| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.535081 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133001 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.121429 |
| GRAMD1B | GRAM domain containing 1B | 0.109596 |
| MCL1 | myeloid cell leukemia 1 | 0.103896 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0990497 |
| YBX3 | Y box binding protein 3 | 0.0829001 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.081851 |
| TPM3 | tropomyosin 3 | 0.0796775 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0737807 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0634647 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0621453 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0618414 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0585313 |
| FMNL2 | formin-like 2 | 0.0580753 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.057359 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0568031 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0549762 |
| HMGA2 | high mobility group AT-hook 2 | 0.0545395 |
| VCL | vinculin | 0.0542856 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0537594 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0536649 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0530216 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0501671 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0494368 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0474456 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.047356 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0469796 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.046906 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0455202 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0452201 |
| PCBP2 | poly(rC) binding protein 2 | 0.045146 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0444617 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0441984 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0441269 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.044111 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0435899 |
| ACTN1 | actinin, alpha 1 | 0.0432911 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0421193 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0414974 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0408337 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0407992 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0399813 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0395298 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0390356 |
| PYGL | phosphorylase, glycogen, liver | 0.0382503 |
| OSMR | oncostatin M receptor | 0.0378948 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0376337 |
| CANX | calnexin | 0.0376014 |
| RAD51B | RAD51 paralog B | 0.0373164 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0372947 |
| KRT18 | keratin 18, type I | 0.0371877 |
| ADAR | adenosine deaminase, RNA-specific | 0.0371848 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0366214 |
| WWOX | WW domain containing oxidoreductase | 0.0364926 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0360253 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0353399 |
| AHNAK | AHNAK nucleoprotein | 0.0347498 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0345605 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0344552 |
| STC1 | stanniocalcin 1 | 0.0343126 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0341991 |
| DST | dystonin | 0.0334596 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.033324 |
| LOXL2 | lysyl oxidase-like 2 | 0.0328325 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0325045 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324314 |
| VMP1 | vacuole membrane protein 1 | 0.0323737 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0322124 |
| EXOC4 | exocyst complex component 4 | 0.031924 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0318258 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0312567 |
| TPM4 | tropomyosin 4 | 0.0311735 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0311123 |
| INTS6 | integrator complex subunit 6 | 0.0309766 |
| AEBP2 | AE binding protein 2 | 0.030725 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0305483 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0302954 |
| CUX1 | cut-like homeobox 1 | 0.0298564 |
| USP34 | ubiquitin specific peptidase 34 | 0.0293919 |
| CTTN | cortactin | 0.0291211 |
| APP | amyloid beta (A4) precursor protein | 0.0290118 |
| RNF213 | ring finger protein 213 | 0.0288932 |
| RAB7A | RAB7A, member RAS oncogene family | 0.028811 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0286563 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0285675 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0284979 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0280594 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0278455 |
| ATXN1 | ataxin 1 | 0.027739 |
| XPOT | exportin, tRNA | 0.0275692 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0275432 |
| DIAPH2 | diaphanous-related formin 2 | 0.0274247 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0265607 |
| CAVIN1 | caveolae associated protein 1 | 0.0260394 |
| BPTF | bromodomain PHD finger transcription factor | 0.0259904 |
| PRKCE | protein kinase C, epsilon | 0.0259317 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0258996 |
| DOCK1 | dedicator of cytokinesis 1 | 0.025699 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0255269 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.0407147 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.039145 |
| PHIP | pleckstrin homology domain interacting protein | -0.0250756 |
| RTN4 | reticulon 4 | -0.0247853 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.024327 |
| TMEM165 | transmembrane protein 165 | -0.0236842 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0222079 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0221856 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0178734 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0177719 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.016956 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0163468 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0160595 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.015747 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.015526 |
| ZNF292 | zinc finger protein 292 | -0.0154443 |
| WASF2 | WAS protein family, member 2 | -0.0152941 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0151523 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0146967 |
| CEP95 | centrosomal protein 95kDa | -0.0144467 |
| RPL35A | ribosomal protein L35a | -0.0144313 |
| RNF38 | ring finger protein 38 | -0.0143895 |
| BBX | bobby sox homolog (Drosophila) | -0.0138386 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0134971 |
| RPL12 | ribosomal protein L12 | -0.0134624 |
| TFG | TRK-fused gene | -0.0134283 |
| EGR1 | early growth response 1 | -0.0133895 |
| HMGA1 | high mobility group AT-hook 1 | -0.0132924 |
| STIL | SCL/TAL1 interrupting locus | -0.013152 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.0126187 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0124889 |
| H1-0 | H1.0 linker histone | -0.0123229 |
| TNPO3 | transportin 3 | -0.0120976 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0120564 |
| FOXO3 | forkhead box O3 | -0.0117707 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0116003 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0113271 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0112331 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0111603 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0111164 |
| ZFR | zinc finger RNA binding protein | -0.011094 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.011024 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0109812 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0109167 |
| GNAS | GNAS complex locus | -0.0108364 |
| FBXO34 | F-box protein 34 | -0.0104781 |
| PREPL | prolyl endopeptidase-like | -0.010458 |
| CDK19 | cyclin-dependent kinase 19 | -0.0104408 |
| PFN1 | profilin 1 | -0.0103524 |
| TMEM39A | transmembrane protein 39A | -0.0103121 |
| RASA2 | RAS p21 protein activator 2 | -0.0103083 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0101751 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0101631 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.0101195 |
| RPS15 | ribosomal protein S15 | -0.0101133 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0101127 |
| RPS21 | ribosomal protein S21 | -0.0100674 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00990289 |
| ZFP64 | ZFP64 zinc finger protein | -0.00990143 |
| CCNL1 | cyclin L1 | -0.00985915 |
| GGNBP2 | gametogenetin binding protein 2 | -0.00983708 |
| RAP1A | RAP1A, member of RAS oncogene family | -0.00982101 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0097949 |
| GOLGA4 | golgin A4 | -0.00971866 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.00969708 |
| THOC1 | THO complex 1 | -0.00969035 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.00954617 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0095176 |
| CCDC14 | coiled-coil domain containing 14 | -0.009515 |
| MTF2 | metal response element binding transcription factor 2 | -0.00944318 |
| CIRSR | corepressor of RBPJ and splicing regulator | -0.00940655 |
| GOLT1B | golgi transport 1B | -0.00930563 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00926596 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.00925759 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.009233 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0091873 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.00918596 |
| XPO1 | exportin 1 | -0.00904706 |
| SMC4 | structural maintenance of chromosomes 4 | -0.00902012 |
| OGA | O-GlcNAcase | -0.00901766 |
| NCOA6 | nuclear receptor coactivator 6 | -0.00898312 |
| RPL37A | ribosomal protein L37a | -0.00895792 |
| RPS29 | ribosomal protein S29 | -0.00894705 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.00893756 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0088918 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00888047 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00887592 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.00881454 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.00877076 |
| RFX7 | regulatory factor X, 7 | -0.00874025 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00873268 |
| RPL28 | ribosomal protein L28 | -0.00864773 |
| TMEM263 | transmembrane protein 263 | -0.00863397 |
| COG5 | component of oligomeric golgi complex 5 | -0.00860587 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00851133 |
| NEK7 | NIMA-related kinase 7 | -0.00851074 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | -0.00846121 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.00839001 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.00824474 |
| NDC80 | NDC80 kinetochore complex component | -0.00807341 |
