JAK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Janus kinase 2|This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3717)
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Genes

343 genes differentially expressed following the JAK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FPR2 formyl peptide receptor 2 2.61152
UCN urocortin 2.61152
GNLY granulysin 2.61152
CELF3 CUGBP, Elav-like family member 3 2.61152
PGAM4 phosphoglycerate mutase family member 4 2.61152
TRIM15 tripartite motif containing 15 2.61152
CD160 CD160 molecule 2.61152
PDYN prodynorphin 2.61152
GPR151 G protein-coupled receptor 151 2.61152
SSTR1 somatostatin receptor 1 2.61152
PNMA5 paraneoplastic Ma antigen family member 5 2.61152
MAP3K7CL MAP3K7 C-terminal like 2.61152
EQTN equatorin, sperm acrosome associated 2.61152
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.61152
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.61152
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.61152
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.61152
TAS2R5 taste receptor, type 2, member 5 2.61152
PRLHR prolactin releasing hormone receptor 2.61152
CFHR3 complement factor H-related 3 2.61152
GJA4 gap junction protein, alpha 4, 37kDa 2.61152
CCDC112 coiled-coil domain containing 112 2.61152
TMPRSS11F transmembrane protease, serine 11F 2.61152
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.61152
PCDHGB3 protocadherin gamma subfamily B, 3 2.61152
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.61152
CLEC19A C-type lectin domain family 19, member A 2.61152
APOBR apolipoprotein B receptor 2.61152
FABP12 fatty acid binding protein 12 2.61152
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.61152
SP6 Sp6 transcription factor 2.61152
HMX3 H6 family homeobox 3 2.61152
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.61152
OIT3 oncoprotein induced transcript 3 2.61152
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.61152
NWD2 NACHT and WD repeat domain containing 2 2.61152
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.61152
TDRD9 tudor domain containing 9 2.61152
JDP2 Jun dimerization protein 2 2.61152
SFTPB surfactant protein B 2.61152
CSH2 chorionic somatomammotropin hormone 2 2.61152
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.61152
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.61152
PAX4 paired box 4 2.61152
PRL prolactin 2.61152
ASB12 ankyrin repeat and SOCS box containing 12 2.61152
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 2.61152
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.61152
TNIP3 TNFAIP3 interacting protein 3 2.61152
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.61152
ZNF765 zinc finger protein 765 2.61152
SPMIP10 sperm microtubule inner protein 10 2.61152
YIPF7 Yip1 domain family, member 7 2.61152
DUSP2 dual specificity phosphatase 2 2.61152
DUSP8 dual specificity phosphatase 8 2.61152
FMO1 flavin containing monooxygenase 1 2.61152
FOXN4 forkhead box N4 2.61152
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.61152
SMLR1 small leucine-rich protein 1 2.61152
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.61152
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.61152
ASB9 ankyrin repeat and SOCS box containing 9 2.61152
YPEL4 yippee-like 4 (Drosophila) 2.61152
OTOF otoferlin 2.61152
GIPC3 GIPC PDZ domain containing family, member 3 2.61152
CIMIP7 ciliary microtubule inner protein 7 2.61152
CPNE8-AS1 CPNE8 antisense RNA 1 2.61152
REELD1 reeler domain containing 1 2.61152
NHERF4 NHERF family PDZ scaffold protein 4 2.61152
CTXND1 cortexin domain containing 1 2.61152
GLYATL1B glycine-N-acyltransferase like 1B 2.61152
CCDC190 coiled-coil domain containing 190 2.61152
CALHM5 calcium homeostasis modulator family member 5 2.61152
H3-5 H3.5 histone 2.61152
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.61152
DOK7 docking protein 7 2.61152
GPR37L1 G protein-coupled receptor 37 like 1 2.61152
AATF apoptosis antagonizing transcription factor 2.61152
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.61152
SLAMF6 SLAM family member 6 2.61152
RNF113B ring finger protein 113B 2.61152
PRKCE protein kinase C, epsilon 2.61152
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.61152
