| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | 0.122923 |
| COL6A3 | collagen, type VI, alpha 3 | 0.115215 |
| VEGFA | vascular endothelial growth factor A | 0.111723 |
| FNDC3B | fibronectin type III domain containing 3B | 0.111638 |
| NDRG1 | N-myc downstream regulated 1 | 0.0884379 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0866262 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0856518 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0781288 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0618485 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0618249 |
| CADM1 | cell adhesion molecule 1 | 0.0610146 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0579725 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0578684 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.051995 |
| LOXL2 | lysyl oxidase-like 2 | 0.0509819 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0466286 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0463525 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0445807 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.044 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0420297 |
| PDE10A | phosphodiesterase 10A | 0.0417766 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0397841 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0394028 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0388056 |
| MYO10 | myosin X | 0.0369335 |
| EGFR | epidermal growth factor receptor | 0.0359532 |
| RUNX1 | runt-related transcription factor 1 | 0.0358995 |
| COL5A1 | collagen, type V, alpha 1 | 0.0351282 |
| ASPH | aspartate beta-hydroxylase | 0.0328949 |
| CALR | calreticulin | 0.0323539 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0323498 |
| GOLGB1 | golgin B1 | 0.0313955 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0302544 |
| NAV2 | neuron navigator 2 | 0.0288116 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0285498 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0280475 |
| PTK2 | protein tyrosine kinase 2 | 0.0278599 |
| PLEC | plectin | 0.0275068 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0270104 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0268988 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0251688 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0247723 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0244224 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0241338 |
| NAV1 | neuron navigator 1 | 0.0240805 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0240268 |
| APP | amyloid beta (A4) precursor protein | 0.0239976 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0237585 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0236776 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0234569 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0234534 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0233228 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0230142 |
| RND3 | Rho family GTPase 3 | 0.0225814 |
| FMNL2 | formin-like 2 | 0.0223068 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222747 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0215175 |
| CD44 | CD44 molecule (Indian blood group) | 0.0213928 |
| ARRDC3 | arrestin domain containing 3 | 0.0213539 |
| ATXN1 | ataxin 1 | 0.0211504 |
| TNS1 | tensin 1 | 0.0210325 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0204775 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0203589 |
| EFNA5 | ephrin-A5 | 0.0201062 |
| PGM3 | phosphoglucomutase 3 | 0.020078 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0200609 |
| HYOU1 | hypoxia up-regulated 1 | 0.0200205 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.019945 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0198872 |
| ACTN1 | actinin, alpha 1 | 0.0197807 |
| NOTCH2 | notch 2 | 0.0190533 |
| CCNY | cyclin Y | 0.0189945 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0189117 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0187154 |
| FLNA | filamin A, alpha | 0.0185639 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0185249 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0182105 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0180015 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0178712 |
| HDAC9 | histone deacetylase 9 | 0.0177537 |
| MRTFA | myocardin related transcription factor A | 0.0176877 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0176506 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.0172225 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0171063 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0167063 |
| COPA | coatomer protein complex, subunit alpha | 0.0166841 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0166066 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0165675 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0165469 |
| SIK3 | SIK family kinase 3 | 0.0164542 |
| XPOT | exportin, tRNA | 0.0164035 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0163115 |
| SQSTM1 | sequestosome 1 | 0.016287 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0160201 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0160104 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0160057 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0159556 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0157867 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0157685 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0156827 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.112357 |
