division cycle 27 | -0.0216359 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0214659 |
| ANXA5 | annexin A5 | -0.021462 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0213366 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0212872 |
| CCND1 | cyclin D1 | -0.0212674 |
| COL6A3 | collagen, type VI, alpha 3 | -0.021127 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0208273 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0206504 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0204042 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0203798 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0203676 |
| RYBP | RING1 and YY1 binding protein | -0.0201141 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0200304 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0199686 |
| CSNK1E | casein kinase 1, epsilon | -0.0195508 |
| FAM162A | family with sequence similarity 162, member A | -0.0194227 |
| INSIG1 | insulin induced gene 1 | -0.0191534 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0190853 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0187457 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0186794 |
| ANXA2 | annexin A2 | -0.018638 |
| RRBP1 | ribosome binding protein 1 | -0.0185787 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0185078 |
| PTEN | phosphatase and tensin homolog | -0.0183078 |
| TXNIP | thioredoxin interacting protein | -0.0182975 |