MEOX1 mesenchyme homeobox 1 2.61152
SCN10A sodium channel, voltage gated, type X alpha subunit 2.61152
PTGDR2 prostaglandin D2 receptor 2 2.61152
MTNR1B melatonin receptor 1B 2.61152
PCDHA3 protocadherin alpha 3 2.61152
C1QL3 complement component 1, q subcomponent-like 3 2.61152
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.61152
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.61152
ZNF705B zinc finger protein 705B 2.61152
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.61152
PRG4 proteoglycan 4 2.61152
WNT9B wingless-type MMTV integration site family, member 9B 2.61152
OPN4 opsin 4 2.61152
OR10K1 olfactory receptor, family 10, subfamily K, member 1 2.61152
CELA2A chymotrypsin-like elastase family, member 2A 2.61152
CLDN22 claudin 22 2.61152
GJD4 gap junction protein, delta 4, 40.1kDa 2.61152
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.61152
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.61152
PALMD palmdelphin 2.61152
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.61152
CPA4 carboxypeptidase A4 2.61152
IGIP IgA-inducing protein 2.61152
MEFV Mediterranean fever 2.61152
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.61152
RANBP3L RAN binding protein 3-like 2.61152
NKX6-2 NK6 homeobox 2 2.61152
MYLK2 myosin light chain kinase 2 2.61152
C2CD4A C2 calcium-dependent domain containing 4A 2.61152
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.61152
INSL4 insulin-like 4 (placenta) 2.61152
CTF1 cardiotrophin 1 2.61152
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.61152
ERICH3 glutamate-rich 3 2.61152
THBD thrombomodulin 2.61152
TMED6 transmembrane emp24 protein transport domain containing 6 2.61152
HCRT hypocretin (orexin) neuropeptide precursor 2.61152
CLRN2 clarin 2 2.61152
SPATA31E1 SPATA31 subfamily E, member 1 2.61152
ANKRD65 ankyrin repeat domain 65 2.61152
BAHCC1 BAH domain and coiled-coil containing 1 2.61152
CSDC2 cold shock domain containing C2, RNA binding 2.61152
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.61152
UTS2B urotensin 2B 2.61152
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.61152
GOLGA6A golgin A6 family, member A 2.61152
PIP prolactin-induced protein 2.61152
TPPP2 tubulin polymerization-promoting protein family member 2 2.61152
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.61152
SLC36A3 solute carrier family 36, member 3 2.61152
SIGLEC11 sialic acid binding Ig-like lectin 11 2.61152
ZFP92 ZFP92 zinc finger protein 2.61152
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.61152
WNT7B wingless-type MMTV integration site family, member 7B 2.61152
LMOD2 leiomodin 2 (cardiac) 2.61152
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.61152
FADD Fas (TNFRSF6)-associated via death domain 2.61152
SOSTDC1 sclerostin domain containing 1 2.61152
OTOP2 otopetrin 2 2.61152
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.61152
RAB40AL RAB40A, member RAS oncogene family-like 2.61152
CATIP ciliogenesis associated TTC17 interacting protein 2.61152
GSTA2 glutathione S-transferase alpha 2 2.61152
ACRBP acrosin binding protein 2.61152
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.61152
ZNF534 zinc finger protein 534 2.61152
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.61152
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.61152
POTEF POTE ankyrin domain family, member F 2.61152
LMX1A LIM homeobox transcription factor 1, alpha 2.61152
ACAD11 acyl-CoA dehydrogenase family, member 11 2.61152
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.61152
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.61152
RBBP8NL RBBP8 N-terminal like 2.61152
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.61152
CCDC87 coiled-coil domain containing 87 2.61152
EBI3 Epstein-Barr virus induced 3 2.61152
SPDEF SAM pointed domain containing ETS transcription factor 2.61152
IRX4 iroquois homeobox 4 2.61152
GPR179 G protein-coupled receptor 179 2.61152
PADI1 peptidyl arginine deiminase, type I 2.61152
TMPRSS13 transmembrane protease, serine 13 2.61152
CCNO cyclin O 2.61152
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.61152
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.61152
CPO carboxypeptidase O 2.61152
CLPS colipase, pancreatic 2.61152
ERMN ermin, ERM-like protein 2.61152
