Ixazomib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0736553
HDAC9 histone deacetylase 9 0.0680053
SOX6 SRY (sex determining region Y)-box 6 0.0602312
BMP2K BMP2 inducible kinase 0.0471721
PDGFC platelet derived growth factor C 0.0435687
PDE4B phosphodiesterase 4B, cAMP-specific 0.0431903
ADAM10 ADAM metallopeptidase domain 10 0.0416569
ZNF608 zinc finger protein 608 0.0412028
EEF2 eukaryotic translation elongation factor 2 0.0390335
ECT2 epithelial cell transforming 2 0.0366684
TJP1 tight junction protein 1 0.0358298
PRELID2 PRELI domain containing 2 0.0340639
SSBP2 single-stranded DNA binding protein 2 0.0329227
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0318253
ZEB1 zinc finger E-box binding homeobox 1 0.0295644
TXNRD1 thioredoxin reductase 1 0.0290931
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.028962
PCBP2 poly(rC) binding protein 2 0.0277776
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0271844
GLI2 GLI family zinc finger 2 0.026308
LPP LIM domain containing preferred translocation partner in lipoma 0.0262822
DPYD dihydropyrimidine dehydrogenase 0.0261635
TGFBR3 transforming growth factor, beta receptor III 0.0258828
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0243907
GLS2 glutaminase 2 (liver, mitochondrial) 0.0242668
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.024153
MYO5C myosin VC 0.0241261
MACROD2 MACRO domain containing 2 0.0234975
VCL vinculin 0.0234782
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0229552
EZR ezrin 0.0229437
GLI3 GLI family zinc finger 3 0.0223206
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0221132
CDC73 cell division cycle 73 0.0217178
PLK2 polo-like kinase 2 0.0215729
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0214366
FAT1 FAT atypical cadherin 1 0.0210616
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0205887
HSPA8 heat shock 70kDa protein 8 0.0204329
NCKAP1 NCK-associated protein 1 0.020323
TMEM65 transmembrane protein 65 0.0201295
DSCAM Down syndrome cell adhesion molecule 0.0200792
ZBTB20 zinc finger and BTB domain containing 20 0.0200788
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0195812
MINDY2 MINDY lysine 48 deubiquitinase 2 0.019532
NUP58 nucleoporin 58 0.0194351
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0192714
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0192079
ZBTB38 zinc finger and BTB domain containing 38 0.0190267
APP amyloid beta (A4) precursor protein 0.0188904
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0188717
ZNF292 zinc finger protein 292 0.0188549
ZMYM2 zinc finger, MYM-type 2 0.018587
IARS1 isoleucyl-tRNA synthetase 1 0.0185743
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0185476
USP34 ubiquitin specific peptidase 34 0.0184414
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0184308
QKI QKI, KH domain containing, RNA binding 0.0183739
CCNL1 cyclin L1 0.0182703
ITCH itchy E3 ubiquitin protein ligase 0.0182307
ARID1A AT rich interactive domain 1A (SWI-like) 0.0176614
FBLN2 fibulin 2 0.0173583
USP24 ubiquitin specific peptidase 24 0.0172019
MBD5 methyl-CpG binding domain protein 5 0.0170953
LOC112694756 uncharaterized LOC112694756 0.0169196
PDIA3 protein disulfide isomerase family A, member 3 0.0168509
SEPTIN11 septin 11 0.0168005
NPAS2 neuronal PAS domain protein 2 0.0166573
TSC22D1 TSC22 domain family, member 1 0.0164272
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0163481
PCGF5 polycomb group ring finger 5 0.0162201
TNRC6B trinucleotide repeat containing 6B 0.0161775
ADAM9 ADAM metallopeptidase domain 9 0.0161554
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0161471
GOLGA4 golgin A4 0.0161223
BRWD1 bromodomain and WD repeat domain containing 1 0.0160576
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0158627
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0158533
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0158033
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0157996
MEF2A myocyte enhancer factor 2A 0.0155821
HELZ helicase with zinc finger 0.0155761
AHNAK AHNAK nucleoprotein 0.0155365
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0152796
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0151297
SGMS2 sphingomyelin synthase 2 0.0150801
FNIP1 folliculin interacting protein 1 0.0150494
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0149221
CREB5 cAMP responsive element binding protein 5 0.0147146
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.014529
TRAK1 trafficking protein, kinesin binding 1 0.0144596
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0143604
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0143204
TBC1D5 TBC1 domain family, member 5 0.0142548
USP25 ubiquitin specific peptidase 25 0.0141473
PMM2 phosphomannomutase 2 0.0141021
