| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.126773 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0918499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0705911 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0641038 |
| DSPP | dentin sialophosphoprotein | 0.0482499 |
| RPS12 | ribosomal protein S12 | 0.0458084 |
| PCBP2 | poly(rC) binding protein 2 | 0.0443959 |
| AREG | amphiregulin | 0.0403499 |
| VEGFA | vascular endothelial growth factor A | 0.0396959 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0382883 |
| LDHA | lactate dehydrogenase A | 0.0377904 |
| LMO7 | LIM domain 7 | 0.0375137 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0362283 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0357433 |
| RPL13A | ribosomal protein L13a | 0.0346484 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0345034 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334458 |
| NEBL | nebulette | 0.0319638 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0313224 |
| EREG | epiregulin | 0.0303221 |
| MUC13 | mucin 13, cell surface associated | 0.0300754 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0283312 |
| CANX | calnexin | 0.0262575 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0260933 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0253241 |
| SQSTM1 | sequestosome 1 | 0.0230377 |
| RPS2 | ribosomal protein S2 | 0.023034 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.02295 |
| GOLGB1 | golgin B1 | 0.0227919 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0222479 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0222198 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0221695 |
| CALR | calreticulin | 0.0216763 |
| RPS3 | ribosomal protein S3 | 0.0206285 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0204409 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0198571 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0193 |
| PDZD8 | PDZ domain containing 8 | 0.0192891 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0192673 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0190232 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0190054 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.018442 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0184288 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0182908 |
| RPSA | ribosomal protein SA | 0.0181839 |
| MYO5B | myosin VB | 0.0173689 |
| OGA | O-GlcNAcase | 0.0170386 |
| APP | amyloid beta (A4) precursor protein | 0.0170009 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0167446 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0167144 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0166834 |
| NCOA7 | nuclear receptor coactivator 7 | 0.016452 |
| HDLBP | high density lipoprotein binding protein | 0.015948 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0159433 |
| TRIM2 | tripartite motif containing 2 | 0.0158232 |
| DUSP16 | dual specificity phosphatase 16 | 0.0157342 |
| BRD2 | bromodomain containing 2 | 0.0156457 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0156237 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0153917 |
| MLEC | malectin | 0.015387 |
| RPL3 | ribosomal protein L3 | 0.0153197 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0148294 |
| TSC22D1 | TSC22 domain family, member 1 | 0.014527 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.014498 |
| POF1B | premature ovarian failure, 1B | 0.0144808 |
| HYOU1 | hypoxia up-regulated 1 | 0.0143936 |
| CCDC47 | coiled-coil domain containing 47 | 0.0143493 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0141872 |
| MYO1E | myosin IE | 0.0140921 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0139959 |
| PRELID2 | PRELI domain containing 2 | 0.013878 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.013734 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0137258 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0134874 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0133404 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.013315 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | 0.0132257 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0130924 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0128752 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0127432 |
| INTS6 | integrator complex subunit 6 | 0.0127388 |
| JAK1 | Janus kinase 1 | 0.012612 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0124857 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0121405 |
| B2M | beta-2-microglobulin | 0.0121183 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0120241 |
| SUCO | SUN domain containing ossification factor | 0.0119628 |
| XPOT | exportin, tRNA | 0.0119325 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.011804 |
| TMSB4X | thymosin beta 4, X-linked | 0.011801 |
| GDF15 | growth differentiation factor 15 | 0.01165 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0116321 |
| ATXN1 | ataxin 1 | 0.0116321 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0116242 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.011506 |
| PLK2 | polo-like kinase 2 | 0.0113594 |
| RSRP1 | arginine/serine-rich protein 1 | 0.0112522 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0112005 |