TSPEAR thrombospondin-type laminin G domain and EAR repeats 2.61152
TBPL2 TATA box binding protein like 2 2.61152
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.61152
TYR tyrosinase 2.61152
KRT3 keratin 3, type II 2.61152
IL17REL interleukin 17 receptor E-like 2.61152
MAGEA2B melanoma antigen family A2B 2.61152
ZMYND15 zinc finger, MYND-type containing 15 2.61152
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.61152
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.61152
ECM1 extracellular matrix protein 1 2.61152
NRP2 neuropilin 2 2.59215
CPEB2 cytoplasmic polyadenylation element binding protein 2 2.59215
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.56718
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2.5602
ZNF629 zinc finger protein 629 2.55369
CCDC197 coiled-coil domain containing 197 2.54529
PDS5B PDS5 cohesin associated factor B 2.54141
BUD31 BUD31 homolog (S. cerevisiae) 2.48262
TEX11 testis expressed 11 2.42541
SLC49A3 solute carrier family 49 member 3 2.40852
SMTNL1 smoothelin-like 1 2.39547
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.30862
ESYT3 extended synaptotagmin-like protein 3 2.29335
FNBP4 formin binding protein 4 2.28006
UTRN utrophin 2.27538
CIZ1 CDKN1A interacting zinc finger protein 1 2.27204
RABL6 RAB, member RAS oncogene family-like 6 2.26207
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.21049
RETREG2 reticulophagy regulator family member 2 2.20916
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 2.20916
SMIM10L2B small integral membrane protein 10 like 2B 2.19689
TLE3 transducin-like enhancer of split 3 2.19511
HMGB3 high mobility group box 3 2.19021
RBM26 RNA binding motif protein 26 2.18255
PMPCA peptidase (mitochondrial processing) alpha 2.17023
SCRIB scribbled planar cell polarity protein 2.13661
VSIG1 V-set and immunoglobulin domain containing 1 2.12548
RNF216 ring finger protein 216 2.12548
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.12548
CUL2 cullin 2 2.12548
FBXO48 F-box protein 48 2.12548
CIAO1 cytosolic iron-sulfur assembly component 1 2.11522
OLFM2 olfactomedin 2 2.09637
LRRC75A leucine rich repeat containing 75A 2.09462
CD63 CD63 molecule 2.08986
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 2.08042
BOD1 biorientation of chromosomes in cell division 1 2.07205
TENM1 teneurin transmembrane protein 1 2.06861
CALR calreticulin 2.06486
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.06486
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.05873
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.05873
TTLL1 tubulin tyrosine ligase-like family member 1 2.0413
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.02718
ARHGAP4 Rho GTPase activating protein 4 2.02112
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 2.01795
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.00883

decreased expression

Symbol Name Standardized Value
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.61152
ZNF843 zinc finger protein 843 -2.61152
NCAPH2 non-SMC condensin II complex, subunit H2 -2.61152
GLIS1 GLIS family zinc finger 1 -2.61152
ZNF25 zinc finger protein 25 -2.61152
TMEM131 transmembrane protein 131 -2.61152
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.61152
CRLF2 cytokine receptor-like factor 2 -2.61152
CASS4 Cas scaffolding protein family member 4 -2.61152
TMEM229B transmembrane protein 229B -2.61152
MFSD6L major facilitator superfamily domain containing 6-like -2.61152
TMEM175 transmembrane protein 175 -2.61152
PSD4 pleckstrin and Sec7 domain containing 4 -2.61152
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.61152
ZFYVE16 zinc finger, FYVE domain containing 16 -2.61152
CFAP119 cilia and flagella associated protein 119 -2.61152
DPRX divergent-paired related homeobox -2.61152
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -2.61152
CAPN2 calpain 2, (m/II) large subunit -2.61152
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.61152
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.61152
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.59935
DGLUCY D-glutamate cyclase -2.59774
PRICKLE3 prickle homolog 3 (Drosophila) -2.59285
ZNF98 zinc finger protein 98 -2.59215
LTF lactotransferrin -2.59215
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -2.59215