IP6K2 inositol hexakisphosphate kinase 2 0.0140542
ANKRD36B ankyrin repeat domain 36B 0.0140279
KDM4C lysine (K)-specific demethylase 4C 0.0139465
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0139169

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.415264
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235695
TPT1 tumor protein, translationally-controlled 1 -0.145435
RPS6 ribosomal protein S6 -0.12364
RPL35A ribosomal protein L35a -0.101549
RPS8 ribosomal protein S8 -0.086866
RPLP1 ribosomal protein, large, P1 -0.0856464
RPL34 ribosomal protein L34 -0.0854591
RPL31 ribosomal protein L31 -0.0852516
RPS13 ribosomal protein S13 -0.0742344
RPL26 ribosomal protein L26 -0.0729268
RPS23 ribosomal protein S23 -0.0719258
RPL37A ribosomal protein L37a -0.0681141
ACTG1 actin gamma 1 -0.0659359
RPS25 ribosomal protein S25 -0.0648936
RPL19 ribosomal protein L19 -0.0645556
RPS3 ribosomal protein S3 -0.0631452
RPS27A ribosomal protein S27a -0.0616844
RPS19 ribosomal protein S19 -0.0611724
RPLP2 ribosomal protein, large, P2 -0.0602805
RPL9 ribosomal protein L9 -0.0586309
EIF1 eukaryotic translation initiation factor 1 -0.058096
RPL23 ribosomal protein L23 -0.0548092
RPS24 ribosomal protein S24 -0.0521842
RPS29 ribosomal protein S29 -0.0513721
RPL11 ribosomal protein L11 -0.0496661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.049008
S100A6 S100 calcium binding protein A6 -0.0477665
NAP1L1 nucleosome assembly protein 1-like 1 -0.0456872
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.045411
S100A9 S100 calcium binding protein A9 -0.0448451
RPS12 ribosomal protein S12 -0.0445439
HSPB1 heat shock 27kDa protein 1 -0.0436513
RPL12 ribosomal protein L12 -0.0434174
RPL36 ribosomal protein L36 -0.0432266
RPS21 ribosomal protein S21 -0.0430368
WSB1 WD repeat and SOCS box containing 1 -0.0427062
ENO2 enolase 2 (gamma, neuronal) -0.0424593
RPL38 ribosomal protein L38 -0.0422963
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0418958
MYL12B myosin, light chain 12B, regulatory -0.0413319
RPL13A ribosomal protein L13a -0.0411126
RPL8 ribosomal protein L8 -0.0401051
KPNB1 karyopherin (importin) beta 1 -0.0397604
S100A10 S100 calcium binding protein A10 -0.0384084
RPL7A ribosomal protein L7a -0.0377428
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0375935
RPL30 ribosomal protein L30 -0.0363195
FTL ferritin, light polypeptide -0.0362718
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0354138
RPLP0 ribosomal protein, large, P0 -0.0351871
RPS27 ribosomal protein S27 -0.0342344
RPL27A ribosomal protein L27a -0.033964
RPL5 ribosomal protein L5 -0.033151
H3-3B H3.3 histone B -0.0330413
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0319356
RPL10A ribosomal protein L10a -0.0317759
RPS16 ribosomal protein S16 -0.0317492
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0303056
RPL28 ribosomal protein L28 -0.0296997
RPS5 ribosomal protein S5 -0.0295751
RPL32 ribosomal protein L32 -0.0291823
TUBB4B tubulin, beta 4B class IVb -0.0290469
RPL37 ribosomal protein L37 -0.0290238
RPS28 ribosomal protein S28 -0.0279353
RPL35 ribosomal protein L35 -0.0269055
HLA-B major histocompatibility complex, class I, B -0.0262056
FAM162A family with sequence similarity 162, member A -0.0257996
RPL36A ribosomal protein L36a -0.025495
RPL15 ribosomal protein L15 -0.0254102
RPS17 ribosomal protein S17 -0.0252847
RPS15 ribosomal protein S15 -0.0251071
ZMYND8 zinc finger, MYND-type containing 8 -0.0246782
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0242582
RACK1 receptor for activated C kinase 1 -0.0241659
RPS14 ribosomal protein S14 -0.0240122
TM4SF1 transmembrane 4 L six family member 1 -0.0238885
CCND1 cyclin D1 -0.0238821
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0237983
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.023648
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0235208
HMGB1 high mobility group box 1 -0.0235026
RPL7 ribosomal protein L7 -0.0233411
NOP56 NOP56 ribonucleoprotein -0.0229546
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0229151
PSD3 pleckstrin and Sec7 domain containing 3 -0.0219095
B2M beta-2-microglobulin -0.0216974
IFITM3 interferon induced transmembrane protein 3 -0.0215825
S100A4 S100 calcium binding protein A4 -0.0215343
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0213467
ASPH aspartate beta-hydroxylase -0.0208638
RPS11 ribosomal protein S11 -0.0208426
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0206174
PRDX2 peroxiredoxin 2 -0.0206078
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0205059
PRDX1 peroxiredoxin 1 -0.0200965
FNDC3B fibronectin type III domain containing 3B -0.0197783
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.019769
EMP3 epithelial membrane protein 3 -0.0196619
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0196296