Ixazomib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NTM neurotrimin 0.0870592
TSC22D2 TSC22 domain family, member 2 0.0683074
TRIO trio Rho guanine nucleotide exchange factor 0.0620178
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0496976
COL11A1 collagen, type XI, alpha 1 0.0490965
COL5A2 collagen, type V, alpha 2 0.0478568
ANKRD33B ankyrin repeat domain 33B 0.0477179
DSCAM Down syndrome cell adhesion molecule 0.0457804
TGFB2 transforming growth factor, beta 2 0.040461
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0403359
HDAC9 histone deacetylase 9 0.0397165
MED13L mediator complex subunit 13-like 0.0377299
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0372629
SAMD4A sterile alpha motif domain containing 4A 0.0362146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0334997
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0328544
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0299202
JUN jun proto-oncogene 0.0295538
GARS1 glycyl-tRNA synthetase 1 0.0293315
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.027382
THBS1 thrombospondin 1 0.0270251
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0264118
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0260895
MB21D2 Mab-21 domain containing 2 0.0249774
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0249225
BHLHE40 basic helix-loop-helix family, member e40 0.0232316
TAS2R14 taste receptor, type 2, member 14 0.0224842
UBE2K ubiquitin-conjugating enzyme E2K 0.0223437
OSBPL10 oxysterol binding protein-like 10 0.0222448
NRG1 neuregulin 1 0.0217381
COL3A1 collagen, type III, alpha 1 0.0213641
BRD2 bromodomain containing 2 0.0213067
CRY1 cryptochrome circadian clock 1 0.0212213
GSK3B glycogen synthase kinase 3 beta 0.0210663
RIMS2 regulating synaptic membrane exocytosis 2 0.0207589
ZEB2 zinc finger E-box binding homeobox 2 0.0207089
HMCN1 hemicentin 1 0.0206226
GMDS GDP-mannose 4,6-dehydratase 0.0205248
H2AC6 H2A clustered histone 6 0.0204001
PICALM phosphatidylinositol binding clathrin assembly protein 0.0203371
MCL1 myeloid cell leukemia 1 0.0197115
ZC3H15 zinc finger CCCH-type containing 15 0.0194014
ENAH enabled homolog (Drosophila) 0.0193941
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0192196
FNDC3B fibronectin type III domain containing 3B 0.0188334
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0187192
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0185433
SLC38A1 solute carrier family 38, member 1 0.018372
KIF5B kinesin family member 5B 0.018307
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180549
SLC44A5 solute carrier family 44, member 5 0.0179706
ZNF217 zinc finger protein 217 0.0177134
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0176919
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0176539
PLK2 polo-like kinase 2 0.0175236
RFPL4B ret finger protein-like 4B 0.0174839
SET SET nuclear proto-oncogene 0.01744
ATXN1 ataxin 1 0.0174399
PCDH18 protocadherin 18 0.0173686
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0173436
GSE1 Gse1 coiled-coil protein 0.0170295
APLP2 amyloid beta (A4) precursor-like protein 2 0.0166608
BRWD1 bromodomain and WD repeat domain containing 1 0.0166242
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.016476
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0164445
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0161218
KDM6A lysine (K)-specific demethylase 6A 0.0158969
UBE2B ubiquitin-conjugating enzyme E2B 0.0158597
NBAS neuroblastoma amplified sequence 0.0158404
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0154326
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0153223
CCNY cyclin Y 0.0152274
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0151655
WNK1 WNK lysine deficient protein kinase 1 0.0151077
PUM2 pumilio RNA-binding family member 2 0.0150993
MTMR3 myotubularin related protein 3 0.0149549
FNBP1L formin binding protein 1-like 0.0149447
MTCL1 microtubule crosslinking factor 1 0.0148931
POU2F1 POU class 2 homeobox 1 0.0148134
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0148096
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0147013
MAML2 mastermind-like 2 (Drosophila) 0.0146412
NFIB nuclear factor I/B 0.0145885
TMEM64 transmembrane protein 64 0.0145786
ITSN2 intersectin 2 0.0145501
RB1CC1 RB1-inducible coiled-coil 1 0.0144379
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143937
DDIT4 DNA-damage-inducible transcript 4 0.0143231
SRP54 signal recognition particle 54kDa 0.0142126
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0141809
ZFP30 ZFP30 zinc finger protein 0.0141354
YAP1 Yes-associated protein 1 0.0141272
BMPR1A bone morphogenetic protein receptor, type IA 0.0141193
PRKCSH protein kinase C substrate 80K-H 0.0141038
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0141016
ARRDC3 arrestin domain containing 3 0.0140925
