| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0896518 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0810115 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.058899 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0579638 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0482142 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0416352 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0411805 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400799 |
| TPM3 | tropomyosin 3 | 0.0382366 |
| FLNA | filamin A, alpha | 0.0360423 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0348336 |
| LOXL2 | lysyl oxidase-like 2 | 0.0333674 |
| NAV2 | neuron navigator 2 | 0.0331957 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0317224 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0312064 |
| RUNX1 | runt-related transcription factor 1 | 0.0306905 |
| HDAC9 | histone deacetylase 9 | 0.030547 |
| LDHA | lactate dehydrogenase A | 0.030237 |
| APP | amyloid beta (A4) precursor protein | 0.02876 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0284143 |
| DST | dystonin | 0.0262188 |
| CDH13 | cadherin 13 | 0.026028 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0256418 |
| FLNB | filamin B, beta | 0.0253193 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.025127 |
| EGFR | epidermal growth factor receptor | 0.0250659 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.024871 |
| MYOF | myoferlin | 0.0237745 |
| SEPTIN9 | septin 9 | 0.0236587 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0235172 |
| PCBP2 | poly(rC) binding protein 2 | 0.0228211 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0225637 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0216595 |
| MSN | moesin | 0.0214028 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0211884 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0211279 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0210112 |
| CANX | calnexin | 0.019882 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0198724 |
| CD109 | CD109 molecule | 0.019683 |
| VEGFA | vascular endothelial growth factor A | 0.0196419 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0194019 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0190865 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0190489 |
| PLEC | plectin | 0.019004 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018525 |
| CENPF | centromere protein F, 350/400kDa | 0.0184579 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0181833 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0181808 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.017926 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0178481 |
| RND3 | Rho family GTPase 3 | 0.0175502 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0173817 |
| SQSTM1 | sequestosome 1 | 0.0169266 |
| HELZ | helicase with zinc finger | 0.0168309 |
| DSPP | dentin sialophosphoprotein | 0.0163965 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0158991 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0156561 |
| ARRDC3 | arrestin domain containing 3 | 0.0155373 |
| FNIP1 | folliculin interacting protein 1 | 0.014827 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0147908 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0147439 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0147401 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0146167 |
| ACTN1 | actinin, alpha 1 | 0.0145212 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0144955 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0144362 |
| ERBIN | erbb2 interacting protein | 0.0142985 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0142288 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0142274 |
| EFNA5 | ephrin-A5 | 0.0140795 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0140589 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0139651 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.013904 |
| CALR | calreticulin | 0.0137945 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0137266 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0136921 |
| FAM107B | family with sequence similarity 107, member B | 0.0136834 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0135909 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0134769 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0134673 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0134471 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0134163 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0134 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0133993 |
| FOSL1 | FOS-like antigen 1 | 0.013387 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0131115 |
| ANO6 | anoctamin 6 | 0.0130999 |
| SUCO | SUN domain containing ossification factor | 0.0130795 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0130167 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0129681 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.012843 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0128265 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0127947 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0127664 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0126803 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0126282 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0125879 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0125157 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.01249 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.200098 |
| VIM | vimentin | -0.173365 |
| MT2A | metallothionein 2A | -0.116579 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111646 |
| PLAT | plasminogen activator, tissue | -0.0973813 |
| HLA-B | major histocompatibility complex, class I, B | -0.079251 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0727224 |
| S100A10 | S100 calcium binding protein A10 | -0.0705917 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0673789 |
| B2M | beta-2-microglobulin | -0.0640335 |
| CSTB | cystatin B (stefin B) | -0.0630727 |
| S100A6 | S100 calcium binding protein A6 | -0.0560179 |
| LMNA | lamin A/C | -0.0543006 |
| PRSS23 | protease, serine, 23 | -0.0495894 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0483205 |
| FN1 | fibronectin 1 | -0.0481205 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0477414 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0444674 |
| COL1A2 | collagen, type I, alpha 2 | -0.0436461 |
| COL3A1 | collagen, type III, alpha 1 | -0.0428517 |
| PTMA | prothymosin, alpha | -0.042515 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0412202 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.041108 |
| SUCNR1 | succinate receptor 1 | -0.04087 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0401334 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.039939 |
| MT1X | metallothionein 1X | -0.0375579 |
| S100A4 | S100 calcium binding protein A4 | -0.0375468 |
| CAVIN1 | caveolae associated protein 1 | -0.0370777 |
| LOX | lysyl oxidase | -0.0365058 |
| MX2 | MX dynamin-like GTPase 2 | -0.0362048 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0355799 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0339674 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0336726 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0336322 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0332656 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.032931 |
| HLA-C | major histocompatibility complex, class I, C | -0.0311621 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0296245 |
| RPL35A | ribosomal protein L35a | -0.0291525 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0290973 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0284727 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0283318 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.027985 |
| RIGI | RNA sensor RIG-I | -0.0272353 |
| FTL | ferritin, light polypeptide | -0.0272322 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.02624 |
| MAP1B | microtubule-associated protein 1B | -0.0253912 |
| SEC61G | Sec61 gamma subunit | -0.0253248 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0252816 |
| S100A11 | S100 calcium binding protein A11 | -0.0251516 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0250775 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0250698 |
| LRRC17 | leucine rich repeat containing 17 | -0.0248571 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0241533 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0237424 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0231761 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0229901 |
| FBN1 | fibrillin 1 | -0.0228979 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0224099 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.02174 |
| RRBP1 | ribosome binding protein 1 | -0.0215585 |
| GNAS | GNAS complex locus | -0.0214305 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0211312 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0207904 |
| H3-3B | H3.3 histone B | -0.0200945 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0200288 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0199127 |
| NPR2 | natriuretic peptide receptor 2 | -0.0197553 |
| ACTG1 | actin gamma 1 | -0.0192633 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0190598 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0190395 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.018991 |
| TAGLN2 | transgelin 2 | -0.0187051 |
| COL1A1 | collagen, type I, alpha 1 | -0.0186122 |
| TUBB | tubulin, beta class I | -0.0185648 |
| RPS24 | ribosomal protein S24 | -0.0185616 |
| S100A9 | S100 calcium binding protein A9 | -0.0180847 |
| CD99 | CD99 molecule | -0.0177223 |
| RPS19 | ribosomal protein S19 | -0.0177118 |
| KRT81 | keratin 81, type II | -0.0173382 |
| CD63 | CD63 molecule | -0.0173026 |
| RPL23 | ribosomal protein L23 | -0.0169818 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0169684 |
| RPL34 | ribosomal protein L34 | -0.0168076 |
| RPLP2 | ribosomal protein, large, P2 | -0.0166952 |
| RPL28 | ribosomal protein L28 | -0.016644 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0165811 |
| RPL36 | ribosomal protein L36 | -0.0165382 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0163654 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0162056 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0161018 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0160575 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0159797 |
| IL7R | interleukin 7 receptor | -0.0156448 |
| CD44 | CD44 molecule (Indian blood group) | -0.0153983 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0153574 |
| FAM162A | family with sequence similarity 162, member A | -0.0153279 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0152389 |
| SERF2 | small EDRK-rich factor 2 | -0.0152307 |
