Ixazomib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ixazomib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ixazomib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.156867
VEGFA vascular endothelial growth factor A 0.149883
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.124285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0885238
CD44 CD44 molecule (Indian blood group) 0.0831697
FNDC3B fibronectin type III domain containing 3B 0.0803838
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0779575
ARRDC3 arrestin domain containing 3 0.0676545
MYH9 myosin, heavy chain 9, non-muscle 0.062804
HDAC9 histone deacetylase 9 0.0613161
ZBTB38 zinc finger and BTB domain containing 38 0.0612353
NAV2 neuron navigator 2 0.0605497
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0604356
PCBP2 poly(rC) binding protein 2 0.0583687
CALR calreticulin 0.0556609
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0548502
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0538824
TGFBI transforming growth factor, beta-induced, 68kDa 0.053247
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0511465
SPTBN1 spectrin, beta, non-erythrocytic 1 0.050278
ASPH aspartate beta-hydroxylase 0.0502753
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0497441
MCL1 myeloid cell leukemia 1 0.0465232
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0457525
MSN moesin 0.0430851
PPARD peroxisome proliferator-activated receptor delta 0.0426924
STC1 stanniocalcin 1 0.0414177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0411613
AKAP12 A kinase (PRKA) anchor protein 12 0.0408369
ADM adrenomedullin 0.0394588
MKI67 marker of proliferation Ki-67 0.0391951
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0389702
UBA6 ubiquitin-like modifier activating enzyme 6 0.0387621
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0381954
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0374567
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0371746
B2M beta-2-microglobulin 0.0366443
MT2A metallothionein 2A 0.0362465
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0354897
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0354833
TPM3 tropomyosin 3 0.0352831
RND3 Rho family GTPase 3 0.0350153
COG5 component of oligomeric golgi complex 5 0.034367
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0337362
RPL3 ribosomal protein L3 0.0334301
APLP2 amyloid beta (A4) precursor-like protein 2 0.0328553
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0326792
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0322715
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0321794
EFNA5 ephrin-A5 0.0321388
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0319695
PGM3 phosphoglucomutase 3 0.0319283
HLA-E major histocompatibility complex, class I, E 0.0318028
RPSA ribosomal protein SA 0.0316418
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0310931
LOXL2 lysyl oxidase-like 2 0.0310475
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0304873
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298686
GOLGA4 golgin A4 0.0297591
PALM2AKAP2 PALM2 and AKAP2 fusion 0.029744
BRD2 bromodomain containing 2 0.0296072
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0290772
PICALM phosphatidylinositol binding clathrin assembly protein 0.0290483
GPC6 glypican 6 0.0287943
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0287044
IGFBP7 insulin-like growth factor binding protein 7 0.0286047
ERRFI1 ERBB receptor feedback inhibitor 1 0.028313
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0281401
IL6 interleukin 6 0.0280995
WDFY1 WD repeat and FYVE domain containing 1 0.0279803
SNX9 sorting nexin 9 0.0275102
MYO10 myosin X 0.0270281
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0269236
IRAK2 interleukin-1 receptor-associated kinase 2 0.0268678
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0267433
SND1 staphylococcal nuclease and tudor domain containing 1 0.0266411
APP amyloid beta (A4) precursor protein 0.0264297
NFE2L1 nuclear factor, erythroid 2-like 1 0.0260935
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0260797
IQGAP1 IQ motif containing GTPase activating protein 1 0.0260158
MBNL1 muscleblind-like splicing regulator 1 0.0259309
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0258242
GOLGB1 golgin B1 0.0254383
GADD45B growth arrest and DNA-damage-inducible, beta 0.0252892
KTN1 kinectin 1 (kinesin receptor) 0.0252355
KDM2A lysine (K)-specific demethylase 2A 0.0251661
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0250535
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0247426
SOX9 SRY (sex determining region Y)-box 9 0.0246825
CD59 CD59 molecule, complement regulatory protein 0.0246723
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0246592
AHI1 Abelson helper integration site 1 0.0245276
TGM2 transglutaminase 2 0.02442
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0243924
TMF1 TATA element modulatory factor 1 0.0243438
DIAPH1 diaphanous-related formin 1 0.0241031
