| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0729796 |
| FTL | ferritin, light polypeptide | 0.0371098 |
| HMGA2 | high mobility group AT-hook 2 | 0.0276772 |
| RPS6 | ribosomal protein S6 | 0.0270927 |
| RPL35A | ribosomal protein L35a | 0.0269307 |
| INTS6 | integrator complex subunit 6 | 0.0219602 |
| AREG | amphiregulin | 0.0205175 |
| EGR1 | early growth response 1 | 0.0195585 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0188007 |
| RPS26 | ribosomal protein S26 | 0.017246 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0164058 |
| RPS19 | ribosomal protein S19 | 0.0148296 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.013518 |
| RPS20 | ribosomal protein S20 | 0.0128463 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0127918 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0126995 |
| HLA-A | major histocompatibility complex, class I, A | 0.012614 |
| UBXN4 | UBX domain protein 4 | 0.0125429 |
| PFN1 | profilin 1 | 0.0117513 |
| CCDC88A | coiled-coil domain containing 88A | 0.0113573 |
| RPS27 | ribosomal protein S27 | 0.0112568 |
| HMGA1 | high mobility group AT-hook 1 | 0.0107616 |
| EPHA6 | EPH receptor A6 | 0.0103857 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.010224 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.00977548 |
| TTLL3 | tubulin tyrosine ligase-like family member 3 | 0.00968579 |
| TEX14 | testis expressed 14 | 0.00939514 |
| GOLGB1 | golgin B1 | 0.00938761 |
| B2M | beta-2-microglobulin | 0.00913243 |
| ATP5MF | ATP synthase membrane subunit f | 0.00912103 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.00905781 |
| WWOX | WW domain containing oxidoreductase | 0.00884538 |
| NDRG1 | N-myc downstream regulated 1 | 0.00882233 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00865602 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00864784 |
| RPL21 | ribosomal protein L21 | 0.00845831 |
| RAB7A | RAB7A, member RAS oncogene family | 0.00841472 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00836434 |
| MEF2D | myocyte enhancer factor 2D | 0.00826321 |
| MT2A | metallothionein 2A | 0.00817555 |
| DVL3 | dishevelled segment polarity protein 3 | 0.00815078 |
| CSMD1 | CUB and Sushi multiple domains 1 | 0.00804219 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.00798956 |
| RPLP0 | ribosomal protein, large, P0 | 0.0078061 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0078014 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.00779934 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.00779777 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00767898 |
| FADS2 | fatty acid desaturase 2 | 0.0076651 |
| MAGEA4 | melanoma antigen family A4 | 0.00766047 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 0.00763048 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.00755687 |
| FOXM1 | forkhead box M1 | 0.00745595 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.00737933 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0073593 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.00735492 |
| RPL9 | ribosomal protein L9 | 0.00730346 |
| ANK2 | ankyrin 2, neuronal | 0.00724018 |
| MBD6 | methyl-CpG binding domain protein 6 | 0.00721942 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | 0.0071847 |
| TGFB1 | transforming growth factor, beta 1 | 0.00710743 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00700877 |
| SMIM44 | small integral membrane protein 44 | 0.00685749 |
| C1S | complement component 1, s subcomponent | 0.00683637 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00682703 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.00681384 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.00680382 |
| NUCB2 | nucleobindin 2 | 0.00677261 |
| RPL13A | ribosomal protein L13a | 0.00677128 |
| MED26 | mediator complex subunit 26 | 0.00670477 |
| RPS4X | ribosomal protein S4, X-linked | 0.0066535 |
| NRXN3 | neurexin 3 | 0.00662306 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.00660493 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00659465 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.00641198 |
| MYO10 | myosin X | 0.0063764 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00633738 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00630885 |
| BAG6 | BCL2-associated athanogene 6 | 0.00624698 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00620896 |
| PSMB6 | proteasome (prosome, macropain) subunit, beta type, 6 | 0.00620699 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.00615249 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00612663 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.00610613 |
| RETREG2 | reticulophagy regulator family member 2 | 0.00607985 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.00606098 |
| HOMER1 | homer scaffolding protein 1 | 0.00604986 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.00604129 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00600004 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.00599728 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.00598378 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.00597349 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.00593304 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.00589767 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00589422 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.00588214 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.00585055 |