CLCF1 cardiotrophin-like cytokine factor 1 -2.59215
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.59215
FGF7 fibroblast growth factor 7 -2.59215
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.59215
KIF1C-AS1 KIF1C antisense RNA 1 -2.59215
ADAMTSL2 ADAMTS-like 2 -2.59215
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.59215
ALDOB aldolase B, fructose-bisphosphate -2.59215
AKR1C1 aldo-keto reductase family 1, member C1 -2.59215
MOSPD2 motile sperm domain containing 2 -2.59215
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.59215
PROB1 proline-rich basic protein 1 -2.59215
PRRT4 proline-rich transmembrane protein 4 -2.59215
PCDHA6 protocadherin alpha 6 -2.59215
UMOD uromodulin -2.59215
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.59215
OR6B1 olfactory receptor, family 6, subfamily B, member 1 -2.59215
NTSR1 neurotensin receptor 1 (high affinity) -2.59215
CPZ carboxypeptidase Z -2.59215
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.59215
PCDHGB7 protocadherin gamma subfamily B, 7 -2.59215
MAB21L3 mab-21-like 3 (C. elegans) -2.59215
TMEM31 transmembrane protein 31 -2.59215
TMEM255A transmembrane protein 255A -2.59215
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.59215
CLCNKA chloride channel, voltage-sensitive Ka -2.59215
HKDC1 hexokinase domain containing 1 -2.59215
CISH cytokine inducible SH2-containing protein -2.59215
TMEM215 transmembrane protein 215 -2.59215
GPR171 G protein-coupled receptor 171 -2.59215
AGBL2 ATP/GTP binding protein-like 2 -2.53605
TFCP2 transcription factor CP2 -2.49105
ATG12 autophagy related 12 -2.48024
DSCAML1 Down syndrome cell adhesion molecule like 1 -2.47732
ETV1 ets variant 1 -2.47732
MED22 mediator complex subunit 22 -2.47255
MDC1 mediator of DNA-damage checkpoint 1 -2.47019
MON1A MON1 secretory trafficking family member A -2.46997
FUS FUS RNA binding protein -2.46569
KIFC2 kinesin family member C2 -2.46508
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.44971
ACSM3 acyl-CoA synthetase medium-chain family member 3 -2.44971
ZNF253 zinc finger protein 253 -2.42023
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -2.41563
NPIPB2 nuclear pore complex interacting protein family member B2 -2.40296
AMPD3 adenosine monophosphate deaminase 3 -2.39265
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.33423
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -2.32741
DGCR8 DGCR8 microprocessor complex subunit -2.32451
PEX13 peroxisomal biogenesis factor 13 -2.31169
FOXM1 forkhead box M1 -2.30245
APLF aprataxin and PNKP like factor -2.27941
LRRC37B leucine rich repeat containing 37B -2.27204
GHR growth hormone receptor -2.2713
STAT5B signal transducer and activator of transcription 5B -2.25639
MAPK1 mitogen-activated protein kinase 1 -2.24928
CTTN cortactin -2.24928
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -2.24751
MSS51 MSS51 mitochondrial translational activator -2.24751
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.23173
MCOLN3 mucolipin 3 -2.23173
SFMBT2 Scm-like with four mbt domains 2 -2.1987
AXIN1 axin 1 -2.19375
BRCA1 breast cancer 1, early onset -2.17357
GFOD2 glucose-fructose oxidoreductase domain containing 2 -2.1687
MRNIP MRN complex interacting protein -2.15566
UBAP2 ubiquitin associated protein 2 -2.15566
UNK unkempt family zinc finger -2.14738
UST uronyl-2-sulfotransferase -2.12548
ADIRF adipogenesis regulatory factor -2.11741
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -2.11741
ARMCX6 armadillo repeat containing, X-linked 6 -2.11078
HCST hematopoietic cell signal transducer -2.11078
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.11077
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.09637
RAI1 retinoic acid induced 1 -2.08135
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 -2.08135
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.08135
ERF Ets2 repressor factor -2.07704
PMEL premelanosome protein -2.06861
MCAM melanoma cell adhesion molecule -2.05873
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) -2.05409
FCHSD2 FCH and double SH3 domains 2 -2.0413
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -2.03753
ZNF678 zinc finger protein 678 -2.03567
FBRSL1 fibrosin-like 1 -2.01747
GOLGA5 golgin A5 -2.01747