| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.185521 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.163777 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.139442 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.116992 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0790112 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0724966 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0707949 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0685855 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0675256 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0641721 |
| CMIP | c-Maf inducing protein | 0.0624199 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0576546 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0537296 |
| EGFR | epidermal growth factor receptor | 0.0519615 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.051732 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0514213 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0503995 |
| PYGL | phosphorylase, glycogen, liver | 0.0502178 |
| SVIL | supervillin | 0.049662 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0489618 |
| KYNU | kynureninase | 0.0483562 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0482855 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0462436 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.046101 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0409361 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0409036 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0400415 |
| FMNL2 | formin-like 2 | 0.0380434 |
| ATXN1 | ataxin 1 | 0.0376979 |
| GLIS3 | GLIS family zinc finger 3 | 0.0372328 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0366813 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0349681 |
| RPL35A | ribosomal protein L35a | 0.0349632 |
| PARD3 | par-3 family cell polarity regulator | 0.0346679 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0346419 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0344739 |
| USP34 | ubiquitin specific peptidase 34 | 0.0343867 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0327961 |
| RAD51B | RAD51 paralog B | 0.0322518 |
| EHBP1 | EH domain binding protein 1 | 0.0316904 |
| UTRN | utrophin | 0.0315567 |
| NEBL | nebulette | 0.0314566 |
| HLA-B | major histocompatibility complex, class I, B | 0.0313392 |
| NDRG1 | N-myc downstream regulated 1 | 0.0310746 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0305884 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0302012 |
| NF1 | neurofibromin 1 | 0.0299775 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0299049 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0295015 |
| IGF2 | insulin-like growth factor 2 | 0.0293336 |
| MYO1E | myosin IE | 0.0284116 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0281822 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.02756 |
| FLNB | filamin B, beta | 0.0275064 |
| DST | dystonin | 0.0275022 |
| CUX1 | cut-like homeobox 1 | 0.0272934 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0271341 |
| EXOC6B | exocyst complex component 6B | 0.0266551 |
| HLA-A | major histocompatibility complex, class I, A | 0.0266149 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0264375 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0258702 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0257062 |
| PDE10A | phosphodiesterase 10A | 0.0256821 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0256468 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0255435 |
| MYOF | myoferlin | 0.0254287 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0252709 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0251857 |
| IER3 | immediate early response 3 | 0.0247232 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0246782 |
| CYTH1 | cytohesin 1 | 0.0241608 |
| STC1 | stanniocalcin 1 | 0.0238695 |
| SNX14 | sorting nexin 14 | 0.0238419 |
| MT2A | metallothionein 2A | 0.0237023 |
| LDHA | lactate dehydrogenase A | 0.0237006 |
| PATJ | PATJ crumbs cell polarity complex component | 0.023331 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0231314 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0225669 |
| GOLGA4 | golgin A4 | 0.0225452 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0222753 |
| SMAD2 | SMAD family member 2 | 0.0222593 |
| RPLP1 | ribosomal protein, large, P1 | 0.0222476 |
| CAVIN1 | caveolae associated protein 1 | 0.0222462 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0221461 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0220667 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0220625 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0219743 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0218366 |
| ITGB5 | integrin, beta 5 | 0.0213857 |
| FOXP1 | forkhead box P1 | 0.0213582 |
| RNF216 | ring finger protein 216 | 0.0211788 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0211664 |
| LOXL2 | lysyl oxidase-like 2 | 0.0211649 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0210285 |
| ACTN1 | actinin, alpha 1 | 0.0210174 |
| SBF2 | SET binding factor 2 | 0.0208131 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0207832 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0207716 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0205216 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0203122 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.118655 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.107077 |
| RPS27A | ribosomal protein S27a | -0.101418 |
| FGB | fibrinogen beta chain | -0.100172 |
| UBC | ubiquitin C | -0.0872158 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0805587 |
| TXNRD1 | thioredoxin reductase 1 | -0.0804376 |
| GRAMD1B | GRAM domain containing 1B | -0.0746609 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0691081 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0689173 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0682491 |
| RPL23 | ribosomal protein L23 | -0.0629381 |
| PTMA | prothymosin, alpha | -0.0615111 |
| TPM3 | tropomyosin 3 | -0.0575506 |
| POTEF | POTE ankyrin domain family, member F | -0.0539553 |
| ENO1 | enolase 1, (alpha) | -0.0537167 |
| VIM | vimentin | -0.0513466 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.050554 |
| RTN4 | reticulon 4 | -0.0489881 |
| TMSB10 | thymosin beta 10 | -0.046 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0444931 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0438521 |
| YBX1 | Y box binding protein 1 | -0.0428904 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0374242 |
| RPL4 | ribosomal protein L4 | -0.0371727 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0369577 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0345643 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0340007 |
| WDR43 | WD repeat domain 43 | -0.0333048 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.03294 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0322342 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0320297 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0312421 |
| MKI67 | marker of proliferation Ki-67 | -0.0308765 |
| AHNAK | AHNAK nucleoprotein | -0.0305185 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0304613 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0299024 |
| PKM | pyruvate kinase, muscle | -0.0292511 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0289799 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0286737 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0283289 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0282598 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.028226 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0280159 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0276073 |
| ANLN | anillin, actin binding protein | -0.0272373 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0272111 |
| RHOA | ras homolog family member A | -0.0270857 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0260862 |
| RHEB | Ras homolog enriched in brain | -0.0251521 |
| SET | SET nuclear proto-oncogene | -0.024775 |
| ECT2 | epithelial cell transforming 2 | -0.0242559 |
| CALU | calumenin | -0.0241618 |
| FAM168A | family with sequence similarity 168, member A | -0.0241422 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0240853 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.0239161 |
| TPX2 | TPX2, microtubule-associated | -0.0235476 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0234696 |
| TNPO1 | transportin 1 | -0.0231687 |
| HDGF | hepatoma-derived growth factor | -0.0230568 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0228808 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0227833 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0227742 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0226097 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0225471 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0224983 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0224063 |
| USP3 | ubiquitin specific peptidase 3 | -0.0224036 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0223628 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0221619 |
| S100A6 | S100 calcium binding protein A6 | -0.0220084 |
| YBX3 | Y box binding protein 3 | -0.0214474 |
| NUP58 | nucleoporin 58 | -0.0210339 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.020957 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.020919 |
| TUBA1B | tubulin, alpha 1b | -0.0206548 |
| TPD52 | tumor protein D52 | -0.0202627 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0202391 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0201574 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0198404 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0198191 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0194935 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0192286 |
| XPO1 | exportin 1 | -0.0192257 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0189587 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0189066 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0188856 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | -0.018825 |
| LDHB | lactate dehydrogenase B | -0.0187374 |
| FGG | fibrinogen gamma chain | -0.0187121 |
| IPO7 | importin 7 | -0.0186051 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0185931 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0185593 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -0.018519 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0179424 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0178848 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | -0.0178517 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.017501 |
| JUN | jun proto-oncogene | -0.0174871 |
| TAGLN2 | transgelin 2 | -0.0174229 |