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0140802
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0140731
GRB10 growth factor receptor-bound protein 10 0.0140637
MBNL1 muscleblind-like splicing regulator 1 0.0140561

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.102072
GPC3 glypican 3 -0.0698376
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.060408
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0569124
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0503761
MDK midkine (neurite growth-promoting factor 2) -0.0441598
RPL35A ribosomal protein L35a -0.0409421
RPS12 ribosomal protein S12 -0.0359646
ENO1 enolase 1, (alpha) -0.0350083
PCLO piccolo presynaptic cytomatrix protein -0.0328224
RPLP1 ribosomal protein, large, P1 -0.0327808
RPS6 ribosomal protein S6 -0.0327269
GNAS GNAS complex locus -0.0316291
CENPF centromere protein F, 350/400kDa -0.0308803
RPLP2 ribosomal protein, large, P2 -0.0307582
RPS8 ribosomal protein S8 -0.0302926
SEPTIN7 septin 7 -0.0297149
RPL31 ribosomal protein L31 -0.0289239
MKI67 marker of proliferation Ki-67 -0.0282837
TMSB10 thymosin beta 10 -0.0281258
SOX5 SRY (sex determining region Y)-box 5 -0.027163
TPT1 tumor protein, translationally-controlled 1 -0.0260052
RPL11 ribosomal protein L11 -0.025976
RPL37A ribosomal protein L37a -0.025897
PKM pyruvate kinase, muscle -0.025812
RPL19 ribosomal protein L19 -0.0258026
PTMA prothymosin, alpha -0.0252856
RPL9 ribosomal protein L9 -0.025006
RIGI RNA sensor RIG-I -0.0249451
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0248597
SRRM2 serine/arginine repetitive matrix 2 -0.0244793
FAF1 Fas (TNFRSF6) associated factor 1 -0.0237809
GLI3 GLI family zinc finger 3 -0.0234921
ISG15 ISG15 ubiquitin-like modifier -0.0234278
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0231249
NCAM2 neural cell adhesion molecule 2 -0.0227159
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0225081
SNX6 sorting nexin 6 -0.0224872
CCL5 chemokine (C-C motif) ligand 5 -0.0223414
RPS27A ribosomal protein S27a -0.0223287
CNRIP1 cannabinoid receptor interacting protein 1 -0.0222057
RPS13 ribosomal protein S13 -0.0221345
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0220305
RPS5 ribosomal protein S5 -0.0219916
ADGRV1 adhesion G protein-coupled receptor V1 -0.0218903
CENPE centromere protein E, 312kDa -0.0215679
PCBP2 poly(rC) binding protein 2 -0.0214961
RACK1 receptor for activated C kinase 1 -0.0214911
RASAL2 RAS protein activator like 2 -0.0214624
FOXP2 forkhead box P2 -0.0214353
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0212372
B2M beta-2-microglobulin -0.0209567
RAD21 RAD21 homolog (S. pombe) -0.0208557
HIP1 huntingtin interacting protein 1 -0.0208462
RPL8 ribosomal protein L8 -0.0204996
HSPB1 heat shock 27kDa protein 1 -0.0204754
RPS19 ribosomal protein S19 -0.0203463
AHNAK AHNAK nucleoprotein -0.0200747
PGK1 phosphoglycerate kinase 1 -0.0200563
RPL38 ribosomal protein L38 -0.0199631
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0194554
RPS4X ribosomal protein S4, X-linked -0.0193552
ZNF385D zinc finger protein 385D -0.019317
RAD51B RAD51 paralog B -0.0191669
ANK2 ankyrin 2, neuronal -0.0191657
PCYOX1 prenylcysteine oxidase 1 -0.0189974
RPS29 ribosomal protein S29 -0.0186711
NACA nascent polypeptide-associated complex alpha subunit -0.018663
MRPS30 mitochondrial ribosomal protein S30 -0.0186628
TPX2 TPX2, microtubule-associated -0.0185335
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0184684
EAPP E2F-associated phosphoprotein -0.0184532
YBX1 Y box binding protein 1 -0.0184369
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0184319
SMC4 structural maintenance of chromosomes 4 -0.0183156
SORBS2 sorbin and SH3 domain containing 2 -0.0181635
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0180621
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0180233
MEIS2 Meis homeobox 2 -0.0179627
ADGRL3 adhesion G protein-coupled receptor L3 -0.017906
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0176356
PRRC2C proline-rich coiled-coil 2C -0.0176298
RPS21 ribosomal protein S21 -0.0175073
RPS10 ribosomal protein S10 -0.0174533
CLOCK clock circadian regulator -0.0174424
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0174308
RPS25 ribosomal protein S25 -0.0172877
SMYD3 SET and MYND domain containing 3 -0.017271
RPL5 ribosomal protein L5 -0.0172293
APOE apolipoprotein E -0.0169906
SOX2 SRY (sex determining region Y)-box 2 -0.016846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0168336
PRTG protogenin -0.0168203
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0167388
RPS24 ribosomal protein S24 -0.0166585
RPL26 ribosomal protein L26 -0.0166384
MPG N-methylpurine-DNA glycosylase -0.0165057
BEX3 brain expressed X-linked 3 -0.0164548
PRR16 proline rich 16 -0.0163619
PCDH9 protocadherin 9 -0.0160888