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240699
ACTN1 actinin, alpha 1 0.0238409
MYADM myeloid-associated differentiation marker 0.0238084
KLHL29 kelch-like family member 29 0.0235008

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.26184
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110344
CADM1 cell adhesion molecule 1 -0.108375
MARCKS myristoylated alanine-rich protein kinase C substrate -0.105255
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.10411
GLIS3 GLIS family zinc finger 3 -0.102074
DST dystonin -0.100299
FTL ferritin, light polypeptide -0.0937608
ZMYND8 zinc finger, MYND-type containing 8 -0.0890186
IER3 immediate early response 3 -0.0838083
TPT1 tumor protein, translationally-controlled 1 -0.0745981
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0610797
AHNAK AHNAK nucleoprotein -0.0602638
RAI14 retinoic acid induced 14 -0.0585176
COL6A3 collagen, type VI, alpha 3 -0.0580977
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0576611
TMSB10 thymosin beta 10 -0.0570046
ACTG1 actin gamma 1 -0.0566887
SLC35F3 solute carrier family 35, member F3 -0.0554352
FN1 fibronectin 1 -0.0541024
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.053566
EXT1 exostosin glycosyltransferase 1 -0.0535061
PSD3 pleckstrin and Sec7 domain containing 3 -0.0496437
PLIN2 perilipin 2 -0.0472042
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0462156
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.045756
ENO1 enolase 1, (alpha) -0.0447943
CCBE1 collagen and calcium binding EGF domains 1 -0.0447152
BASP1 brain abundant, membrane attached signal protein 1 -0.0432028
HMGA2 high mobility group AT-hook 2 -0.0423712
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0421127
WSB1 WD repeat and SOCS box containing 1 -0.0404367
SOD2 superoxide dismutase 2, mitochondrial -0.0403436
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0402753
WFDC10B WAP four-disulfide core domain 10B -0.0400636
COL1A1 collagen, type I, alpha 1 -0.039554
BICC1 BicC family RNA binding protein 1 -0.0390161
RPL37A ribosomal protein L37a -0.0375088
HLA-B major histocompatibility complex, class I, B -0.0373963
PTPRK protein tyrosine phosphatase, receptor type, K -0.037342
RPL11 ribosomal protein L11 -0.0372342
COL8A1 collagen, type VIII, alpha 1 -0.0364493
MYOF myoferlin -0.036352
RPL35A ribosomal protein L35a -0.0359306
PGK1 phosphoglycerate kinase 1 -0.0358254
TRIO trio Rho guanine nucleotide exchange factor -0.0347732
RPS23 ribosomal protein S23 -0.033533
SLC38A2 solute carrier family 38, member 2 -0.0334487
NRN1 neuritin 1 -0.0333568
VCL vinculin -0.0332629
NABP1 nucleic acid binding protein 1 -0.0331111
RPL38 ribosomal protein L38 -0.0330704
NCKAP5 NCK-associated protein 5 -0.032954
KDM5B lysine (K)-specific demethylase 5B -0.0327623
RRBP1 ribosome binding protein 1 -0.0327166
SFRP1 secreted frizzled-related protein 1 -0.0326596
PNISR PNN-interacting serine/arginine-rich protein -0.0322882
DIAPH2 diaphanous-related formin 2 -0.0319473
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0318489
RPS24 ribosomal protein S24 -0.0316406
FBXO32 F-box protein 32 -0.0313113
GLIPR1 GLI pathogenesis-related 1 -0.0310103
CAVIN1 caveolae associated protein 1 -0.0309259
WTAP Wilms tumor 1 associated protein -0.0308118
KRT19 keratin 19, type I -0.0304896
LOX lysyl oxidase -0.0298151
CUL4B cullin 4B -0.0297394
DLG1 discs, large homolog 1 (Drosophila) -0.0294673
NF1 neurofibromin 1 -0.0291324
LMNA lamin A/C -0.0289034
DTNA dystrobrevin, alpha -0.0280581
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0280347
TENM2 teneurin transmembrane protein 2 -0.0274755
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0274182
LSAMP limbic system-associated membrane protein -0.0264357
RAB7A RAB7A, member RAS oncogene family -0.0263518
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0259901
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0258788
TULP4 tubby like protein 4 -0.025787
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.025701
BABAM2 BRISC and BRCA1 A complex member 2 -0.0256207
RBM39 RNA binding motif protein 39 -0.0255958
PALLD palladin, cytoskeletal associated protein -0.0255944
FRMD5 FERM domain containing 5 -0.0255385
FAM20C family with sequence similarity 20, member C -0.0253498
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0251879
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0251415
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0250789
TNNC1 troponin C type 1 (slow) -0.0249817
RPL9 ribosomal protein L9 -0.0249631
BBX bobby sox homolog (Drosophila) -0.0249053
SDK1 sidekick cell adhesion molecule 1 -0.0248291
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0247081
ABHD12 abhydrolase domain containing 12 -0.0247009
MYLK myosin light chain kinase -0.0244451
GNAS GNAS complex locus -0.024338
INTS6 integrator complex subunit 6 -0.0243258
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0242713
KLF7 Kruppel-like factor 7 (ubiquitous) -0.024076
LOC112694756 uncharaterized LOC112694756 -0.0239905