| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ixazomib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ixazomib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0975282 |
| MCL1 | myeloid cell leukemia 1 | 0.0951187 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0839666 |
| PCBP2 | poly(rC) binding protein 2 | 0.0774725 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.073727 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0588625 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0584515 |
| VIM | vimentin | 0.0504535 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0471441 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0439896 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0427684 |
| NDRG1 | N-myc downstream regulated 1 | 0.0423344 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0414895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0398147 |
| TPM3 | tropomyosin 3 | 0.0376303 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0369732 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0353869 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0343193 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0336551 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0336191 |
| RPL3 | ribosomal protein L3 | 0.0330212 |
| MSN | moesin | 0.0324438 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0315957 |
| PKM | pyruvate kinase, muscle | 0.0312698 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0309001 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0308337 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0286428 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0286423 |
| CANX | calnexin | 0.028241 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0276608 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0276224 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0271805 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0264396 |
| FNIP1 | folliculin interacting protein 1 | 0.0262018 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0258406 |
| LSAMP | limbic system-associated membrane protein | 0.0251432 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0249016 |
| HLA-A | major histocompatibility complex, class I, A | 0.0246294 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0238405 |
| RPS12 | ribosomal protein S12 | 0.0236566 |
| AUTS2 | autism susceptibility candidate 2 | 0.0234275 |
| PRELID2 | PRELI domain containing 2 | 0.0232371 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0227942 |
| DENND1A | DENN/MADD domain containing 1A | 0.0227053 |
| RPS27 | ribosomal protein S27 | 0.022299 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0222171 |
| GPC6 | glypican 6 | 0.0220261 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0219434 |
| RAD51B | RAD51 paralog B | 0.0217507 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0217051 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0216232 |
| RPS2 | ribosomal protein S2 | 0.021404 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0211403 |
| RPS6 | ribosomal protein S6 | 0.0208607 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0206068 |
| LDHA | lactate dehydrogenase A | 0.0202625 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0200856 |
| RPL37 | ribosomal protein L37 | 0.0199499 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0198616 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0197793 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0197752 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0191874 |
| NBEAL1 | neurobeachin-like 1 | 0.0191276 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0190413 |
| ENO1 | enolase 1, (alpha) | 0.0187658 |
| LAMA5 | laminin, alpha 5 | 0.0187099 |
| UBC | ubiquitin C | 0.0185722 |
| FLNA | filamin A, alpha | 0.0185474 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0180747 |
| POTEF | POTE ankyrin domain family, member F | 0.0179193 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.01783 |
| RPS8 | ribosomal protein S8 | 0.0177682 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0176806 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.017662 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0176531 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0175597 |
| VEGFA | vascular endothelial growth factor A | 0.0175312 |
| EZR | ezrin | 0.0173893 |
| PTEN | phosphatase and tensin homolog | 0.0172035 |
| NRXN3 | neurexin 3 | 0.0171916 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.017115 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0171142 |
| TENM2 | teneurin transmembrane protein 2 | 0.0170342 |
| RPS4X | ribosomal protein S4, X-linked | 0.0169144 |
| CHL1 | cell adhesion molecule L1-like | 0.0167374 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0166298 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0165884 |
| FAM13A | family with sequence similarity 13, member A | 0.0165402 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0164116 |
| FAM107B | family with sequence similarity 107, member B | 0.016401 |
| RPS11 | ribosomal protein S11 | 0.0164007 |
| HYOU1 | hypoxia up-regulated 1 | 0.0162066 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0161904 |
| CALR | calreticulin | 0.0161005 |
| DTNA | dystrobrevin, alpha | 0.0159967 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0159725 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0159486 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0159088 |
| HDGF | hepatoma-derived growth factor | 0.0156191 |
| XYLT1 | xylosyltransferase I | 0.0154268 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.188764 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.164791 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.15847 |
| GDA | guanine deaminase | -0.154566 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.134404 |
| SMYD3 | SET and MYND domain containing 3 | -0.118904 |
| PDE10A | phosphodiesterase 10A | -0.107196 |
| TXNRD1 | thioredoxin reductase 1 | -0.0975835 |
| ASPH | aspartate beta-hydroxylase | -0.0964806 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0955172 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0867796 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0831647 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0816388 |
| EFNA5 | ephrin-A5 | -0.0777673 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0768601 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0767303 |
| COL5A2 | collagen, type V, alpha 2 | -0.0761895 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0748547 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0716725 |
| KYNU | kynureninase | -0.0604393 |
| NEK7 | NIMA-related kinase 7 | -0.0582081 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0578885 |
| PCBP3 | poly(rC) binding protein 3 | -0.057521 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0513348 |
| TNPO1 | transportin 1 | -0.0510602 |
| NPAS2 | neuronal PAS domain protein 2 | -0.050648 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0500707 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0498525 |
| NRCAM | neuronal cell adhesion molecule | -0.0498113 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.047878 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0461357 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0432255 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0420553 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0412364 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0411413 |
| TMSB10 | thymosin beta 10 | -0.0407245 |
| RBM39 | RNA binding motif protein 39 | -0.0400266 |
| CTSC | cathepsin C | -0.0393901 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0390618 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0386673 |
| ENAH | enabled homolog (Drosophila) | -0.0375276 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0372501 |
| GNAS | GNAS complex locus | -0.0366318 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0361373 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0357347 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0357233 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0356419 |
| FN1 | fibronectin 1 | -0.034667 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0343636 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0342573 |
| OSMR | oncostatin M receptor | -0.0329073 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0323039 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0317799 |
| FTL | ferritin, light polypeptide | -0.0314333 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0298841 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0295491 |
| PALLD | palladin, cytoskeletal associated protein | -0.0291843 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0285733 |
| PHF20 | PHD finger protein 20 | -0.0283242 |
| RTN1 | reticulon 1 | -0.0268948 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.0268552 |
| OGA | O-GlcNAcase | -0.0268272 |
| ACTG1 | actin gamma 1 | -0.0267607 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0263252 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0261355 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0261324 |
| AOPEP | aminopeptidase O (putative) | -0.0257381 |
| NTN4 | netrin 4 | -0.0256154 |
| MYOF | myoferlin | -0.0255287 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.025469 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0251834 |
| PTGR1 | prostaglandin reductase 1 | -0.0248901 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0247091 |
| PRKD3 | protein kinase D3 | -0.0246664 |
| VCL | vinculin | -0.024571 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0244833 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0242858 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0241638 |
| SRGN | serglycin | -0.0240648 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0240345 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0239074 |
| BMERB1 | bMERB domain containing 1 | -0.0238177 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.0238056 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0234992 |
| PDE7B | phosphodiesterase 7B | -0.0234023 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0230082 |
| FRMD4B | FERM domain containing 4B | -0.022945 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0223475 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0220874 |
| MKI67 | marker of proliferation Ki-67 | -0.0220783 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0219736 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0219519 |
| NF1 | neurofibromin 1 | -0.0217265 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0216138 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0215129 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0213582 |
| KIAA0825 | KIAA0825 | -0.0212914 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0212652 |
| RPS24 | ribosomal protein S24 | -0.0210775 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0210148 |
