Ixazomib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.404924
C3 complement component 3 0.162218
SPTBN1 spectrin, beta, non-erythrocytic 1 0.15036
IGFBP1 insulin-like growth factor binding protein 1 0.149281
EEF2 eukaryotic translation elongation factor 2 0.109745
SVIL supervillin 0.106541
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.100457
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0987559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0871563
TIMP1 TIMP metallopeptidase inhibitor 1 0.0602388
PCBP2 poly(rC) binding protein 2 0.0555852
ENO1 enolase 1, (alpha) 0.0537533
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0524527
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0523914
DDIT4 DNA-damage-inducible transcript 4 0.0503375
ASPH aspartate beta-hydroxylase 0.0455984
RPL3 ribosomal protein L3 0.0430149
PEG3 paternally expressed 3 0.040006
APLP2 amyloid beta (A4) precursor-like protein 2 0.0398072
MT2A metallothionein 2A 0.0385002
VEGFA vascular endothelial growth factor A 0.036745
MYH9 myosin, heavy chain 9, non-muscle 0.0365913
ZNF292 zinc finger protein 292 0.0360099
NFE2L1 nuclear factor, erythroid 2-like 1 0.0355859
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.035463
NDRG1 N-myc downstream regulated 1 0.0341568
FNDC3B fibronectin type III domain containing 3B 0.0337324
KYNU kynureninase 0.0316534
TNS1 tensin 1 0.0312893
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0308658
TPM3 tropomyosin 3 0.030833
CTSB cathepsin B 0.0302433
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0299075
KMT2C lysine (K)-specific methyltransferase 2C 0.0296138
HOOK2 hook microtubule-tethering protein 2 0.0293786
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0290688
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0288148
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0278001
ARFGEF3 ARFGEF family member 3 0.0270875
BHLHE40 basic helix-loop-helix family, member e40 0.0266662
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0266104
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0262494
USP47 ubiquitin specific peptidase 47 0.0261624
TF transferrin 0.02613
HSPA1A heat shock 70kDa protein 1A 0.0246171
DOCK5 dedicator of cytokinesis 5 0.0240506
CCL20 chemokine (C-C motif) ligand 20 0.0235879
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.02328
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.023196
HSPA1B heat shock 70kDa protein 1B 0.0225519
TNIP1 TNFAIP3 interacting protein 1 0.0225177
EIF4B eukaryotic translation initiation factor 4B 0.0221981
EEF1G eukaryotic translation elongation factor 1 gamma 0.0218871
CRLS1 cardiolipin synthase 1 0.0214181
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0213201
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0211703
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0211433
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0211164
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0209325
SPAG9 sperm associated antigen 9 0.0208665
RAD51B RAD51 paralog B 0.0205611
JAG1 jagged 1 0.0205019
ARRDC3 arrestin domain containing 3 0.0204854
CEMIP2 cell migration inducing hyaluronidase 2 0.0203625
GRB10 growth factor receptor-bound protein 10 0.0201798
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0200595
MXI1 MAX interactor 1, dimerization protein 0.0200535
RNASET2 ribonuclease T2 0.0200471
GSE1 Gse1 coiled-coil protein 0.019697
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0196115
UBXN7 UBX domain protein 7 0.019543
DSCAM Down syndrome cell adhesion molecule 0.0193402
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0193186
HIPK3 homeodomain interacting protein kinase 3 0.0192832
RAB6A RAB6A, member RAS oncogene family 0.0190789
FAM13A family with sequence similarity 13, member A 0.0189659
OLA1 Obg-like ATPase 1 0.0188949
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0188251
OSMR oncostatin M receptor 0.0188153
USP6NL USP6 N-terminal like 0.0188085
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0187773
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0187455
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0184967
KIAA1217 KIAA1217 0.0184303
WDFY3 WD repeat and FYVE domain containing 3 0.0182009
SOD2 superoxide dismutase 2, mitochondrial 0.0181569
OPTN optineurin 0.0180622
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0175224
DSG2 desmoglein 2 0.0174996
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0174638
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0173944
B2M beta-2-microglobulin 0.0173747
NPTN neuroplastin 0.0173422
FBXO42 F-box protein 42 0.0171339
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.017111
PIAS2 protein inhibitor of activated STAT, 2 0.0170595
RB1CC1 RB1-inducible coiled-coil 1 0.0170412
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0169632
KDM6A lysine (K)-specific demethylase 6A 0.0169574
