| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ixazomib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.158555 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.128095 |
| POTEF | POTE ankyrin domain family, member F | 0.0984281 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0831666 |
| MT2A | metallothionein 2A | 0.0830705 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0815543 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0677736 |
| PLEC | plectin | 0.0649398 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0600156 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0599806 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0592918 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0579716 |
| LAMC2 | laminin, gamma 2 | 0.0575018 |
| MX1 | MX dynamin-like GTPase 1 | 0.0571565 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0545211 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0523733 |
| DTNA | dystrobrevin, alpha | 0.0496025 |
| TPM3 | tropomyosin 3 | 0.0489514 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0477078 |
| TMSB10 | thymosin beta 10 | 0.0462261 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0460908 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.045821 |
| HMGA1 | high mobility group AT-hook 1 | 0.0454837 |
| MSN | moesin | 0.0447886 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0446826 |
| BRD2 | bromodomain containing 2 | 0.0443598 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0440795 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0440302 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0439693 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0439453 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0438215 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0435023 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0423127 |
| PLSCR1 | phospholipid scramblase 1 | 0.0412755 |
| CDCP1 | CUB domain containing protein 1 | 0.0399998 |
| CD44 | CD44 molecule (Indian blood group) | 0.0397665 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0397471 |
| MAP1B | microtubule-associated protein 1B | 0.0393668 |
| ADAR | adenosine deaminase, RNA-specific | 0.0372205 |
| MYO1E | myosin IE | 0.0370557 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0369317 |
| NAV2 | neuron navigator 2 | 0.0365052 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0361693 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0361452 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0359054 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0359023 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0358786 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0354087 |
| MCL1 | myeloid cell leukemia 1 | 0.0351829 |
| DIAPH1 | diaphanous-related formin 1 | 0.034193 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0341294 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0334365 |
| IFI44L | interferon-induced protein 44-like | 0.0330951 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0329151 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0326764 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0324644 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0323775 |
| HLA-B | major histocompatibility complex, class I, B | 0.0323524 |
| MYO10 | myosin X | 0.0316927 |
| RBM25 | RNA binding motif protein 25 | 0.0313004 |
| SMAD3 | SMAD family member 3 | 0.0310517 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0306869 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.030669 |
| ARRDC3 | arrestin domain containing 3 | 0.0304685 |
| TJP1 | tight junction protein 1 | 0.0303649 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0302924 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0302603 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.029694 |
| TXNIP | thioredoxin interacting protein | 0.0295407 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0294837 |
| ERBIN | erbb2 interacting protein | 0.0293909 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0293076 |
| HDAC9 | histone deacetylase 9 | 0.0287362 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0285599 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0284191 |
| TXNRD1 | thioredoxin reductase 1 | 0.0283652 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0277946 |
| OSMR | oncostatin M receptor | 0.0275174 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0274571 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0268941 |
| VGLL3 | vestigial-like family member 3 | 0.0268931 |
| SP100 | SP100 nuclear antigen | 0.0268614 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0267969 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0256521 |
| RCOR1 | REST corepressor 1 | 0.0255923 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0254934 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0250111 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0248911 |
| ACTG1 | actin gamma 1 | 0.0248636 |
| FBXO32 | F-box protein 32 | 0.024593 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0241723 |
| RPL3 | ribosomal protein L3 | 0.0240829 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0238104 |
| RIGI | RNA sensor RIG-I | 0.0237537 |
| VMP1 | vacuole membrane protein 1 | 0.0235852 |
| FLNA | filamin A, alpha | 0.0235738 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.023489 |
| RASA2 | RAS p21 protein activator 2 | 0.0229161 |
| MED13 | mediator complex subunit 13 | 0.0229068 |