| VIM | vimentin | -0.104526 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.100174 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0881095 |
| MT2A | metallothionein 2A | -0.0602762 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0560347 |
| FTL | ferritin, light polypeptide | -0.0464559 |
| TMSB10 | thymosin beta 10 | -0.043335 |
| FN1 | fibronectin 1 | -0.0420932 |
| TPM4 | tropomyosin 4 | -0.0404154 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0358746 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0338275 |
| COL1A2 | collagen, type I, alpha 2 | -0.0327552 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0317318 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0308742 |
| PTMA | prothymosin, alpha | -0.0299791 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0269732 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0259825 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0256848 |
| EGR1 | early growth response 1 | -0.0231398 |
| STC1 | stanniocalcin 1 | -0.022688 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0221987 |
| CAVIN1 | caveolae associated protein 1 | -0.022092 |
| MAP1B | microtubule-associated protein 1B | -0.0215148 |
| ACTG1 | actin gamma 1 | -0.0202146 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.020191 |
| POSTN | periostin, osteoblast specific factor | -0.0193281 |
| MT1X | metallothionein 1X | -0.0186591 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0184942 |
| RPL35A | ribosomal protein L35a | -0.0184924 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.01809 |
| S100A6 | S100 calcium binding protein A6 | -0.0174526 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0169564 |
| HLA-B | major histocompatibility complex, class I, B | -0.016611 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0162057 |
| VCAN | versican | -0.0156811 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.015628 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0155321 |
| LIMA1 | LIM domain and actin binding 1 | -0.0153068 |
| PALLD | palladin, cytoskeletal associated protein | -0.014781 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0146824 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0146134 |
| NREP | neuronal regeneration related protein | -0.0140776 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0139175 |
| RPS19 | ribosomal protein S19 | -0.013787 |
| HMGA2 | high mobility group AT-hook 2 | -0.0137445 |
| ENO1 | enolase 1, (alpha) | -0.0135872 |
| EBF1 | early B-cell factor 1 | -0.0134951 |
| EHD2 | EH-domain containing 2 | -0.0129827 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0128896 |
| PFN1 | profilin 1 | -0.0124912 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.012473 |
| S100A9 | S100 calcium binding protein A9 | -0.0119332 |
| PKM | pyruvate kinase, muscle | -0.0119118 |
| RPL30 | ribosomal protein L30 | -0.0116909 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0116607 |
| ATP13A3 | ATPase type 13A3 | -0.0116025 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0115859 |
| CALD1 | caldesmon 1 | -0.0114882 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0112948 |
| WASF2 | WAS protein family, member 2 | -0.0111792 |
| RPLP2 | ribosomal protein, large, P2 | -0.0111133 |
| CENPE | centromere protein E, 312kDa | -0.0110697 |
| CENPF | centromere protein F, 350/400kDa | -0.010858 |
| RPS5 | ribosomal protein S5 | -0.0108116 |
| RPL11 | ribosomal protein L11 | -0.0107334 |
| LOX | lysyl oxidase | -0.0107117 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0105929 |
| H1-0 | H1.0 linker histone | -0.0105664 |
| RNF220 | ring finger protein 220 | -0.010471 |
| RPS8 | ribosomal protein S8 | -0.0104598 |
| PLAUR | plasminogen activator, urokinase receptor | -0.010278 |
| B2M | beta-2-microglobulin | -0.0102662 |
| TPI1 | triosephosphate isomerase 1 | -0.0102173 |
| DSTN | destrin (actin depolymerizing factor) | -0.0101873 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0101634 |
| RPL19 | ribosomal protein L19 | -0.0101173 |
| FRMD4A | FERM domain containing 4A | -0.00997016 |
| LMNA | lamin A/C | -0.00995095 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00992672 |
| SULF1 | sulfatase 1 | -0.0099243 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00980954 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.00976605 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00953707 |
| THY1 | Thy-1 cell surface antigen | -0.00950211 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00942087 |
| RPL37A | ribosomal protein L37a | -0.00932954 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00925786 |
| PRR11 | proline rich 11 | -0.00924526 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.00919641 |
| INSIG1 | insulin induced gene 1 | -0.00918176 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.00915373 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.00906195 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00905124 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00904956 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.00904191 |
| TUBB | tubulin, beta class I | -0.00897671 |
| CCDC80 | coiled-coil domain containing 80 | -0.0089036 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00883054 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.00875774 |