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0169104

decreased expression

Symbol Name Standardized Value
FBF1 Fas (TNFRSF6) binding factor 1 -0.14963
SLC38A2 solute carrier family 38, member 2 -0.118268
GPC3 glypican 3 -0.106282
APOA2 apolipoprotein A-II -0.103937
APOB apolipoprotein B -0.103245
VCL vinculin -0.0958138
EHBP1 EH domain binding protein 1 -0.095477
DLC1 DLC1 Rho GTPase activating protein -0.0867914
NKD1 naked cuticle homolog 1 (Drosophila) -0.0866961
ITGAV integrin, alpha V -0.0865901
PTCHD4 patched domain containing 4 -0.0781395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0754947
RERE arginine-glutamic acid dipeptide (RE) repeats -0.065071
TM4SF1 transmembrane 4 L six family member 1 -0.0623539
TRIM26 tripartite motif containing 26 -0.0611281
TPT1 tumor protein, translationally-controlled 1 -0.0594716
BCL2L1 BCL2-like 1 -0.0587706
EGR1 early growth response 1 -0.0586204
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0566273
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0563274
NPAS2 neuronal PAS domain protein 2 -0.0517665
LMCD1 LIM and cysteine-rich domains 1 -0.0495998
RBM39 RNA binding motif protein 39 -0.0450386
PTPRM protein tyrosine phosphatase, receptor type, M -0.044325
ZBTB20 zinc finger and BTB domain containing 20 -0.0441599
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0433473
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0431449
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0431018
RPL11 ribosomal protein L11 -0.0428584
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0410892
PLIN2 perilipin 2 -0.040956
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0390345
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0390185
ZNF644 zinc finger protein 644 -0.0386351
FN1 fibronectin 1 -0.0382333
AMBP alpha-1-microglobulin/bikunin precursor -0.0375003
FTL ferritin, light polypeptide -0.0362942
PTPRK protein tyrosine phosphatase, receptor type, K -0.0360502
LYZ lysozyme -0.0353738
GMDS GDP-mannose 4,6-dehydratase -0.0347061
STAU1 staufen double-stranded RNA binding protein 1 -0.0344146
STK17A serine/threonine kinase 17a -0.0339362
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.033258
PEG10 paternally expressed 10 -0.033211
APOA1 apolipoprotein A-I -0.0320999
GNAS GNAS complex locus -0.0318075
UBASH3B ubiquitin associated and SH3 domain containing B -0.0316707
RRBP1 ribosome binding protein 1 -0.0309205
DNAH17 dynein, axonemal, heavy chain 17 -0.0308714
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0307351
MYO1E myosin IE -0.0303848
A2M alpha-2-macroglobulin -0.0299565
CMIP c-Maf inducing protein -0.029878
RPS27A ribosomal protein S27a -0.029234
DST dystonin -0.0289298
RPL37A ribosomal protein L37a -0.0282348
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0281835
GPC6 glypican 6 -0.0279894
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0279084
FRMD5 FERM domain containing 5 -0.0278341
ABLIM1 actin binding LIM protein 1 -0.0278214
ARL5A ADP-ribosylation factor-like 5A -0.0275479
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.027449
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0270837
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0269697
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0268989
CP ceruloplasmin (ferroxidase) -0.026828
ZFHX3 zinc finger homeobox 3 -0.0265533
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0264659
RPS8 ribosomal protein S8 -0.0264108
SELENOP selenoprotein P -0.0263916
IGF2 insulin-like growth factor 2 -0.0261443
GK glycerol kinase -0.0258656
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0257555
ZHX2 zinc fingers and homeoboxes 2 -0.0255719
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.025464
RPS24 ribosomal protein S24 -0.025235
TNRC6B trinucleotide repeat containing 6B -0.025134
RPL35A ribosomal protein L35a -0.0250078
SYNJ2 synaptojanin 2 -0.0244682
MBNL3 muscleblind-like splicing regulator 3 -0.02427
MAML2 mastermind-like 2 (Drosophila) -0.0240584
VIL1 villin 1 -0.0236951
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0235156
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0232569
PERP PERP, TP53 apoptosis effector -0.0230252
CADM1 cell adhesion molecule 1 -0.0229126
PLAC8 placenta-specific 8 -0.0227275
GCC2 GRIP and coiled-coil domain containing 2 -0.022672
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0226636
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0225551
RPS29 ribosomal protein S29 -0.0225471
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0225211
NCOA7 nuclear receptor coactivator 7 -0.0222958
RPL38 ribosomal protein L38 -0.0221959
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0220291
RPL9 ribosomal protein L9 -0.021893
HDAC4 histone deacetylase 4 -0.0217551
ACOX3 acyl-CoA oxidase 3, pristanoyl -0.0216991
TMEM123 transmembrane protein 123 -0.0216704