JAK1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description Janus kinase 1|Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3716)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_JAK1
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Genes

32 co-expressed genes for JAK1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABHD17A abhydrolase domain containing 17A
ADGRE5 adhesion G protein-coupled receptor E5
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
BIN2 bridging integrator 2
BTN3A3 butyrophilin, subfamily 3, member A3
CD247 CD247 molecule
CLEC2B C-type lectin domain family 2, member B
CTSW cathepsin W
CYTH1 cytohesin 1
CYTIP cytohesin 1 interacting protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GPR65 G protein-coupled receptor 65
GSAP gamma-secretase activating protein
HLA-E major histocompatibility complex, class I, E
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK1 Janus kinase 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
NCR3 natural cytotoxicity triggering receptor 3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKCH protein kinase C, eta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB29 RAB29, member RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SNRK SNF related kinase
STK10 serine/threonine kinase 10
STK38 serine/threonine kinase 38
SUN2 Sad1 and UNC84 domain containing 2