| RPSA | ribosomal protein SA | 0.00584705 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.00583851 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.00581832 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.191922 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122854 |
| RPS27A | ribosomal protein S27a | -0.108291 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.10446 |
| MMP12 | matrix metallopeptidase 12 | -0.102651 |
| UBC | ubiquitin C | -0.0966822 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0938687 |
| PTMA | prothymosin, alpha | -0.0775386 |
| AHNAK | AHNAK nucleoprotein | -0.0756926 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0734975 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0706046 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0688713 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0617721 |
| TMSB10 | thymosin beta 10 | -0.0614385 |
| ENO1 | enolase 1, (alpha) | -0.058261 |
| ANXA1 | annexin A1 | -0.0554621 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0530587 |
| NLGN1 | neuroligin 1 | -0.0514358 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0506301 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0493561 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0485292 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0476955 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0461821 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0459474 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.043341 |
| ASPH | aspartate beta-hydroxylase | -0.0415434 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0406111 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.040599 |
| ACTG1 | actin gamma 1 | -0.0404896 |
| RPL23 | ribosomal protein L23 | -0.040249 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0398068 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0396231 |
| DST | dystonin | -0.0395138 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0394918 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0382027 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0380586 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0372073 |
| XPO1 | exportin 1 | -0.0371065 |
| USP34 | ubiquitin specific peptidase 34 | -0.0369697 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0358146 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0355836 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.035366 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0347887 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0347779 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.034491 |
| MED13L | mediator complex subunit 13-like | -0.034395 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0343177 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0337863 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0337344 |
| CLDN1 | claudin 1 | -0.0334943 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332608 |
| PCDH7 | protocadherin 7 | -0.0330246 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0325985 |
| TMEM41B | transmembrane protein 41B | -0.0325493 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0320509 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0314977 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0302733 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0298858 |
| ZNF217 | zinc finger protein 217 | -0.029005 |
| JMJD1C | jumonji domain containing 1C | -0.0287115 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0286292 |
| ZNF804A | zinc finger protein 804A | -0.0285435 |
| RPS3 | ribosomal protein S3 | -0.0280382 |
| ECT2 | epithelial cell transforming 2 | -0.027896 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0275274 |
| RPL26 | ribosomal protein L26 | -0.0274722 |
| VMP1 | vacuole membrane protein 1 | -0.0273619 |
| NF1 | neurofibromin 1 | -0.0271624 |
| YBX1 | Y box binding protein 1 | -0.0267427 |
| ZNF292 | zinc finger protein 292 | -0.0264572 |
| TXNRD1 | thioredoxin reductase 1 | -0.0263558 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0262301 |
| H1-0 | H1.0 linker histone | -0.0261973 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0261953 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.026038 |
| CEP192 | centrosomal protein 192kDa | -0.0260081 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0258837 |
| TMEM123 | transmembrane protein 123 | -0.0258459 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0258205 |
| RHOA | ras homolog family member A | -0.0256852 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0256162 |
| TNPO1 | transportin 1 | -0.0255884 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0255311 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0254277 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0253055 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0247502 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0247375 |
| LMO7 | LIM domain 7 | -0.024367 |
| IL6ST | interleukin 6 signal transducer | -0.0242569 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -0.0240971 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0240871 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0238986 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0238726 |
| NEK7 | NIMA-related kinase 7 | -0.0237827 |
| IPO7 | importin 7 | -0.0236616 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0235242 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0235229 |
| RBM39 | RNA binding motif protein 39 | -0.0234796 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0232107 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.023172 |