| RPSA | ribosomal protein SA | 0.0228605 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.131674 |
| FN1 | fibronectin 1 | -0.120879 |
| LMO7 | LIM domain 7 | -0.110384 |
| PGK1 | phosphoglycerate kinase 1 | -0.0850562 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.082029 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0819979 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0770522 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0745875 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0714892 |
| FTL | ferritin, light polypeptide | -0.0688564 |
| CSTB | cystatin B (stefin B) | -0.0652141 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0648675 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0586143 |
| FAM162A | family with sequence similarity 162, member A | -0.058374 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0580464 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0574954 |
| TOP1 | topoisomerase (DNA) I | -0.0539525 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0529534 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0527185 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0513488 |
| RPS3 | ribosomal protein S3 | -0.0511617 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0502335 |
| RPL35A | ribosomal protein L35a | -0.0492687 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0440419 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0432792 |
| TMEM263 | transmembrane protein 263 | -0.0432319 |
| ENO1 | enolase 1, (alpha) | -0.04306 |
| ASPH | aspartate beta-hydroxylase | -0.0422782 |
| CD2AP | CD2-associated protein | -0.0415114 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0413622 |
| RPS27A | ribosomal protein S27a | -0.0411353 |
| FAM13A | family with sequence similarity 13, member A | -0.0403744 |
| GNAS | GNAS complex locus | -0.0402479 |
| TMEM123 | transmembrane protein 123 | -0.0395222 |
| EPCAM | epithelial cell adhesion molecule | -0.0386567 |
| LDHA | lactate dehydrogenase A | -0.0379577 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0374649 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0370383 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0358971 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0349396 |
| DSPP | dentin sialophosphoprotein | -0.034586 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.034013 |
| S100A6 | S100 calcium binding protein A6 | -0.0333078 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0331049 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0328918 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.031956 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0311941 |
| CCND1 | cyclin D1 | -0.031178 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.030304 |
| CANX | calnexin | -0.0302596 |
| RPS13 | ribosomal protein S13 | -0.0301827 |
| H1-0 | H1.0 linker histone | -0.0293558 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288149 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0287468 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0287253 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0284053 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0274497 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0273584 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0273303 |
| MYO6 | myosin VI | -0.0270271 |
| MUC20 | mucin 20, cell surface associated | -0.0267682 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0265335 |
| LMAN1 | lectin, mannose-binding, 1 | -0.026382 |
| PHF3 | PHD finger protein 3 | -0.0263129 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0261034 |
| AHNAK | AHNAK nucleoprotein | -0.0260568 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0248893 |
| RBM39 | RNA binding motif protein 39 | -0.0246409 |
| CCDC47 | coiled-coil domain containing 47 | -0.024492 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0242157 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0241263 |
| MORF4L1 | mortality factor 4 like 1 | -0.0239496 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0238662 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0236619 |
| GLCCI1 | glucocorticoid induced 1 | -0.0231317 |
| RYBP | RING1 and YY1 binding protein | -0.023068 |
| RPS8 | ribosomal protein S8 | -0.0228235 |
| TFG | TRK-fused gene | -0.0227533 |
| RRBP1 | ribosome binding protein 1 | -0.0226893 |
| MEF2A | myocyte enhancer factor 2A | -0.0226345 |
| HOPX | HOP homeobox | -0.0226191 |
| RPL37A | ribosomal protein L37a | -0.0225833 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0225426 |
| SVIL | supervillin | -0.0224646 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.022168 |
| CD63 | CD63 molecule | -0.0221265 |
| RAI14 | retinoic acid induced 14 | -0.0218935 |
| ZNF217 | zinc finger protein 217 | -0.0216592 |
| RPS6 | ribosomal protein S6 | -0.0211925 |
| RHEB | Ras homolog enriched in brain | -0.0210824 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0208852 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.0207185 |
| LDHB | lactate dehydrogenase B | -0.0203983 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0203939 |
| QKI | QKI, KH domain containing, RNA binding | -0.0203281 |
| VIM | vimentin | -0.020314 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0201883 |
| STEAP4 | STEAP family member 4 | -0.0200904 |
| BPTF | bromodomain PHD finger transcription factor | -0.0199334 |
| RPL9 | ribosomal protein L9 | -0.0198722 |