| PHF3 | PHD finger protein 3 | 0.0111308 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.011127 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.237163 |
| TMSB10 | thymosin beta 10 | -0.223628 |
| PTMA | prothymosin, alpha | -0.217998 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.117103 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0905975 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0898709 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0861113 |
| FLNB | filamin B, beta | -0.0816679 |
| S100A6 | S100 calcium binding protein A6 | -0.0800444 |
| RPS6 | ribosomal protein S6 | -0.0669414 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.06501 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0605281 |
| ANTXR2 | anthrax toxin receptor 2 | -0.056085 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0540189 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0524115 |
| ANXA2 | annexin A2 | -0.0516804 |
| ACTG1 | actin gamma 1 | -0.049444 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0491541 |
| KRT8 | keratin 8, type II | -0.04847 |
| TNS4 | tensin 4 | -0.0472136 |
| RNF217 | ring finger protein 217 | -0.0472134 |
| ACTN4 | actinin, alpha 4 | -0.0465558 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0465129 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0462026 |
| ITGA6 | integrin, alpha 6 | -0.0461325 |
| KRT18 | keratin 18, type I | -0.0456665 |
| CALB1 | calbindin 1, 28kDa | -0.0453643 |
| POTEF | POTE ankyrin domain family, member F | -0.0450845 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0442631 |
| FERMT1 | fermitin family member 1 | -0.0416035 |
| ONECUT3 | one cut homeobox 3 | -0.0408455 |
| RPLP2 | ribosomal protein, large, P2 | -0.0405978 |
| TFF1 | trefoil factor 1 | -0.0397141 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0395228 |
| TPM4 | tropomyosin 4 | -0.0385929 |
| HMGA1 | high mobility group AT-hook 1 | -0.0385294 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0384192 |
| S100A10 | S100 calcium binding protein A10 | -0.0369771 |
| GPHN | gephyrin | -0.036858 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0367117 |
| S100A9 | S100 calcium binding protein A9 | -0.0364616 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0362796 |
| RPS19 | ribosomal protein S19 | -0.036274 |
| EHBP1 | EH domain binding protein 1 | -0.0360246 |
| RPS24 | ribosomal protein S24 | -0.0351349 |
| AHNAK | AHNAK nucleoprotein | -0.0350462 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0346158 |
| ITGB4 | integrin, beta 4 | -0.0335914 |
| RPL34 | ribosomal protein L34 | -0.0333712 |
| RPS21 | ribosomal protein S21 | -0.0327363 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0324468 |
| RPL35A | ribosomal protein L35a | -0.0315074 |
| FRMD5 | FERM domain containing 5 | -0.0312912 |
| FOSL1 | FOS-like antigen 1 | -0.0312426 |
| RPS25 | ribosomal protein S25 | -0.0311731 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0311579 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0308923 |
| PFN1 | profilin 1 | -0.0302038 |
| SH3D19 | SH3 domain containing 19 | -0.0299567 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0297419 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0295125 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0292719 |
| KLK10 | kallikrein-related peptidase 10 | -0.0289455 |
| HMGB1 | high mobility group box 1 | -0.0288628 |
| LMNA | lamin A/C | -0.0283039 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0282772 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0281128 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0280458 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0278886 |
| RPL23 | ribosomal protein L23 | -0.0276257 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0275142 |
| RIN2 | Ras and Rab interactor 2 | -0.0268046 |
| EZR | ezrin | -0.0262913 |
| CCND1 | cyclin D1 | -0.0259164 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0258671 |
| H1-0 | H1.0 linker histone | -0.0253186 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0252017 |
| KRT19 | keratin 19, type I | -0.0249156 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0247784 |
| TUBA1B | tubulin, alpha 1b | -0.0246413 |
| MUC17 | mucin 17, cell surface associated | -0.0246001 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0243291 |
| RPL7A | ribosomal protein L7a | -0.0239393 |
| DIAPH2 | diaphanous-related formin 2 | -0.0238709 |
| MSI2 | musashi RNA-binding protein 2 | -0.0238098 |
| NFIA | nuclear factor I/A | -0.0238026 |
| PRSS3 | protease, serine, 3 | -0.0237401 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0237049 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0235801 |
| LSAMP | limbic system-associated membrane protein | -0.0235469 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0235454 |
| SBF2 | SET binding factor 2 | -0.0234008 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0232414 |
| RPL36A | ribosomal protein L36a | -0.0228675 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0227669 |
| CBX3 | chromobox homolog 3 | -0.0220598 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0219336 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0218939 |
| BCL2L1 | BCL2-like 1 | -0.0218903 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0216792 |
